Kufambira mberi kwakasiyana-siyana leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) chirwere chisingawanzoitika chinokuvadza izvo (myelin) inovhara uye inodzivirira tsinga mune chena nyaya yeuropi.

Iyo John Cunningham hutachiona, kana JC hutachiona (JCV) inokonzera PML. JC hutachiona inozivikanwa zvakare seyevanhu polyomavirus 2. Pakazosvika makore gumi, vanhu vazhinji vatapukirwa nehutachiona uhwu kunyangwe husingatombokonzere zviratidzo. Asi vanhu vane immune system isina kusimba vari panjodzi yekuvandudza PML. Zvinokonzera kushomeka kwema immune zvinosanganisira:

• HIV / AIDS (chisingawanzo kukonzerwa ne PML izvozvi nekuda kwekutarisira zvirinani kweHIV / AIDS).
• Mimwe mishonga inodzvinyirira immune system inonzi monoclonal antibodies. Mishonga yakadai inogona kushandiswa kudzivirira kuradzikwa kwechirango kana kurapa multiple sclerosis, rheumatoid arthritis uye zvimwe autoimmune kusagadzikana, uye mamiriro akafanana.
• Cancers, senge leukemia uye Hodgkin lymphoma.

Zviratidzo zvinogona kusanganisira chero zvinotevera:

• Kurasikirwa kwekubatana, kusagadzikana
• Kurasikirwa kwemutauro kugona (aphasia)
• Kurasikirwa kwendangariro
• Matambudziko ekuona
• Kuneta kwemakumbo nemaoko zvinowedzera
• Unhu hunochinja

Anopa hutano anoita bvunzo dzepanyama uye obvunza nezve zviratidzo.

Miedzo inogona kusanganisira:

• Brain biopsy (mune zvisingawanzoitika zviitiko)
• Cerebrospinal fluid bvunzo yeiyo JCV
• CT scan yehuropi
• Electroencephalogram (EEG)
• MRI yeuropi

Mune vanhu vane HIV / AIDS, kurapwa kwekusimbisa immune system kunogona kutungamira mukudzoka kubva kuzviratidzo zve PML. Hapana kumwe kurapwa kwakaratidza kushanda kune PML.

PML mamiriro anotyisidzira hupenyu. Zvichienderana nekuti hutachiona hwakanyanya sei, inosvika hafu yevanhu vanoonekwa kuti vane PML vanofa mukati memwedzi mishoma yekutanga taura nemupi wako nezve sarudzo dzekuchengetedza.

PML; John Cunningham hutachiona; JCV; Yevanhu polyomavirus 2; JC hutachiona

• Grey uye chena nyaya yehuropi
• Leukoencephalopathy

Berger JR, Nath A. Cytomegalovirus, Epstein-Barr hutachiona, uye inononoka hutachiona hutachiona hwehutachiona hwehutachiona. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chitsama 346.

Tan CS, Koralnik IJ. JC, BK, uye mamwe ma-polyomaviruses: inofambira mberi multifocal leukoencephalopathy (PML). Mune: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, uye Bennett's Maitiro uye Maitiro Ezvirwere zvinotapukira. 9th ed. Philadelphia, PA: Elsevier; 2020: chits. 144.