Antineutrophil Cytoplasmic Antibodies (ANCA) Bvunzo

Zvemukati

• Chii chinonzi antineutrophil cytoplasmic antibodies (ANCA) bvunzo?
• Chii chinoshandiswa?
• Nei ndichida bvunzo yeANCA?
• Chii chinoitika panguva yebvunzo yeANCA?
• Ndichafanira here kuita chero chinhu kugadzirira bvunzo?
• Pane here njodzi kune bvunzo?
• Zvinorevei mhedzisiro yacho?
• Pane chimwe chinhu here chandinofanira kuziva nezve muyedzo weANCA?
• Zvinyorwa

Chii chinonzi antineutrophil cytoplasmic antibodies (ANCA) bvunzo?

Muedzo uyu unotarisa antineutrophil cytoplasmic antibodies (ANCA) muropa rako. Maantibodies mapuroteni anoitwa nema immune system ako kuti arwise zvinhu zvekunze semavirusi uye mabhakitiriya. Asi maANCAs anorwisa maseru ane hutano anozivikanwa se neutrophils (rudzi rwechena reropa) nekukanganisa. Izvi zvinogona kutungamira kuchirwere chinozivikanwa se autoimmune vasculitis. Autoimmune vasculitis inokonzera kuzvimba uye kuzvimba kwemitsipa yeropa.

Tsinga dzeropa dzinotakura ropa kubva pamoyo wako kuenda kunhengo dzako, zvinyama, uye mamwe masisitimu, uye wozodzoka zvakare. Mhando dzetsinga dzeropa dzinosanganisira tsinga, tsinga, uye capillari. Kuzvimba mumidziyo yeropa kunogona kukonzera matambudziko akakomba ehutano. Matambudziko anosiyana zvichienderana nekuti ndeipi tsinga dzeropa uye masisitimu emuviri anokanganiswa.

Kune maviri makuru marudzi eANCA. Chimwe nechimwe chinotarisa puroteni chaiyo mukati memasero machena eropa:

• PANCA, inotarisa puroteni inonzi MPO (myeloperoxidase)
• cANCA, inotarisa puroteni inonzi PR3 (proteinase 3)

Muedzo unogona kuratidza kuti une rimwe kana maviri marudzi emasoja ekudzivirira chirwere. Izvi zvinogona kubatsira wako mupi wekuchengetedza hutano kuongorora uye kurapa kusagadzikana kwako.

Mamwe mazita: ANCA antibodies, cANCA pANCA, cytoplasmic neutrophil antibodies, serum, anticytoplasmic autoantibodies

Chii chinoshandiswa?

Bvunzo yeANCA inowanzo shandiswa kutsvaga kana iwe uine mhando ye autoimmune vasculitis. Kune mhando dzakasiyana dzechirwere ichi. Dzese dzinokonzeresa kuzvimba nekuzvimba kwemitsipa yeropa, asi mhando imwe neimwe inobata tsinga dzakasiyana dzeropa uye zvikamu zvemuviri. Mhando dze autoimmune vasculitis dzinosanganisira:

• Granulomatosis ine polyangiitis (GPA), yaimbonzi chirwere cheWegener. Iyo inowanzo bata mapapu, itsvo, uye zvitadzo.
• Microscopic polyangiitis (MPA). Dambudziko iri rinogona kukanganisa nhengo dzinoverengeka mumuviri, kusanganisira mapapu, itsvo, tsinga, uye ganda.
• Eosinophilic granulomatosis ine polyangiitis (EGPA), yakambodaidzwa kuti Churg-Strauss syndrome. Ichi chirwere chinowanzo kukanganisa ganda nemapapu. Iyo inowanzo kukonzera asthma.
• Polyarteritis nodosa (PAN). Dambudziko iri rinowanzo bata moyo, itsvo, ganda, uye pakati sisitimu yetsinga.

Bvunzo yeANCA inogona zvakare kushandiswa kuongorora kurapwa kweaya matambudziko.

Nei ndichida bvunzo yeANCA?

