Crizotinib

Zvemukati

• Usati watora crizotinib,
• Crizotinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Crizotinib inoshandiswa kurapa mamwe marudzi easina-madiki maseru kenza yemapapu (NSCLC) iyo yakapararira kumatunhu ari pedyo kana kune zvimwe zvikamu zvemuviri. Iyo inoshandiswa zvakare kurapa imwe mhando yeaplastic hombe cell lymphoma (ALCL) iyo yadzoka kana isingateerere kune mamwe marapirwo (s) mune vamwe vanhu vakuru uye vana gore rimwe zera nekure. Crizotinib iri mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito chechimwe chinhu chinowanzoitika chinogona kudikanwa kubatsira maseru ekenza kuwanda.

Crizotinib inouya sekapuleti kutora nemuromo. Inowanzo kutorwa pamwe kana pasina chikafu kaviri pazuva. Tora crizotinib panguva dzakatenderedza nguva dzakafanana zuva rega rega. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora crizotinib chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza macapsules akazara; usatsemure, kutsenga, kana kuvapwanya. Usabata macapsule akaputswa kana kupwanywa.

Chiremba wako anogona kumbomira kurapwa kwenguva pfupi kana zvachose, kudzikisa dosi, kana kukuudza kuti utore mishonga yako kashoma kana uchinge wawana mhedzisiro yemhedzisiro yecrizotinib. Udza chiremba wako kuti uri kunzwa sei panguva yekurapwa kwako.

Ramba uchitora crizotinib kunyangwe iwe uchinzwa zvakanaka. Usarega kutora crizotinib usina kutaura nachiremba wako.

Kumbira wemishonga wako kana chiremba kopi yemashoko emugadziri wemurwere.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora crizotinib,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune crizotinib, chero mimwe mishonga, kana chero chinhu chinosanganiswa mumacrizotinib capsules. Kumbira mushonga wako wemishonga kana kutarisa ruzivo rwemurwere wemugadziri kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi mishonga yekunyorera uye isina kunyoreswa, mavitamini, uye zvinovaka muviri zvaunotora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: amiodarone (Cordarone, Pacerone); mamwe maantibhakitiriya akadai secacithromycin (Biaxin); mimwe mishonga inodzivirira yakadai seitraconaozole (Sporanox), ketoconazole (Nizoral), uye voriconazole (Vfend); imwe mishonga yeropa; chloroquine (Aralen); chlorpromazine (Thorazine); citalopram (Celexa); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); dihydroergotamine (DHHE 45, Migranal); disopyramide (Norpace); dofetilide (Tikosyn); kudonha (Inapsine); ergotamine (Ergomar, muCafergot, muMigergot); erythromycin (EES, Erythrocin); fentanyl (Abstral, Actiq, Fentora, Lazanda, Onsolis); flecainide (Tambocor); mimwe mishonga yehutachiona hwehutachiwana hwevanhu (HIV) senge atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, muKaletra), uye saquinavir (Invirase); mimwe mishonga yekubatwa senge carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, uye phenytoin (Dilantin); mesoridazine (Serentil); methadone (Dolophine); moxifloxacin (Avelox); nefazodone; pentamidine (NebuPent, Pentam); pimozide (Orap); procainamide (Pronestyl); quinidine (muNuedexta); rifabutin (Mycobutin), rifampin (Rimactane, Rifadin, muRifater); sirolimus (Rapamune); sotalol (Betapace); tacrolimus (Prograf); telithromycin (Ketek); thioridazine (Mellaril); uye vandetanib (Caprelsa). Mimwe mimwe mishonga inogona zvakare kubatana ne crizotinib, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa. Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's wort.
• udza chiremba wako kana iwe uine kana wakambove nerefu QT syndrome (chinetso chisingawanzo mwoyo chinogona kukonzeresa kurova kwemoyo zvisina kujairika, kufenda, kana kufa kamwe kamwe), kurova kwehana kunononoka, kutadza kwemoyo, matambudziko ekuona, matambudziko emapapu kunze kwekenza yemapapu, kana chiropa kana chirwere cheitsvo.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Iwe unozofanirwa kuve nepamuviri bvunzo usati watanga kurapwa ne crizotinib. Kana iwe uri munhukadzi, iwe unofanirwa kushandisa kuberekwa panguva yekurapa kwako uye kwemazuva makumi mana nemashanu mushure mekupedzisira kwako dose. Kana iwe uri murume, iwe neako mukadzi mukadzi iwe unofanirwa kushandisa kuberekwa panguva yekurapwa kwako uye kwemazuva makumi mapfumbamwe mushure mekupedzisira kwako dosi. Taura nachiremba wako nezvenzira ipi yekudzivirira kubata pamuviri yaunofanira kushandisa. Kana iwe ukava nepamuviri paunotora crizotinib, dana chiremba wako pakarepo. Crizotinib inogona kukuvadza fetus.
• udza chiremba wako kana iwe uchiyamwisa. Usamwisa mukaka panguva yekurapa kwako uye kwemazuva makumi mana nemashanu mushure mekuita kwako kwekupedzisira.
• iwe unofanirwa kuziva kuti uyu mushonga unogona kudzora kubereka muvarume nevakadzi. Taura nachiremba wako nezve njodzi dzekutora crizotinib.
• kana uri kuvhiyiwa, kusanganisira kuvhiya mazino, udza chiremba kana chiremba wemazino kuti urikutora crizotinib.
• iwe unofanirwa kuziva kuti crizotinib inogona kukonzera matambudziko ekuona, dzungu, uye kuneta zvakanyanya. Usatyaire mota kana kushandisa michina kusvikira iwe waziva kuti uyu mushonga unokubata sei.

Usadye grapefruit kana kunwa muto wemazambiringa uchinwa mushonga uyu.

Tora dosi rakarasika nekukurumidza kana uchinge warangarira. Nekudaro, kana iri isingasviki maawa matanhatu usati warongerwa kutora yako inotevera dosi, ruka iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Crizotinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• manyoka
• kuvimbiswa
• kurwadziwa nemudumbu
• maronda mumuromo
• chinja mukugona kuravira chikafu
• chirungurira
• musoro
• chiveve, kupisa, kana kugwinha maoko kana tsoka
• kunetseka kurara kana kuramba wakarara

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• mweya wekufema
• kukosora
• kupindwa nechando
• kuzvimba kwemaoko, maoko, tsoka, makumbo, kana makumbo ezasi
• kurwadziwa pachipfuva
• kunonoka kurova kwemoyo
• mapundu
• kushaya simba
• kuneta zvakanyanya
• kurwadziwa kuchikamu chepamusoro chepamusoro chedumbu
• kusvotwa
• kurutsa
• kunetseka kumedza
• yero yeganda kana maziso
• weti yakasviba
• kuvava
• kupindwa nechando
• kubuda ropa zvisina kujairika kana kupwanya
• kuona kana kuona kwakapotsa
• shanduko pane zvakaratidzwa
• kunzwisisika kuchiedza
• achiona kupenya kamwe kamwe kwechiedza
• kuona matsva kana kuwedzerwa mafashama (makwapa mune zvaunoona)

Crizotinib inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo runowanikwawo pamhepo pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira bvunzo bvunzo usati watanga kurapwa kwako kuti uone kana gomarara rako rinogona kurapwa ne crizotinib uye zvakare kuraira kumwe kuongorora kwebazi panguva yekurapwa kwako kuti utarise mhinduro yemuviri wako kune crizotinib. Chiremba wako anozoongororawo moyo wako uye kuwedzerwa kweropa nguva dzose panguva yekurapa kwako.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Xalkori^®