Kutora Biologics uye Kuwanazve Kudzora Kwako Psoriatic Arthritis

Zvemukati

• Chii chinonzi biologics?
• Mhando dze biologics
• Abatacept
• Adalimumab
• Certolizumab pegol
• Etanercept
• Golimumab
• Infliximab
• Ustekinumab
• Masanganiswa ekurapa
• Side migumisiro uye yambiro
• Biologics chimwe chikamu chePsA manejimendi kuronga

Mhedziso

Psoriatic arthritis (PsA) chirwere chisingaperi, uye kurapwa kunoenderera kunodiwa kudzivirira kusagadzikana kwekubatana zvachose. Mushonga wakakodzera unogona zvakare kurerutsa huwandu hweArthritis flare-ups.

Biologics ingori imwe yemhando yemishonga inoshandiswa kurapa PsA. Izvi zvinoshanda nekudzvinyirira immune system yako saka inomira kurwisa majoini ane hutano uye ichikonzera kurwadziwa nekukuvara.

Chii chinonzi biologics?

Biologics ndiwo madiki echirwere-kugadzirisa antirheumatic zvinodhaka (DMARDs). MaDMARD anomisa immune system yako kubva mukukonzeresa kuzvimba kwePAA uye nemamwe mamiriro ekudzivirira muviri.

Kuderedza kuzvimba kune maviri makuru mhedzisiro:

• Panogona kuve nekurwadziwa kushoma nekuti kuzvimba panzvimbo dzakabatana ndiko kunokonzera kubatana.
• Kukuvadza kunogona kuderedzwa.

Biologics inoshanda nekudzivirira immune system mapuroteni anogadzira kuzvimba. Kusiyana nemamwe maDMARD, biologics inoitiswa nekumukisa kana jekiseni chete.

Biologics inonyorerwa sekutanga-kurapwa kurapwa kwevanhu vane anoshanda PsA. Kana iyo yekutanga biologic iwe yaedza ikasabvisa zviratidzo zvako, chiremba wako anogona kukuchinjisa iwe kune chakasiyana chinodhaka mukirasi ino.

Mhando dze biologics

Mhando ina dzebiologics dzinoshandiswa kurapa PsA:

• tumor necrosis factor-alpha (TNF-alpha) inhibitors: adalimumab (Humira), certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi Aria), infliximab (Remicade)
• interleukin 12/23 (IL-12/23) inhibitors: ustekinumab (Stelara)
• interleukin 17 (IL-17 inhibitors): ixekizumab (Taltz), secukinumab (Cosentyx)
• T cell inhibitors: abatacept (Orencia)

Iyi mishonga inovhara chaiwo mapuroteni anoratidza immune system yako kurwisa maseru ane hutano, kana iwo anonongedzera maseru ekudzivirira ane chekuita nemhinduro yekuzvimba. Icho chinangwa chega chega biologic subtype ndechekudzivirira iyo yekuvhiringidza maitiro kubva kutanga.

Dzakawanda biologics dziripo. Aya anotevera ndiwo anowanzo nyorwa kuPSA.

Abatacept

Abatacept (Orencia) ndeye T cell inhibitor. T masero machena masero eropa. Ivo vanoita chinzvimbo mune immune mhinduro, uye mukukonzera kuzvimba. Orencia inonongedza T maseru kuunza kudzora.

Orencia inobatawo rheumatoid arthritis (RA) uye vechidiki idiopathic arthritis (JIA). Inowanikwa sekumupinza kuburikidza netsinga, kana sejekiseni raunozvipa iwe.

Adalimumab

Adalimumab (Humira) inoshanda nekudzivirira TNF-alpha, puroteni inosimudzira kuzvimba. Vanhu vane PsA vanogadzira yakawandisa TNF-alpha mune yavo ganda uye majoini.

Humira mushonga unopinda jekiseni. Iyo zvakare yakatemerwa chirwere cheCrohn uye mamwe marudzi eArthritis.

Certolizumab pegol

Certolizumab pegol (Cimzia) ndeimwe TNF-alpha mushonga. Yakagadzirirwa kurapa mafomu echisimba ePPA, pamwe nechirwere cheCrohn, RA, uye ankylosing spondylitis (AS).

Cimzia inopihwa seyako-yega jekiseni.

Etanercept

Etanercept (Enbrel) zvakare iri TNF-alpha mushonga. Icho chiri pakati pemishonga yakare inogamuchirwa yekurapa PsA, uye inoshandiswa kurapa mamwe marudzi eArthritis.

Enbrel inozvibaya-jekiseni kamwe chete kana kaviri pasvondo.

Golimumab

Golimumab (Simponi) ndeye TNF-alpha mushonga wakagadzirirwa kurapa anoshanda PsA. Iyo zvakare yakatemerwa kune zvine mwero-kune-zvakanyanya RA, zvine mwero-kune-zvakanyanya ulcerative colitis (UC), uye inoshanda AS.