Wako mupi wezvehutano anogona kuraira bvunzo yeANCA kana iwe uine zviratidzo zve autoimmune vasculitis. Zviratidzo zvinosanganisira:

• Kupindwa nechando
• Kuneta
• Kuonda
• Tsvina uye / kana majoini akabatana

Zviratidzo zvako zvinogona kukanganisa imwe kana zvimwe zvakasarudzika nhengo mumuviri wako. Kazhinji zvinokanganisa nhengo uye zviratidzo zvavanokanganisa zvinosanganisira:

• Maziso
  • Kutsvuka
  • Kuona kwakashata
  • Kurasikirwa kwemaonero
• Nzeve
  • Kurira munzeve (tinnitus)
  • Kunzwa kurasikirwa
• Sinuses
  • Sinus kurwadziwa
  • Dzihwa
  • Mhuno inobuda ropa
• Ganda
  • Rashes
  • Maronda kana maronda, rudzi rwehosha yakadzika inononoka kupora uye / kana inoramba ichidzoka
• Mapapu
  • Kukosora
  • Kunetseka kufema
  • Kurwadziwa pachifuva
• Itsvo
  • Ropa mune weti
  • Weti inopupuma, iyo inokonzerwa neprotein iri mune weti
• Kutya system
  • Unhu uye kurira munzvimbo dzakasiyana dzemuviri

Chii chinoitika panguva yebvunzo yeANCA?

Nyanzvi yezvehutano inotora muyero weropa kubva mutsinga iri muruoko rwako, uchishandisa tsono diki. Mushure mekunge tsono yaiswa, kashoma reropa kanounganidzwa muthubhu yekuyedza kana muhombodo. Unogona kunzwa kakuruma kana tsono ichipinda kana kubuda. Izvi zvinowanzotora maminetsi asingasviki mashanu.

Ndichafanira here kuita chero chinhu kugadzirira bvunzo?

Iwe haudi chero akakosha ekugadzirira bvunzo yeANCA.

Pane here njodzi kune bvunzo?

Pane njodzi shoma yekuongororwa ropa. Unogona kunge uine marwadzo mashoma kana kupwanya panzvimbo yakaiswa tsono, asi zviratidzo zvizhinji zvinokurumidza kupera.

Zvinorevei mhedzisiro yacho?

Kana mhedzisiro yako yanga isina kunaka, zvinoreva kuti zviratidzo zvako zvinogona kunge zvisina kukonzerwa ne autoimmune vasculitis.

Kana zvibodzwa zvako zvaive zvakanaka, zvinogona kureva kuti une autoimmune vasculitis. Iyo inogona zvakare kuratidza kana maCANCA kana maPANCA akawanikwa. Izvi zvinogona kubatsira kuona kuti ndeupi rudzi rwevasculitis yauinayo.

Hazvina mhosva kuti nderipi rudzi rwemaantibhakusi akawanikwa, ungangoda imwe bvunzo, inozivikanwa sey biopsy, kuratidza chirwere. Bhiopsy maitiro anobvisa sampuro diki yetissue kana masero ekuyedzwa. Anopa hutano hwako anogona zvakare kuraira mimwe bvunzo kuyera huwandu hweANCA muropa rako.

Kana iwe parizvino uchirapwa autoimmune vasculitis, mhedzisiro yako inogona kuratidza kana kurapwa kwako kuri kushanda.

Kana iwe uine mibvunzo nezve mhedzisiro yako, taura nemupi wako wezvehutano.

Dzidza zvakawanda nezve bvunzo dzemarabhoritari, mareferenzi masosi, uye mhinduro dzekunzwisisa

Pane chimwe chinhu here chandinofanira kuziva nezve muyedzo weANCA?

Kana mhedzisiro yako yeANCA ichiratidza kuti une autoimmune vasculitis, pane nzira dzekurapa nekugadzirisa mamiriro acho. Marapirwo anogona kusanganisira mushonga, marapirwo anobvisa kwenguva pfupi ANCAs kubva muropa rako, uye / kana kuvhiyiwa.

