Androgen kusagadzikana kwehurwere

Androgen insensitivity syndrome (AIS) ndipo apo munhu anenge ari murume (ane X uye imwe Y chromosome) asingabatane nehomoni dzevanhurume (inonzi androgens). Nekuda kweizvozvo, munhu wacho ane zvimwe zvehunhu hwemunhukadzi, asi chimiro chemurume.

AIS inokonzerwa nehutachiona hurema pane X chromosome. Kukanganisa uku kunoita kuti muviri utadze kupindura kumahormone anoburitsa chitarisiko chechirume.

Iyo syndrome yakakamurwa muzvikamu zviviri zvikuru:

• Pedzisa AIS
• Chikamu AIS

Mukuzara kweAIS, nhengo yemurume uye zvimwe zvikamu zvemuviri zvemurume zvinokundikana kukura. Pakuberekwa, mwana anotaridzika semusikana. Iyo yakazara fomu yechirwere inoitika mune yakawanda seye 1 mu20,000 kuzvarwa kuri kurarama.

Muchikamu cheAIS, vanhu vane huwandu hwakasiyana hwehunhu hwevanhurume.

Partial AIS inogona kusanganisira mamwe matambudziko, akadai se:

• Kukundikana kweimwe kana ese ari maviri testes kuburukira muchikanda mushure mekuzvarwa
• Hypospadias, mamiriro ezvinhu umo kuvhurwa kweiyo urethra kuri pasi pekunze kwepenisi, pachinzvimbo chekumusoro.
• Reifenstein syndrome (inozivikanwawo seGilbert-Dreyfus syndrome kana Lubs syndrome)

Infertile male syndrome inoonekwawo sechimwe chikamu cheAIS.

Munhu ane AIS yakazara anoita kunge mukadzi asi haana chibereko. Vane hapwa shoma shoma uye pubic vhudzi. Panguva yekuyaruka, hunhu hwevakadzi hwekuita bonde (senge mazamu) unokura. Zvisinei, munhu wacho haasi kuenda kumwedzi uye anobereka.

Vanhu vane chikamu cheAIS vanogona kuve neese murume nemukadzi hunhu hunhu. Vazhinji vane chikamu chinovhara chekunze nyinyo, yakawedzera clitoris, uye ipfupi nyinyo.

Panogona kuve ne:

• Mukadzi kana mukadzi asina chibereko kana chibereko
• Inguinal hernia nemachende anogona kunzwiwa panguva yemuviri bvunzo
• Kazhinji mazamu echikadzi
• Miedzo mudumbu kana dzimwe nzvimbo dzeatypical mumuviri

Kuzadza AIS hakuwanzo kuwanikwa panguva yehucheche. Dzimwe nguva, kukura kunonzwika mudumbu kana kugomera kunoshanduka kuve testiki kana ichiongororwa nekuvhiyiwa. Vanhu vazhinji vane chirwere ichi havana kuongororwa kusvika vasingawane kuenda kumwedzi kana kunetsekana kubata pamuviri.

Chikamu cheAIS chinowanzoonekwa panguva yehucheche nekuti munhu wacho anogona kunge aine hunhu hwechirume nevakadzi.

Miedzo inoshandiswa kuongorora iyi mamiriro inogona kusanganisira:

• Ropa rinoshanda kutarisa mazinga e testosterone, luteinizing hormone (LH), uye follicle-inosimudzira mahormone (FSH)
• Kuongorora mageneti (karyotype) kuona magadzirirwo emunhu
• Pelvic ultrasound

Mimwe miedzo yeropa inogona kuitwa kuti ubatsire kutaura mutsauko pakati peAIS uye kushomeka kwe androgen.

Machende ari munzvimbo isiriyo anogona kutadza kubviswa kusvika mwana apedza kukura nekuyaruka. Panguva ino, ma testes anogona kubviswa nekuti anogona kuita cancer, kungofanana nechero testicle isina kukodzera.

Estrogen kutsiva kunogona kupihwa mushure mekuyaruka.

Kurapa uye kupihwa murume kana murume kunogona kuita iri nyaya yakaoma, uye inofanirwa kunongedzwa kumunhu wega wega.

Maonero eAIS akazara akanaka kana chibodzwa chemu testicle chabviswa panguva yakafanira yekudzivirira cancer.

Matambudziko anosanganisira:

• Kushaya mbereko
• Zvepfungwa uye zvemagariro nyaya
• Gomarara repachiedza

Fonera wako mupi wezvehutano kana iwe kana mwana wako aine zviratidzo kana zviratidzo zvechirwere.

Testicular feminization

• Utano hwemurume hwekubereka
• Mukadzi wekubereka anatomy
• Mukadzi wekubereka anatomy
• Karyotyping

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Donohoue PA. Kukanganisika kwekusimudzira bonde. Mune: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Chinyorwa chePediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020: chap 606.

Yu RN, Dhaimani DA. Kukanganisika kwekusimudzira bonde: etiology, ongororo, uye manejimendi manejimendi. Mune: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. Campbell-Walsh-Wein Urology. 12th ed. Philadelphia, PA: Elsevier; 2021: chitsauko 48.