Pancreatic islet sero bundu

Pancreatic islet cell tumor ibundu risinganzwisisike repancreas iro rinotanga kubva parudzi rwechitokisi chinonzi islet cell.

MuPancreas ine hutano, masero anonzi islet maseru anogadzira mahormone anodzora mashandiro emuviri akawanda. Izvi zvinosanganisira huwandu hweshuga yeropa uye kugadzirwa kwemudumbu acid.

Mamota anomuka kubva kune islet maseru epancreas anogona zvakare kuburitsa akasiyana mahormone, ayo anogona kutungamira kune chaiwo zviratidzo.

Pancreatic islet maseru mamota anogona kunge asiri enancer (benign) kana cancer (yakaipa).

Islet maseru mamota anosanganisira:

• Gastrinoma (Zollinger-Ellison chirwere)
• Glucagonoma
• Insulinoma
• Somatostatinoma
  
• VIPoma (Verner-Morrison chirwere)

Nhoroondo yemhuri yeakawanda endocrine neoplasia, mhando I (MEN I) ndiyo njodzi yekukudziridzwa kweslet cell tumors.

Zviratidzo zvinoenderana nekuti ihormone inogadzirwa nei nebundu.

Semuenzaniso, insulinomas inogadzira insulin, iyo inoderedza huwandu hweshuga yeropa. Zviratidzo zvinogona kusanganisira:

• Kunzwa kuneta kana kupera simba
• Kubvunda kana kudikitira
• Kutemwa nemusoro
• Nzara
• Kutya, kushushikana, kana kunzwa kushatirwa
• Kufunga kusina kujeka kana kunzwa kusagadzikana
• Kaviri kana kujeka kuona
• Kurumidza kana kurova kurova kwemoyo

Kana shuga yako yeropa ikadzika zvakanyanya, unogona kufenda, kubatwa nepfari, kana kutopinda pakoma.

Gastrinomas inogadzira iyo hormone gastrin, iyo inotaurira muviri kuti uite mudumbu acid. Zviratidzo zvinogona kusanganisira:

• Marwadzo emudumbu
• Manyoka
• Maronda mudumbu uye mudumbu mudiki
• Kusvipa ropa (pano neapo)

Glucagonomas inogadzira iyo hormone glucagon, iyo inobatsira muviri kusimudza huwandu hweshuga yeropa. Zviratidzo zvinogona kusanganisira:

• Chirwere cheshuga
• Dzvuku, blistery rash mune iyo groin kana magaro
• Kuonda
• Kakawanda kuita weti uye nyota

Somatostatinomas inogadzira iyo hormone somatostatin. Zviratidzo zvinogona kusanganisira:

• Yakakwira ropa shuga
• Matombo
• Chitarisiko cheyero paganda, uye maziso
• Kuonda
• Manyoka ane tsvina inosvipa zvituru

VIPomas inogadzira iyo hormone vasoactive intestinal peptide (VIP) iyo inosanganisirwa mukuchengetedza mwero wemunyu, sodium, potasium uye zvimwe zvicherwa mune iyo GI turakiti. VIPomas inogona kukonzera:

• Manyoka akakura anogona kutungamira mukushaya mvura mumuviri
• Yakaderera ropa potasiamu mazinga, uye yakakwira calcium mazinga
• Dumbu rinorwadza
• Kuonda

Anokuchengetedza hutano anotora nhoroondo yako yekurapa uye oongorora bvunzo.

Kuongororwa kweropa kunogona kusiyana, zvichienderana nezviratidzo, asi kunogona kusanganisira:

• Kutsanya glucose level
• Chikamu cheGastrin
• Glucose kubvumidza bvunzo
• Secretin inosimudzira bvunzo yepancreas
• Ropa glucagon level
• Ropa insulin C-peptide
• Ropa insulin mwero
• Kutsanya serum somatostatin nhanho
• Serum vasoactive mudumbu peptide (VIP) nhanho

Kufungidzira bvunzo kunogona kuitwa:

• Abdominal CT scan
• Abdominal ultrasound
• Endoscopic Ultrasound
• MRI yemudumbu

Muenzaniso weropa unogona zvakare kutorwa kubva mutsinga iri mupancreas yekuyedzwa.

