Glasdegib

Zvemukati

• Usati watora glasdegib,
• Glasdegib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukasira:
• Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

Glasdegib haifanire kutorwa nevarwere vane nhumbu kana vanogona kuve nepamuviri. Pane njodzi huru yekuti glasdegib inokonzeresa kuremara kwekuzvara (matambudziko epanyama aripo pakuzvarwa) kana kufa kwemwana asati aberekwa.

Kana iwe uri mukadzi anogona kuve nepamuviri, iwe unofanirwa kuve uine yakashata yepamuviri bvunzo mukati memazuva manomwe usati watanga kurapwa ne glasdegib. Iwe unozofanirwa kushandisa anoshanda ekuzvarwa kwekuzvarwa panguva yaunenge uchirapa ne glasdegib uye kwemazuva makumi matatu mushure meyero yako yekupedzisira. Taura nachiremba wako nezve sarudzo dzekuzvarwa dzinoshanda kwauri.

Kana iwe uri murume ane mukadzi mukadzi uyo anogona kuve nepamuviri kana ndiani ane nhumbu, iwe unofanirwa kuziva glasdegib anogona kunge aripo mune urume uye anogona kukuvadza mwana asati aberekwa. Shandisa kondomu panguva yekurapa kwako ne glasdegib uye kwemazuva makumi matatu mushure mekupedzisira dhizeti kunyangwe iwe uine vasectomy (kuvhiyiwa kudzivirira urume kubva mukusiya muviri wako nekukonzera nhumbu). Usape urume panguva yekurapa kwako uye kweinenge mazuva makumi matatu mushure mekupedzisira kwako kwekupedzisira.

Kana iwe wakamboita bonde zvisina dziviriro, funga kuti yako yekuzvarwa yakundikana, kana kufunga iwe kana mukadzi wako mukadzi angave ave nepamuviri daidza chiremba wako ipapo ipapo

Usape ropa kana zvigadzirwa zveropa panguva yekurapwa kwako ne glasdegib uye kwemazuva makumi matatu mushure meyero yako yekupedzisira.

Chiremba wako kana wemishonga anokupa iro gadziriro yeruzivo yemurwere (Gwaro Rekurapa) paunotanga kurapwa ne glasdegib uye pese paunozadza mushonga wako. Verenga iwo ruzivo nokungwarira uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kana webhusaiti yemugadziri kuti utore Gwaro reMishonga.

Glasdegib inoshandiswa pamwe ne cytarabine seyakatanga kurapwa yeacute myeloid leukemia (AML; mhando yekenza inotanga mumasero machena eropa) muvanhu vanopfuura makore makumi manomwe neshanu ekuberekwa, kana kune vanhu vakuru vane mamwe marapirwo uye vasingakwanise kurapwa nemamwe mishonga yemakemikari. Glasdegib iri mukirasi yemishonga inonzi hedgehog pathway inhibitors. Inoshanda nekudzivirira chiito cheprotein inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kumisa kana kunonoka kupararira kwekenza masero.

Glasdegib inouya sehwendefa kutora nemuromo. Inowanzo kupihwa pamwe kana pasina chikafu kamwe pazuva pazuva kwemwedzi mitanhatu, kana sekureba sekurudzirwa nachiremba wako. Tora glasdegib kwakatenderedza nguva yakafanana zuva rega rega. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora glasdegib chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza mapiritsi akazara; usatsemure, kutsenga, kana kuvapwanya.

Kana iwe ukarutsa mushure mekutora glasdegib, usatore imwe dosi. Enderera yako yenguva dzose dosing purogiramu.

