Atripla (efavirenz / emtricitabine / tenofovir disoproxil fumarate)

Zvemukati

• Chii chinonzi Atripla?
• Atripla generic
• Atripla mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Kurera huremu
• Pancreatitis
• Zvikanganiso muvana
• Mapundu
• Kushungurudzika
• Kudzivirira kuzviuraya
• Atripla mutengo
• Mari uye inishuwarenzi rubatsiro
• Atripla anoshandisa
• Atripla yeHIV
• Zvishandiso zvisina kubvumidzwa
• Atripla yevana
• Atripla muyero
• Mafomu emishonga uye simba
• Chiyero cheHIV
• Chiremba wevana
• Ko kana ndikapotsa dosi?
• Ndichada here kushandisa mushonga uyu kwenguva refu?
• Kunamatira kune yako Atripla kurapwa chirongwa
• Dzimwe nzira dzeAtripla
• Mimwe mishonga yekubatanidza
• Mimwe mishonga
• Atripla vs. Genvoya
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Atripla vs. mimwe mishonga
• Atripla vs. Truvada
• Atripla vs.Complera
• Nzira yekutora Atripla
• Nguva
• Kutora Atripla pane isina chinhu mudumbu
• Atripla inogona kupwanywa here?
• Atripla uye doro
• Atripla kudyidzana
• Atripla nemimwe mishonga
• Atripla uye Viagra
• Atripla nemishonga uye zvinowedzera
• Atripla uye zvekudya
• Iyo Atripla inoshanda sei
• Zvinotora nguva yakareba sei kuti zvishande?
• Ndichada here kutora uyu mushonga kwenguva refu?
• Atripla nepamuviri
• Atripla uye kuyamwisa
• Mibvunzo yakajairika nezve Atripla
• Atripla inogona kukonzera kushushikana here?
• Atripla inorapa HIV here?
• Atripla inogona kudzivirira Mukondombera here?
• Chii chinoitika kana ndikapotsa akawanda madosi eAtripla?
• Atripla yambiro
• FDA yambiro: Kuwedzera kwehepatitis B (HBV)
• Dzimwe yambiro
• Atripla kudarika
• Ovhadhozi zviratidzo
• Zvekuita kana ovhadhozi
• Kupera kweApripla
• Ruzivo rwehunyanzvi rweAtripla
• Nzira yekuita
• Pharmacokinetics uye metabolism
• Contraindications
• Kuchengetedza

Chii chinonzi Atripla?

Atripla imushonga-zita mushonga unoshandiswa kurapa HIV muvanhu vakuru nevana. Inotarisirwa kune vanhu vanorema anosvika 88 mapaundi (40 kilograms).

Atripla inogona kushandiswa yega seyakakwana kurapwa regimen (chirongwa). Inogona zvakare kushandiswa musanganiswa nemimwe mishonga. Iyo inouya sehwendefa rimwe chete rine matatu emishonga:

• efavirenz (600 mg), inova isiri-nucleoside reverse transcriptase inhibitor (NNRTI)
• tenofovir disoproxil fumarate (300 mg), inova nucleoside analog reverse transcriptase inhibitor (NRTI)
• emtricitabine (200 mg), inova zvakare nucleoside analog reverse transcriptase inhibitor (NRTI)

Nhungamiro dzazvino hadzikurudzire Atripla senzira yekurapa yekusarudza yekutanga kune vanhu vazhinji vane HIV. Izvi zvinodaro nekuti kune marapirwo matsva angave akachengeteka kana kushanda zvakanyanya kune vanhu vazhinji. Zvisinei, Atripla inogona kunge yakakodzera kune vamwe vanhu. Chiremba wako achasarudza kurapwa kwakanyanya kwauri.

Zvakakosha kuziva kuti Atripla haina kubvumidzwa kudzivirira Mukondombera.

Atripla generic

Atripla inowanikwa chete sezita-zita remishonga. Haisi ikozvino inowanikwa mune generic fomu.

Atripla ine matatu anoshanda emushonga zvinoshandiswa: efavirenz, emtricitabine, uye tenofovir disoproxil fumarate. Imwe yeaya madhiragi inowanikwa ega ega mumhando dzakajairika. Panogona zvakare kuve nemimwe miunganidzwa yemishonga iyi inowanikwa seyakagadzirwa.

Atripla mhedzisiro

Atripla inogona kukonzeresa zvinyoro kana zvakakomba mhedzisiro. Iyi inotevera rondedzero ine mamwe emakiyi mhedzisiro mhedzisiro anogona kuitika uchitora Atripla. Rondedzero iyi haisanganisi zvese zvinokanganisa mhedzisiro.

Kuti uwane rumwe ruzivo nezve zvingangoitika mhedzisiro yeAtripla, kana matipi ekuti ungagadzirise sei zvinokanganisa mhedzisiro, taura nachiremba wako kana wemishonga.

Zvimwe zvakajairika mhedzisiro

Iyo inowanzoitika mhedzisiro mhedzisiro yeAtripla inogona kusanganisira:

• manyoka
• kusvotwa
• musoro
• simba rakaderera
• hope dzisina kujairika
• kunetseka kuisa pfungwa
• dzungu
• kunetseka kurara
• kuora mwoyo
• mapundu kana kuvava ganda
• kuwedzera cholesterol

Mazhinji emhedzisiro mhedzisiro iyi akapusa mhedzisiro mune zvakasikwa. Kana vakanyanya kuomarara kana kuita kuti zviome kuramba uchinwa mushonga wako, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Matambudziko akakomba kubva kuAtripla haana kujairika, asi anogona kuitika. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une emergency emergency.

Yakanyanya mhedzisiro mhedzisiro uye zviratidzo zvavo zvinogona kusanganisira zvinotevera:

• Kuwedzera kwakanyanya kwehepatitis B (HBV). Zviratidzo zvinogona kusanganisira:
  • kuneta
  • weti yakasviba
  • kurwadziwa nemuviri uye kushaya simba
  • yero yeganda rako uye nekuchena kwemeso ako
• Mapundu. Iyi divi mhedzisiro inowanzoitika mukati memavhiki maviri ekutanga Atripla uye inoenda yega mukati memwedzi. Zviratidzo zvinogona kusanganisira:
  • yakatsvuka, inonhuwa ganda
  • mapundu paganda
• Kukuvara kwechiropa. Zviratidzo zvinogona kusanganisira:
  • yero yeganda rako uye nekuchena kwemeso ako
  • kurwadziwa munzvimbo yepamusoro yekurudyi yedumbu rako (mudumbu nzvimbo)
  • kusvotwa uye kurutsa
• Maitiro anochinja. Zviratidzo zvinogona kusanganisira:
  • kuora mwoyo
  • pfungwa dzekuzviuraya
  • hunhu
  • kupenga kuita
• Zvinotyisa system matambudziko. Zviratidzo zvinogona kusanganisira:
  • kuona zvisipo
• Itsvo kukuvara. Zviratidzo zvinogona kusanganisira:
  • kurwadziwa kwepfupa
  • kurwadziwa mumaoko ako kana makumbo
  • pfupa kutsemuka
  • kurwadziwa kwemhasuru kana kushaya simba
• Bone kurasikirwa. Zviratidzo zvinogona kusanganisira:
  • kurwadziwa kwepfupa
  • kurwadziwa mumaoko ako kana makumbo
  • pfupa kutsemuka
• Kugwinha. Zviratidzo zvinogona kusanganisira:
  • kurasikirwa kwekuziva
  • mhasuru
  • akarumanisa mazino
• Kuvaka kweiyo lactic acid uye kukuvara kwechiropa. Zviratidzo zvinogona kusanganisira:
  • kuneta
  • kurwadziwa kwemhasuru uye kushaya simba
  • kurwadziwa kana kusagadzikana mudumbu rako (mudumbu)
• Immune reconstitution syndrome (apo immune system inovandudzika nekukurumidza uye inotanga "kushanda zvakanyanya"). Zviratidzo zvinogona kusanganisira:
  • kupindwa nechando
  • kuneta
  • hutachiona
  • kuzvimba lymph nodes
  • mapundu kana ronda reganda
  • kunetseka kufema
  • kuzvimba kwakakomberedza maziso ako
• Shanduko mukuiswa kwemafuta uye chimiro chemuviri. Zviratidzo zvinogona kusanganisira:
  • kuwedzerwa mafuta kutenderedza yako yepakati (torso)
  • kugadzirwa kwemafuta ane bundu kumusana kwemapfudzi ako
  • akawedzera mazamu (mune zvese varume nevakadzi)
  • kurasikirwa nehuremu kumeso kwako, maoko, uye makumbo

