Zvese zvaunoda Kuti Uzive Nezve Cushing's Syndrome

Zvemukati

• Mhedziso
• Cushing's syndrome zviratidzo
• Muvana
• Mune vakadzi
• Mune varume
• Cushing's syndrome inokonzeresa
• Corticosteroids
• Mamota
• Chirwere cheCushing
• Cushing's syndrome kurapwa
• Cushing's syndrome kuongororwa
• Kuongorora chinokonzera Cushing's syndrome
• Cushing's syndrome kudya
• Cushing's syndrome njodzi dzinokonzera
• Cushing's syndrome manejimendi
• Cushing's syndrome maonero

Mhedziso

Cushing's syndrome kana hypercortisolism, inoitika nekuda kwekukwirira kwakanyanya kwehomoni cortisol. Izvi zvinogona kuitika nekuda kwezvikonzero zvakasiyana.

Muzviitiko zvakawanda, kuwana kurapwa kunogona kubatsira iwe kubata ako cortisol mazinga.

Cushing's syndrome zviratidzo

Zviratidzo zvakajairika zveichi chiitiko ndezvi:

• kurema kuwedzera
• mafuta anoisa, kunyanya pakati pepakati, kumeso (kuchikonzera kutenderera, kumeso kwakaita kunge mwedzi), uye pakati pemapfudzi nechekumusoro kumashure (zvichikonzera nyati hump)
• pepuru anotambanudza mamaki pazamu, maoko, dumbu, uye chidya
• ganda rakatetepa rinozvipwanya nyore
• kukuvara kweganda kunonoka kupora
• acne
• kuneta
• kushaya simba kwetsandanyama

Kunze kwezviratidzo zvakajairika pamusoro, pane zvimwe zviratidzo izvo dzimwe nguva zvinogona kucherechedzwa kune vanhu vane Cushing's syndrome.

Izvi zvinogona kusanganisira:

• shuga yakakwira muropa
• kuwedzera nyota
• kuwedzera weti
• osteoporosis
• kukwirira kweropa (hypertension)
• musoro
• mafungiro
• kushushikana
• kugumbuka
• kuora mwoyo
• kuwedzera kwehutachiona

Muvana

Vana vanogona kuve neCushing's syndrome futi, kunyangwe ivo vachikura zvishoma nezvishoma kupfuura vanhu vakuru. Zvinoenderana neongororo ye2019, nezve matsva eCushing's syndrome zviitiko gore rega rega zvinoitika muvana.

Pamusoro pezviratidzo zviri pamusoro, vana vane Cushing's syndrome vanogona zvakare kuva ne:

• kufutisa
• inononoka mwero wekukura
• kukwirira kweropa (hypertension)

Mune vakadzi

Cushing's syndrome yakanyanya kuvakadzi kupfuura varume. Sekureva kweNational Institutes of Health (NIH), katatu zvakapetwa sevakadzi vazhinji vanova neCushing's syndrome kana ichienzaniswa nevarume.

Vakadzi vane Cushing's syndrome vanogona kuwedzera kumeso uye bvudzi remuviri.

Izvi zvinowanzoitika pane:

• kumeso nemutsipa
• chipfuva
• dumbu
• zvidya

Pamusoro pezvo, vakadzi vane Cushing's syndrome vanogona zvakare kuona kusarongeka kuenda kumwedzi. Mune zvimwe zviitiko, kuenda kumwedzi kunenge kusipo zvachose. Kusarapwa kweCushing's syndrome muvakadzi kunogona kutungamira kumatambudziko kuve nepamuviri.

Mune varume

Sezvazviri kune vakadzi nevana, varume vane Cushing's syndrome vanogona zvakare kuona zvimwe zviratidzo.

Varume vane Cushing's syndrome vanogona kunge vaine:

• kusagadzikana kwe erectile
• kurasikirwa nebonde
• kuderera kwekubereka

Cushing's syndrome inokonzeresa

Cushing's syndrome inokonzerwa nekuwandisa kwehormone cortisol. Matanho ako adrenal anoburitsa cortisol.

