BRCA Genetic Bvunzo

Zvemukati

• Chii chinonzi BRCA genetic test?
• Chii chinoshandiswa?
• Nei ndichida BRCA genetic test?
• Chii chinoitika panguva ye BRCA genetic test?
• Ndichafanira here kuita chero chinhu kugadzirira bvunzo?
• Pane here njodzi kune bvunzo?
• Zvinorevei mhedzisiro yacho?
• Pane chimwe chinhu here chandinofanira kuziva nezve BRCA genetic test?
• Zvinyorwa

Chii chinonzi BRCA genetic test?

A BRCA genetic test inotarisa shanduko, inozivikanwa sekuchinja, mumageneti anonzi BRCA1 uye BRCA2. Magene zvikamu zveDNA zvakapfuudzwa kubva kuna mai nababa vako. Ivo vanotakura ruzivo rwunotarisa hunhu hwako hwakasarudzika, sekukwirira uye ruvara rwemaziso. Mageneti zvakare ane chekuita nemamwe mamiriro ehutano. BRCA1 uye BRCA2 majini anodzivirira masero nekugadzira mapuroteni anobatsira kudzivirira mapundu kubva pakuumbwa.

Kuchinja mu BRCA1 kana BRCA2 geni kunogona kukonzera kukuvara kwemasero kunogona kutungamira kugomarara. Vakadzi vane mutated BRCA gene vane njodzi yakakwira yekubata kenza yemazamu kana ovari. Varume vane gene mutated BRCA vari panjodzi yakanyanya yekuwana gomarara repazamu kana reprostate. Haasi munhu wese anowana nhaka ye BRCA1 kana BRCA2 mutation achawana cancer. Zvimwe zvinhu, zvinosanganisira mararamiro ako uye nharaunda, zvinogona kukanganisa kenza yako njodzi.

Kana iwe ukaona kuti une BRCA shanduko, unogona kukwanisa kutora matanho ekudzivirira hutano hwako.

Mamwe mazita: BRCA gene bvunzo, BRCA geni 1, BRCA geni 2, kenza yemazamu inokanganisa gene1, kenza yemazamu inokanganisa geni 2

Chii chinoshandiswa?

Bvunzo iyi inoshandiswa kutsvaga kana iwe uine BRCA1 kana BRCA2 geni mutation. A BRCA geni mutation inogona kuwedzera njodzi yako yekubata cancer.

Nei ndichida BRCA genetic test?

BRCA kuyedza haina kukurudzirwa kune vanhu vazhinji. BRCA geni shanduko haigone, ichingobata chete 0.2 muzana yehuwandu hweUS. Asi iwe ungangoda bvunzo iyi kana iwe uchifunga kuti uri pangozi yakanyanya yekuchinja. Iwe uri mukana wekuve ne BRCA shanduko kana iwe:

• Iva kana uine kenza yemazamu yakaonekwa isati yasvika makore makumi mashanu
• Iva kana uine kenza yemazamu mumazamu maviri
• Kuve kana kuve nekenza yemazamu uye ovari
• Iva nemumwe kana nhengo dzemhuri dzine gomarara repazamu
• Iva nehama yechirume ine gomarara repazamu
• Iva nehama yako yatowanikwa iine BRCA mutation
• Ari eAshkenazi (Eastern Europe) madzitateguru echiJuda. Shanduko dze BRCA dzakanyanya kuwanda muboka iri zvichienzaniswa nehuwandu hwevanhu. Shanduko dze BRCA zvakare dzakajairika muvanhu vanobva kune mamwe matunhu eEurope, kusanganisira, Iceland, Norway, neDenmark.

Chii chinoitika panguva ye BRCA genetic test?

Nyanzvi yezvehutano inotora muyero weropa kubva mutsinga iri muruoko rwako, uchishandisa tsono diki. Mushure mekunge tsono yaiswa, kashoma reropa kanounganidzwa muthubhu yekuyedza kana muhombodo. Unogona kunzwa kakuruma kana tsono ichipinda kana kubuda. Izvi zvinowanzotora maminetsi asingasviki mashanu.

