Panobinostat

Zvemukati

• Usati watora panobinostat,
• Panobinostat inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana izvo zvakanyorwa muchikamu CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:
• Zviratidzo zvekuwedzeredza zvinogona kusanganisira zvinotevera:

Panobinostat inogona kukonzera manyoka akanyanya uye mamwe akakomba gastrointestinal (GI; inokanganisa dumbu kana ura) mhedzisiro. Kana iwe ukasangana nechimwe cheanotevera zviratidzo, dana chiremba wako nekukurumidza: mudumbu kurwadza; zvigaro zvakasununguka; manyoka; kurutsa; kana mukanwa wakaoma, weti yakasviba, kudikitira kudikitira, ganda rakaoma, uye zvimwe zviratidzo zvekushaya mvura. Taura nachiremba wako nezve izvo zvaunofanirwa kuita kana iwe uchikura manyoka panguva yekurapa kwako nepanobinostat. Uyezve taura nachiremba wako usati watora chero laxatives kana stool softeners iwe uchiri kutora mushonga uyu.

Panobinostat inogona kukonzera zvakakomba kana kutyisidzira hupenyu matambudziko emwoyo panguva yekurapa kwako. Udza chiremba wako kana iwe uchangobva kuve nekurwadziwa kwemoyo kana iwe uine refu QT syndrome (mamiriro anowedzera njodzi yekukura isina kujairika kurova kwemoyo kunogona kukonzera kupera simba kana kufa kamwe kamwe), angina (kurwadziwa pachipfuva), kana mamwe matambudziko emoyo. Chiremba wako acharaira bvunzo senge electrocardiogram (ECG; bvunzo iyo inorekodha chiitiko chemagetsi chemwoyo) usati uye panguva yekurapa kwako kuti uone kana zvakachengeteka kuti iwe utore panobinostat. Kana ukasangana nechimwe chezviratidzo zvinotevera, fonera chiremba wako nekukasira: kurwadziwa pachipfuva, kukurumidza, kurova, kana kurova kwemoyo zvisina kujairika, hura husina musoro, kunzwa kupera simba, dzungu, miromo ine ruvara-rwebhuruu, mweya wekufema, kana kuzvimba kwemaoko, maoko, tsoka, makumbo, kana makumbo ezasi.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira mimwe bvunzo kuti atarise mhinduro yemuviri wako panobinostat.

Chiremba wako kana wemishonga anokupa iro gadziriro yeruzivo yemurwere (Medication Guide) paunotanga kurapwa nepanobinostat uye nguva yega yega paunozadza mushonga wako. Verenga iwo ruzivo nokungwarira uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kana webhusaiti yemugadziri kuti utore Gwaro reMishonga.

Taura nachiremba wako nezve njodzi dzekutora panobinostat.

Panobinostat inoshandiswa pamwe chete ne bortezomib (Velcade) uye dexamethasone kurapa vanhu vane myeloma yakawanda (rudzi rwekenza yemongo wemapfupa) vakatorapwa mimwe mishonga miviri, kusanganisira bortezomib (Velcade). Panobinostat iri mukirasi yemishonga inonzi histone deacetylase (HDAC) inhibitors. Inoshanda nekuuraya cancer maseru.

Panobinostat inouya sekapuleti kutora nemuromo. Inowanzo kutorwa pamwe kana pasina chikafu kamwe zuva nezuva pane mamwe mazuva e21-zuva kutenderera. Iyo kutenderera inogona kudzokororwa kweanosvika gumi nematanhatu mairi. Tora panobinostat panenge panguva imwechete pazuva rega rega rakarongwa. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora panobinostat chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza macapsule akazara negirazi remvura; usazvipwanya, kutsenga, kana kuvhura. Bata ma capsules zvishoma sezvinobvira. Kana ukabata panobinostat capsule yakaputsika kana mushonga uri mu capsule, geza nzvimbo iyoyo yemuviri wako nesipo nemvura. Kana mushonga uri muhombodo ukapinda mumuromo mako, mumhino, kana maziso, geza nemvura yakawanda.

Kana iwe ukarutsa mushure mekutora panobinostat, usatore imwe dosi. Enderera yako yenguva dzose dosing purogiramu.