Kurera huremu

Kurera huremu kwaive kusiri kwechero mhedzisiro yakaitika muzvidzidzo zvekiriniki zveAtripla. Zvisinei, kurapwa kweHIV kazhinji kunogona kukonzera kurema. Izvi zvinodaro nekuti HIV inogona kukonzera kuonda, saka kurapa mamiriro acho kunogona kukonzera kudzoka kwehumwe huremu hwakanga hwarasika.

Vanhu vanotora Atripla vanogona kucherechedza kuti mafuta emuviri wavo atamira kunzvimbo dzakasiyana dzemuviri wavo. Izvi zvinonzi lipodystrophy. Mafuta emuviri anokwanisa kuungana akatarisana nepakati pemuviri wako, senge muchiuno chako, mazamu, uye mutsipa. Inogona zvakare kusuduruka kubva pamaoko ako nemakumbo.

Hazvizivikanwe kana izvi zvinoitika zvinopera nekufamba kwenguva, kana kana zvikanyangarika mushure mekumira kushandisa Atripla. Kana iwe ukawana izvi mhedzisiro, udza chiremba wako. Vanogona kukuchinjira kune mumwe mushonga.

Pancreatitis

Izvo zvisingawanzoitika, asi pancreatitis (inflamed pancreas) yakaonekwa muvanhu vachitora zvinodhaka zvine efavirenz. Efavirenz ndeimwe yemishonga mitatu iri muAtripla.

Kuwedzera kwehuwandu hwepancreatic enzyme kwakaonekwa kune vamwe vanhu vachitora efavirenz, asi hazvizivikanwe kana izvi zvaive zvakabatana nepancreatitis.

Udza chiremba wako kana uri kusangana nezvinobvira zviratidzo zvepancreatitis. Izvi zvinosanganisira kurwadziwa mumuviri wako, kuda kurutsa kana kurutsa, kurova kwemwoyo nekukurumidza, uye dumbu rakapfava kana kuzvimba. Chiremba wako anogona kukuchinjira kune mumwe mushonga.

Ongorora: Pancreatitis yakaonekwa kazhinji nekushandiswa kwemimwe mishonga yeHIV senge didanosine.

Zvikanganiso muvana

Muzvidzidzo zvekiriniki zveAtripla, yakawanda mhedzisiro muvana yaive yakafanana neiya yevakuru. Rash yaive imwe yemhedzisiro yakaitika kazhinji muvana.

Rash yakaitika mu32% yevana, nepo chete 26% yevakuru vakawana mapundu. Rash muvana kazhinji yaiwanzoonekwa mazuva makumi maviri nemasere mushure mekutanga kurapwa naAtripla. Kuti udzivise kuputika mumwana wako, chiremba wavo anogona kukurudzira kushandisa mishonga yekurapa yakadai seantihistamines usati watanga kurapwa kweAtripla.

Zvimwe zvinowanzoitika mhedzisiro zvinoonekwa muvana asi kwete vanhu vakuru zvinosanganisira shanduko muganda reganda, senge mabara kana ganda rakasviba. Izvi zvinowanzoitika pamaoko emawoko kana pasi petsoka. Zvimwe zvinokanganisa zvakare zvinosanganisira kupererwa neropa, nezviratidzo senge mashoma emagetsi, kurova kwemoyo nekukurumidza, uye kutonhora maoko nemakumbo.

Mapundu

Rash inowanzoitika mhedzisiro yeAtripla kurapwa.

Mumakiriniki ekuedzwa, kuputika kwakaitika mu26% yevakuru vakagamuchira efavirenz, mumwe wemishonga muAtripla. Pakave nemishumo yehasha dzakakomba nekushandisa efavirenz, asi zvakangoitika mu0.1% yevanhu vakadzidza. Rashes dzakakonzeresa kuputika kana maronda akavhurika akaitika mune angangoita 0.9% yevanhu.

Mazhinji mapundu anoonekwa ne efavirenz aive akapfava kusvika pakati nepakati, aine nzvimbo dzakatsvuka uye dzine zvigamba uye mamwe mapundu paganda. Rudzi urwu rwekupenga runonzi maculopapular rash. Aya mapundu anowanzoonekwa mukati memavhiki maviri ekutanga kwekurapa efavirenz uye akaenda mukati memwedzi wekuonekwa kwawo.

Udza chiremba wako kana iwe ukagadzira kukurumidza paunenge uchitora Atripla. Kana iwe ukava nemablisters kana fever, rega kutora Atripla uye udane chiremba wako ipapo ipapo. Chiremba wako anogona kukupa mishonga yekurapa maitiro. Kana kuputika kwacho kwakanyanya, vanogona kukuchinjira kumushonga wakasiyana.

Ongorora: Kana munhu akatanga kubatira HIV, kukurumidza kunogona kuva chiratidzo chekutanga. Uku kupenga kunowanzoita kwemavhiki maviri kusvika mana. Asi kana iwe uine hutachiona hweHIV kwechinguva uye uchangotanga kurapwa naAtripla, kupenga kutsva kungangove kuri kukonzerwa neAtripla.

Kushungurudzika

Kushungurudzika kwaive kwakajairika divi mhedzisiro mumakiriniki miedzo yeAtripla. Izvo zvakaitika mu9% yevanhu vaitora mushonga.

Udza chiremba wako ipapo kana iwe uine zviratidzo zvekuora mwoyo. Izvi zvinogona kusanganisira kunzwa kwekusuwa, kusava netariro, uye kurasikirwa kwekufarira zviitiko zvezuva nezuva. Chiremba wako anogona kukuchinjira kune mumwe mushonga weHIV. Ivo vanogona zvakare kukurudzira kurapwa kwezviratidzo zvako zvekuora mwoyo.

Kudzivirira kuzviuraya

• Kana iwe uchiziva mumwe munhu ari panjodzi yekukurumidza yekuzvikuvadza, kuzviuraya, kana kukuvadza mumwe munhu:
• Fonera 911 kana iyo yemuno emergency emergency.
• Gara nemunhu kusvikira rubatsiro rwehunyanzvi rwasvika.
• Bvisa chero zvombo, mishonga, kana zvimwe zvinogona kukuvadza zvinhu.
• Teerera kumunhu pasina kutonga.
• Kana iwe kana mumwe munhu waunoziva uine pfungwa dzekuzviuraya, nhare yekudzivirira inogona kubatsira. Iyo National Suicide Prevention Lifeline inowanikwa maawa makumi maviri nemana pazuva pa800-273-8255.

Atripla mutengo

Sezvo nemishonga yese, mutengo weAtripla unogona kusiyana.

Mari yako chaiyo inoenderana neinishuwarenzi yako yekuvhara.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari kubhadhara Atripla, kana kana iwe uchida rubatsiro kuti unzwisise yako inishuwarenzi kufukidza, rubatsiro rwuripo.

Gilead Sciences, Inc., iyo inogadzira Atripla, inopa chirongwa chinonzi Advancing Access. Kuti uwane rumwe ruzivo uye kuti uzive kana iwe uchikodzera rutsigiro, fona 800-226-2056 kana shanyira iyo webhusaiti chirongwa.

