Chirwere lymphocytic leukemia (CLL)

Chronic lymphocytic leukemia (CLL) kenza yemhando yemasero machena eropa anonzi maLymphocyte. Aya maseru anowanikwa mumwongo wemapfupa uye zvimwe zvikamu zvemuviri. Bone mwongo ndiyo nyoro nyoro iri pakati pemabhonzo iyo inobatsira kuumba ese masero eropa.

CLL inokonzera kuwedzera kunonoka mune imwe mhando yemasero machena eropa anonzi B lymphocyte, kana B masero. Cancer masero anopararira kuburikidza neropa uye mapfupa emongo. CLL inogona zvakare kukanganisa ma lymph node kana zvimwe nhengo senge chiropa uye spleen. CLL pakupedzisira inogona kukonzera kuti mwongo wemapfupa urasikirwe nebasa rayo.

Chikonzero cheCLL hachizivikanwe. Iko hakuna chinongedzo kune radiation. Hazvina kujeka kana mamwe makemikari anogona kukonzera CLL. Kujekesa kune Agent Orange panguva yeHondo yeVietnam kwakabatana neyakawedzera njodzi yekuvandudza CLL.

CLL inowanzo bata vakuru vanhu, kunyanya avo vanopfuura makore makumi matanhatu. Vanhu vari pasi pemakore makumi mashanu havawanzo kukura CLL. CLL inowanzoitika kune vachena kupfuura mune mamwe madzinza. Inowanzoitika kune varume kupfuura vakadzi. Vamwe vanhu vane CLL vane nhengo dzemhuri dzine chirwere.

Zviratidzo zvinowanzo kukura zvishoma nezvishoma. CLL kazhinji haina kukonzera zviratidzo pakutanga. Inogona kuwanikwa nekuongororwa kweropa kunoitwa muvanhu nekuda kwezvimwe zvikonzero.

Zviratidzo zveCLL zvinogona kusanganisira:

• Yakawedzera lymph node, chiropa, kana spleen
• Kuwedzera kudikitira, kudikitira usiku
• Kuneta
• Kupindwa nechando
• Zvirwere zvinoramba zvichidzoka (zvinodzokazve), kunyangwe kurapwa
• Kurasikirwa nechido kana kuzara nekukurumidza nekukurumidza (kutanga kuguta)
• Kuonda

Anopa hutano anoita bvunzo dzepanyama uye obvunza nezve zviratidzo zvako.

Kuyedza kuongorora CLL kunogona kusanganisira:

• Yakazara kuverenga kweropa (CBC) neropa maseru kusiyanisa.
• Kuyerera cytometry bvunzo yemachena maseru eropa.
• Fluorescent in situ hybridization (FISH) inoshandiswa kutarisa uye kuverenga majini kana ma chromosomes. Bvunzo iyi inogona kubatsira kuongorora CLL kana kutungamira kurapwa.
• Kuedzwa kweimwe geni shanduko kunogona kubatsira kufanotaura kuti kenza inopindura sei kurapwa.

Vanhu vane CLL vanowanzove nechena chena masero eropa.

Kuyedzwa kunotarisa shanduko muDNA mukati memasero ekenza kunogona kuitwa. Mhedzisiro kubva kuiyi bvunzo uye kubva kustaging bvunzo inobatsira wako mupi kuona kurapwa kwako

Kana iwe uine nhanho yekutanga CLL, mupi wako anongokucherechedza zvakanyanya. Kurapa hakuwanzo kupihwa yekutanga-nhanho CLL, kunze kwekunge iwe uine:

• Zvirwere zvinoramba zvichidzoka
• Leukemia iri kukurumidza kukura
• Yakadzika tsvuku masero eropa kana platelet kuverenga
• Kuneta, kurasikirwa nehavi, kurasikirwa uremu, kana kubuda ziya usiku
• Kuzvimba lymph node

Chemotherapy, kusanganisira yakanangwa mishonga, inoshandiswa kurapa CLL. Wako mupi anoona kuti ndeupi mhando yemishonga yakakunakira iwe.

Kuwedzerwa ropa kana kuwedzerwa kweplatelet kunogona kudikanwa kana kuwanda kweropa kuri kushoma.

Bone marora kana stem cell kuisirwa inogona kushandiswa kune vechidiki vane yakakwira kana yakanyanya njodzi njodzi CLL. Kudhirowa ndiyo chete kurapwa uko kunopa kurapa kweCLL, asi zvakare kune njodzi. Mupiki wako anokurukura nenjodzi nezvakanakira newe.

Iwe nemupi wako mungangoda kugadzirisa zvimwe zvinonetsa panguva yekurapa kweeukemia, kusanganisira:

• Kugadzirisa zvipfuwo zvako panguva yekemotherapy
• Zvinetso zvekubuda ropa
• Muromo wakaoma
• Kudya macalorie akakwana
• Kudya zvakachengeteka panguva yekurapa gomarara

Unogona kudzikisira kushushikana kwehurwere nekujoinha boka rekutsigira gomarara. Kugovana nevamwe vane zvakajairika zviitiko uye matambudziko zvinogona kukubatsira kuti usazonzwa kusurukirwa.

Wako mupi anogona kukurukura newe maonero eCLL yako zvichibva padanho rayo uye nemabatiro ainoita kurapwa.

Zvinetso zveCLL uye kurapwa kwayo kunogona kusanganisira:

• Autoimmune hemolytic anemia, mamiriro umo masero matsvuku eropa anoparadzwa ne immune system
• Kubuda ropa kubva pasi peplatelet kuverenga
• Hypogammaglobulinemia, mamiriro umo mune yakaderera mwero yezvirwere kupfuura zvakajairwa, izvo zvinogona kuwedzera njodzi yehutachiona.
• Idiopathic thrombocytopenic purpura (ITP), chirwere chekubuda ropa
• Zvirwere zvinoramba zvichidzoka (zvinodzokororwa)
• Kuneta kunogona kubva pane zvinyoro kusvika kune zvakanyanya
• Mimwe kanzira, inosanganisira yakanyanya kutyisa lymphoma (Richter shanduko)
• Zvimwe zvinokanganisa chemotherapy

Daidza mupi kana iwe ukawedzera lymph node kana kuwanda kusinganzwisisike, kupwanya, kudikitira zvakanyanya, kana kurasikirwa uremu.

CLL; Leukemia - chisingaperi lymphocytic (CLL); Kenza yeropa - chisingaperi lymphocytic leukemia; Kenza yemongo wemapfupa - chisingaperi lymphocytic leukemia; Lymphoma - chisingaperi lymphocytic leukemia

• Bone marrow kuisirwa - kubuda

• Bone marora kushuvira
• Auer tsvimbo
• Chisingaperi lymphocytic leukemia - maikorosikopu maonero
• Antibodies

Awan FT, Byrd JC. Chisingaperi lymphocytic leukemia. Mune: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020: chits. 99.

National Cancer Institute webhusaiti. Chisingaperi lymphocytic leukemia kurapwa (PDQ) - hutano nyanzvi vhezheni. www.cancer.gov/types/leukemia/hp/cll-treatment-pdq. Yakagadziridzwa Ndira 22, 2020. Yakasvika muna Kukadzi 27, 2020.

National Yakakwana Cancer Network webhusaiti. NCCN kiriniki yekudzidzira maitiro mune oncology. Chisingaperi lymphocytic leukemia / diki lymphocytic lymphoma. Shanduro 4.2020. www.nccn.org/professionals/physician_gls/pdf/cll.pdf. Yakagadziridzwa Zvita 20, 2019. Yakasvika muna Kukadzi 27, 2020.