Iwe unotora Simponi kamwe chete pamwedzi kuburikidza nekuzvibaya-wega.

Infliximab

Infliximab (Remicade) ishanduro yeTNF-alpha mishonga. Iwe unowana infusion kuhofisi yechiremba katatu mukati memavhiki matanhatu. Mushure mekutanga kurapwa, infusions inopihwa mwedzi miviri yega yega.

Remicade inobatawo chirwere cheCrohn, UC, uye AS. Vanachiremba vanogona kuirairira iyo RA, pamwe ne methotrexate.

Ixekizumab

Ixekizumab (Taltz) iri IL-17 inhibitor. Iyo inovharira IL-17, iyo inobatanidzwa mukupindura kwekuputira kwemuviri.

Iwe unowana Taltz seyakateedzana majekiseni pasi peganda vhiki mbiri dzese, uyezvezve pavhiki ina dzese.

Secukinumab

Secukinumab (Cosentyx) ndeimwe IL-17 inhibitor. Inotenderwa kurapwa psoriasis uye PsA, pamwe neAS.

Iwe unozvitora sepfuti pasi peganda rako.

Ustekinumab

Ustekinumab (Stelara) iri IL-12/23 inhibitor. Iyo inovhara mapuroteni IL-12 uye IL-23, ayo anokonzera kuzvimba muPsA. Stelara anotenderwa kurapa anoshanda PsA, plaque psoriasis, uye zvine mwero-kune-zvakanyanya chirwere cheCrohn.

Stelara anouya sejekiseni. Mushure mekujowa kwekutanga, inoitiswa zvakare mushure memasvondo mana, uyezve kamwe chete pamasvondo gumi nemaviri.

Masanganiswa ekurapa

Kune zvine mwero kusvika zvakanyanya PsA, biologics yakakosha mukugadzirisa zvese zvenguva pfupi uye zverefu-zvenguva zviratidzo uye zvinetswa. Zvisinei, chiremba wako anogonawo kukurudzira mamwe marapirwo.

Chiremba wako anogona kunyorera nonsteroidal anti-anogumbura zvinodhaka (NSAIDs) ekurwadziwa kwekubatana. Izvi zvinoderedzawo kuzvimba. Over-the-counter (OTC) shanduro, senge ibuprofen (Advil), inowanikwa zvakanyanya, pamwe neyekunyora-simba mafomula.

Sezvo kushandiswa kwenguva refu kunogona kuwedzera njodzi yekubuda ropa mudumbu, matambudziko emoyo, uye sitiroko, maNSAID anofanirwa kushandiswa zvishoma uye padosi repasi rinogoneka.

Dai iwe waive ne psoriasis pamberi pePSA, saka ungangodawo marapirwo ekubatsira kudzora kuputika kweganda nematambudziko ezvipikiri. Dzimwe nzira dzokurapa dzinosanganisira corticosteroids, light therapy, uye mishonga yekuzodza.

Side migumisiro uye yambiro

Mhedzisiro inowanzoitika yebiologics ndeyekugadziriswa kweganda (senge kutsvuka uye mapundu) panzvimbo yejekiseni. Nekuti biologics inodzora immune system yako, iwe unogona zvakare kunge uri panjodzi yekuwedzera hutachiona.

Zvishoma zvakajairika, asi zvakakomba, mhedzisiro inosanganisira:

• kuwedzera psoriasis
• chirwere chepamusoro chekufema
• tibhii
• lupus-senge zviratidzo (senge mhasuru uye kurwadziwa kwemajoini, fivhiri, uye kurasikirwa nebvudzi)

Taura newa rheumatologist nezve izvi zvinogona kuitika mhedzisiro, uye wongorora mamiriro ako nokungwarira. Fona ipapo ipapo kana iwe uchifungidzira kuti une zvakashata mhinduro kumishonga yako.

Zvakare, vakadzi vane nhumbu kana vari kuronga kuve nepamuviri vanofanirwa kushandisa biologics nekutarisira.

Kunyangwe izvo zvinoitika pamwana ari kukura zvisati zvanyatsonzwisiswa, pane mukana wekupokana nepamuviri. Zvichienderana nekuoma kwePsA, vamwe vanachiremba vanokurudzira kumisa kurapwa panguva yekuzvitakura.

Biologics chimwe chikamu chePsA manejimendi kuronga

Biologics inounza tariro kune vakawanda vane PsA. Kwete biologics chete inobatsira kugadzirisa zviratidzo zvePPA, zvakare inoderedza hunhu hunoparadza hwekuputika kwakadzika.

Zvakadaro, zvakakosha kuti urangarire kuti biologics inongova chikamu chimwe cheyakareba chirongwa chako chePS manejimendi. Taura nachiremba wako nezve shanduko yemararamiro uye mimwe mishonga inogona kubatsira.