Atripla anoshandisa

Chikafu neDrug Administration (FDA) inobvumidza mishonga yemishonga yakadai saAtripla kurapa mamwe mamiriro. Atripla yakangobvumidzwa kurapa HIV.

Atripla yeHIV

Atripla inobvumidzwa kurapa HIV muvanhu vakuru nevana vanorema anosvika 88 mapaundi (40 kilograms). Atripla inoshandiswa chero pachayo kana musanganiswa nemimwe mishonga yeHIV.

Mishonga mitsva yakawanda yeHIV inogamuchirwa kune vanhu vasina kumbobvira vatora mishonga yeHIV kana vakagadzikana pane imwe kurapwa kweHIV. Atripla haina iyo chaiyo yakatenderwa kushandiswa.

Zvishandiso zvisina kubvumidzwa

Atripla haina kubvumidzwa kune chero kumwe kushandiswa. Inofanirwa kushandiswa chete kurapa HIV.

Atripla yehepatitis B

Atripla haina kubvumirwa hepatitis B uye haifanirwe kushandiswa kurapa. Zvisinei, mumwe wemishonga iri muAtripla (tenofovir disoproxil fumarate) inoshandiswa kurapa chirwere chehepatitis B.

Atripla yePEP

Atripla haina kubvumidzwa uye haifanire kushandiswa kune post-exposure prophylaxis (PEP). PEP inoreva kushandiswa kwemishonga yeHIV mushure mekugona kusangana neHIV kudzivirira hutachiona.

Uye zvakare, Atripla haina kubvumidzwa uye haifanire kushandiswa pre-exposure prophylaxis (PrEP). PrEP inoreva kushandiswa kwemishonga yeHIV zvisati zvaitika kusangana neHIV kudzivirira hutachiona.

Iyo yega FDA-inogamuchirwa mushonga wePrEP ndiTruvada, iyo ine emtricitabine uye tenofovir disoproxil fumarate. Kunyange Atripla iine zvese izvi zvinodhaka, haina kuongororwa senzira yekurapa yeHIV.

Atripla yevana

Atripla inogona kushandiswa kurapa hutachiona hweHIV muvanhu vezera ripi zvaro chero bedzi vachirema mapaundi anosvika makumi masere nemasere (makumi mana emakirogiramu). Izvi zvinosanganisira vana.

Atripla muyero

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Zvisinei, iva nechokwadi chekutora muyero uyo chiremba wako anokuraira iwe.

Mafomu emishonga uye simba

Atripla inouya sehwendefa remuromo. Hwendefa rega rega rine mishonga mitatu:

• 600 mg ye efavirenz
• 300 mg ye tenofovir disoproxil fumarate
• 200 mg emtricitabine

Chiyero cheHIV

Imwe piritsi yeAtripla inofanirwa kutorwa kamwe chete zuva nezuva pane isina chinhu mudumbu (isina chikafu). Muzviitiko zvakawanda, inofanira kutorwa panguva yekurara.

Chiremba wevana

Iyo Atripla dosage yevana yakafanana neiyo muyero wevakuru. Muyero haushanduke zvinoenderana nezera.

Ko kana ndikapotsa dosi?

Kana iwe uri kutora Atripla uye uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchitora. Kana iri nguva ingangoita yeyako dosi inotevera, ingo tora iyo inotevera dosi. Iwe haufanire kupeta yako dosi kuti ugadzire iyo yakarasika dhosi.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Kana iwe nachiremba wako mukasarudza kuti Atripla kurapwa kwakanaka kwauri, ungangoda kuitora kwenguva refu.

Kana ukangotanga kurapwa, usamire kutora Atripla usina kutaura nachiremba wako kutanga.

Kunamatira kune yako Atripla kurapwa chirongwa

Kutora mahwendefa eAtripla chaizvo sekuudzwa kwazvinoitwa nachiremba wako kwakakosha. Kutora Atripla nguva dzose kuchawedzera mukana wako wekubudirira kurapwa.

Kushaya madosi kunogona kukanganisa mashandiro anoita Atripla kurapa HIV. Kana iwe ukarasikirwa nemadhizaini, iwe unogona kukura kuramba Atripla. Izvi zvinoreva kuti mushonga wacho haugone kushanda kurapa yako HIV.

Kana iwe uine hepatitis B pamwe neHIV, une imwezve njodzi. Kushaya madosi eAtripla kunogona kukonzera hepatitis B yako kuti iwedzere.

Ive neshuwa yekutevera zvirevo zvechiremba wako uye tora Atripla kamwe pazuva, zuva rega rega, kunze kwekunge chiremba wako akakuudza neimwe nzira. Kushandisa chiyeuchidzo chishandiso kunogona kubatsira mukuona kuti iwe unotora Atripla zuva rega rega.

Kana iwe uine chero mibvunzo kana zvinonetsa nezve yako Atripla kurapwa, taura nachiremba wako. Vanogona kubatsira kugadzirisa chero nyaya dzaungave uinadzo uye kubatsira kuona kuti Atripla iri kukushandira zvakanaka.

Dzimwe nzira dzeAtripla

Pamusoro peAtripla, kune mimwe mishonga yakawanda inogona kurapa HIV. Zvimwe zvinogona kunge zvakakukodzera iwe kupfuura vamwe. Kana iwe uchifarira kutsvaga imwe nzira yeAtripla, taura nachiremba wako kuti udzidze zvimwe pamusoro pemimwe mishonga inogona kukushandira zvakanaka.

Mimwe mishonga yekubatanidza

Vanhu vese vane hutachiwana hweHIV vanowanzoda kutora zvinopfuura mumwe chete mushonga. Nechikonzero ichi, kune akawanda musanganiswa wemishonga yeHIV inowanikwa. Iyi mishonga ine zvinopfuura imwechete zvinodhaka. Atripla musanganiswa wemishonga ine mishonga mitatu: emtricitabine, tenofovir disoproxil fumarate, uye efavirenz.

Mienzaniso yemimwe mishonga yekubatanidza inowanikwa pakurapa HIV inosanganisira:

• Biktarvy (bictegravir, emtricitabine, uye tenofovir alafenamide)
• Complera (emtricitabine, rilpivirine, uye tenofovir disoproxil fumarate)
• Descovy (emtricitabine uye tenofovir alafenamide)
• Genvoya (elvitegravir, cobicistat, emtricitabine, uye tenofovir alafenamide)
• Juluca (dolutegravir uye rilpivirine)
• Odefsey (emtricitabine, rilpivirine, uye tenofovir alafenamide)
• Stribild (elvitegravir, cobicistat, emtricitabine, uye tenofovir disoproxil fumarate)
• Symtuza (darunavir, cobicistat, emtricitabine, uye tenofovir alafenamide)
• Triumeq (abacavir, dolutegravir, uye lamivudine)
• Truvada (emtricitabine uye tenofovir disoproxil fumarate)

Mimwe mishonga

Kune mumwe nemumwe munhu ane hutachiona hweHIV, chiremba wavo achamurongera chirongwa chekurapwa kunyanya iye. Izvi zvinogona kuve musanganiswa wemishonga, kana inogona kunge iri yoga yoga madhiragi.

Mazhinji emishonga anowanikwa akabatana mishonga yeHIV anowanikwa ega. Chiremba wako anogona kukuudza zvakawanda nezvemishonga inogona kushanda zvakanyanya kwauri.

Atripla vs. Genvoya

Iwe unogona kushamisika kuti Atripla inofananidzwa sei nemimwe mishonga inorayirwa kushandiswa kwakafanana. Pano, tinotarisa kuti Atripla naGenvoya zvakafanana uye zvakasiyana.