Ive neshuwa yekuudza chiremba wako kuti unonzwa sei panguva yekurapwa kwako. Chiremba wako anogona kudzikisira muyero wako wepanobinostat kana kumisa kurapwa kwako kwechinguva kana zvachose, kana iwe ukava nemhedzisiro yemhedzisiro.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora panobinostat,

• udza chiremba wako uye wemishonga kana uri weergoria kune panobinostat, chero mimwe mishonga, kana chero chinhu chinosanganiswa mumapanobinostat capsules. Kumbira wemishonga wako kana tarisa Gwaro Rekurapa kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemiti yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: amiodarone (Cordarone, Nexterone, Pacerone); antifungals senge itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), uye voriconazole (Vfend); atomoxetine (Strattera); bepridil (Vascor; haichawanikwi muU.S.); boceprevir (Victrelis); carbamazepine (Carbatrol, Tegretol, Teril, nevamwe); chloroquine (Aralen); clarithromycin (Biaxin, muPrevPac); conivaptan (Vaprisol); desipramine (Norpramin); dextromethorphan; disopyramide (Norpace); dolasetron (Anzemet); mimwe mishonga yeHIV yakadai seininavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, muKaletra, muViekira Pak), saquinavir (Invirase); methadone (Dolophine, Methadose); metoprolol (Lopressor, Toprol-XL); moxifloxacin (Avelox); nebivolol (Bystolic); nefazodone; ondansetron (Zofran, Zuplenz); perphenazine; pimozide (Orap); phenobarbital; phenytoin (Dilantin, Phenytek); procainamide; quinidine (muNuedexta); rifampin (Rifadin, Rimactane, muRifamate, muRifater); sotalol (Betapace, Sorine, Sotylize); telaprevir (Incivek; haichawanikwi muU.S.); telithromycin (Ketek); thioridazine; tolterodine (Detrol); uye venlafaxine (Effexor). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St John's wort.
• udza chiremba wako kana iwe uine hutachiona kana uine kana wakambove nematambudziko ekubuda ropa kana chirwere chechiropa.
• udza chiremba wako kana iwe uine pamuviri kana kuronga kuva nepamuviri. Panobinostat inogona kukuvadza fetus. Shandisa kuberekwa kudzivirira kubata pamuviri panguva yekurapa kwako nepanobinostat uye kweinenge mwedzi mumwe mushure mekupedzisira dosi. Kana iwe uri murume uye mumwe wako anogona kubata pamuviri, iwe unofanirwa kushandisa kondomu paunenge uchinwa mushonga uyu uye kwemazuva makumi mapfumbamwe mushure mekurapwa kwako kwapera. Kumbira chiremba wako kana iwe uine mibvunzo nezve mhando dzekudzivirira kuberekwa dzinoshanda kwauri. Kana iwe ukava nepamuviri uchitora panobinostat, dana chiremba wako nekukurumidza.
• udza chiremba wako kana iwe uchiyamwisa. Iwe haufanire kuyamwa uchi tora panobinostat.
• kana uri kuvhiyiwa, kusanganisira kuvhiya mazino, udza chiremba kana chiremba wemazino kuti urikutora panobinostat.

Usadye pomegranati, grapefruit kana nyeredzi muchero kana kunwa mazambiringa mazambiringa kana mutamba mutamba uchinwa mushonga uyu.

Kana anga ave maawa gumi nemaviri kana mashoma kubva pawakange wakarongerwa kutora iyo dosi, tora iyo yakarasika dosi nekukurumidza kana uchinge uchayeuka izvozvo. Kana anga ave anopfuura maawa gumi nemaviri kubva pane yako yakarongwa dhizaini, svetuka iyo dose uye enderera yako yenguva dzose dosing purogiramu Usatore dosi yakapetwa kaviri kuti uwane yekushayikwa.

Panobinostat inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• kuonda
• musoro

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana izvo zvakanyorwa muchikamu CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• nhema, mira, kana zvituru zvine ropa
• kurutsa kweropa kana kurutsa zvinhu zvinoita kunge kofi nzvimbo
• kupwanya kusingawanzo kana kubuda ropa
• weti yepingi kana shava
• ropa muhombodo
• kuvhiringidzika
• shanduko mukutaura kwako
• fivha, kukosora, kutonhora, kudikitira kana zvimwe zviratidzo zvehutachiona
• ganda rakachenuruka
• kusvotwa, kurutsa, kurasikirwa nechido, weti yakasviba, kurwadziwa mudumbu, kuneta zvakanyanya, kushaya simba, kana kuita yero kweganda kana chena maziso

Panobinostat inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nechiedza, kupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Zviratidzo zvekuwedzeredza zvinogona kusanganisira zvinotevera:

• manyoka
• kusvotwa
• kurutsa
• kuderera kwechido

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Farydak^®