Zvinyorwa

1. Allina Hutano [Internet]. Minneapolis: Allina Utano; Kuyera kweC-ANCA; [yakataurwa 2019 May 3]; [angangoita matatu skrini. Inowanikwa kubva ku: https://account.allinahealth.org/library/content/49/150100
2. Allina Hutano [Internet]. Minneapolis: Allina Utano; P-ANCA kuyerwa; [yakataurwa 2019 May 3]; [angangoita matatu skrini. Inowanikwa kubva: https://account.allinahealth.org/library/content/49/150470
3. Cleveland Clinic [Internet]. Cleveland (OH): Cleveland Clinic; c2019. Maronda Emakumbo neAtsoka; [yakataurwa 2019 May 3]; [angangoita matatu skrini. Inowanikwa kubva: https://my.clevelandclinic.org/health/diseases/17169-leg-and-foot-ulcers
4. Lab Kuedza Pamhepo [Internet]. Washington DC: American Association yeKiriniki Chemistry; c2001–2019. ANCA / MPO / PR3 Maantibodi; [yakagadziridzwa 2019 Kubvumbi 29; yakataurwa 2019 May 3]; [angangoita maviri skrini. Inowanikwa kubva ku: https://labtestsonline.org/tests/ancampopr3-antibodies
5. Lab Kuedza Pamhepo [Internet]. Washington DC: American Association yeKiriniki Chemistry; c2001–2019. Biopsy; [yakagadziridzwa 2017 Jul 10; yakataurwa 2019 May 3]; [angangoita maviri skrini. Inowanikwa kubva: https://labtestsonline.org/glossary/biopsy
6. Lab Kuedza Pamhepo [Internet]. Washington DC: American Association yeKiriniki Chemistry; c2001–2019. Vasculitis; [yakagadziridzwa 2017 Sep 8; yakataurwa 2019 May 3]; [angangoita maviri skrini. Inowanikwa kubva ku: https://labtestsonline.org/conditions/vasculitis
7. Mansi IA, Opran A, Rosner F. ANCA-Inosanganiswa Diki-Mudziyo Vasculitis. Ndiri Chiremba weNzara [Internet]. 2002 Kubvumbi 15 [yakataurwa 2019 Chivabvu 3]; 65 (8): 1615-1621. Inowanikwa kubva: https://www.aafp.org/afp/2002/0415/p1615.html
8. Mayo Clinic Laboratories [Indaneti]. Mayo Foundation Yekurapa Dzidzo uye Tsvagiridzo; c1995–2019. Bvunzo ID: ANCA: Cytoplasmic Neutrophil Antibodies, Serum: Clinical and Interpretive; [yakataurwa 2019 May 3]; [angangoita mana skrini. Inowanikwa kubva: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9441
9. National Mwoyo, Mapapu, uye Ropa Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Kuedzwa kweropa; [yakataurwa 2019 May 3]; [angangoita matatu skrini. Inowanikwa kubva: https://www.nhlbi.nih.gov/health-topics/blood-tests
10. National Mwoyo, Mapapu, uye Ropa Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Vasculitis; [yakataurwa 2019 May 3]; [angangoita maviri skrini. Inowanikwa kubva: https://www.nhlbi.nih.gov/health-topics/vasculitis
11. Radice A, Sinico RA. Antineutrophil Cytoplasmic Antibodies (ANCA). Autoimmunity [Indaneti]. 2005 Feb [yakataurwa 2019 Chivabvu 3]; 38 (1): 93–103. Inowanika kubva: https://www.ncbi.nlm.nih.gov/pubmed/15804710
12. UNC Kidney Center [Internet]. Chapel Hill (NC): UNC Kidney Center; c2019. ANCA Vasculitis; [yakagadziridzwa 2018 Sep; yakataurwa 2019 May 3]; [angangoita matatu skrini. Inowanikwa kubva: https://unckidneycenter.org/kidneyhealthlibrary/glomerular-disease/anca-vasculitis

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