Inobatsira neakawanda emabasa emuviri wako, kusanganisira:

• kudzora kumanikidza kweropa uye nemoyo system
• kuderedza immune immune system yekupindura
• kushandura makabhohaidhiretsi, mafuta, uye mapuroteni kuita simba
• kuenzanisa migumisiro ye insulini
• kupindura kunetseka

Mumuviri wako unogona kuburitsa yakakwira mazinga ecortisol nekuda kwezvikonzero zvakasiyana, zvinosanganisira:

• kudzvinyirira kwakanyanya, kusanganisira kushushikana kwakanangana nechirwere chakakomba, kuvhiyiwa, kukuvara, kana nhumbu, kunyanya mutrimester yekupedzisira
• mitambo yekumhanya
• kushaya zvokudya zvinovaka muviri
• kudhakwa
• kushushikana, kusagadzikana kwekutya, kana huwandu hwakanyanya hwekunetseka mupfungwa

Corticosteroids

Chikonzero chakajairika cheCushing's syndrome ndiko kushandiswa kwemishonga yecorticosteroid, senge prednisone, mune yakakwira doses kwenguva yakareba. Vanoona nezvehutano vanokwanisa kunyorera izvi kuti zvirape zvirwere zvinoputira, senge lupus, kana kudzivirira kurambwa kwenhengo yakaisirwa.

Yakakwira madosi ejekiseni steroids ekurapa kurwadziwa musana kunogona kukonzera Cushing's syndrome. Nekudaro, yakaderera dosi steroids muchimiro chemweya inhalants, senge iwo anoshandiswa asthma, kana makirimu, senge iwo akarairwa eczema, kazhinji haana kukwana kukonzera mamiriro acho.

Mamota

Mhando dzinoverengeka dzemamota dzinogona zvakare kutungamira kune yakakwira kugadzirwa kwecortisol.

Zvimwe zvacho zvinosanganisira:

• Pituitary gland mamota. Iyo pituitary gland inoburitsa yakawandisa adrenocorticotropic hormone (ACTH), iyo inomutsa kugadzirwa kwecortisol mune adrenal glands. Ichi chinonzi chirwere cheCushing.
• Ectopic bundu. Aya ndiwo mamota kunze kwepituitary anogadzira ACTH. Zvinowanzoitika mumapapu, pancreas, thyroid, kana thymus gland.
• Adrenal gland isina kujairika kana bundu. An adrenal abnormality kana bundu rinogona kutungamira kune zvisina kujairika maitiro ekugadzirwa kwecortisol, izvo zvinogona kukonzera Cushing's syndrome.
• Yakakurumbira Cushing's syndrome. Kunyangwe Cushing's syndrome isingawanzogarwa nhaka, zvinokwanisika kuve nehunhu hwakagara nhaka hwekuvandudza mamota eiyo endocrine gland.

Chirwere cheCushing

Kana Cushing's syndrome ichikonzerwa nepituitary gland iri kuwedzeredza ACTH iyo inozoita cortisol, inonzi chirwere cheCushing.

Sezvakaita Cushing's syndrome, chirwere cheCushing chinokanganisa vakadzi vazhinji kupfuura varume.

Cushing's syndrome kurapwa

Icho chinangwa cheCushing's syndrome kurapwa ndechekuderedza iwo mazinga ecortisol mumuviri wako. Izvi zvinogona kuitwa nenzira dzinoverengeka. Marapirwo aunogashira anoenderana nezvinokonzera mamiriro ako.

Anopa hutano hwako anogona kupa mushonga kuti ubatsire kubata cortisol mazinga. Mimwe mishonga inoderedza kugadzirwa kwecortisol mumasero adrenal kana kudzikisa kugadzirwa kweACTH mune yepituitary gland. Mimwe mishonga inovhara mhedzisiro yecortisol pane yako nyama.

Mienzaniso inosanganisira:

• ketoconazole (Nizoral)
• mitotane (Lysodren)
• metyrapone (Metopirone)
• pasireotide (Chiratidzo)
• mifepristone (Korlym, Mifeprex) mune vanhu vane rudzi rwechipiri chirwere cheshuga kana kusagadzikana kweglucose

Kana iwe ukashandisa corticosteroids, shanduko mumushonga kana muyero inogona kudikanwa. Usaedze kuchinja dosi iwe pachako. Iwe unofanirwa kuita izvi pasi pekutarisirwa kwepedyo kwechiremba.

