Eculizumab Jekiseni

Zvemukati

• Usati wagamuchira jekiseni re eculizumab,
• Eculizumab jekiseni inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana izvo zvakanyorwa muchikamu CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Kugamuchira eculizumab jekiseni kunogona kuwedzera njodzi yekuti iwe unozokudziridza hutachiona hwe meningococcal (hutachiona hunogona kukanganisa kufukidzwa kwehuropi uye musana wesipinha uye / kana kungapararira kuburikidza neropa) panguva yekurapwa kwako kana kwechinguva chakatevera. Zviratidzo zveMeningococcal zvinogona kukonzera kufa munguva pfupi. Iwe unozofanirwa kugamuchira mushonga we meningococcal kweinenge mavhiki maviri usati watanga kurapwa kwako nejekiseni yeeculizumab kudzikisa njodzi yekuti uchaita rudzi urwu rwehutachiona. Kana iwe wakagamuchira uyu mushonga munguva yakapfuura, ungangoda kugamuchira booster dose usati watanga kurapwa kwako. Kana chiremba wako achinzwa kuti iwe unoda kutanga kurapwa neeculizumab jekiseni ipapo ipapo, iwe uchagamuchira yako meningococcal jekiseni nekukurumidza sezvazvinogona.

Kunyangwe iwe ukatambira mushonga we meningococcal, pachine njodzi yekuti iwe unogona kukura chirwere che meningococcal panguva kana mushure mekurapwa kwako nejekiseni reeculizumab. Kana ukasangana nechimwe chezviratidzo zvinotevera, fonera chiremba wako nekukasira kana kuwana rubatsiro rwechimbichimbi rwekurapwa: kutemwa nemusoro kunouya pamwe nekurutsa kana kurutsa, fivha, mutsipa wakaomarara, kana musana wakaomarara; fever ye103 ° F (39.4 ° C) kana kupfuura; mapundu nefivha; kuvhiringidzika; mhasuru kurwadza uye zvimwe zviratidzo zvakaita sefuru; kana kana maziso ako aine chiedza.

Udza chiremba wako kana iwe uine fever kana zvimwe zviratidzo zvehutachiona usati watanga kurapwa kwako neeculizumab injection. Chiremba wako haazokupe eculizumab jekiseni kana iwe uchinge uchinge uchinge uine hutachiona hwemaningococcal.

Chiremba wako achakupa kadhi rekuchengetedza murwere neruzivo nezve njodzi yekukura chirwere che meningococcal mukati kana kwenguva yakati rebei mushure mekurapwa kwako. Takura kadhi iri newe nguva dzose panguva yekurapwa kwako uye kwemwedzi mitatu mushure mekurapwa kwako. Ratidza kadhi kune vese vanopa hutano vanokurapa kuitira kuti vazive nezve njodzi yako.

Chirongwa chinonzi Soliris REMS chakamisikidzwa kudzikisa njodzi dzekugamuchira jekiseni re eculizumab. Unogona chete kugamuchira eculizumab jekiseni kubva kuna chiremba akanyoresa muchirongwa ichi, akataura newe nezve njodzi dzechirwere chemaningococcal, akakupa kadhi rekuchengetedza murwere, uye akave nechokwadi chekuti wawana mushonga wemaningococcal.

Chiremba wako kana wemishonga anokupa iro gadziriro yeruzivo yemurwere (Medication Guide) paunotanga kurapwa nejekiseni reeculizumab uye nguva yega yega yaunogamuchira jekiseni. Verenga iwo ruzivo nokungwarira uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kana webhusaiti yemugadziri kuti utore Gwaro reMishonga.

Taura nachiremba wako nezve njodzi dzekugamuchira eculizumab jekiseni.

Eculizumab jekiseni inoshandiswa kurapa paroxysmal nocturnal hemoglobinuria (PNH: rudzi rweanemia mune ayo masero matsvuku eropa akaputsika mumuviri, saka hapana masero akakwana ane hutano kuunza oxygen kumativi ese emuviri). Eculizumab jekiseni inoshandiswawo kurapa atypical hemolytic uremic syndrome (aHUS; chinzvimbo chakagara nhaka umo madiki eropa anovhara mumuviri uye anogona kukonzera kukuvara kumidziyo yeropa, masero eropa, itsvo, uye zvimwe zvikamu zvemuviri). Eculizumab jekiseni inoshandiswawo kurapa imwe nzira ye myasthenia gravis (MG; kusagadzikana kwenzara kunokonzeresa kushomeka kwemhasuru). Iyo inoshandiswawo kurapa neuromyelitis optica spectrum kusagadzikana (NMOSD; autoimmune kusagadzikana kweiyo nervous system inobata maziso eziso uye musana wesipinha) kune vamwe vanhu vakuru. Eculizumab jekiseni iri muboka remishonga inonzi monoclonal antibodies. Inoshanda nekudzivirira chiitiko chechikamu chedziviriro yezvirwere mumuviri chinogona kukuvadza masero eropa muvanhu vane PNH uye izvo zvinokonzeresa kugwamba kwevanhu vane HUS. Izvo zvinoshandawo nekuvharira chiitiko chechimwe chikamu chemuviri wechirwere chemuviri chinogona kukuvadza zvimwe zvikamu zvecentral nervous system muvanhu vane NMOSD kana nekukanganisa kutaurirana pakati pemitsipa nemhasuru mune vanhu vane MG.