Zvishandiso

Vaviri Atripla naGenvoya vanobvumidzwa kurapa HIV. Genvoya inogamuchirwa kuti ishandiswe muvanhu vezera ripi zvaro chero bedzi vachirema mapaundi makumi mashanu nemashanu (25 kilograms). Atripla, kune rumwe rutivi, inogamuchirwa kuti ishandiswe muvanhu vezera ripi zvaro chero bedzi vachinge vaine huremu hunosvika 88 mapaundi (40 kilograms).

Mafomu emishonga uye manejimendi

Ose Atripla naGenvoya anouya sematafura emuromo anotorwa kamwe chete zuva nezuva. Genvoya inofanirwa kutorwa nechikafu, nepo Atripla ichifanira kutorwa isina chinhu mudumbu. Uye nepo Genvoya inogona kutorwa chero nguva masikati, zvinokurudzirwa kuti utore Atripla panguva yekurara kuti ubatsire kudzivirira zvimwe zvinokanganisa.

Hwendefa rega rega reAtripla rine mishonga emtricitabine, efavirenz, uye tenofovir disoproxil fumarate. Hwendefa rega rega reGenvoya rine mishonga emtricitabine, elvitegravir, cobicistat, uye tenofovir alafenamide.

Side migumisiro uye njodzi

Atripla naGenvoya vane mhedzisiro yakafanana mumuviri uye nekudaro zvinokonzeresa mhedzisiro yakafanana. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemamwe maitiro anowanzoitika anogona kuitika neAtripla, naGenvoya, kana nemishonga iyi miviri (kana ikatorwa zvakasiyana).

• Zvinogona kuitika naAtripla:
  • kuora mwoyo
  • epamusoro mweya wekufema
  • kushushikana
  • huro inorwadza
  • kurutsa
  • dzungu
  • mapundu
  • kunetseka kurara
• Zvinogona kuitika naGenvoya:
  • yakawedzera mazinga eLDL cholesterol
• Zvinogona kuitika neese Atripla naGenvoya:
  • manyoka
  • kusvotwa
  • musoro
  • kuneta
  • yakawedzera huwandu hwecholesterol

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yezvakakomba mhedzisiro inogona kuitika neAtripla, naGenvoya, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika naAtripla:
  • hutano hwepfungwa shanduko, senge kushushikana kwakanyanya kana hunhu hwehasha
  • kugwinha
  • shanduko munzvimbo yemafuta mumuviri wese
• Zvinogona kuitika naGenvoya:
  • mashoma akasarudzika akakomba mhedzisiro
• Zvinogona kuitika neese Atripla naGenvoya:
  • kurasikirwa nefupa
  • kuwedzera kwakanyanya kwehepatitis B * (kana uchitova nehutachiona)
  • immune reconstitution syndrome (apo immune system inovandudzika nekukurumidza uye yotanga "kushanda zvakanyanya")
  • kukuvara kweitsvo *
  • lactic acidosis (inotyisa buildup yeasidhi mumuviri)
  • chirwere chakakomba chechiropa (chakawedzera chiropa ne steatosis)

Atripla naGenvoya vese vane yambiro yebhokisi kubva kuDAA maererano nekuwedzera kwehepatitis B. Yambiro irimo mubhokisi ndiyo yambiro yakasimba inodiwa neDAA. Inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

Tenofovir, mumwe wemishonga iri muGenvoya neAtripla, wakabatanidzwa nekukuvara kweitsvo. Zvisinei, mhando ye tenofovir muGenvoya (tenofovir alafenamide) ine njodzi shoma yekukuvara kweitsvo pane iyo iri muAtripla (tenofovir disoproxil fumarate).

Kubudirira

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki, asi ongororo dzakawana zvese Atripla naGenvoya kuti vabudirire pakurapa HIV.

Nekudaro, hapana mushonga unokurudzirwa senzira yekutanga yekurapa kune vanhu vazhinji vane HIV. Izvi zvinodaro nekuti Atripla naGenvoya mese mishonga yakura yeHIV, uye kune mishonga mitsva iriko inowanzo kuve sarudzo dziri nani. Mishonga mitsva yeHIV inowanzo shanda zvakanyanya uye ine mhedzisiro shoma pane yakura mishonga.

Atripla naGenvoya vanogona kunge vakakodzera kune vamwe vanhu, asi kazhinji, ivo havasi vekutanga sarudzo iyo vanachiremba vangakurudzira vanhu vazhinji.

Mariro

Atripla naGenvoya ese ari maviri zita-zita mishonga. Izvo hazviwanikwe mumhando dzakajairika, izvo zvinowanzo kuve zvakachipa pane zita remazita ezita.

Zvinoenderana nekufungidzira paGoodRx.com, Atripla inogona kuita mari isingasviki pane Genvoya. Mutengo chaiwo waungabhadhare chero mushonga unobva pane yako inishuwarenzi chirongwa, nzvimbo yako, uye pharmacy yaunoshandisa.

Atripla vs. mimwe mishonga

Pamusoro peGenvoya (pamusoro), mimwe mishonga inorayirwa kurapa HIV. Pazasi pane kuenzanisa pakati peAtripla neimwe mishonga yeHIV.

Atripla vs. Truvada

Atripla musanganiswa wemishonga ine mishonga emtricitabine, tenofovir disoproxil fumarate, uye efavirenz. Truvada zvakare musanganiswa wemishonga, uye ine maviri emimwewo mishonga iri muAtripla: emtricitabine uye tenofovir disoproxil fumarate.

Zvishandiso

Ose Atripla neTruvada anotenderwa kurapwa kweHIV. Atripla inogamuchirwa kuti ishandiswe yega, asi Truvada inogamuchirwa chete kuti ishandiswe ne dolutegravir (Tivicay) kana zvimwe zvinodhaka zveHIV.

Atripla inogamuchirwa kuti ishandiswe muvanhu vezera ripi zvaro chero bedzi vachirema mapaundi makumi masere (makumi mana emakirogiramu). Truvada inobvumidzwa kurapa hutachiona hweHIV muvanhu vezera ripi zvaro chero bedzi vaine huremu hunosvika makumi matatu nemaviri (17 kilograms).

Truvada inobvumidzwawo kudzivirira Mukondombera. Atripla inongobvumidzwa kurapa HIV.

Mafomu emishonga uye manejimendi

Ose Atripla neTruvada anouya sematafura emuromo anotorwa kamwe chete zuva nezuva. Truvada inogona kutorwa pamwe kana pasina chikafu, nepo Atripla ichifanira kutorwa isina chinhu mudumbu. Uye nepo Truvada inogona kutorwa chero nguva masikati, zvinokurudzirwa kuti utore Atripla panguva yekurara kuti ubatsire kudzivirira zvimwe zvinokanganisa.

Side migumisiro uye njodzi

Atripla ine mishonga imwechete seTruvada, pamwe efavirenz. Naizvozvo, ivo vane mhedzisiro yakafanana.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemamwe maitiro anowanzoitika anogona kuitika pamwe neAtripla neTruvada (kana inotorwa zvakasiyana). Ongorora: Iyo mhedzisiro yeTruvada yakanyorwa pano iri kubva kukiriniki kuyedzwa uko Truvada yakatorwa ne efavirenz.

• Zvinogona kuitika pamwe neAtripla neTruvada:
  • manyoka
  • kusvotwa uye kurutsa
  • dzungu
  • musoro
  • kuneta
  • kunetseka kurara
  • huro inorwadza
  • mweya wekufema
  • hope dzisina kujairika
  • mapundu
  • yakawedzera huwandu hwecholesterol

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yezvakakomba mhedzisiro inogona kuitika neAtripla kana neese ari maviri madhiragi (kana akatorwa ega). Ongorora: Iyo mhedzisiro yeTruvada yakanyorwa pano iri kubva kukiriniki kuyedzwa uko Truvada yakatorwa ne efavirenz.

