Chirwere cheLymphocytic Leukemia (CLL)

Zvemukati

• Chii chinonzi chronic lymphocytic leukemia (CLL)?
• Ndezvipi zviratidzo zveCLL?
• Chii chinonzi kurapwa kweCLL?
• Chemotherapy
• Radiation
• Targeted Therapies
• Bone marora kana peripheral ropa stem sero kuisirwa
• Kuisirwa ropa
• Kuvhiya
• CLL inoonekwa sei?
• Yakazara kuwanda kweropa (CBC) nechena reropa (WBC) musiyano
• Kuongorora Immunoglobulin
• Bone marora bhiopsy
• CT scan
• Kuyerera cytometry uye cytochemistry
• Genomic uye mamorekuru kuyedzwa
• Ndeipi chiyero chekupona chevanhu vane CLL?
• CLL inoiswa sei?
• Chii chinokonzeresa CLL, uye pane zvinhu zvine njodzi kuchirwere ichi?
• Pane here zvinganetse kurapwa?
• Ndeipi iyo yakareba-tarisiro yeCLL?

Getty Mifananidzo

Chii chinonzi chronic lymphocytic leukemia (CLL)?

Leukemia rudzi rwekenza inosanganisira masero eropa revanhu nemasero anogadzira ropa. Kune mhando dzakawanda dzeleukemia, imwe neimwe ichikanganisa mhando dzakasiyana dzemasero eropa. Chronic lymphocytic leukemia, kana CLL, inobata ma lymphocyte.

MaLymphocyte imhando yeropa chena (WBC). CLL inokanganisa B lymphocyte, ayo anonziwo B masero.

Masero akajairwa B anotenderera muropa rako uye anobatsira muviri wako kurwisa hutachiona. Cancer B maseru haarwise hutachiona sezvinoita maseru B chaiwo. Sezvo huwandu hwemaseru B ane kenza unowedzera zvishoma nezvishoma, iwo anowedzera kunze lymphocyte zvakajairwa.

CLL ndiyo yakajairika mhando yeleukemia muvanhu vakuru. Iyo National Cancer Institute (NCI) inofungidzira kuti 21,040 mitsva mitsva ichaitika muUnited States mu2020.

Ndezvipi zviratidzo zveCLL?

Vamwe vanhu vane CLL vanogona kunge vasina chero zviratidzo, uye kenza yavo inogona kungowanikwa panguva yekujairirwa kweropa.

Kana iwe uine zviratidzo, zvinowanzo sanganisira:

• kuneta
• kupindwa nechando
• kazhinji kutapukirwa kana kurwara
• kusanzwisisika kana kusatarisirwa kuonda
• husiku hweziya
• chills
• kuzvimba lymph nodes

Munguva yekuongorora kwepanyama, chiremba wako anogona zvakare kuona kuti yako spleen, chiropa, kana lymph node zvakawedzerwa. Izvi zvinogona kuve zviratidzo zvekuti gomarara rapararira kunhengo idzi. Izvi zvinowanzoitika mune yepamusoro kesi dzeCLL.

Kana izvi zvikaitika kwauri, unogona kunzwa mapundu anorwadza mumutsipa wako kana kunzwa kwekuzara kana kuzvimba mudumbu rako.

Chii chinonzi kurapwa kweCLL?

Kana iwe uine njodzi-yakadzika CLL, chiremba wako anogona kukuraira iwe kuti umirire uye utarise zviratidzo zvitsva. Chirwere chako chinogona kusanyanya kuwedzera kana kuda kurapwa kwemakore. Vamwe vanhu havatombodi kurapwa.

Mune zvimwe zviitiko zveiyo yakaderera-njodzi CLL, chiremba wako anogona kukurudzira kurapwa. Semuenzaniso, vanogona kukurudzira kurapwa kana iwe uine:

• kuramba uchingorwara hutachiona
• yakaderera masero eropa kuverenga
• kuneta kana kudikitira usiku
• lymph nodes inorwadza

Kana iwe uine yepakati- kana yakanyanya njodzi njodzi CLL, chiremba wako anogona kukuraira kuti uenderere mberi nekurapwa ipapo.

Pazasi pane mamwe marapiro anga kurudzirwe nachiremba wako.

Chemotherapy

Chemotherapy ndiyo inonyanya kurapwa yeCLL. Zvinosanganisira kushandisa mishonga kuuraya cancer maseru. Zvichienderana nemishonga chaiyo yaunorayirwa nachiremba, unogona kuitora nemutsinga kana nemuromo.

Radiation

Mune maitiro aya, masimba ane simba-zhinji kana mafungu anoshandiswa kuuraya cancer maseru. Radiation haiwanzoshandiswa kuCLL, asi kana iwe uine marwadzo ekuzvimba, akazvimba marapi, radiation radiation inogona kubatsira kudzikamisa uye kubvisa marwadzo ako.