Eculizumab jekiseni inouya semhinduro (mvura) kujowa mukati (mukati mutsinga) pamusoro pemaminitsi makumi matatu nemashanu nachiremba kana mukoti muhofisi yezvokurapa. Inowanzo kupihwa vakuru kamwe chete pasvondo kwevhiki shanu uyezve kamwe kamwe pasvondo. Vana vanogona kugamuchira eculizumab jekiseni pane imwe purogiramu, zvinoenderana nezera ravo uye huremu hwemuviri. Mamwe madosi eeculizumab jekiseni anopiwa pamberi kana mushure meimwewo marapirwo ePNH, aHUS, MG, kana NMOSD.

Chiremba wako angangotanga iwe padosi yakaderera yeeculizumab jekiseni uye wedzera yako dose mushure memasvondo mana.

Eculizumab jekiseni inogona kukonzeresa kukanganisika kweanogadzirisa. Chiremba wako anokucherechedza zvakanyatsonaka paunenge uchigamuchira jekiseni re eculizumab uye kweawa rimwe mushure mekugamuchira mushonga. Chiremba wako anogona kunonoka kana kumisa yako infusion kana iwe uine allergic reaction. Kana ukasangana nechimwe chezviratidzo zvinotevera, udza chiremba wako nekukurumidza: kurwadziwa pachipfuva; kunzwa kupera simba; mapundu; mikoko; kuzvimba kwemaziso, kumeso, miromo, rurimi kana huro; hoarseness; kana kunetseka kufema kana kumedza.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati wagamuchira jekiseni re eculizumab,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune eculizumab jekiseni, chero mimwe mishonga, kana chero chinhu chinosanganiswa mujekiseni reeculizumab. Kumbira wemishonga wako kana tarisa Gwaro Rekurapa kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvekuwedzera pane zvekudya, uye mishonga yemakwenzi yauri kutora kana kuronga kutora. Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
• udza chiremba wako kana iwe wakambove kana chero imwe hutano mamiriro (s).
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Kana iwe ukava nepamuviri uchigamuchira eculizumab jekiseni, fonera chiremba wako.
• kana mwana wako achizorapwa nejekiseni reeculizumab, mwana wako anofanira kubayiwa nhomba kuStreptococcus pneumoniae uye Haemophilus influenza mhando b (Hib) asati atanga kurapwa. Taura nachiremba wemwana wako nezve kupa mwana wako majekiseni aya uye chero mamwe majekiseni anodiwa nemwana wako.
• kana uri kurapwa PNH, iwe unofanirwa kuziva kuti mamiriro ako anogona kukonzera masero matsvuku eropa kuwanda mushure mekumira kugamuchira eculizumab jekiseni. Chiremba wako anozokutarisa zvine hungwaru uye anogona kuraira bvunzo dzemarabhoritari mukati memavhiki masere ekutanga mushure mekupedza kurapwa kwako. Shevedza chiremba wako ipapo ipapo kana iwe ukagadzira chero cheanotevera zviratidzo: kuvhiringidzika, kurwadziwa muchipfuva, kunetseka kufema, kana zvimwe zviratidzo zvisina kujairika.
• kana iwe uri kurapwa kweAHUS, iwe unofanirwa kuziva kuti mamiriro ako anogona kukonzeresa kugwamba kweropa mumuviri wako mushure mekumira kugamuchira eculizumab jekiseni. Chiremba wako anozokutarisa zvine hungwaru uye anogona kuraira bvunzo dzemarabhoritari mumavhiki gumi nemaviri ekutanga wapedza kurapwa kwako. Fonera chiremba wako ipapo ipapo kana iwe ukagadzira chero cheanotevera zviratidzo: kamwe kamwe kunetseka kutaura kana kunzwisisa kutaura; kuvhiringidzika; kukurumidza kushaya simba kana kugwinha kweruoko kana gumbo (kunyanya kune rimwe divi remuviri) kana rechiso; kamwe-kamwe kunetseka kufamba, dzungu, kurasikirwa kwechiyero kana kubatana; kufenda; pfari; kurwadziwa muchipfuva; kunetseka kufema; kuzvimba mumaoko kana makumbo; kana zvimwe zviratidzo zvisina kujairika.

Kunze kwekunge chiremba wako akakuudza neimwe nzira, ramba uchidya zvakajairika.

Kana iwe ukarasikirwa musangano kuti ugamuchire muyero weiyo eculizumab jekiseni, fonera chiremba wako ipapo ipapo.

Eculizumab jekiseni inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• musoro
• dzihwa
• kurwadziwa kana kuzvimba mumhino kana pahuro
• kukosora
• kunetseka kurara kana kuramba wakarara
• kuneta zvakanyanya
• dzungu
• mhasuru kana kurwadziwa kwemajoini
• kurwadziwa shure
• kurwadziwa mumaoko kana makumbo
• maronda mumuromo
• manyoka
• kusvotwa
• kurutsa
• kurwadziwa nemudumbu
• kunorwadza kana kuoma kuita weti

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana izvo zvakanyorwa muchikamu CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• kupindwa nechando
• kuzvimba kwemaoko, maoko, tsoka, makumbo, kana makumbo ezasi
• kukurumidza kurova kwemoyo
• kushaya simba
• ganda rakachenuruka
• mweya wekufema

Eculizumab jekiseni inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika paunenge uchigamuchira mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira mamwe marabhoritari bvunzo kuti atarise mhinduro yemuviri wako kune eculizumab jekiseni.

Kumbira wemishonga wako chero mibvunzo iwe unayo nezve eculizumab jekiseni.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Soliris^®