• Zvinogona kuitika naAtripla:
  • kugwinha
  • shanduko munzvimbo yemafuta mumuviri wese
• Zvinogona kuitika pamwe neAtripla neTruvada:
  • hutano hwepfungwa shanduko, senge kushushikana kwakanyanya kana hunhu hwehasha
  • kuwedzera kwakanyanya kwehepatitis B * (kana uchitova nehutachiona)
  • immune reconstitution syndrome (apo immune system inovandudzika nekukurumidza uye yotanga "kushanda zvakanyanya")
  • kurasikirwa nefupa
  • kukuvara kweitsvo *
  • lactic acidosis (inotyisa buildup yeasidhi mumuviri)
  • chirwere chakakomba chechiropa (chakawedzera chiropa ne steatosis)

Atripla naTruvada vese vane yambiro yebhokisi kubva kuDAA maererano nekuwedzera kwehepatitis B. Yambiro yebhokisi ndiyo yambiro yakasimba iyo FDA inoda. Inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

Tenofovir, mumwe wemishonga iri muTruvada neAtripla, yakabatanidzwa nekukuvara kweitsvo.

Kubudirira

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki, asi zvidzidzo zvakawana zvese Atripla neTruvada kuti ive inoshanda pakurapa HIV.

Kunyangwe Atripla inogona kushanda mukurapa HIV, haina kukurudzirwa senzira yekutanga yekurapa yeHIV. Izvi zvinodaro nekuti mishonga mitsva inogonawo kubata Mukondombera asi inogona kuve nemhedzisiro mishoma pane Atripla.

Truvada inoshandiswa pamwe chete ne dolutegravir (Tivicay), zvisinei, inokurudzirwa semushonga wekutanga-sarudzo kuvanhu vazhinji vane HIV.

Mariro

Atripla naTruvada vese vari vaviri zita-zita mishonga. Izvo hazviwanikwe mumafomu ejeniki, ayo anowanzo kuve akadhura pane echiratidzo-zita zvinodhaka.

Zvinoenderana nekufungidzira paGoodRx.com, Atripla inogona kudhura zvishoma kupfuura Truvada. Mutengo chaiwo waungabhadhare chero mushonga unobva pane yako inishuwarenzi chirongwa, nzvimbo yako, uye pharmacy yaunoshandisa.

Atripla vs.Complera

Atripla musanganiswa wemishonga ine mishonga emtricitabine, tenofovir disoproxil fumarate, uye efavirenz. Complera iriwo musanganiswa wemishonga, uye ine maviri emimwewo mishonga iri muAtripla: emtricitabine uye tenofovir disoproxil fumarate. Yayo yechitatu yezvinodhaka chinhu chinonzi rilpivirine.

Zvishandiso

Ose Atripla neComplera anotenderwa kurapwa kweHIV.

Atripla inogamuchirwa kuti ishandiswe muvanhu vezera ripi zvaro chero bedzi vachirema mapaundi makumi masere (makumi mana emakirogiramu). Complera, kune rumwe rutivi, inogamuchirwa kuti ishandiswe muvanhu vezera ripi zvaro chero bedzi vachinge vaine huremu hunosvika mazana manomwe emapaunzi (35 kilograms).

Complera inowanzoshandiswa chete kune vanhu vane hutachiona hwehutachiona hwakaderera vasati vatanga kurapwa. Atripla haina ichi chibvumirano.

Mafomu emishonga uye manejimendi

Ose Atripla neComplera anouya sematafura emuromo anotorwa kamwe chete zuva nezuva. Complera inofanira kutorwa nechikafu, nepo Atripla ichifanira kutorwa isina chinhu mudumbu. Uye apo Complera inogona kutorwa chero nguva masikati, zvinokurudzirwa kuti utore Atripla panguva yekurara kuti ubatsire kudzivirira zvimwe zvinokanganisa.

Side migumisiro uye njodzi

Atripla neComplera zvine mishonga yakafanana. Naizvozvo, ivo vane mhedzisiro yakafanana.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemamwe maitiro anowanzoitika anogona kuitika neAtripla, neComplera, kana nemishonga yose (kana inotorwa zvakasiyana).

• Zvinogona kuitika naAtripla:
  • mashoma mashoma akasarudzika mhedzisiro
• Zvinogona kuitika neComplera:
  • mashoma mashoma akasarudzika mhedzisiro
• Inogona kuitika neese Atripla uye Complera:
  • manyoka
  • kusvotwa uye kurutsa
  • dzungu
  • musoro
  • kuneta
  • kunetseka kurara
  • huro inorwadza
  • epamusoro mweya wekufema
  • hope dzisina kujairika
  • mapundu
  • kuora mwoyo
  • kushushikana
  • yakawedzera huwandu hwecholesterol

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yemigumisiro yakakomba iyo inogona kuitika neAtripla, neComplera, kana nemishonga yose (kana inotorwa zvakasiyana).

• Zvinogona kuitika naAtripla:
  • kugwinha
  • shanduko munzvimbo yemafuta mumuviri wese
• Zvinogona kuitika neComplera:
  • kuzvimba muguruva rako
  • nduru
• Inogona kuitika neese Atripla uye Complera:
  • hutano hwepfungwa shanduko, senge kushushikana kwakanyanya kana hunhu hwehasha
  • kuwedzera kwakanyanya kwehepatitis B * (kana uchitova nehutachiona)
  • immune reconstitution syndrome (apo immune system inovandudzika nekukurumidza uye yotanga "kushanda zvakanyanya")
  • kurasikirwa nefupa
  • kukuvara kweitsvo *
  • lactic acidosis (inotyisa buildup yeasidhi mumuviri)
  • chirwere chakakomba chechiropa (chakawedzera chiropa ne steatosis)

Atripla naComplera vese vane yambiro yebhokisi kubva kuDAA maererano nekuwedzera kwehepatitis B. Yambiro irimo mubhokisi ndiyo yambiro yakasimba iyo FDA inoda. Inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

Tenofovir, mumwe wemishonga muComplera neAtripla, yakabatanidzwa nekukuvara kweitsvo.

Kubudirira

Iko kushandiswa kwemishonga inowanikwa muAtripla (efavirenz, emtricitabine, uye tenofovir disoproxil fumarate) yakafananidzwa zvakananga nekushandiswa kweComplera muchidzidzo chekiriniki. Marapirwo maviri aya akawanikwa achishanda zvakaenzana pakurapwa kweHIV.

Muvanhu vanga vasati vamborapwa hutachiwana hweHIV, vese Complera pamwe neAtripla drug mubatanidzwa vakave nekubudirira kurapwa kwe77% pavhiki 96. Kurapa kwainzi kwakabudirira kana hutachiona hwemunhu hwakanga husingasvike makumi mashanu pakupera kwechidzidzo.

Zvisinei, 8% yevanhu vakatora Atripla zvinodhaka zvakasanganiswa havana kubatsirwa, asi 14% yevanhu vakatora Complera havana kubatsirwa. Izvi zvinoratidza kuti Complera inogona kunge iine kurapa kwakanyanya kutadza kupfuura iyo Atripla drug mubatanidzwa.

Atripla kana Complera haina kukurudzirwa senzira yekutanga-yekurapa kuvanhu vazhinji vane HIV. Iyi mishonga inogona kukodzera kune vamwe vanhu, asi kazhinji, mitsva mishonga inokurudzirwa kazhinji. Izvi zvinodaro nekuti mishonga mitsva, seBiktarvy kana Triumeq, inogona kushanda zvirinani uye iine mashoma mhedzisiro.

Mariro

Atripla naComplera zvese zvinodhaka-zita zvinodhaka. Ikozvino hapana mafomu akajairika anowanikwa chero mushonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira kubva kuGoodRx.com, Atripla neComplera zvinowanzobhadhara zvakafanana. Mutengo chaiwo waungabhadhare chero mushonga unobva pane yako inishuwarenzi chirongwa, nzvimbo yako, uye pharmacy yaunoshandisa.