Targeted Therapies

Mishonga yakanangwa inotarisa pane chaiwo majini, mapuroteni, kana zvinyama zvinobatsira pakurarama kwemasero ekenza. Izvi zvinogona kusanganisira:

• monoclonal antibodies, ayo anonamatira kumapuroteni
• kinase inhibitors iyo inogona kuparadza cancer maseru nekuvharira mamwe kinase enzymes

Bone marora kana peripheral ropa stem sero kuisirwa

Kana iwe uine njodzi-yepamusoro CLL, kurapwa uku kunogona kuve sarudzo. Izvo zvinosanganisira kutora maseru emukati kubva mumongo wefupa kana ropa remupi - kazhinji nhengo yemhuri - uye kuapinza mumuviri wako kuti ubatsire kusimbisa mongo wemapfupa.

Kuisirwa ropa

Kana yako masero eropa akaverengwa akaderera, ungangoda kugamuchira kuwedzerwa kweropa kuburikidza neiyo intravenous (IV) mutsara kuti uwedzere iwo.

Kuvhiya

Mune zvimwe zviitiko, chiremba wako anogona kukurudzira kuvhiyiwa kuti abvise spleen kana yawedzera nekuda kweCLL.

CLL inoonekwa sei?

Kana chiremba wako achifungidzira kuti une CLL, vanogona kushandisa bvunzo dzakasiyana kuti vasimbise kuongororwa. Semuenzaniso, ivo vangango hodha imwe kana yakawanda yeanotevera bvunzo.

Yakazara kuwanda kweropa (CBC) nechena reropa (WBC) musiyano

Chiremba wako anogona kushandisa iyi kuongororwa kweropa kuyera huwandu hwemhando dzakasiyana dzemasero muropa rako, kusanganisira akasiyana marudzi eWBCs.

Kana iwe uine CLL, iwe unenge uine mamwe ma lymphocyte kupfuura zvakajairwa.

Kuongorora Immunoglobulin

Chiremba wako anogona kushandisa iyi bvunzo yeropa kuti adzidze kana iwe uine ma antibodies akakwana kurwisa hutachiona.

Bone marora bhiopsy

Mune maitiro aya, chiremba wako anoisa tsono ine yakakosha chubhu muhudyu yako pfupa kana chipfuva chemazamu kuti utore sampu yemapfupa ako ekuyedzwa.

CT scan

Chiremba wako anogona kushandisa iyo mifananidzo inogadzirwa neCT scan kuti utarise kuzvimba kwema lymph node muchipfuva kana mudumbu.

Kuyerera cytometry uye cytochemistry

Nedzidzo idzi, makemikari kana dhayi zvinoshandiswa kuona mamaki akasarudzika pamasero ekenza kubatsira kuona mhando yeropaemia. Muenzaniso weropa ndizvo zvese zvinodiwa pakuyedzwa uku.

Genomic uye mamorekuru kuyedzwa

Aya maedzo anotarisa magene, mapuroteni, uye chromosome shanduko dzinogona kuve dzakasarudzika kune mamwe marudzi eleukemia. Ivo vanobatsirawo kuona kuti chirwere ichi chichafambira mberi nekukurumidza sei uye kubatsira chiremba wako kusarudza nzira dzokurapa dzaungashandisa.

Iko kuongorora kwemajini kuwana shanduko dzakadai kana shanduko kunogona kusanganisira fluorescence in situ hybridization (FISH) kuyedza uye polymerase chain reaction.

Ndeipi chiyero chekupona chevanhu vane CLL?

Iyo makore mashanu-ekupona mwero wevaAmerican neCLL ndeye 86.1 muzana, sekureva kweNCI. Sangano rinofungidzirawo kuti CLL ichaunza kufa kwevanhu mazana mana nemakumi matanhatu muUnited States muna2020.

Kupona kwemitengo kwakaderera kune vanhu vakura vane mamiriro.

CLL inoiswa sei?

Kana chiremba wako akaona kuti une CLL, ivo vanozoraira kumwe kuyedza kuyera kukura kwechirwere. Izvi zvinobatsira chiremba wako kuronga danho rekenza, rinozotungamira chirongwa chako chekurapa.

Kuti uise CLL yako, chiremba wako angangoda kuraira kweropa kuti uwane yako tsvuku sero (RBC) kuverenga uye yakatarwa yeropa lymphocyte kuverenga. Ivo zvakare vangangotarisa kana ako lymph node, spleen, kana chiropa zvakawedzerwa.

Pasi peiyo Rai system yekumisikidza, CLL yakarongedzwa kubva pa0 kusvika ku4. Rai nhanho 0 CLL ndiyo yakanyanya kuomarara, nepo Rai nhanho yechina iri yepamusoro.

