Ndeipi Biologic Zvinodhaka Sarudzo yeCrohn's Chirwere?

Zvemukati

• Chii chinonzi biologic zvinodhaka?
• Iwo matatu marudzi ebiologics
• Anti-TNF mishonga
• Interleukin inhibitors
• Anti-integrin antibodies
• Nhanho-kumusoro maringe nepamusoro-pasi kurapwa
• Zvimwe zvinokanganisa
• Kufunga kwakakosha
• Tiibhii
• Zvirwere
• Mamiriro emoyo
• Dzimwe nyaya

Mhedziso

Chirwere cheCrohn chinokonzeresa kuzvimba, kuzvimba, uye kutsamwiswa mumutsara wedumbu.

Kana iwe wakamboedza mamwe marapirwo echirwere cheCrohn, kana kunyangwe iwe uchangobva kuongororwa, chiremba wako anogona kufunga kunyorera biologic zvinodhaka. Biologics mishonga yekunyorera iyo inobatsira kudzikisa kuzvimba kunokuvadza kubva kuchirwere cheCrohn.

Chii chinonzi biologic zvinodhaka?

Biologics inogadzirwa nemajini mishonga inotarisa mamwe mamorekuru mumuviri unobatanidzwa mukukonzera kuzvimba.

Vanachiremba vanowanzopa biologics kune avo vane chirwere cheCrohn chinopikisa chisiri kupindura kune imwe mishonga, kana kune vanhu vane zviratidzo zvakakomba.Pamberi pe biologics, paive nesarudzo shoma dzekuvhiya dzevanhu vane chirwere chekupokana.

Biologic zvinodhaka zvinoshanda kukurumidza kuunza kuregererwa. Munguva yekuregererwa, kuzvimba uye zviratidzo zvemudumbu zvinoenda. Biologics inogona zvakare kushandiswa pane yakareba-nguva hwaro kubatsira kuchengetedza nguva dzekuregererwa.

Iwo matatu marudzi ebiologics

Mhando yeiyo biologic chiremba wako anoratidza zvinoenderana nekuoma kwezviratidzo zvako uye nenzvimbo yechirwere. Munhu wese akasiyana. Mumwe mushonga wekubereka unogona kushanda zvirinani kune vamwe kupfuura vamwe. Iwe ungatofanira kuedza mishoma mishonga usati wawana zvinoshanda kwauri.

Biological Therapies yechirwere cheCrohn inowira mune chimwe chezvikamu zvitatu: anti-tumor necrosis factor (anti-TNF) marapirwo, interleukin inhibitors, uye anti-integrin antibodies.

Anti-TNF Therapies inotarisa puroteni inobatanidzwa mukuzvimba. Yechirwere cheCrohn, anti-TNF Therapies inoshanda nekudzivirira kuzvimba kunokonzerwa neprotein iyi mumatumbu.

Interleukin inhibitors anoshanda zvakafanana, nekuvhara mapuroteni anowanzoitika anokonzera kuzvimba mumatumbu. Anti-inosanganisa inovhara mamwe maseru emuviri anokonzera kuzvimba.

Biologics inowanzo kupihwa chero subcutaneously (ine tsono kuburikidza neganda) kana intravenously (kuburikidza neIV chubhu). Vanogona kupihwa mavhiki maviri kusvika masere ega ega, zvichienderana nemushonga. Unofanira kuenda kuchipatara kana kukiriniki kune akawanda marapirwo aya.

Iyo FDA yakabvumidza akati wandei mishonga yemakemikari yekurapa chirwere cheCrohn.