Nzira yekutora Atripla

Iwe unofanirwa kutora Atripla zvinoenderana nachiremba wako kana rairo yemupi wezvehutano.

Nguva

Iwe unofanirwa kutora Atripla panguva imwechete mazuva ese, kunyanya panguva yekurara. Kuitora panguva yekurara kunogona kubatsira kurerutsa mimwe mhedzisiro, senge dambudziko rekutarisa uye dzungu.

Kutora Atripla pane isina chinhu mudumbu

Iwe unofanirwa kutora Atripla pane isina chinhu mudumbu (isina chikafu). Kutora Atripla nechikafu kunogona kuwedzera mhedzisiro yemushonga. Kuva nemishonga yakawandisa muhurongwa hwako kunogona kutungamira kumatambudziko akakomba.

Atripla inogona kupwanywa here?

Kazhinji, hazvikurudzirwi kupatsanura, kupwanya, kana kutsenga mahwendefa eAtripla. Vanofanira kumedzwa zvakakwana.

Kana uchinetseka kumedza mapiritsi akazara, taura nachiremba wako nezvemimwe mishonga inogona kushanda zvirinani kwauri.

Atripla uye doro

Zviri nani kudzivirira kunwa doro uchitora Atripla. Izvi zvinodaro nekuti kusanganisa doro uye Atripla kunogona kutungamira kumimwe mhedzisiro kubva kumushonga. Izvi zvinogona kusanganisira:

• dzungu
• matambudziko ekurara
• kuvhiringidzika
• kuona zvisipo
• kunetseka kuisa pfungwa

Kana iwe uchinetseka kudzivirira doro, rega chiremba wako azive usati watanga kurapwa naAtripla. Ivo vanogona kupa zano mumwe mushonga.

Atripla kudyidzana

Atripla inogona kusangana nemishonga yakawanda yakasiyana pamwe nezvimwe zvinowedzera uye zvekudya.

Kukurukurirana kwakasiyana kunogona kukonzera mhedzisiro. Semuenzaniso, vamwe vanogona kukanganisa mashandiro anoita mushonga, asi mamwe anogona kukonzera kuwedzera mhedzisiro.

Atripla nemimwe mishonga

Pazasi pane runyorwa rwemishonga inogona kusangana neAtripla. Urongwa urwu hauna mishonga yose inogona kuwirirana naAtripla. Kune mimwe mimwe mishonga inogona kuwirirana neAtripla.

Usati watora Atripla, ita shuwa yekuudza chiremba wako uye wemishonga nezve zvese zvirevo, pamusoro-pe-counter, uye mimwe mishonga yaunotora. Zvakare, vaudze nezve chero mavitamini, mahebhu, uye zvinowedzera zvaunoshandisa. Kugovera ruzivo urwu kunogona kubatsira iwe kudzivirira kusangana kunogona kuitika.

Kana iwe uine mibvunzo nezve kudyidzana kwezvinodhaka zvinogona kukukanganisa, bvunza chiremba wako kana wemishonga.

Mimwe mishonga yeHIV

Atripla inopindirana nemimwe mishonga yakawanda yeHIV. Usatanga kutora mishonga yakawanda yeHIV kunze kwekunge warairwa kudaro nachiremba wako. Kutora Atripla nemamwe madhiragi eHIV kunogona kudzikisa mhedzisiro yemishonga iyi kana kuwedzera njodzi yako yemhedzisiro.

Mienzaniso yemishonga iyi yeHIV inosanganisira:

• protease inhibitors, senge:
  • atazanavir
  • fosamprenavir calcium
  • indinavir
  • darunavir / ritonavir
  • lopinavir / ritonavir
  • ritonavir
  • saquinavir
• non-nucleoside reverse transcriptase inhibitors (NNRTIs), senge:
  • rilpivirine
  • etravirine
  • doravirine
• maraviroc, inova inopikisa CCR5
• didanosine, inova nucleoside reverse transcriptase inhibitor (NRTI)
• raltegravir, inova integrase inhibitor

Zvimwe hepatitis C zvinodhaka

Kutora Atripla neimwe hepatitis C zvinodhaka zvinogona kuita kuti iyo mishonga isanyanya kushanda. Izvo zvinogona zvakare kuita kuti muviri wako uve unodzivirira kune hepatitis C zvinodhaka. Nekuramba, iyo mishonga inogona kusashanda zvachose kwauri. Kune zvimwe hepatitis C zvinodhaka, kutora Atripla navo kunogona kuwedzera mhedzisiro yeAtripla.

Mienzaniso yehepatitis C mishonga isingafanirwe kutorwa neAtripla inosanganisira:

• Epclusa (sofosbuvir / velpatasvir)
• Harvoni (ledipasvir / sofosbuvir)
• Mavyret (glecaprevir / pibrentasvir)
• Olysio (simeprevir)
• Victrelis (yoceprevir)
• Vosevi (sofosbuvir / velpatasvir / voxilaprevir)
• Zepatier (elbasvir / grazoprevir)

Antifungal zvinodhaka

Kutora Atripla nemimwe mishonga inorwisa mafungal kunogona kuita kuti iyo mishonga isanyanya kushanda. Izvo zvinogona zvakare kuwedzera mamwe mhedzisiro. Mienzaniso yeiyi antifungal mishonga inosanganisira:

• itraconazole
• ketoconazole
• posaconazole
• voriconazole

Zvinodhaka zvinogona kukanganisa itsvo basa

Kutora Atripla nemamwe madhiragi anokanganisa mashandiro anoita itsvo dzako kunogona kuwedzera mhedzisiro yeAtripla. Izvi zvinogona kutungamira mukuwedzera mhedzisiro. Mienzaniso yemishonga iyi inosanganisira:

• mamwe antiviral zvinodhaka, akadai se:
  • acyclovir
  • adefovir dipivoxil
  • cidofovir
  • ganciclovir
  • valacyclovir
  • valganciclovir
• aminoglycosides, senge gentamicin
• nonsteroidal anti-inflammatory drug (NSAIDs), senge ibuprofen, piroxicam, kana ketorolac, pavanoshandiswa pamwechete kana mune yakakwira madhizaini

Mishonga iyo mhedzisiro inogona kuderedzwa

Kune akawanda madhiragi ayo mhedzisiro inogona kudzikiswa kana ikatorwa neAtripla. Mienzaniso yemishonga iyi inosanganisira:

• mamwe maanticonvulsants, akadai se:
  • carbamazepine
  • phenytoin
  • phenobarbital
• mamwe antidepressants, akadai se:
  • bupropion
  • sertraline
• calcium chiteshi blockers, senge:
  • diltiazem
  • felodipine
  • nicardipine
  • nifedipine
  • verapamil
• mamwe ma statins (cholesterol mishonga), akadai se:
  • atorvastatin
  • pravastatin
  • simvastatin
• mimwe mishonga inoderedza mashandiro e immune system yako, se:
  • cyclosporine
  • tacrolimus
  • sirolimus
• mamwe mapiritsi ekudzivirira kuberekwa, akadai seethinyl estradiol / norgestimate
• mimwe mishonga inoshandiswa mumidziyo yekudzivirira kuberekwa, yakadai seetonogestrel
• chijyyyyyychiyyyyyyyyyyyyyyyvanaegore
• rifabutin
• mimwe mishonga inobata malaria, yakadai se:
  • artemether / lumefantrine
  • atovaquone / proguanil
  • methadone

Warfarin

Kutora Atripla newarfarin (Coumadin, Jantoven) kunogona kuita warfarin zvakanyanya kana kushomeka. Kana iwe ukatora warfarin, taura nachiremba wako nezve zvingangoitika mhedzisiro yekutora iyi mishonga pamwe chete.

