Glucose-6-phosphate dehydrogenase kushomeka

Glucose-6-phosphate dehydrogenase (G6PD) kushomeka mamiriro ayo masero matsvuku eropa anodonha kana muviri uchinge waoneswa kune mamwe madhiragi kana kushungurudzika kwehutachiona. Iyo inhaka, zvinoreva kuti inopfuudzwa mumhuri.

Kushomeka kweG6PD kunoitika kana munhu akashaya kana asina kukwana enzyme inonzi glucose-6-phosphate dehydrogenase. Iyi enzyme inobatsira masero matsvuku eropa kushanda nemazvo.

Zvishoma G6PD inotungamira mukuparadzwa kwemasero matsvuku eropa. Izvi zvinonzi hemolysis. Kana maitiro aya achinyatso kuitika, inonzi hemolytic episode. Zvikamu zvacho zvinowanzo kuve zvipfupi. Izvi zvinodaro nekuti muviri unoramba uchigadzira maseru matsvuku eropa, ayo ane chiitiko chakajairika.

Tsvuku tsvuku yeropa kuparadzwa kunogona kukonzerwa nezvirwere, zvimwe zvekudya (senge fava bhinzi), uye mimwe mishonga, inosanganisira:

• Antimalarial mishonga yakadai sequinine
• Aspirin (yakakwira mizinga)
• Nonsteroidal anti-anogumbura zvinodhaka (NSAIDs)
• Quinidine
• Sulfa zvinodhaka
• Mishonga inorwisa mabhakitiriya yakadai sequinolones, nitrofurantoin
  

Mamwe makemikari, akadai seaya ari mumothballs, anogona zvakare kukonzera episode.

MuUnited States, kushomeka kweG6PD kunowanzoitika pakati pevatema kupfuura vachena. Varume vane mikana yekuva nedambudziko iri kupfuura vakadzi.

Iwe uri mukana wekuvandudza mamiriro aya kana iwe:

• Ndo African American
• Ivo veMiddle East vakadzikama, kunyanya Kurdish kana Sephardic Jewish
• Vari murume
• Iva nenhoroondo yemhuri yekushomeka

Chimiro chechirwere ichi chinowanzoitika kuvachena veMediterranean. Iyi fomu inosanganiswawo neakanyanya episodes yehemolysis. Zvikamu zvakareba uye zvakanyanya kuomarara kupfuura mune mamwe marudzi echirwere.

Vanhu vane chirwere ichi havaratidze chero zviratidzo zvechirwere kudzamara masero matsvuku eropa aonekwa kune mamwe makemikari mune chikafu kana mushonga.

Zviratidzo zvinowanzoitika muvarume uye zvinogona kusanganisira:

• Weti yakasviba
• Kupindwa nechando
• Marwadzo mudumbu
• Yakawedzera spleen uye chiropa
• Kuneta
• Pallor
• Kukurumidza kurova kwemoyo
• Kufema kwekufema
• Yeruvara rweganda (jaundice)

Kuongororwa kweropa kunogona kuitwa kuti uone huwandu hweG6PD.

Mimwe bvunzo inogona kuitwa inosanganisira:

• Chikamu cheBilirubin
• Yakazara kuverenga ropa
• Hemoglobin - weti
• Haptoglobin chikamu
• LDH bvunzo
• Methemoglobin yekuderedza bvunzo
• Reticulocyte kuverenga

Kurapa kunogona kusanganisira:

• Mishonga yekurapa hutachiona, kana iripo
• Kumisa chero mishonga iri kukonzeresa kutsvuka kwesero reropa
• Kuwedzerwa, mune dzimwe nguva

Muzviitiko zvakawanda, zvikamu zvehemolytic zvinoenda zvavo.

Mune zvisingawanzoitika kesi, itsvo kutadza kana kufa kunogona kuitika zvichitevera chiitiko chakakomba chehemolytic.

Fonera wako mupi wezvehutano kana iwe uine zviratidzo zveichi chiitiko.

Fonera mupiki wako kana iwe uchinge waonekwa uine G6PD kushomeka uye zviratidzo hazvinyangarika mushure mekurapwa.

Vanhu vane kushomeka kweG6PD vanofanirwa kunyatsodzivirira zvinhu zvinogona kukonzera episode. Taura nemupi wako nezve yako mishonga.

Genetic kuraira kana kuyedzwa kunogona kuwanikwa kune avo vane nhoroondo yemhuri yemamiriro acho.

G6PD kushomeka; Hemolytic anemia nekuda kwekushomeka kweG6PD; Anemia - hemolytic nekuda kwekushomeka kweG6PD

• Masero eropa

Gregg XT, Prchal JT. Tsvuku dzeropa masero enzymopathies. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chitsiko 44.

Lissauer T, Carroll W. Haematological matambudziko. Mune: Lissauer T, Carroll W, eds. Yakafananidzirwa Rugwaro rwePaediatrics. 5 ed. Philadelphia, PA: Elsevier; 2018: chits. 23.

Michel M. Autoimmune uye intravascular hemolytic anemias. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chits. 151.