Anti-TNF mishonga

• adalimumab (Humira, Kununurwa)
• certolizumab pegol (Cimzia)
• infliximab (Remicade, Remsima, Inflectra)

Interleukin inhibitors

• ustekinumab (Stelara)

Anti-integrin antibodies

• natalizumab (Tysabri)
• vedolizumab (Entyvio)

Nhanho-kumusoro maringe nepamusoro-pasi kurapwa

Biologic Therapies inogona kuve chishandiso chakasimba pakurapa uye manejimendi chirwere cheCrohn. Pane nzira mbiri dzakasiyana dzekurapa biologic:

• Step-up therapy ndiyo yaive yakajairika nzira kudzamara mirau mitsva yaburitswa muna 2018. Iyi nzira inoreva kuti iwe nachiremba wako edzai mamwe marapirwo akati wandei musati matanga biologic.
• Yepamusoro-pasi kurapa kunoreva kuti biologic mishonga inotangwa kare kare mukurapa maitiro. Iyi ndiyo zvino nzira inosarudzika mune dzakawanda zviitiko zvine mwero kusvika kune zvakanyanya chirwere cheCrohn.

Nekudaro, nzira dzakasiyana dzinogona kushanda zvirinani kune vanhu vakasiyana zvichienderana nekuoma uye nzvimbo yechirwere.

Zvimwe zvinokanganisa

Biologics inowanzove nemhedzisiro mhedzisiro isinganyanye kuomarara kupfuura mamwe mishonga yechirwere cheCrohn, senge corticosteroids, iyo inodzvinyirira immune system yese.

Zvakadaro, kune mamwe mhedzisiro iwe yaunofanirwa kuziva nezvayo usati watora biologic mushonga.

Mimwe mhedzisiro mhedzisiro yebiologics inosanganisira:

• kutsvuka, kuruma, kupwanya, kurwadziwa, kana kuzvimba kwakatenderedza jekiseni saiti
• musoro
• kupisa kana kutonhora
• kunetseka kufema
• yakaderera BP
• mikoko kana mapundu
• kurwadziwa nemudumbu
• kurwadziwa shure
• kusvotwa
• kukosora kana kurwadziwa pahuro

Kufunga kwakakosha

Biologics inogona kunge isina kuchengetedzeka kune wese munhu. Taura nachiremba wako kana iwe uine tibhii (TB), unowanzobatwa nezvirwere, kana uine moyo moyo.

Tiibhii

Biologic zvinodhaka zvinoshandiswa nechirwere cheCrohn zvinogona kuwedzera njodzi yekumutsiridza hutachiona hwehutachiona muvanhu vakafumurwa. TB chirwere chakakomba, chinotapukira chemapapu.

Chiremba wako anofanira kukuyedza TB usati watanga kurapwa ne biologic. Utachiona hweTB hunogona kurara mumuviri. Vamwe vanhu vakafumurwa chirwere vanogona kunge vasingazvizive.

Kana iwe wakambosangana neTB, chiremba wako anogona kukurudzira kurapwa kweTB usati watora biologic.

Zvirwere

Biologics inogona kudzikisa kugona kwemuviri kurwisa zvimwe hutachiona. Kana iwe uchinge wakanangana nehutachiona, chiremba wako anogona kukurudzira imwe mhando yekurapa.

Mamiriro emoyo

Anti-TNF mishonga inogona kuva nenjodzi kune vanhu vane mamwe mamiriro emoyo, sekushaya moyo. Kukundikana kwemoyo ndiko apo moyo usingakwanise kupomba ropa rakaringana kusangana nezvinodiwa nemuviri.

Udza chiremba wako nekukurumidza sezvinobvira kana iwe ukawana kupfupika kwemweya wekufema kana kuzvimba kwetsoka uchitora biologic yechirwere cheCrohn. Izvi zvinogona kunge zviri zviratidzo zvekutadza kwemoyo.

Dzimwe nyaya

Biologic kurapa pano neapo kwakabatanidzwa nematambudziko akakomba ehutano. Mune vanhu vanotora biologic zvinodhaka, zvinotevera matambudziko ehutano hazviwanzo kutaurwa:

• kumwe kunetseka kweropa (kupwanya, kubuda ropa)
• matambudziko etsinga (kusanganisira, kupera simba, kushaya simba, kurira, kana kukanganiswa kwekuona, sekusaona zvakanaka, kuona zvakapetwa, kana kusarongeka)
• lymphoma
• kukuvara kwechiropa
• kukanganiswa kweakanyanya kukanganiswa

Taura nachiremba wako kuti uone kurapwa kwakanakira iwe uye zvaunoda.