Chinhu cheVII kushomeka

Chinhu cheVII (chinomwe) kushomeka chirwere chinokonzerwa nekushaikwa kweprotein inonzi factor VII muropa. Inotungamira kumatambudziko nekugwamba kweropa (coagulation).

Paunobuda ropa, akateedzana maitiro anoitika mumuviri ayo anobatsira kuwanda kweropa fomu. Maitiro aya anonzi coagulation cascade. Inosanganisira mapuroteni akasarudzika anonzi coagulation, kana zvinogwambisa ropa. Iwe unogona kuve nemukana wepamusoro wekubuda ropa zvakanyanya kana chimwe kana zvimwe zvezvinhu izvi zvisipo kana zvisiri kushanda sezvavanofanira.

Chinhu VII ndechimwe chakadai coagulation chinhu. Chinhu cheVII kushomeka chinomhanya mumhuri (chakagara nhaka) uye hachiwanzoitika. Vabereki vaviri vanofanirwa kuve nejenasi yekuendesa chirwere kuvana vavo. Nhoroondo yemhuri yechirwere chekubuda ropa inogona kuita njodzi.

Kukosha kweFactor VII kunogona kunge kuri nekuda kweimwe mamiriro kana kushandiswa kwemimwe mishonga. Izvi zvinonzi zvakawanikwa chinhu VII kushomeka. Inogona kukonzerwa ne:

• Low vitamini K (vamwe vana vanozvarwa vaine vhitamini K kushomeka)
• Chirwere chakakomba chechiropa
• Kushandiswa kwemishonga inodzivirira kugwamba (anticoagulants senge warfarin)

Zviratidzo zvinogona kusanganisira chero zvinotevera:

• Kubuda ropa kubva mumamousu membranes
• Kubuda ropa muzvibatanidzwa
• Kubuda ropa mumhasuru
• Kutuka zviri nyore
• Kubuda kumwedzi kwakanyanya kubuda ropa
• Mhino dzemhino dzisingamire nyore
• Tambo yembilical ichibuda ropa mushure mekuzvarwa

Miedzo inogona kuitwa inosanganisira:

• Yakasarudzika thromboplastin nguva (PTT)
• Plasma factor VII chiitiko
• Prothrombin nguva (PT)
• Kusanganisa kudzidza, yakakosha PTT bvunzo yekusimbisa chinhu VII kushomeka

Kubuda ropa kunogona kudzorwa nekutora intravenous (IV) infusions yeplasma yakajairwa, inosanganisa ye factor VII, kana inogadzirwa nemajini (recombinant) factor VII.

Iwe unozoda kurapwa kazhinji panguva dzekubuda ropa zvikamu nekuti factor VII haigare kwenguva refu mukati memuviri. Fomu yechinhu VII inonzi NovoSeven inogona zvakare kushandiswa.

Kana iwe uine chinokonzera VII kushomeka nekuda kwekushaikwa kwevhitamini K, unogona kutora vhitamini iyi nemuromo, kuburikidza nemajekiseni pasi peganda, kana kuburikidza nemutsinga (mukati).

Kana iwe uine chirwere ichi chekubuda ropa, ita shuwa ku:

• Udza vanokupa hutano usati waita chero maitiro, kusanganisira kuvhiya uye basa remazino.
• Udza nhengo dzemhuri yako nekuti vanogona kunge vaine chirwere chakafanana asi havasati vazviziva.

Izvi zviwanikwa zvinokwanisa kupa rumwe ruzivo nezve kushomeka kweFactor VII:

• National Hemophilia Foundation: Zvimwe Kusakwana Kwezvinhu - www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies
• National Sangano reRare Dambudziko - rarediseases.org/rare-diseases/factor-vii-deficiency
• NLM Genetics Kumba Referensi - ghr.nlm.nih.gov/condition/factor-vii-deficiency

Iwe unogona kutarisira mhedzisiro yakanaka nekurapwa kwakakodzera.

Yakagara nhaka chinhu VII kushomeka ihwo hupenyu hwese mamiriro.

Maonero echinhu chinowanikwa VII kushomeka zvinoenderana nechikonzero. Kana iyo ichikonzerwa nechirwere chechiropa, mhedzisiro inoenderana nekuti chirwere chechiropa chako chinogona kurapwa sei. Kutora zvinowedzera vhitamini K kuchabata kushomeka kwevhitamini K.

Zvinetso zvinogona kusanganisira:

• Kuwedzera kubuda ropa (kubuda ropa)
• Sitiroko kana mamwe matambudziko ehurongwa hwemitsipa kubva mudumbu renjodzi kubuda ropa
• Joint matambudziko mumatambudziko akakomba apo kubuda ropa kunoitika kazhinji

Wana kurapwa kwekukurumidzira pakarepo kana iwe uine zvakanyanya, zvisina kutsanangurwa kubuda ropa.

Iko hakuna kuzivikanwa kudzivirira kwekugara nhaka chinhu VII kushomeka. Kana kushomeka kwevhitamini K chiri chikonzero, kushandisa vhitamini K kunogona kubatsira.

Proconvertin kushomeka; Kunze kwekushomeka kwechinhu; Serum prothrombin kutendeuka accelerator kushomeka; Chirwere cheAlexander

• Ropa kugadzirwa
• Ropa rinovhara

Gailani D, Wheeler AP, Neff AT. Kazhinji coagulation factor kushaikwa. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chits. 137.

Horo JE. Hemostasis uye kuwanda kweropa. MuImba JE, ed. Guyton uye Horo Chinyorwa cheMedhi Physiology. 13 ed. Philadelphia, PA: Elsevier; 2016: chits. 37.

Ragni MV. Hemorrhagic kusagadzikana: coagulation factor kushomeka. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits. 174.