Chiremba wako angangoda kukanganisa kurapwa kwako, kudzikisa dosi yako, kana kumisa kurapwa kwako zvichienderana nemhinduro yako kumushonga uye chero mhedzisiro iwe yaunosangana nayo. Ive neshuwa yekuudza chiremba wako kuti uri kunzwa sei panguva yekurapwa kwako ne glasdegib.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora glasdegib,

• udza chiremba wako uye wemishonga kana uri weergoria kune glasdegib, chero mimwe mishonga, kana chero chinhu chinowanikwa mumahwendefa e glasdegib. Kumbira wemishonga wako kana tarisa Gwaro Rekurapa kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi mishonga yekunyorera uye isina kunyoreswa, mavitamini, uye zvinovaka muviri zvaunotora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: amiodarone (Nexterone, Pacerone), carbamazepine (Carbatrol, Equetro, Tegretol, vamwe), chlorpromazine, cilostazol, citalopram (Celexa), clarithromycin, disopyramide (Norpace), dofetilide, donepezil (Acepezil) dronedarone (Multaq), efavirenz (Sustiva, muAtripla, Symfi), escitalopram (Lexapro), flecainide (Tambocor), fluconazole (Diflucan), haloperidol (Haldol), ibutilide (Corvert), indinavir (Crixivan), Itraconaz ), ketaconazole, methadone (Dolophine, Methadose), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), ondansetron (Zofran, Zuplenz), phenobarbital, phenytoin (Dilantin, Phenytek), pimozide (Orapone), Actoglit , Duetact, Actoplus Met), procainamide, quinidine (muNuedexta), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, muRifater, Rifamate), ritonavir (Norvir, muViekira Pak, Kaletra, Technivie), sotalol (Betapace). , Sotylize), uye thioridazine. Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kubatana ne glasdegib, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's wort.
• udza chiremba wako kana iwe kana wakambove nenguva yakareba yeQT (chinetso chisingawanzo mwoyo chinogona kukonzeresa kurova kwemoyo zvisina kufanira, kufenda, kana kufa kamwe kamwe), kutadza kwemoyo (mamiriro umo moyo usingakwanise kupomba ropa rakakwana kune mamwe mativi emuviri) , kana mashoma masosi emagesium kana potasium muropa rako.
• udza chiremba wako kana iwe uchiyamwisa. Iwe haufanire kuyamwa-kuyamwa panguva yekurapa kwako ne glasdegib uye kwemazuva makumi matatu mushure mekupedzisira kwako.
• iwe unofanirwa kuziva kuti uyu mushonga unogona kudzora kubereka muvarume. Taura nachiremba wako nezve njodzi dzekutora glasdegib.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Tora dosi rakarasika nekukurumidza kana uchinge warangarira. Zvisinei, kana isingasviki maawa gumi nemaviri kusvikira yako inotevera dhivha, ruka iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Glasdegib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• mhasuru
• mhasuru, bhonzo kana kurwadziwa pamwe chete
• kuneta zvakanyanya
• kusvotwa
• kurutsa
• marwadzo emudumbu
• kuvimbiswa
• kurwadziwa kana maronda mumuromo mako kana pahuro
• kuderera kwechido
• chinja munzira iyo zvinhu zvinonaka
• kuonda
• musoro
• mapundu
• kuzvimba kwemaoko kana makumbo
• kurasikirwa nevhudzi
• kurwadziwa nemazino

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukasira:

• kunzwa kupera simba, musoro wakareruka, kana kuita dzungu; nekukurumidza kana zvisina kujairika kurova kwemoyo
• kupwanya kusingawanzo kana kubuda ropa
• fivha yoga kana pamwe nechando, kushaya simba. kana zvimwe zviratidzo zvehutachiona
• kuderera kwekuita weti
• kurwadziwa pachipfuva

Glasdegib inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe uye kusvika kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakavharira makapu ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye kubva kwavari uye kusvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa mishonga yako ndeyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

• kusvotwa
• kurutsa
• kuneta zvakanyanya
• dzungu

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira mamwe marabhoritari eedzo senge electrocardiograms (EKG, bvunzo inorekodha chiitiko chemagetsi chemwoyo) uye kuongororwa kweropa pamberi uye panguva yekurapa kuti uve nechokwadi chekuti zvakakotsekana kuti utore glasdegib uye kutarisa mhinduro yemuviri wako kumushonga .

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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