Tumota dzinogona kunge dzakaipa, zvinoreva cancer, kana benign, zvinoreva kuti haina cancer.

Kana mamiriro ako achikonzerwa nebundu, wako mupi wekuchengetedza hutano angangoda kubvisa bundu kuvhiya. Kana bundu risingakwanise kubviswa, wako mupi wezvehutano anogona zvakare kukurudzira radiation radiation kana chemotherapy.

Cushing's syndrome kuongororwa

Cushing's syndrome inogona kunyanya kunetseka kuongorora. Izvi zvinodaro nekuti mazhinji ezviratidzo, sekuwedzera uremu kana kuneta, anogona kuve nezvimwe zvikonzero. Pamusoro pezvo, Cushing's syndrome pachayo inogona kuve nezvakawanda zvakasiyana zvikonzero.

Anopa hutano hwako anoongorora nhoroondo yako yekurapa. Ivo vanozobvunza mibvunzo nezve zviratidzo, chero mamiriro ehutano aungave iwe, uye chero mishonga iwe yaunogona kupihwa.

Vachaitawo bvunzo dzepanyama pavachatsvaga zviratidzo senge hump yenyati, uye kutambanudza mamaki nemavanga.

Tevere, ivo vanogona kuraira bvunzo dzevarabhoritari, kusanganisira:

• Maawa makumi maviri nemasere weti yemahara cortisol bvunzo: Kune bvunzo iyi, iwe unozobvunzwa kuti utore yako weti pane iyo 24-awa nguva. Iwo mazinga ecortisol anozozoedzwa.
• Salivary cortisol kuyerwa: Mune vanhu vasina Cushing's syndrome, mazinga ecortisol anodonha manheru. Uyu muyedzo unoyera padanho recortisol mumuteedzero wemate uyo waunganidzwa husiku husiku kuti uone kana mazinga ecortisol akakwirira zvakanyanya.
• Low-dose dexamethasone kudzvinyirira bvunzo: Kune bvunzo iyi, iwe unozopihwa muyero we dexamethasone manheru. Ropa rako rinozoongororwa muyero wekortisol mangwanani. Kazhinji, dexamethasone inokonzeresa huwandu hwecortisol kudonha. Kana iwe uine Cushing's syndrome, izvi hazviitike.

Kuongorora chinokonzera Cushing's syndrome

Mushure mekugashira kuongororwa kweCushing's syndrome, mupi wako wezvehutano anofanira achiri kuona chikonzero chekuwedzera kwecortisol kugadzirwa.

Kuyedza kubatsira kuziva chikonzero kunogona kusanganisira:

• Ropa adrenocorticotropin hormone (ACTH) bvunzo: Nhanho dze ACTH muropa dzinoyerwa. Akadzika masosi eADTH uye akakwirira mazinga ecortisol aigona kuratidza kuvepo kwethumba pane adrenal gland.
• Corticotropin-inosunungura mahormone (CRH) yekumisikidza bvunzo: Mune bvunzo iyi, pfuti yeCRH inopihwa. Izvi zvinokwidziridza mazinga e ACTH uye cortisol mune vanhu vane pituitary tumors.
• Yakakwira-dose dexamethasone kudzvinyirira bvunzo: Izvi zvakafanana nemuedzo wepasi-wepasi, kunze kwekunge iro rakakwirira dhizeti re dexamethasone rinoshandiswa. Kana cortisol nhanho dzichidonha, iwe unogona kunge uine pituitary bundu. Kana vasina kudaro unogona kunge uine bundu reectopic.
• Petrosal sinus sampling: Ropa rinotorwa kubva mutsinga padhuze nepituitary uye zvakare kubva mutsinga iri kure nepituitary. Pfuti yeCRH inopihwa. Akakwira mazinga e ACTH muropa padhuze nepituitary anogona kuratidza pituitary bundu. Akaenzana mazinga kubva kune ese sampuli anoratidza ectopic bundu.
• Kufungidzira zvidzidzo: Izvi zvinogona kusanganisira zvinhu senge CT neMRI inoongorora. Izvo zvinoshandiswa kufungidzira adrenal uye pituitary gland kutsvaga mamota.

