Chisingaperi myelogenous leukemia (CML)

Chisingaperi myelogenous leukemia (CML) kenza inotanga mukati mefupa remongo. Iyi ndiyo nyama yakapfava iri pakati pemabhonzo inobatsira kuumba masero eropa ese.

CML inokonzeresa kukura kusingadzorwe kwemasero asina kusimba uye akakura anoita imwe mhando yesero reropa jena rinonzi myeloid masero. Maseru anorwara anovaka mumongo nemuropa.

Chikonzero cheCML chakabatana nechromosome isina kujairika inonzi chromosome yePhiladelphia.

Kuratidzika kwemwaranzi kunogona kuwedzera njodzi yekuvandudza CML. Kuratidzwa kwemwaranzi kunogona kubva pakurapwa nemwaranzi kwaishandiswa kare kurapa kenza yehutachiona kana Hodgkin lymphoma kana kubva kunjodzi yenyukireya.

Zvinotora makore mazhinji kukudziridza leukemia kubva pakuratidzwa nemwaranzi. Vazhinji vanhu vanorapwa kenza ine radiation havaite leukemia. Uye vanhu vazhinji vane CML havana kuburitswa nemwaranzi.

CML inowanzoitika muvakuru vezera repakati nepakati uye muvana.

Chisingaperi myelogenous leukemia yakaiswa muzvikamu:

• Chisingaperi
• Inokurumidza
• Blast dambudziko

Chikamu chisingaperi chinogona kutora kwemwedzi kana makore. Chirwere ichi chinogona kunge chine mashoma kana kusave nezviratidzo panguva ino. Vanhu vazhinji vanoonekwa panguva ino, kana vachinge vaongororwa ropa vakaitirwa zvimwe zvikonzero.

Iyo yekumhanyisa chikamu chikamu chinotyisa. Masero eleukemia anokura nekukurumidza. Zviratidzo zvakajairika zvinosanganisira kupisa muviri (kunyangwe pasina hutachiona), kurwadziwa kwepfupa, uye kuzvimba kwepleen.

Kusabatwa CML kunotungamira kune iyo blast dambudziko danho. Kubuda ropa uye hutachiona zvinogona kuitika nekuda kwekukanganisa kwemongo wemapfupa.

Zvimwe zviratidzo zvinogona kuitika zvekuputika dambudziko zvinosanganisira:

• Kutuka
• Kuwedzera kudikitira (husiku hweziya)
• Kuneta
• Kupindwa nechando
• Kumanikidza pasi pemabvu ezasi kuruboshwe kubva kuzvimba spleen
• Rash - madiki madiki anonongedza matsvuku paganda (petechiae)
• Kushaya simba

Kuongorora kwepanyama kunowanzo kuratidza kuputika kwepleen. Kuverenga kwakazara kweropa (CBC) kunoratidza kuwanda kwemasero machena eropa ane mafomu mazhinji asina kukura aripo uye kuwanda kwenhamba yemaplatelet. Izvi zvikamu zveropa zvinobatsira kuvhara ropa.

Mimwe bvunzo inogona kuitwa inosanganisira:

• Bone marora bhiopsy
• Ropa uye mapfupa emahora kuyedza kuvepo kweiyo Philadelphia chromosome
• Platelet kuverenga

Mishonga inotarisa iyo isina kujairika protein inogadzirwa nePhiladelphia chromosome kazhinji ndiyo yekurapa kwekutanga kweCML. Iyi mishonga inogona kutorwa semapiritsi. Vanhu vanorapwa nemishonga iyi vanowanzoenda mukuregererwa nekukurumidza uye vanogona kugara mukuregererwa kwemakore mazhinji.

Dzimwe nguva, chemotherapy inoshandiswa kutanga kudzora chena masero eropa kuverenga kana yakanyanya kukwirira pakuongororwa.

Iyo blast dambudziko danho rakanyanya kunetseka kurapa. Izvi zvinodaro nekuti kune huwandu hwakawanda kwazvo hwevasina kuchena masero eropa (masero eleukemia) asingagone kurapwa.

Mushonga unozivikanwa chete weCML ndeyekupfekedza mwongo wemapfupa, kana stem cell kuisirwa. Vanhu vazhinji, zvakadaro, havadi kuisirwa nekuti mishonga yakanangwa iri kubudirira. Kurukura zvaunogona kuita neconcologist wako.

Iwe nemupi wako wekuchengetwa kwehutano ungangoda kubata zvimwe zvakawanda zvinonetsa kana zvinonetsa panguva yako yekurapa chirwere cheleukemia, kusanganisira:

• Kugadzirisa zvipfuwo zvako panguva yekemotherapy
• Zvinetso zvekubuda ropa
• Kudya macalorie akakwana iwe uchirwara
• Kuzvimba uye kurwadziwa mumuromo mako
• Kudya zvakachengeteka panguva yekurapa gomarara

Unogona kudzikisira kushushikana kwehurwere nekujoinha boka rekutsigira gomarara. Kugovana nevamwe vane zvakajairika zviitiko uye matambudziko zvinogona kukubatsira kuti usazonzwa kusurukirwa.

Mishonga yakanangwa yakagadzirisa zvakanyanya maonero evanhu vane CML. Kana izvo zviratidzo nezviratidzo zveCML zvikaenda uye kuwanda kweropa uye pfupa remongo wemapfupa kunoratidzika kunge kwakajairika, munhu anoonekwa seregererwo. Vanhu vazhinji vanogona kuramba vachiregererwa kwemakore mazhinji vari pamushonga uyu.

Stem cell kana bone marrow kuisirwa inowanzo kutariswa kune vanhu vane chirwere chinodzoka kana kuwedzera kuipa pavanotora mishonga yekutanga. Kuisazve kunogona kukurudzirwa kune vanhu vanoonekwa muchikamu chinokurumidza kana dambudziko rekufema.

Blast dambudziko rinogona kutungamira kumatambudziko, kusanganisira hutachiona, kubuda ropa, kuneta, kusatsanangurika fivha, uye matambudziko eitsvo. Chemotherapy inogona kuve nemhedzisiro yakaipa, zvichienderana nemishonga inoshandiswa.

Dzivisa kusangana nemwaranzi pazvinogoneka.

CML; Chisingaperi myeloid leukemia; CGL; Chisingaperi granulocytic leukemia; Leukemia - isingagumi granulocytic

• Bone marrow kuisirwa - kubuda

• Bone marora kushuvira
• Chisingaperi myelocytic leukemia - microscopic maonero
• Chisingaperi myelocytic leukemia
• Chisingaperi myelocytic leukemia

Kantarjian H, Cortes J. Chisingaperi myeloid leukemia. Mune: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020: chap 98.

National Cancer Institute webhusaiti. Chisingaperi myelogenous leukemia kurapwa (PDQ) hutano nyanzvi vhezheni. www.cancer.gov/types/leukemia/hp/cml-treatment-pdq. Yakagadziridzwa Kukadzi 8, 2019. Yakasvika munaKurume 20, 2020.

National Yakakwana Cancer Network webhusaiti. NCCN kiriniki yekudzidzira nhungamiro mune oncology: (NCCN nhungamiro) .Ichronic myeloid leukemia. Shanduro 3.2020. www.nccn.org/professionals/physician_gls/pdf/cml.pdf. Yakagadziridzwa Ndira 30, 2020. Yakasvika paKurume 23, 2020.

Radich J. Chisingaperi myeloid leukemia. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chits. 175.