Dzimwe nguva, kuvhiyiwa kunodiwa kuti uongorore uye ubate iyi mamiriro. Munguva iyi maitiro, chiremba anovhiya anoongorora pancreas neruoko uye ne ultrasound.

Kurapa kunoenderana nerudzi rwebundu uye kana iri cancer.

Mamota ane kenza anogona kukura nekukurumidza uye kupararira kune dzimwe nhengo. Vanogona kunge vasingarapike. Mamota anowanzo bviswa nekuvhiya, kana zvichibvira.

Kana masero ekenza akapararira kuchiropa, chikamu chechiropa chinogonawo kubviswa, kana zvichibvira. Kana kenza yapararira, chemotherapy inogona kushandiswa kuyedza kudzikamisa mamota.

Kana kugadzirwa kusingaenzaniswi kwemahormone kuri kukonzera zviratidzo, unogona kugamuchira mishonga yekurwisa mhedzisiro yavo. Semuenzaniso, ine gastrinomas, kuwanda kweiyo gastrin inotungamira kune yakawandisa acid mudumbu. Mishonga inovhara dumbu acid kuburitsa inogona kudzikisa zviratidzo.

Unogona kudzikisira kushushikana kwehurwere nekujoinha boka rekutsigira gomarara. Kugovana nevamwe vane zvakajairika zviitiko uye matambudziko zvinogona kukubatsira kuti usazonzwa kusurukirwa.

Unogona kurapwa kana bundu rikavhiyiwa risati rapararira kune dzimwe nhengo. Kana bundu riine cancer, chemotherapy inogona kushandiswa, asi kazhinji haigone kurapa vanhu.

Zvinetso zvinotyisidzira hupenyu (senge yakanyanya shuga yeropa) zvinogona kuitika nekuda kwekuwandisa kwehormone kugadzirwa, kana kana kenza ikapararira mumuviri wese.

Zvinetso zvemamota aya zvinosanganisira:

• Chirwere cheshuga
• Mahormone matambudziko (kana bundu rikaburitsa mamwe marudzi emahormone)
• Yakanyanya yakaderera ropa shuga (kubva ku insulinomas)
• Akakomba maronda mudumbu uye mudumbu ura (kubva gastrinomas)
• Kupararira kwebundu kusvika kuchiropa

Fonera mupi wako kana iwe ukava nezviratidzo zvemamota aya, kunyanya kana uine nhoroondo yemhuri yeVANHU I.

Iko hakuna kuzivikanwa kudzivirira kweaya mamota.

Kenza - chirwatata; Kenza - chirwatata; Kenza yepancreatic; Islet maseru mamota; Islet yeLangerhans bundu; Bundu reNeuroendocrine; Peptic ulcer - islet sero bundu; Hypoglycemia - islet sero bundu; Zollinger-Ellison chirwere; Verner-Morrison chirwere; Gastrinoma; Insulinoma; VIPoma; Somatostatinoma; Glucagonoma

• Endocrine masero
• Pancreas

Foster DS, Norton JA. Manejimendi epancreatic islet maseru mamota kusanganisa gastrinoma. Mune: Cameron AM, Cameron JL, eds. Parizvino Kuvhiya Therapy. 13 ed. Philadelphia, PA: Elsevier; 2020: 581-584.

National Cancer Institute webhusaiti. Pancreatic cancer cancer (PDQ) - hutano nyanzvi vhezheni. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Yakagadziridzwa Ndira 2, 2020. Yakasvika muna Kukadzi 25, 2020.

National Yakakwana Cancer Network webhusaiti. NCCN kiriniki yekudzidzira nhungamiro mune oncology (NCCN nhungamiro). Neuroendocrine uye adrenal mamota. Shanduro 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Yakagadziridzwa Kurume 5, 2019. Yakasvika muna Kukadzi 25, 2020.

National Yakakwana Cancer Network webhusaiti. NCCN nhungamiro yevarwere. Neuroendocrine mamota. 2018. www.nccn.org/patients/guidelines/content/PDF/neuroendocrine-patient.pdf.