Polymyositis - mukuru

Polymyositis uye dermatomyositis hazviwanzo kupisa zvirwere. (Mamiriro acho anonzi dermatomyositis kana ichisanganisira ganda.) Zvirwere izvi zvinotungamira kukundikana kwemhasuru, kuzvimba, unyoro, uye kukuvara kwetishu. Ivo chikamu cheboka rakakura rezvirwere zvinonzi myopathies.

Polymyositis inokanganisa tsandanyama tsandanyama. Iyo inozivikanwawo seidiopathic inoputira myopathy. Chikonzero chaicho hachizivikanwe, asi chinogona kunge chiine chekuita nekuzvidzivirira kwega kana hutachiona.

Polymyositis inogona kukanganisa vanhu chero zera. Inowanzoitika kune vanhu vakuru vari pakati pemakore makumi mashanu nemakumi matanhatu, uye muvana vakuru. Inobata vakadzi zvakapetwa kaviri sevarume. Izvo zvakajairika muAfrican America kupfuura vachena vanhu.

Polymyositis chirwere che systemic. Izvi zvinoreva kuti zvinokanganisa muviri wese. Tsvina kushaya simba uye unyoro zvinogona kuve zviratidzo zve polymyositis. Rash chiratidzo cheyakafanana mamiriro, dermatomyositis.

Zviratidzo zvakajairika zvinosanganisira:

• Tsvina kushaya simba mumapfudzi nehudyu. Izvi zvinogona kuita kuti zvive zvakaoma kusimudza maoko pamusoro pemusoro, kusimuka kubva pakagara, kana kukwira masitepisi.
• Zvakaoma kumedza.
• Kutambudzika kwemhasuru.
• Zvinetso nezwi (zvinokonzerwa nehutera husina kusimba huro).
• Kufema kwekufema.

Unogona zvakare kuva:

• Kuneta
• Kupindwa nechando
• Joint kurwadziwa
• Kupererwa nechido
• Kuomarara kwemangwanani
• Kuonda
• Kuputika kweganda kumusana kweminwe, pamaziso, kana kumeso

Miedzo inogona kusanganisira:

• Autoimmune antibodies uye bvunzo dzekuputika
• CPK
• Serum aldolase
• Electromyography
• MRI yemhasuru yakakanganiswa
• Tsvina biopsy
• Myoglobin mune weti
• ECG
• Chest x-ray uye CT scan yechipfuva
• Pulmonary basa bvunzo
• Esophageal kumedza kudzidza
• Myositis chaiyo uye inosanganisirwa autoantibodies

Vanhu vane chirwere ichi vanofanirawo kunyatso tariswa zviratidzo zvecancer.

Mushonga mukuru ndiko kushandiswa kwemishonga yecorticosteroid. Muyero wemishonga unodzurwa zvishoma nezvishoma sezvo simba remhasuru rinovandudza. Izvi zvinotora anenge mavhiki mana kusvika matanhatu. Iwe uchagara pane yakaderera muyero wecorticosteroid mushonga mushure meizvozvo.

Mishonga yekudzvinyirira immune system inogona kushandiswa kutsiva iyo corticosteroids. Iyi mishonga inogona kusanganisira azathioprine, methotrexate kana mycophenolate.

Kune chirwere chinoramba chichishanda kunyangwe necorticosteroids, intravenous gamma globulin yakaedzwa nezvakasiyana mhedzisiro. Biologic zvinodhaka zvakare zvinogona kushandiswa. Rituximab inoita kunge inonyanya kuvimbisa. Izvo zvakakosha kutonga kunze mamwe mamiriro mune vanhu vasingateerere kurapwa. Kudzokorora musuru biopsy kunogona kudikanwa kuti izvi zvionekwe.

Kana mamiriro acho akabatana nebundu, zvinogona kuvandudza kana bundu rikabviswa.

Mhinduro kurapa inosiyana, zvichibva pamatambudziko. Vazhinji sevashanu muvanhu vashanu vanogona kufa mukati memakore mashanu ekukudziridza mamiriro.

Vanhu vazhinji, kunyanya vana, vanopora kubva pakurwara uye havadi kuramba vachirapwa. Kune vanhu vakuru vazhinji, zvisinei, mishonga inodzivirira muviri inodiwa kudzora chirwere.

Maonero evanhu vane chirwere chemapapu neanti-MDA-5 antibody haina kunaka kunyangwe kurapwa kwazvino.

Muvanhu vakuru, kufa kunogona kukonzerwa ne:

• Kushaya zvokudya zvinovaka muviri
• Chirwere chemabayo
• Kukundikana kwekufema
• Yakakomba, refu-refu mhasuru kushaya simba

Zvikonzero zvikuru zvekufa igomarara uye chirwere chemapapu.

Zvinetso zvinogona kusanganisira:

• Calcium inoisa mumhasuru dzakabatwa, kunyanya muvana vane chirwere ichi
• Gomarara
• Chirwere chemwoyo, chirwere chemapapu, kana matambudziko emimba

Fonera wako mupi wezvehutano kana iwe uine zviratidzo zveichi chirwere. Tsvaga kurapwa kwekukurumidzira kana iwe uine kufema kwekufema uye kunetseka kumedza.

• Mashura epamberi epamusoro

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Dalakas MC. Zvirwere zvinopisa tsandanyama. N Engl J Med. 2015; 373 (4): 393-394. PMID: 26200989 www.ncbi.nlm.nih.gov/pubmed/26200989.

Greenberg SA. Inopisa myopathies. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chitsiko 269.

Nagaraju K, Gladue HS, Lundberg IE.Zvirwere zvinopisa zvemhasuru uye mamwe maopathies. Mune: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley uye Firestein's Bhuku reRheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017: chits. 85.

Yoshida N, Okamoto M, Kaieda S, et al. Mubatanidzwa weanti-aminoacyl-chinja RNA synthetase antibody uye anti-melanoma kusiyanisa-inosanganisirwa gene 5 antibody nemhinduro yekurapa ye polymyositis / dermatomyositis-inosanganisirwa yepakati yemapapu chirwere. Kufuridzira Investig. 2017; 55 (1): 24-32. PMID: 28012490 www.ncbi.nlm.nih.gov/pubmed/28012490.