Kuzadzisa

Kuteedzera ndiko kuyedza kweropa kunoyera chiitiko chemamwe mapuroteni muchikamu chemvura cheropa rako.

Iyo yekuwedzera system iboka remapuroteni anoda kusvika makumi matanhatu ari muplasma yeropa kana pamusoro pemamwe maseru. Mapuroteni anoshanda nema immune system ako uye anoita basa rekuchengetedza muviri kubva kuzvirwere, uye kubvisa maseru akafa nezvimwe zvekunze. Kazhinji, vanhu vanogona kugara nhaka kushomeka kwevamwe vanozadzisa mapuroteni. Vanhu ava vanowanzo tenderwa nezvimwe hutachiona kana autoimmune kusagadzikana.

Iko kune mapfumbamwe makuru ekuwedzera mapuroteni. Ivo vakanzi C1 kuburikidza neC9. Ichi chinyorwa chinotsanangura bvunzo iyo inoyera zvizere zvinozadzisa zviitiko.

Muenzaniso weropa unodiwa. Izvi zvinowanzo kutorwa kuburikidza netsinga. Maitiro acho anonzi venipuncture.

Iko hakuna kugadzirira kwakakosha.

Kana tsono ikaiswa kukweva ropa, vamwe vanhu vanonzwa kurwadziwa zvishoma. Vamwe vanogona kungonzwa kubaya kana kubaya. Mushure meizvozvo, panogona kunge paine kurovera.

Yakazara yekuzadzisa chiitiko (CH50, CH100) inotarisa pane zvese zviitiko zveyekutsigira system. Muzviitiko zvakawanda, kumwe kuyedzwa uko kwakanyanya kunangana nechirwere chinofungidzirwa kunoitwa kutanga. C3 neC4 ndizvo zvinowanisa zvinhu zvinoyerwa kazhinji.

Chiyero chekuwedzera chinogona kushandiswa kuongorora vanhu vane autoimmune kusagadzikana. Inoshandiswa zvakare kuona kana kurapwa kwemamiriro avo kuri kushanda. Semuenzaniso, vanhu vane lupus erythematosus inoshanda vanogona kunge vane yakaderera-kupfuura-yakajairwa mazinga eanobatsira mapuroteni C3 neC4.

Kuteedzera zviitiko zvinosiyana mumuviri wese. Semuenzaniso, mune vanhu vane rheumatoid arthritis, basa rekuwedzera muropa rinogona kunge rakajairika kana rakakwira-kupfuura-rinowanzoitika, asi rakadzika kwazvo-kupfuura-rinowanzoitika mujoin fluid.

Vanhu vane hutachiona hutachiona hwehutachiona uye kushamisika kazhinji vane yakaderera kwazvo C3 uye zvikamu zveinozivikanwa seimwe nzira nzira. C3 inowanzo kuve yakaderera muzvirwere zvefungal uye zvimwe hutachiona hwehutachiona hwakadai semarariya.

Mhedzisiro mhedzisiro yemuyedzo uyu ndeiyi:

• Yese ropa rinozadza mwero: 41 kusvika 90 hemolytic mayuniti
• C1 chikamu: 14.9 kusvika 22.1 mg / dL
• C3 mazinga: 88 kusvika 201 mg / dL
• C4 mazinga: 15 kusvika 45 mg / dL

Ongorora: mg / dL = mamirigiramu padhisita.

Ongorora: zvakajairika kukosha masenduru anogona kusiyana zvishoma pakati pema laboratories akasiyana. Taura nemupi wako wezvehutano nezve zvinorehwa nemimwe miedzo yako.

Iyi mienzaniso iripamusoro inoratidza zviyero zvakajairika zvemhedzisiro yeiyi bvunzo. Mamwe marabhoritari anoshandisa zviyero zvakasiyana kana anogona kuyedza mienzaniso dzakasiyana.

Kuwedzera kwekuwedzera chiitiko kunoonekwa mu:

• Gomarara
• Zvimwe hutachiona
• Ulcerative colitis

Kuderera kwekuwedzera chiitiko kunoonekwa mu:

• Cirrhosis
• Glomerulonephritis
• Nhaka angioedema
• Hepatitis
• Itsvo kuisazve kurambwa
• Lupus nephritis
• Kushaya zvokudya zvinovaka muviri
• Systemic lupus erythematosus
• Kazhinji kugarwa kunowedzera kukwana

Njodzi dzakabatana nekutorwa kweropa idiki, asi dzinogona kusanganisira:

• Kuwedzera kubuda ropa
• Kufenda kana kunzwa kushaya musoro
• Hematoma (ropa rinoungana pasi peganda)
• Utachiona (hushoma njodzi chero nguva ganda parinovhunika)

Iyo "complement cascade" ndeye akateedzana maitiro anoitika muropa. Iyo Cascade inomutsa iyo yekuwedzera mapuroteni. Mhedzisiro yacho yuniti yekurwisa inogadzira maburi mu membrane yebhakitiriya, ichivauraya.

Zadzisa chiyero; Simbisa mapuroteni

• Kuongorora ropa

Chernecky CC, Berger BJ. C. Muna: Chernecky CC, Berger BJ, eds. Rabhoritari Kuyedza uye Maitiro Ekuongorora. 6th ed. St Louis, MO: Elsevier Saunders; 2013: 266-432.

Holers VM. Komberedza uye ayo anogamuchira: hutsva hutsva muzvirwere zvevanhu. Annu Rev Immunol. 2014; 3: 433-459. PMID: 24499275 www.ncbi.nlm.nih.gov/pubmed/24499275.

Merle NS, Chechi SE, Fremeaux-Bacchi V, Roumenina LT. Komberedza sisitimu chikamu I - mamorekuru maitiro ekumisikidza uye mutemo. Pamberi Immunol. 2015; 6: 262. PMID: 26082779 www.ncbi.nlm.nih.gov/pubmed/26082779.

Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT. Komberedza sisitimu chikamu II: basa rekuzvidzivirira. Pamberi Immunol. 2015; 6: 257. PMID: 26074922 www.ncbi.nlm.nih.gov/pubmed/26074922.

Morgan BP, Harris CL. Kwiridzira, chinangwa chekurapa muzvirwere zvinoputira uye zvinogumbura. Nat Rev Zvinodhaka Discov. 2015; 14 (2): 857-877. PMID: 26493766 www.ncbi.nlm.nih.gov/pubmed/26493766.