Membranoproliferative glomerulonephritis

Membranoproliferative glomerulonephritis chirwere cheitsvo chinosanganisira kuzvimba uye shanduko kune itsvo maseru. Zvinogona kutungamira kukundikana kwetsvo.

Glomerulonephritis iko kuzvimba kweiyo glomeruli. Iyo glomeruli yeitsvo inobatsira kusefa marara uye zvinwiwa zvinobva muropa kuita weti.

Membranoproliferative glomerulonephritis (MPGN) chimiro che glomerulonephritis inokonzerwa neyakajairika immune mhinduro. Deposits yemasoja ekudzivirira anovaka mune chikamu cheitsvo inonzi glomerular yepasi membrane. Iyi membrane inobatsira kusefa marara uye zvimwe zvinwiwa zvinobva muropa.

Kukuvara kweiyi membrane kunokanganisa kugona kweitsvo kugadzira weti zvakajairika. Inogona kubvumira ropa uye mapuroteni kuti adonhedze mumugini. Kana mapuroteni akakwana achidonhera mumuti, mvura inogona kubuda kubva mutsinga dzeropa kuenda mumatumbu emuviri, zvichitungamira kuzvimba (edema). Nitrogen tsvina zvigadzirwa zvinogona zvakare kuvaka muropa (azotemia).

Iwo mafomu maviri echirwere ichi MPGN I uye MPGN II.

Vanhu vazhinji vane chirwere vane mhando I. MPGN II yakanyanya kushomeka. Iyo zvakare inowedzera kuwedzera kukurumidza kupfuura MPGN I.

Zvinokonzera MPGN zvinogona kusanganisira:

• Zvirwere zvekuzvimiririra (systemic lupus erythematosus, scleroderma, Sjögren syndrome, sarcoidosis)
• Gomarara (leukemia, lymphoma)
• Zvirwere (hepatitis B, hepatitis C, endocarditis, malaria)

Zviratidzo zvinogona kusanganisira chero zvinotevera:

• Ropa mune weti
• Shanduko mumamiriro epfungwa senge kudzikira kwekusvinura kana kudzikira kwekusimbisa
• Makore ane weti
• Rima weti (utsi, cola, kana tii mavara)
• Kuderera muhuwandu weti
• Kuzvimba kwechero chikamu chemuviri

Anopa hutano anozokuongorora obvunza nezve zviratidzo zvako. Iye mupi anogona kuona kuti iwe une zviratidzo zvekuwanda kwemvura mumuviri, senge:

• Kuzvimba, kazhinji mumakumbo
• Ruzha rusina kujairika kana uchiteerera kumoyo wako nemapapu ne stethoscope
• Unogona kunge uine BP yakakwira

Iyi bvunzo inotevera inobatsira kusimbisa kuongororwa:

• BUN uye creatinine ropa bvunzo
• Ropa rinozadza mazinga
• Kuongorora urinal
• Weti mapuroteni
• Itsvo biopsy (kuratidza membranoproliferative GN I kana II)

Kurapa kunoenderana nezviratidzo. Zvinangwa zvekurapa ndezvekuderedza zviratidzo, kudzivirira kusangana, uye kunonoka kufambira mberi kwechirwere.

Iwe ungangoda shanduko mukudya. Izvi zvinogona kusanganisira kudzikisira sodium, zvinwiwa, kana mapuroteni kubatsira kudzora kukwirisa kweropa, kuzvimba, uye kuwanda kwemarara muropa.

Mishonga inogona kupihwa inosanganisira:

• Ropa rekumanikidza mishonga
• Dipyridamole, ine kana isina aspirin
• Diuretics
• Mishonga yekudzvinyirira immune system, yakadai secyclophosphamide
• Steroid

Kurapa kunoshanda muvana kupfuura kune vakuru. Dialysis kana itsvo kupinza zvinogona kupedzisira zvichidikanwa kugadzirisa itsvo kutadza.

Iyo hosha inowanzo zvishoma nezvishoma ichiwedzera uye pakupedzisira inoguma nekusingaperi itsvo kutadza.

Hafu yevanhu vane chirwere ichi vanokura kwenguva refu (chisingaperi) itsvo kutadza mukati memakore gumi. Izvi zvinonyanya kuitika kune avo vane akakwirisa ehuwandu hweprotein mumuti yavo.

Matambudziko anogona kukonzerwa nechirwere ichi anosanganisira:

• Acute nephritic chirwere
• Chakakomba itsvo kutadza
• Chirwere chetsvo chisingaperi

Dana kuti usangane nemupi wako kana:

• Iwe une zviratidzo zveichi chiitiko
• Zviratidzo zvako zvinowedzera kana kusaenda
• Iwe unovandudza zviratidzo zvitsva, kusanganisira kuderera kweweti kubuda

Kudzivirira hutachiona hwakadai sehepatitis kana kugadzirisa zvirwere zvakaita se lupus kunogona kubatsira kudzivirira MPGN.

Membranoproliferative GN ini; Membranoproliferative GN II; Mesangiocapillary glomerulonephritis; Membranoproliferative glomerulonephritis; Lobular GN; Glomerulonephritis - membranoproliferative; MPGN mhando I; MPGN mhando II

• Itsvo anatomi

Roberts ISD. Zvirwere zveitsvo. Mu: Muchinjikwa SS, ed. Underwood's Pathology: Inzira yeKliniki. 7th ed. Philadelphia, PA: Elsevier; 2019: chitsiko 21.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ. Chirwere chepakutanga chinoratidzira. Mune: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner uye Rector Iyo Itsvo. 11th ed. Philadelphia, PA: Elsevier; 2020: chits. 31.

Sethi S, De Vriese AS, Fervenza FC. Membranoproliferative glomerulonephritis uye cryoglobulinemic glomerulonephritis. Muna: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Yakakwana Kliniki Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019: chitsiko 21.