Sjögren chirwere

Sjögren syndrome chirwere chemuviri umo maronda anokonzeresa misodzi nemate zvinoparadzwa. Izvi zvinokonzera kuoma muromo uye kuoma maziso. Mamiriro acho anogona kukanganisa zvimwe zvikamu zvemuviri, kusanganisira itsvo nemapapu.

Chikonzero cheSjögren syndrome hachizivikanwe. Iyo autoimmune kusagadzikana. Izvi zvinoreva kuti muviri unorwisa hura hwakanaka kuburikidza nekukanganisa. Iyo syndrome inowanzoitika mukati mevakadzi vane makore makumi mana kusvika makumi mashanu. Izvo hazviwanzo muvana.

Primary Sjögren syndrome inotsanangurwa semeso akaoma uye mukanwa wakaoma pasina imwe autoimmune kusagadzikana.

Sekondari Sjögren syndrome inoitika pamwe chete nechimwe autoimmune kusagadzikana, senge:

• Rheumatoid arthritis (RA)
• Systemic lupus erythematosus
• Scleroderma
• Polymyositis
• Hepatitis C inogona kukanganisa maseru ematehwe uye inoita kunge Sjögren syndrome
• Chirwere cheIgG4 chinogona kutaridzika seSjogren syndrome uye chinofanirwa kutariswa

Meso akaoma uye mukanwa wakaoma ndizvo zviratidzo zvakajairika zveichi chirwere.

Zviratidzo zvemaziso:

• Itching maziso
• Kunzwa kuti chinhu chiri muziso

Muromo uye huro zviratidzo:

• Zvakaoma kumedza kana kudya chikafu chakaoma
• Kurasikirwa kwepfungwa yekuravira
• Zvinetso kutaura
• Mate makobvu kana tambo
• Maronda emuromo kana kurwadziwa
• Kuora kwemeno uye chingamu kuzvimba
• Kuchema

Zvimwe zviratidzo zvinogona kusanganisira:

• Kuneta
• Kupindwa nechando
• Chinja muvara remaoko kana tsoka nekutonhora kutonhora (Raynaud phenomenon)
• Kurwadziwa pamwe chete kana kuzvimba kwemajoini
• Kuzvimba gland
• Mapundu eganda
• Unhu uye kurwadziwa nekuda kweuropathy
• Kukosora uye kupfupika kwemweya nekuda kwechirwere chemapapu
• Kusarongeka kwemoyo
• Nausea uye chirungurira
• Vaginal kuoma kana kunorwadza weti

Bvunzo yakakwana yemuviri ichaitwa. Bvunzo inoratidza maziso akaoma uye mukanwa wakaoma. Panogona kunge paine maronda emuromo, mazino akaora kana chingamu kuzvimba. Izvi zvinoitika nekuda kwekuoma kwemuromo. Wako wekuchengeta hutano anotarisa mumuromo mako yehutachiona hutachiona (candida). Ganda rinogona kuratidza kumhanyisa, bvunzo yemapapu inogona kunge isina kujairika, dumbu richakwenenzverwa nekuwedzera kwechiropa. Majoini anozoongororwa arthritis. Iyo neuro bvunzo ichatsvaga kushomeka.

Unogona kuve nemiedzo inotevera yaitwa:

• Pedzisa kemisitiri yeropa ine enzyme yechiropa
• Yakazara kuverenga kweropa nemusiyano
• Kuongorora urinal
• Antinuclear antibodies (ANA) bvunzo
• Anti-Ro / SSA uye anti-La / SSB antibodies
• Rheumatoid chinhu
• Kwayedza ye cryoglobulins
• Zadzisa mazinga
• Mapuroteni electrophoresis
• Kwayedza hepatitis C neHIV (kana iri panjodzi)
• Utachiona miedzo
• Schirmer bvunzo yekugadzira misodzi
• Kufananidza kweiyo salivary gland: ne ultrasound kana neMRI
• Salivary gland biopsy
• Ganda biopsy kana kuputika kuripo
• Kuongorora kwemaziso ne ophthalmologist
• Chest x-ray

Chinangwa ndechokubvisa zviratidzo.

