Nephrogenic chirwere cheshuga insipidus

Nephrogenic chirwere cheshuga insipidus (NDI) chirwere umo kukanganisika mumatubhu madiki (tubules) muitsvo kunoita kuti munhu apfuure weti yakawanda uye kurasikirwa nemvura yakawandisa.

Kazhinji, itsvo tubules inobvumidza yakawanda mvura muropa kuti isvinwe uye idzokere muropa.

NDI inoitika apo itsvo tubules dzisingapindure kune hormone mumuviri inonzi antidiuretic hormone (ADH), inonziwo vasopressin. ADH inowanzo kukonzera itsvo kuita kuti weti iwedzere kuwedzera.

Nekuda kwekusapindura kuchiratidzo cheADH, itsvo dzinoburitsa mvura yakawandisa mumurini. Izvi zvinokonzeresa kuti muviri uburitse huwandu hwakawanda hwenyowani yakanyanyisa.

NDI ishoma kwazvo. Congenital nephrogenic chirwere cheshuga insipidus iripo pakuzvarwa. Imhedzisiro yechikanganiso chakapfuudzwa kuburikidza nemhuri. Varume vanowanzo kubatwa, asi vakadzi vanogona kupfuudza jeni iri kuvana vavo.

Kazhinji kazhinji, NDI inokura nekuda kwezvimwe zvikonzero. Izvi zvinonzi chirwere chinowanikwa. Zvinhu zvinogona kukonzeresa fomu yakawanikwa yeichi mamiriro inosanganisira:

• Kuvharika mune weti turakiti
• Yakakwira calcium mazinga
• Low potassium mazinga
• Kushandiswa kwemamwe madhiragi (lithiamu, demeclocycline, amphotericin B)

Unogona kunge uine nyota yakanyanya kana isingadzorwe, uye unoshuva mvura yechando.

Iwe unozogadzira huwandu hwakawanda weti, kazhinji inopfuura 3 litita, uye inosvika gumi nemashanu litita pazuva. Weti yakanyanyisa uye inoita kunge mvura. Ungangoda kuita weti nguva yega yega kana kunyangwe, kunyangwe panguva yehusiku iwe usiri kudya kana kunwa zvakanyanya.

Kana iwe ukasanwa zvinwiwa zvakakwana, kupera simba kwemvura kunogona kukonzeresa. Zviratidzo zvinogona kusanganisira:

• Kuoma mucous membranes
• Ganda rakaoma
• Kuonekwa kwakanyura kumeso
• Sunken fontanelles (nyoro nzvimbo) mune vacheche
• Shanduko mundangariro kana kuenzanisa

Zvimwe zviratidzo zvinogona kuitika nekuda kwekushayikwa kwemvura, zvichikonzera kushaya mvura, zvinosanganisira:

• Kuneta, kunzwa kupera simba
• Kutemwa nemusoro
• Kushatirwa
• Tembiricha yemuviri yakaderera
• Kutambudzika kwemhasuru
• Kukurumidza kurova kwemoyo
• Kuonda
• Shanduko mukusvinura, uye kunyange coma

Anopa hutano anozokuongorora obvunza nezve ako kana emwana zviratidzo.

Kuongorora kwepanyama kunogona kuratidza:

• Kuderera kweropa
• Kukurumidza kupisa
• Shock
• Zviratidzo zvekushaya mvura mumuviri

Miedzo inogona kuratidza:

• Yakakwirira serum osmolality
• Yakakwira weti kuburitsa, zvisinei kuti imvurai yaunonwa
• Itsvo hadziise pfungwa weti paunopihwa ADH (kazhinji mushonga unonzi desmopressin)
• Wakaderera weti osmolality
• Yakajairwa kana yakakwira ADH mazinga

Mimwe bvunzo inogona kuitwa inosanganisira:

• Kuongororwa kweropa reSodium
• Weti 24-awa vhoriyamu
• Weti yevasungwa bvunzo
• Weti chaiyo giravhiti
• Inotarisirwa bvunzo yekushomeka kwemvura
  

Chinangwa chekurapa ndechekudzora huwandu hwemvura yemuviri. Mvura yakawanda ichapihwa. Huwandu hunofanirwa kunge hwakaenzana neuwandu hwemvura irikurasika mumuti weti.

Kana mamiriro acho ari nekuda kwemumwe mushonga, kumisa mushonga kunogona kugadzirisa zviratidzo. Asi, usamire kutora chero mushonga usati watanga kutaura nemupi wako.

Mishonga inogona kupihwa yekuvandudza zviratidzo nekudzikisa weti kubuda.

Kana munhu akanwa mvura yakakwana, mamiriro aya haazove nemhedzisiro pane iyo fluid kana electrolyte balance yemuviri. Dzimwe nguva, kupfuudza weti yakawanda kwenguva yakareba kunogona kukonzera mamwe matambudziko e electrolyte.

Kana munhu wacho akasanwa zvinwiwa zvakakwana, kubuda kwakawanda weti kunogona kukonzera kupera simba uye huwandu hwakawanda hwesodium muropa.

NDI iyo iripo pakuzvarwa ndeyeyakareba mamiriro inoda kurapwa kwehupenyu hwese.

Isina kurapwa, NDI inogona kukonzera chero cheanotevera:

• Kugadzikana kweiyo ureters uye dundira
• Ropa rakakwira sodium (hypernatremia)
• Kunyanya kupera mvura mumuviri
• Shock
• Coma

Fonera mupiki wako kana iwe kana mwana wako aine zviratidzo zvechirwere ichi.

Congenital NDI haigone kudzivirirwa.

Kurapa kusagadzikana kunogona kutungamira kune yakawanikwa fomu yemamiriro acho kunogona kuzvidzivirira kubva mukukura mune zvimwe zviitiko.

Nephrogenic chirwere cheshuga insipidus; Yakawana nephrogenic chirwere cheshuga insipidus; Koberekwa nephrogenic chirwere cheshuga insipidus; NDI

• Urume urinary system

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