Rifampin

Kutora Atripla ne rifampin kunogona kuita kuti Atripla isanyanya kushanda. Imhaka yekuti inogona kudzikisa huwandu hweefavirenz mumuviri wako. Efavirenz mumwe wemishonga inowanikwa muAtripla.

Kana chiremba wako akasarudza kuti unofanirwa kutora Atripla ne rifampin, vanogona kukurudzira kutora imwe 200 mg pazuva re efavirenz.

Atripla uye Viagra

Atripla inogona kuwedzera kukurumidza sildenafil (Viagra) inopfuura nemuviri wako. Izvi zvinogona kuita kuti Viagra isanyanya kushanda.

Kana iwe uchida kutora Viagra panguva yekurapa kwako naAtripla, taura nachiremba wako kutanga. Vanogona kukuraira nezvekuti Viagra ndiyo yakanakira sarudzo kwauri, kana kana paine mumwe mushonga ungashanda zvirinani.

Atripla nemishonga uye zvinowedzera

Kutora wort yeSt. John neAtripla kunogona kuita kuti Atripla isanyanya kushanda. Kana iwe uchida kutora zvigadzirwa izvi pamwechete, taura nachiremba wako kutanga nezve kana zvakachengeteka.

Uye ive shuwa kurega chiremba wako uye wemishonga vazive nezve chero zvigadzirwa zvakasikwa zvaunotora, kunyangwe iwe uchifunga kuti zvakasikwa uye zvakachengeteka. Izvi zvinosanganisira tii, senge green tii, uye mishonga yechinyakare, senge ma-huang.

Atripla uye zvekudya

Kudya mazambiringa mazambiringa paunotora Atripla kunogona kuwedzera mazinga echirwere mumuviri wako. Izvi zvinogona kuwedzera yako mhedzisiro kubva kuAtripla, senge kusvotwa uye kurutsa. Dzivisa kudya mazambiringa mazambiringa kana jisi remuzambiringa panguva yekurapa kwako naAtripla.

Iyo Atripla inoshanda sei

HIV hutachiona hunokuvadza immune system, inova ndiyo dziviriro yemuviri kuchirwere. Kana hutachiwana hweHIV husina kurapwa, hunotora masero ekudzivirira chirwere anonzi maCD4. HIV inoshandisa masero aya kutevedzera (kuita makopi acho pachawo) nekupararira mumuviri wese.

Pasina kurapwa, HIV inogona kukura kuita AIDS. NeAIDS, immune system inova isina kusimba zvekuti munhu anogona kuita mamwe mamiriro, senge pneumonia kana lymphoma. Pakupedzisira, AIDS inogona kupfupisa hupenyu hwemunhu.

Atripla musanganiswa wemishonga ine matatu maantiretroviral mishonga. Iyi mishonga ndeiyi:

• efavirenz, inova isiri-nucleoside reverse transcriptase inhibitor (NNRTI)
• emtricitabine, inova nucleoside analog reverse transcriptase inhibitors (NRTI)
• tenofovir disoproxil fumarate, inova zvakare NRTI

Mishonga iyi mitatu inoshanda nekumisa hutachiwana hweHIV kuti hurege kudzokororwa. Izvi zvishoma nezvishoma zvinoderedza hutachiona hwemunhu, inova huwandu hweHIV mumuviri. Kana mwero uyu wakadzikira zvekuti HIV inenge isisipo mumabvunzo ehutachiwana hweHIV, inonzi haioneke. Utachiona husingaonekwe ndicho chinangwa chekurapwa kweHIV.

Zvinotora nguva yakareba sei kuti zvishande?

Kune chero kurapwa kweHIV, kusanganisira Atripla, zvinotora masvondo masere kusvika makumi maviri nemasere kusvika pautachiona hweHIV husingaonekwe. Izvi zvinoreva kuti munhu anenge achine hutachiwana hweHIV, asi huri padanho repasi zvekuti hauonekwe nekuyedzwa.

Ndichada here kutora uyu mushonga kwenguva refu?

Parizvino hapana mushonga weHIV. Naizvozvo, kuchengetedza hutachiona hweHIV pasi pehutongi, vanhu vazhinji vanogara vachida kutora imwe mhando yemishonga yeHIV.

Kana iwe nachiremba wako mukasarudza kuti Atripla iri kukushandirai zvakanaka, mungangoda kuitora kwenguva refu.

Atripla nepamuviri

Kubata kunofanirwa kudzivirirwa panguva yekurapwa neAtripla, uye kweanenge mavhiki gumi nemaviri mushure mekuguma kurapwa. Izvi zvinodaro nekuti Atripla inogona kukuvadza nhumbu yako.

Kana iwe uine pamuviri kana kuronga kuva nepamuviri, taura nachiremba wako. Vanogona kutaura nezvekurapwa kwakasiyana kweHIV yako. Uye kana iwe ukava nepamuviri uchitora Atripla, dana chiremba wako ipapo ipapo.

Kana iwe ukatora Atripla uchiri nepamuviri, unogona kufunga nezve kujoina iyo Antiretroviral Pregnancy Registry. Iri registry rinoteedzera hutano uye kubata kwevanhu vanotora mishonga yemaARV kana vaine pamuviri. Chiremba wako anogona kukuudza zvakawanda.

Atripla uye kuyamwisa

Iyo mishonga muAtripla inopfuura mumukaka wemvere. Vanhu vari kutora Atripla havafanirwe kuyamwisa, nekuti mwana wavo anotora mushonga uyu kuburikidza nemukaka wemukaka. Kana izvi zvikaitika, mwana anogona kuve nemhedzisiro kubva kumushonga, senge manyoka.

Kumwe kufunga ndeyekuti HIV inogona kupfuudza kumwana kuburikidza nemukaka wemukaka. MuUnited States, iyo Centers for Disease Control and Prevention (CDC) inokurudzira kuti vanhu vane HIV vadzivise kuyamwa.

Zvakadaro, World Health Organisation (WHO) ichiri kukurudzira kuyamwisa vanhu vane HIV mune dzimwe nyika dzakawanda.

Mibvunzo yakajairika nezve Atripla

Heano mhinduro kumimwe inowanzo bvunzwa mibvunzo nezve Atripla.

Atripla inogona kukonzera kushushikana here?

Ehe, Atripla inogona kukonzera kushushikana. Muzvidzidzo zvemakiriniki, 9% yevanhu vanotora mushonga wakagadziriswa kushushikana.

Kana iwe ukacherechedza chero shanduko mumanzwiro ako paunenge uchitora Atripla, taura nachiremba wako ipapo. Vanogona kushandura kurapwa kwako kweHIV, uye vanogona kukupa mamwe mazano ekurapa ayo anogona kubatsira kudzikisira kushushikana kwako.

Atripla inorapa HIV here?

Kwete, parizvino hapana mushonga weHIV. Asi kurapa kwakanaka kunofanirwa kuita kuti hutachiona husingaonekwe. Izvi zvinoreva kuti munhu anenge achine hutachiwana hweHIV, asi huri padanho repasi zvekuti hauonekwe nekuyedzwa. Iyo FDA parizvino inofunga danho risingaonekwe sekurapa kubudirira.

Atripla inogona kudzivirira Mukondombera here?

Kwete, Atripla haina kubvumidzwa kudzivirira Mukondombera. Mushonga chete wakabvumidzwa kudzivirira Mukondombera ndiTruvada, iyo inoshandiswa pre-exposure prophylaxis (PrEP). NePrEP, mishonga inotorwa isati yasvika pakuonekwa neHIV kubatsira kudzivirira kupararira kweutachiona.

Atripla haisati yadzidzwa nezvekushandisa uku, kunyangwe iine zvese zviri zviviri zvinodhaka zvinowanikwa muTruvada (emtricitabine uye tenofovir disoproxil fumarate). Naizvozvo, Atripla haifanire kushandiswa pachinangwa ichi.

