Zvakarurama

Zvemukati

• Usati watora entrectinib,
• Entrectinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Entrectinib inoshandiswa kurapa imwe mhando yekenza isiri-diki yemapapu kenza (NSCLC) muvakuru yakapararira kune dzimwe nhengo dzomuviri. Iyo inoshandiswa zvakare kurapa mamwe marudzi ematota akasimba muvakuru uye vana vane makore gumi nemaviri ekuberekwa uye asingakwanise kurapwa nekuvhiya kana iyo yakapararira kune mamwe mativi emuviri uye yakawedzera mushure mekurapwa nemamwe mishonga yemakemikari. Entrectinib iri mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito chepuroteni isina kujairika iyo inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kumisa kana kunonoka kupararira kwekenza masero.

Entrectinib inouya sekapuleti kutora nemuromo. Inowanzo kutorwa pamwe kana pasina chikafu kamwe pazuva. Tora entrectinib panguva dzakatenderedza nguva imwechete mazuva ese. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora entrectinib chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza macapsules akazara; usavhure, kutsenga, kana kuapwanya.

Kana iwe ukarutsa pakarepo mushure mekutora entrectinib, tora imwe dosi nekukurumidza sezvazvinogona.

Kumbira wemishonga wako kana chiremba kopi yemashoko emugadziri wemurwere.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora entrectinib,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune entrectinib, chero mimwe mishonga, kana chero chinhu chinogadzirwa mumakomputa erepentinib. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemakwenzi yauri kutora kana kuronga kutora. Ive neshuwa yekutaura zvinotevera: aprepitant (Emend), mamwe antifungal mishonga senge fluconazole (Diflucan), itraconazole (Omel, Sporanox), kana ketoconazole; mimwe mishonga ye arrhythmias yakadai sa amiodarone (Nexterone, Pacerone), procainamide, quinidine (muNuedexta), uye sotalol (Betapace, Sorine, Sotylize); azithromycin (Zithromax); clarithromycin (Biaxin, muPrevpac); diltiazem (Cardizem, Tiazac, vamwe); erythromycin (EES, Erythrocin, vamwe); enzalutamide (Xtandi); mimwe mishonga yeHIV yakadai seEfavirenz (Sustiva, muAtripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, muKaletra, vamwe), kana saquinavir (Invirase); lithium (Lithobid); modafinil (Provigil); nefazodone; oxcarbazepine (Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, muActoplus, Duetact, Oseni); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, muRifater); muromo steroid senge dexamethasone, methylprednisolone (Medrol), uye prednisone (Rayos); uye verapamil (Calan). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kubatana ne entrectinib, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's Wort.
• udza chiremba wako kana iwe kana wakambove nemamiriro ezvinhu etsinga, nguva refu yeQT (chinetso chisingawanzo mwoyo chinogona kukonzeresa kurova kwemoyo zvisina kufanira, kufenda, kana kufa kamwe kamwe), kurova kwemoyo kunonoka kana kusingaite, kurwara kwemoyo, kutadza kwemoyo, kana chirwere chemwoyo kana chechiropa.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana kana iwe uronga nezve kubereka mwana. Kana iwe uri munhukadzi, iwe uchafanirwa kutora nhumbu yekubata usati watanga kurapwa uye kushandisa kuberekwa kudzivirira kudzivirira kubata pamuviri panguva yekurapwa kwako uye kweinenge mavhiki mashanu mushure mekuita kwako kwekupedzisira. Kana iwe uri murume, iwe nemumwe wako munofanira kushandisa kuberekwa panguva yekurapa kwenyu ne entrectinib uye kwemwedzi mitatu mushure mekupedzisira kwedosi. Taura nachiremba wako nezve nzira dzekudzivirira kuberekwa dzaunogona kushandisa panguva yekurapa kwako. Kana iwe kana mumwe wako mukava nepamuviri muchitora entrectinib, danai chiremba wako nekukasira. Entrectinib inogona kukuvadza fetus.
• udza chiremba wako kana iwe uchiyamwisa. Iwe haufanire kuyamwa paunenge uchitora entrectinib uye kwemazuva manomwe mushure meiyo yekupedzisira dosi.
• iwe unofanirwa kuziva kuti entrectinib inogona kukonzera dzungu kana kuvhiringidzika. Usatyaire mota kana kushandisa michina kusvikira iwe waziva kuti uyu mushonga unokubata sei.

Usadye grapefruit kana kunwa muto wemazambiringa uchinwa mushonga uyu.

Kana ukarasikirwa nedhiraini nemawa asingasviki maawa gumi nemaviri, tora iyo yakarasika paya paunongo rangarira uye wotora inotevera dosi panguva yakatarwa. Nekudaro, kana iwe ukarasikirwa nedhiza nemaawa anopfuura gumi nemaviri, ruka iro rakarasika dhizaini uye enderera yako yenguva dzose dosing purogiramu Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Entrectinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• kuneta
• kuvimbiswa
• manyoka
• kuravira shanduko
• musoro
• chikosoro, fivha, kana zvimwe zviratidzo zvehutachiona
• mhasuru kana kurwadziwa kwemajoini
• kurwadziwa shure
• uremu hunochinja
• mapundu
• kunetseka kudonha kana kuramba wakarara

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• kuoma nekudzidza, ndangariro, kutarisisa, kana kugadzirisa matambudziko
• mafungiro anochinja senge kushushikana, kushushikana, kusagadzikana, kana kusagadzikana
• kurwadziwa kwepfupa kana kunetseka kufamba
• matambudziko ekuona kana shanduko muchiono
• kurwadziwa pamwe chete, kuomarara, kutsvuka, kana kuzvimba
• kurwadziwa kumusoro kwepamusoro chikamu chedumbu, yero yeganda kana maziso, kurasikirwa kwechido, kana kubuda ropa kana kupwanya nyore
• mweya wekufema; kunetseka kufema kana wakarara pasi; kana kuzvimba kwemaoko, makumbo, maoko, kana tsoka

Entrectinib inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe uye kusvika kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakavharira makapu ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye kubva kwavari uye kusvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa mishonga yako ndeyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira bvunzo bvunzo usati watanga kurapwa kwako kuti uone kana kenza yako inogona kurapwa ne entrectinib. Chiremba wako anogona kuraira kumwe kuongorora kwelebhu usati uye panguva yekurapa kwako kuti utarise mhinduro yemuviri wako kune entrectinib.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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