• Meso akaomarara anogona kurapwa nemisodzi yekunyepedzera, mafuta ekuzora maziso, kana cyclosporine mvura.
• Kana Candida aripo, inogona kurapwa neshuga-isina miconazole kana nystatin yekugadzirira.
• Tumaplaki tudiki twunogona kuiswa mumatanho ekudonhedza misodzi kubatsira misodzi kuti igare pamusoro peziso.

Zvirwere-zvinoshandura antirheumatic zvinodhaka (DMARDs) zvakafanana neaya anoshandiswa RA anokwanisa kugadzirisa zviratidzo zveSjögren syndrome. Izvi zvinosanganisira bundu necrosis factor (TNF) inodzivirira mishonga yakaita seEnbrel, Humira kana Remicaide.

Zvimwe zvinhu zvaunogona kuita kudzikamisa zviratidzo zvinosanganisira:

• Sip mvura zuva rese
• Tsenga chingamu isina shuga
• Dzivisa mishonga inogona kukonzera kuoma kwemuromo, senge antihistamines uye decongestants
• Dzivisa doro

Taura nachiremba wako wemazino nezve:

• Muromo unosuka kutsiva zvicherwa mumeno ako
• Mate anomiririra
• Zvinodhaka zvinobatsira ako mate maseru kuita mamwe mate

Kudzivirira kuora kwemazino kunokonzerwa nekuoma kwemuromo:

• Bhura uye floss mazino ako kazhinji
• Shanyira chiremba wemazino kuti uongorore uye uchenese nguva dzose

Chirwere ichi kazhinji hachisi kutyisidzira hupenyu. Mhedzisiro yacho inoenderana nezvimwe zvirwere zvaunazvo.

Kune njodzi yakakwira ye lymphoma uye kufa kwekutanga apo Sjögren syndrome yanga ichishanda kwenguva yakareba, pamwe nevanhu vane vasculitis, low complements, uye cryoglobulins.

Zvinetso zvinogona kusanganisira:

• Kukuvadza kune ziso
• Mazino mhango
• Itsvo kutadza (kushoma)
• Lymphoma
• Pulmonary chirwere
• Vasculitis (isingawanzo)
• Neuropathy
• Dundira kuzvimba

Fonera mupi wako kana iwe ukaita zviratidzo zveSjögren syndrome.

Xerostomia - Sjögren chirwere; Keratoconjunctivitis sicca - Sjögren; Sicca chirwere

• Antibodies

Baer AN, Alevizos I. Sjögren chirwere. Mu: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7th ed. Philadelphia, PA: Elsevier; 2019: chits. 147.

Mariette X. Sjögren chirwere. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chitsiko 268.

Seror R, Bootsma H, Saraux A, et al. Kutsanangura chirwere zviitiko uye kukiriniki zvine chinangwa kuvandudzwa kwepuraimari Sjögren's syndrome neEULAR primary Sjögren's syndrome chirwere chiitiko (ESSDAI) uye murwere-anotaurwa mareferenzi (ESSPRI) Ann Rheum Dis. 2016; 75 (2): 382-389. PMID: 25480887 www.ncbi.nlm.nih.gov/pubmed/25480887.

Singh AG, Singh S, Matteson EL. Chiyero, njodzi zvinhu uye zvinokonzeresa kufa kune varwere vane Sjögren's syndrome: kuongororwa kwakarongeka uye meta-ongororo yezvidzidzo zveboka. Rheumatology (Oxford). 2016; 55 (3): 450-460. PMID: 26412810 www.ncbi.nlm.nih.gov/pubmed/26412810.

Turner MD. Oral kuratidzwa kwehurongwa hwehurwere. Mune: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology. 6th ed. Philadelphia, PA: Elsevier Saunders; 2015: chitsiko 14.