Munhu asina hutachiwana hweHIV asi ane mukana wekuitapurira anofanira kutaura nachiremba wake. Vanogona kukurudzira sarudzo dzekudzivirira dzakadai sePrEP kana post-exposure prophylaxis (PEP). Vanogona zvakare kuratidza dzimwe nzira dzekudzivirira, sekugara uchishandisa kondomu panguva yepabonde kana yekumashure pabonde.

Chii chinoitika kana ndikapotsa akawanda madosi eAtripla?

Kana iwe uchinge uchirasikirwa akati wandei madosi eAtripla, usatore akawanda madosi kuti ugadzire iwo awakarasikirwa. Pane kudaro, taura nachiremba wako nekukurumidza sezvazvinogona. Vanozokuzivisa iwe anotevera matanho aunofanira kutora.

Izvo zvakakosha kutora Atripla mazuva ese. Izvi zvinodaro nekuti kana ukarasikirwa nemadhizaini, muviri wako unogona kupokana neAtripla. Nekushomeka kwemishonga, mushonga hauchashandi kurapa imwe mamiriro.

Asi kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge warasikirwa.

Atripla yambiro

Mushonga uyu unouya neyambiro zhinji.

FDA yambiro: Kuwedzera kwehepatitis B (HBV)

Mushonga uyu une yambiro yebhokisi. Iyi ndiyo yambiro yakanyanya kubva kuFood and Drug Administration (FDA). Yambiro yebhokisi inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

• Kune vanhu vanotora Atripla uye vane HIV neHBV, kumisa Atripla kunogona kutungamira mukuwedzera HBV. Izvi zvinogona kutungamira kumatambudziko akadai sekukuvara kwechiropa.
• Vese varwere vanofanirwa kuongororwa HBV vasati vatanga kurapwa neAtripla. Zvakare, haufanire kumira kutora Atripla kutoti chiremba wako akakuudza kuti uite.
• Kana iwe uine hutachiwana hweHIV neHBV uye worega kutora Atripla, chiremba wako anofanira kuongorora chiropa chako chinoshanda zvakanyanya kwemwedzi yakati wandei. Kana HBV yako ikawedzera, chiremba wako anogona kutanga iwe paHBV kurapwa.

Dzimwe yambiro

Usati watora Atripla, taura nachiremba wako nezve nhoroondo yako yehutano. Atripla inogona kunge isingave yakakunakira iwe kana uine mamwe marapirwo. Izvi zvinosanganisira:

• Hypersensitivity kune Atripla kana zvigadzirwa zvayo. Kana iwe wakambove neakanyanya kukanganiswa kweatripla kuAtripla kana chero yemishonga irimo, unofanirwa kudzivirira kutora Atripla. Kana chiremba wako akaraira Atripla iwe, ita shuwa yekuvaudza nezve zvawakamboita usati watanga kutora mushonga.

Ongorora: Kuti uwane rumwe ruzivo nezve zvingangoitika zvakaipa zveAtripla, ona iyo "Side mhedzisiro" chikamu pamusoro.

Atripla kudarika

Kutora zvakawandisa zvemushonga uyu kunogona kuwedzera njodzi yako yemhedzisiro.

Ovhadhozi zviratidzo

Zvidzidzo zvekiriniki zveAtripla hazvina kutaura zvinogona kuitika kana zvakawandisa zvemushonga zvikatorwa. Asi zvimwe zvidzidzo zvakaratidza kuti kutora efavirenz yakawandisa, mushonga unowanikwa muAtripla, unogona kuwedzera mimwe mhedzisiro yemushonga. Izvi zvinosanganisira:

• dzungu
• kunetseka kurara
• kuvhiringidzika
• kuona zvisipo
• mhasuru kurira

Zvekuita kana ovhadhozi

Kana iwe ukatora anopfuura rimwe chete Atripla piritsi pazuva, udza chiremba wako. Uye uve shuwa yekuvaudza nezve chero shanduko mune ako maratidziro kana mune manzwiro aunowanzoita.

Kana iwe uchifunga kuti watora zvakawandisa Atripla, fonera chiremba wako kana kutsvaga nhungamiro kubva kuAmerican Association of Poison Control Centres pa800-222-1222 kana kuburikidza nechavo online chishandiso. Asi kana zviratidzo zvako zvakakomba, fonera 911 kana kuenda kukamuri yepedyo yevanokurumidza ipapo.

Kupera kweApripla

Kana Atripla yakapihwa kubva kufamasi, mupiki wemishonga anowedzera zuva rekupera kune zvakanyorwa pahombodo. Zuva iri rinowanzo kuve gore rimwe kubva musi wakapihwa mushonga.

Chinangwa chemazuva ekupera akadaro ndechekuvimbisa kushanda kwemushonga panguva ino. Chimiro chazvino cheKudya neDrug Administration (FDA) ndechekudzivirira kushandisa akapera mishonga.

Inguva yakareba sei mushonga unoramba wakanaka unogona kubva pane zvakawanda zvinhu, zvinosanganisira kuti uye kupi mushonga unochengeterwa. Atripla mapiritsi anofanirwa kuchengetwa mukamuri tembiricha, kutenderera 77 ° F (25 ° C). Ivo vanofanirwawo kuchengetwa mumudziyo wavo wepakutanga, iine muvharo wakanyatsovharwa.

Kana iwe usina kushandisa mishonga yakapfuura nguva yekupera, taura nachiremba wako nezvekuti ungangokwanisa kuishandisa.

Ruzivo rwehunyanzvi rweAtripla

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Nzira yekuita

Atripla katatu antiretroviral mubatanidzwa piritsi rine efavirenz, inova isiri-nucleoside reverse transcriptase inhibitors (NNRTI), uye emtricitabine uye tenofovir disoproxil fumarate, ayo ari maviri nucleoside analog reverse transcriptase inhibitors (NRTIs).

NNRTIs neNRTIs zvese zvinosunga kuHIV reverse transcriptase, iyo inomisa kutendeuka kweHIV RNA kuve HIV DNA. Nekudaro, ivo vanoshanda muzvikamu zvakasiyana zvishoma zveiyo HIV reverse transcriptase enzyme.

Pharmacokinetics uye metabolism

Atripla inofanira kutorwa pane isina chinhu mudumbu. Mishonga mitatu iri muAtripla inokurumidza kufefetwa. Efavirenz inotora yakarebesa kusvika yakadzikama-nyika nhanho (6-10 mazuva). Kubviswa kwehafu-yehupenyu yemitatu mishonga inotevera:

• efavirenz: 40-55 maawa
• emtricitabine: maawa gumi
• tenofovir disoproxil fumarate: maawa gumi nemanomwe

Atripla haina kukurudzirwa kuti ishandiswe mune vanhu vane mwero kana zvakakomba kukuvara kwechiropa. Nekuti efavirenz inogadziriswa nema enzymes echiropa (CYP P450), kushandiswa kweAtripla muvanhu vane chero kukuvara kwechiropa kunofanirwa kuitwa nekuchenjerera.

Kushandisa Atripla hakukurudzirwe kune vanhu vane mwero kusvika pakukomba kwakakomba kweitsvo (CrCl <50 mL / min).

Contraindications

Atripla haifanire kushandiswa kune vanhu vakave neyakaipa yekukanganisa kune efavirenz, inova imwe yemishonga muAtripla.

Atripla haifanire kushandiswa mune vanhu vari kutorawo voriconazole kana elbasvir / grazoprevir.

Kuchengetedza

Atripla inofanirwa kuchengetwa mukati tembiricha yemukati 77 ° F (25 ° C), yakanyatsovharirwa mumudziyo wayo wepakutanga.

Disiki: Medical News Nhasi yaedza nepese painogona napo kuti ive neruzivo rwekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.