Nezvinangwa zvekurapa, iwo matanho akaiswawo muzvikamu zvengozi. Rai nhanho 0 ine njodzi yakaderera, Rai nhanho 1 ne2 ingozi yepakati, uye Rai matanho 3 ne4 ane njodzi huru, anotsanangura American Cancer Society.

Heano mamwe eanowanzoitika CLL zviratidzo padanho rega rega:

• Chikamu 0: akakwirira mazinga ema lymphocyte
• Chikamu 1: zvakakwirira zveiyo lymphocyte; akawedzera lymph node
• Chikamu chechipiri: zvakakwirira zveiyo lymphocyte; lymph nodes inogona kuwedzerwa; akawedzera spleen; inogona kuwedzera chiropa
• nhanho 3: zvakakwirira zveiyo lymphocyte; kupererwa neropa; lymph nodes, spleen, kana chiropa zvinogona kuwedzerwa
• nhanho 4: zvakakwirira zveiyo lymphocyte; lymph nodes, spleen, kana chiropa zvinogona kuwedzerwa; anemia inogona; mashoma maplatelet

Chii chinokonzeresa CLL, uye pane zvinhu zvine njodzi kuchirwere ichi?

Nyanzvi hadzinyatso kuziva chinokonzera CLL. Zvisinei, pane zvinhu zvine njodzi zvinowedzera mukana wemunhu wekuvandudza CLL.

Heano zvimwe zvengozi zvinhu zvine mukana wekusimudzira mukana wemunhu wekuvandudza CLL:

• Zera. CLL haiwanzo kuongororwa muvanhu vari pasi pemakore makumi mana ekuberekwa. Mazhinji emakesi eCLL anoonekwa muvanhu vanopfuura makore makumi mashanu. Ivhareji zera revanhu vanoonekwa vane CLL vane makumi manomwe neshanu.
• Zvepabonde. Inobata varume vakawanda kudarika vakadzi.
• Dzinza. Izvo zvinowanzoitika kune vanhu veRussia neEuropean dzinza uye zvisingawanzo kuwanikwa muvanhu vekuEast Asia neSoutheast Asia dzinza.
• Monoclonal B-sero lymphocytosis. Pane njodzi diki yekuti chiitiko ichi, chinokonzeresa kupfuura zvakajairika mazinga ema lymphocyte, anogona kushanduka kuita CLL.
• Zvakatipoteredza. Dhipatimendi reU.S. reVeterans Affairs raisanganisira kuburitswa neAgent Orange, chombo chemakemikari chakashandiswa panguva yeHondo yeVietnam, sechinhu chine njodzi kuCLL.
• Nhoroondo yemhuri. Vanhu vane hama dzepedyo neCLL kuongororwa vane njodzi yakakwira yeCLL.

Pane here zvinganetse kurapwa?

Chemotherapy inoderedza immune system yako, ichikusiya uchinyanya kubatwa nezvirwere. Iwe unogona zvakare kukura zvisina kujairika mazinga ezvirwere uye yakaderera masero eropa kuverenga panguva yekemotherapy.

Zvimwe zvinowanzoitika mhedzisiro yemakemikari anosanganisira:

• kuneta
• kurasikirwa nevhudzi
• maronda emuromo
• kurasikirwa nenzara
• kusvotwa uye kurutsa

Mune zvimwe zviitiko, chemotherapy inogona kubatsira mukuvandudzwa kweimwe kanzira.

Radiation, kuwedzerwa ropa, uye mwongo wefupa kana peripheral ropa stem masero anoiswa anogona zvakare kusanganisira mhedzisiro.

Kugadzirisa chaiwo mhedzisiro, chiremba wako anogona kuraira:

• IV immunoglobulin
• corticosteroids
• kubvisa spleen
• mushonga rituximab

Taura nachiremba wako nezvezvinotarisirwa mhedzisiro yemhedzisiro yako. Ivo vanogona kukuudza iwe kuti ndezvipi zviratidzo uye mhedzisiro zvinoda kurapwa.

Ndeipi iyo yakareba-tarisiro yeCLL?

Kupona kwemitengo yeCLL kunosiyana siyana. Zera rako, bonde, chromosome kusagadzikana, uye kenza maseru maitiro anogona kukanganisa ako marefu-maonero. Chirwere hachiwanzo kurapwa, asi vanhu vazhinji vanorarama kwemakore mazhinji neCLL.

Kumbira chiremba wako nezve yako chaiyo kesi. Vanogona kukubatsira kuti unzwisise kuti gomarara rako rakafambira mberi zvakadii. Vanogona zvakare kukurukura nzira dzekurapa uye maonero erefu.