BRCA1 uye BRCA2 kuongororwa kwemajini

Iyo BRCA1 uye BRCA2 geni bvunzo kuongororwa kweropa kunogona kukuudza kana iwe uine njodzi yakanyanya yekubatwa negomarara. Zita rekuti BRCA rinobva kumavara maviri ekutanga e brmabvazuva cancer.

BRCA1 uye BRCA2 majini anodzvinyirira tumarara twakaipa (gomarara) muvanhu. Kana majini aya achinja (kuita mutated) haadzvinyiriri mamota sezvaanofanirwa. Saka vanhu vane BRCA1 uye BRCA2 magene ekuchinja vari panjodzi huru yekubatwa nekenza.

Vakadzi vane shanduko iyi vari panjodzi yakanyanya yekubata gomarara repazamu kana gomarara reovari. Kuchinja kunogona kuwedzera njodzi yemukadzi yekukura:

• Gomarara remuromo wechibereko
• Kenza yechibereko
• Gomarara rekoloni
• Mukenza wepancreatic
• Gomarara regallbladder kana kenza yenyuchi
• Kenza yemudumbu
• Melanoma

Varume vane shanduko iyi vanowanzoita gomarara. Kuchinja kunogona kuwedzera njodzi yemurume yekukura:

• Gomarara repazamu
• Mukenza wepancreatic
• Gomarara repachiedza
• Kenza yeprostate

Ingangoita zvikamu zvishanu kubva muzana zvegomarara remuzamu uye gumi kusvika gumi neshanu muzana yekenza yemazai inosanganiswa neBRCA1 uye BRCA2 shanduko.

Usati waedzwa, iwe unofanirwa kutaura neyemagenetic chipangamazano kuti udzidze zvakawanda nezve bvunzo, uye njodzi uye zvakanakira kuyedzwa.

Kana iwe uine nhengo yemhuri ine gomarara repazamu kana gomarara remazai, tsvaga kana munhu iyeye akaedzwa shanduko ye BRCA1 uye BRCA2. Kana munhu iyeye aine shanduko, iwe ungafunge kuyedzwa, zvakare.

Mumwe munhu mumhuri yako anogona kuve ne BRCA1 kana BRCA2 shanduko kana:

• Hama mbiri kana kupfuura dzepedyo (vabereki, vanin'ina, vana) vane gomarara repazamu vasati vava nemakore makumi mashanu
• Hama hama ine gomarara repazamu
• Hama yehukama ine kenza yemazamu neyechibereko
• Hama mbiri dzine cancer yechibereko
• Iwe uri weEastern Europe (Ashkenazi) madzitateguru echiJuda, uye hama yepedyo ine kenza yemazamu kana ovari

Iwe une mukana wakaderera kwazvo wekuve ne BRCA1 kana BRCA2 shanduko kana:

• Iwe hauna hama yaive nekenza yemazamu isati yasvika makore makumi mashanu
• Iwe hauna hama yaive nekenza yemazai
• Iwe hauna hama yaive nekenza yemazamu yemurume

Muedzo usati waitwa, taura kuna chipangamazano pamajini kuti utore kana uchifanira kuyedzwa.

• Huya newe nhoroondo yako yekurapa, nhoroondo yemhuri yekurapa, uye mibvunzo.
• Iwe ungangoda kuunza mumwe munhu newe kuzoteerera uye kunyora zvinyorwa. Zvakaoma kunzwa nekurangarira zvese.

Ukasarudza kuyedzwa, yako yeropa sampu inotumirwa kune lab inoratidzira kuongororwa kwemajini. Iyo labhu ichaedza ropa rako kuitira BRCA1 uye BRCA2 shanduko. Zvinogona kutora vhiki kana mwedzi kuti uwane mhinduro dzekuedzwa.

Kana zvabuda bvunzo zvadzoka, murapi wemazamu anozotsanangura zvabuda uye zvazvinoreva kwauri.

Mhedzisiro yekuyedza mhedzisiro zvinoreva kuti iwe wakagara nhaka iyo BRCA1 kana BRCA2 shanduko.

• Izvi hazvireve kuti une kenza, kana kunyangwe kuti uchawana gomarara. Izvi zvinoreva kuti uri panjodzi huru yekubatwa nekenza.
• Izvi zvinoreva zvakare kuti iwe unogona kana kuti ungadai wakapfuudza shanduko iyi kuvana vako. Pese paunenge uine mwana pane 1 mu2 mukana kuti mwana wako awane shanduko yauinayo.

Kana iwe uchiziva iwe uri pangozi yakanyanya yekubatwa nekenza, unogona kusarudza kana iwe uchizoita chero chinhu zvakasiyana.

• Iwe ungangoda kuongororwa gomarara kazhinji, saka inogona kubatwa nekukurumidza uye kurapwa.
• Panogona kunge paine mushonga waunogona kutora uyo unogona kudzikisira mukana wako wekubatwa negomarara.
• Unogona kusarudza kuvhiyiwa kuti ubvise mazamu kana mazai.

Hapana imwe yeidzi chengetedzo inovimbisa kuti hauzobatwa negomarara.

Kana mhedzisiro yako yekuyedzwa kwe BRCA1 uye BRCA2 shanduko isina kunaka, iye chipangamazano anokuudza kuti izvi zvinorevei. Nhoroondo yemhuri yako ichabatsira mubatsiri wezvemagenge kuti anzwisise mhedzisiro yakaipa.

Mhedzisiro isina kunaka hazvireve kuti hauzobatwe nekenza. Zvinogona kureva kuti une njodzi imwechete yekubatwa nekenza sevanhu vasina shanduko iyi.

Ive neshuwa yekukurukura zvese mhedzisiro yemiyedzo yako, kunyangwe yakaipa mhedzisiro, neako genetic chipangamazano.

Gomarara repazamu - BRCA1 uye BRCA2; Kenza yeOvarian - BRCA1 uye BRCA2

Moyer VA; US Inodzivirira Services Task Force. Kuongororwa kwenjodzi, kugadziriswa kwekuberekwa, uye kuongororwa kwegeneti yekenza inoenderana ne BRCA muvakadzi: US Preventive Services Task Force chirevo chekukurudzira Ann Mukati Med. 2014; 160 (4): 271-281. PMID: 24366376 www.ncbi.nlm.nih.gov/pubmed/24366376.

National Cancer Institute webhusaiti. Kuchinja kwe BRCA: njodzi yekenza uye kuongororwa kwemajini. www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet. Yakagadziridzwa Ndira 30, 2018. Yakasvika Nyamavhuvhu 5, 2019.

Nussbaum RL, McInnes RR, Willard HF. Kenza genetics uye genomics. Mune: Nussbaum RL, McInnes RR, Willard HF, eds. Thompson na Thompson Genetics muMushonga. 8th ed. Philadelphia, PA: Elsevier; 2016: chits.

• Kenza Yezamu
• Kuongorora kweGenetic
• Kenza yeOvarian