Chinhu X kushomeka

Chinhu X (gumi) kushomeka chirwere chinokonzerwa nekushaikwa kweprotein inonzi factor X muropa. Inotungamira kumatambudziko nekugwamba kweropa (coagulation).

Paunobuda ropa, akateedzana maitiro anoitika mumuviri ayo anobatsira kuwanda kweropa fomu. Maitiro aya anonzi coagulation cascade. Inosanganisira mapuroteni akasarudzika anonzi coagulation, kana kugwamba, zvinhu. Unogona kuve nemukana wakakwirira wekubuda ropa zvakawandisa kana chimwe kana zvimwe zvezvinhu izvi zvisipo kana zvisiri kushanda sezvavanofanira.

Factor X ndechimwe chakadai coagulation chinhu. Chinhu X kushomeka kunowanzo kukonzerwa nehurema hwakagara nhaka muchinhu X geni. Izvi zvinonzi zvakagara nhaka chinhu X kushomeka. Kubuda ropa kunobva pane zvinyoro kusvika kune zvakanyanya zvichienderana nekuti kushomeka kwakanyanya sei.

Chinhu X kushomeka kunogona zvakare kuve nekuda kweimwe mamiriro kana kushandiswa kwemimwe mishonga. Izvi zvinonzi zvakawanikwa chinhu X kushomeka. Kuwana chinhu X kushomeka kwakajairika. Inogona kukonzerwa ne:

• Kushaya vhitamini K (vamwe vacheche vanozvarwa vaine kushomeka kwevhitamini K)
• Kuvaka kwemapuroteni asina kujairika mumatumbu uye nhengo (amyloidosis)
• Chirwere chakakomba chechiropa
• Kushandiswa kwemishonga inodzivirira kugwamba (anticoagulants senge warfarin)

Vakadzi vane chinoshomeka X vanokwanisa kutanga vaonekwa kana vaine ropa rinorema kwazvo rekuenda kumwedzi nekubuda ropa mushure mekusununguka. Mamiriro acho anogona kutanga kucherechedzwa muvakomana vachangozvarwa kana vane ropa rinogara kwenguva yakareba kupfuura zvakajairwa mushure mekudzingiswa.

Zviratidzo zvinogona kusanganisira chero zvinotevera:

• Kubuda ropa mumajoini
• Kubuda ropa mumhasuru
• Kutuka zviri nyore
• Kubuda kumwedzi kwakanyanya kubuda ropa
• Mucus membrane kubuda ropa
• Mhino dzemhino dzisingamire nyore
• Tambo yembilical ichibuda ropa mushure mekuzvarwa

Miedzo inogona kuitwa inosanganisira:

• Factor X kuyedza
• Yakasarudzika thromboplastin nguva (PTT)
• Prothrombin nguva (PT)

Kubuda ropa kunogona kudzorwa nekutora intravenous (IV) infusions yeplasma kana concentrate yezvinhu zvinogwamba. Kana iwe uchishaya vhitamini K, chiremba wako anokupa vhitamini K kuti iwe utore nemuromo, kuburikidza nemajekiseni pasi peganda, kana kuburikidza nemutsinga (mukati).

Kana iwe uine chirwere ichi chekubuda ropa, ita shuwa ku:

• Udza vanokupa hutano usati waita chero maitiro, kusanganisira kuvhiya uye basa remazino.
• Udza nhengo dzemhuri yako nekuti vanogona kunge vaine chirwere chakafanana asi havasati vazviziva.

Izvi zviwanikwa zvinokwanisa kupa rumwe ruzivo nezve kushomeka kwechinhu X:

• National Hemophilia Foundation: Zvimwe Kusakwana Kwezvinhu - www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies
• Sangano reNational reRare Disorders --rarediseases.org/rare-diseases/factor-x-deficiency
• NIH Genetics Kumba Referensi - ghr.nlm.nih.gov/condition/factor-x-deficiency

Mhedzisiro yacho yakanaka kana mamiriro acho ari munyoro kana iwe ukawana kurapwa.

Inhaka yechinhu X kushomeka mamiriro ehupenyu hwese.

Maonero echinhu chinowanikwa X kushomeka zvinoenderana nechikonzero. Kana iyo ichikonzerwa nechirwere chechiropa, mhedzisiro inoenderana nekuti chirwere chechiropa chako chinogona kurapwa sei. Kutora zvinowedzera vhitamini K kuchabata kushomeka kwevhitamini K. Kana kusagadzikana kuchikonzerwa neamyloidosis, pane nzira dzakasiyana dzekurapa. Chiremba wako anogona kukuudza zvakawanda.

Kubuda ropa kwakanyanya kana kurasikirwa kweropa kamwe kamwe (hemorrhage) kunogona kuitika. Majoini anogona kukanganisika muchirwere chakakomba kubva pakubuda ropa kwakawanda.

Wana rubatsiro rwekukurumidzira mune zvekurapa kana uine kurasikirwa kusinganzwisisike kana kwakanyanya kweropa.

Iko hakuna kuzivikanwa kudzivirira kwekugara nhaka chinhu X kushomeka. Kana kushomeka kwevhitamini K chiri chikonzero, kushandisa vhitamini K kunogona kubatsira.

Stuart-Prower kushomeka

• Ropa kugadzirwa
• Ropa rinovhara

Gailani D, Wheeler AP, Neff AT. Kazhinji coagulation factor kushaikwa. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chits. 137.

Horo JE. Hemostasis uye kuwanda kweropa. Mune: Horo JE, ed. Guyton uye Horo Chinyorwa cheMedhi Physiology. 13 ed. Philadelphia, PA: Elsevier; 2016: chits. 37.

Ragni MV. Hemorrhagic kusagadzikana: coagulation factor kushomeka. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits. 174.