Cushing's syndrome kudya

Kunyangwe shanduko dzekudya dzisingarape mamiriro ako, dzinogona kubatsira kuchengetedza ako cortisol mazinga kubva mukukwira zvakanyanya kana kubatsira kudzivirira mamwe matambudziko.

Mamwe matipi ezvekudya kune avo vane Cushing's syndrome anosanganisira:

• Chengetedza koriori yako yaunodya. Kuchengeta koriori yako yaunodya kwakakosha sezvo kurema kuri chimwe chezviratidzo zvikuru zveCushing's syndrome.
• Edza kudzivisa kunwa doro. Doro kunwiwa kwakabatanidzwa nekukwira kwecortisol mazinga, kunyanya, sekureva kwechidzidzo cha2007.
• Tarisa shuga yako yeropa. Cushing's syndrome inogona kutungamira kuwanda kweropa, saka edza kusadya chikafu chinogona kukonzera kukwira kweshuga yeropa. Mienzaniso yezvikafu zvekutarisa pakudya inosanganisira miriwo, michero, zviyo zvese, uye hove.
• Dzosera kumashure pane sodium. Cushing's syndrome inosanganisirwa neakakwira BP (hypertension). Nekuda kweizvi, edza kudzikisira yako yekudya sodiamu. Dzimwe nzira dzakareruka dzekuita izvi dzinosanganisira kusawedzera munyu kuchikafu uye kunyatsoverenga zvinyorwa zvekudya kuti utarise zvemukati me sodium.
• Ita shuwa yekuwana yakakwana calcium uye vhitamini D. Cushing's syndrome inogona kunetesa mapfupa ako, ichikuita kuti utadze kupunzika. Ose calcium nevitamini D anogona kubatsira kusimbisa mapfupa ako.

Cushing's syndrome njodzi dzinokonzera

Iyo yakakosha njodzi yekukudziridza Cushing's syndrome iri kutora yakakwira-dose corticosteroids kwenguva yakareba yenguva. Kana mupi wako wezvehutano akaraira corticosteroids kuti irape mamiriro ehutano, vabvunze nezve muyero uye kuti uchavatora kwenguva yakareba sei.

Zvimwe zvinhu zvine njodzi zvinogona kusanganisira:

• mhando-2 chirwere cheshuga chisina kunyatsogadziriswa
• kukwirira kweropa (hypertension)
• kufutisa

Zvimwe zviitiko zveCushing's syndrome zvinokonzerwa nekuumbwa kwechirwere. Kunyangwe paine mukana wekuve nemajini ekuvandudza endocrine tumors (yemhuri Cushing's syndrome), hapana nzira yekudzivirira mamota kubva pakuumba.

Cushing's syndrome manejimendi

Kana uine Cushing's syndrome, zvakakosha kuti igadziriswe nemazvo. Kana iwe ukasawana kurapwa kwayo, Cushing's syndrome inogona kutungamira kune akasiyana siyana anogona kuve akakomba matambudziko ehutano.

Izvi zvinogona kusanganisira:

• osteoporosis, iyo inogona kuwedzera njodzi yako yekutyoka kwemapfupa
• mhasuru kurasikirwa (atrophy) uye kushaya simba
• kukwirira kweropa (hypertension)
• mhando 2 chirwere cheshuga
• kazhinji hutachiona
• chirwere chemwoyo kana sitiroko
• kushushikana kana kushushikana
• kugadzirisa matambudziko sekutambudzika kuisa pfungwa kana matambudziko nekurangarira
• kuwedzera kwechirwere chiripo

Cushing's syndrome maonero

Kana ukakurumidza kutanga kurapwa, zvirinani mhedzisiro inotarisirwa. Zvakakosha kucherechedza kuti maonero ako ega anoenderana nechakakonzeresa uye kurapwa kwaunogashira.

Zvinogona kutora nguva kuti zviratidzo zvako zviwedzere. Ive neshuwa yekubvunza wako wekuchengeta hutano mupi wehutano hwekudya mirau, chengeta yekutevera, uye wedzera rako rezviitiko zvishoma nezvishoma.

Mapoka ekutsigira anogona kukubatsira kutsungirira Cushing's syndrome. Chipatara chako chemunharaunda kana mupi wezvehutano anogona kukupa iwe ruzivo nezve mapoka anosangana munzvimbo yako.