Ndichafanira here kuita chero chinhu kugadzirira bvunzo?

Iwe haudi chero gadziriro yakakosha yekuyedzwa kwe BRCA. Asi iwe ungangoda kusangana neyemajini chipangamazano kutanga kuti uone kana iyo bvunzo yakakunakira iwe. Mupi wezano wako anogona kutaura newe nezve njodzi uye mabhenefiti ekuongororwa kwemajini uye kuti mhedzisiro dzakasiyana dzinogona kureva.

Iwe unofanirwa zvakare kufunga nezve kuwana magineti kurairwa mushure mekuedzwa kwako. Mupi wezano wako anogona kukurukura kuti mhedzisiro yako ingakanganisa sei iwe nemhuri yako, zvese pakurapwa uye pamoyo.

Pane here njodzi kune bvunzo?

Pane njodzi shoma yekuongororwa ropa. Unogona kunge uine marwadzo mashoma kana kupwanya panzvimbo yakaiswa tsono, asi zviratidzo zvizhinji zvinokurumidza kupera.

Zvinorevei mhedzisiro yacho?

Mazhinji mhedzisiro inotsanangurwa seisina kunaka, isina chokwadi, kana yakanaka, uye zvinowanzoreva zvinotevera:

• Mhedzisiro yakaipa zvinoreva kuti hapana BRCA gene shanduko yakawanikwa, asi hazvireve kuti hauzombowana cancer.
• Mhedzisiro isina chokwadi zvinoreva imwe mhando ye BRCA geni mutation yakawanikwa, asi inogona kana inogona kusabatanidzwa neyakawedzera kenza njodzi. Iwe ungangoda mimwe bvunzo uye / kana kuongorora kana mhedzisiro yako yanga isina chokwadi.
• Mhedzisiro yakanaka zvinoreva shanduko mu BRCA1 kana BRCA2 yakawanikwa. Izvi zvinoshandura zvinokuisa padanho repamusoro rekubata cancer. Asi havazi vese vane shanduko vanowana cancer.

Zvinogona kutora mavhiki akati kuti uwane zvawanikwa. Kana iwe uine mibvunzo nezve mhedzisiro yako, taura nemupi wako wezvehutano uye / kana wako genetic chipangamazano.

Dzidza zvakawanda nezve bvunzo dzemarabhoritari, mareferenzi masosi, uye mhinduro dzekunzwisisa

Pane chimwe chinhu here chandinofanira kuziva nezve BRCA genetic test?

Kana zvabuda zvikaratidza kuti une BRCA geni shanduko, unogona kutora matanho anogona kudzikisa njodzi yako wekenza yemazamu. Izvi zvinosanganisira:

• Zvimwe zvinowanzoitika zvecancer kuongorora bvunzo, senge mammograms uye ultrasound. Kenza iri nyore kurapa kana yawanikwa mumatanho ekutanga.
• Kutora mapiritsi ekudzivirira kubereka kwenguva yakati rebei. Kutora mapiritsi ekudzivirira kubereka kweanopfuura makore mashanu kwakaratidzirwa kudzikisa njodzi yecancer yechibereko mune vamwe vakadzi vane BRCA geni shanduko. Kutora mapiritsi kweanopfuura makore mashanu kudzikisa gomarara hakukurudzirwe. Dai wanga uchitora mapiritsi ekudzivirira kubereka usati watora bvunzo ye BRCA, udza mupi wako wezvehutano kuti waive nemakore mangani pawakatanga kunwa mapiritsi uye kwenguva yakareba sei. Iye kana iye anozobva arumbidza kana iwe kana uchifanira kuramba uchizvitora.
• Kutora mishonga yekurwisa gomarara. Mimwe mishonga, yakadai seinonzi tamoxifen, yakaratidzirwa kudzikisa njodzi kuvakadzi vane njodzi yakanyanya yekenza yemazamu.
• Kuitwa oparesheni, inozivikanwa sekudzivirira mastectomy, kubvisa hutano hwemazamu. Kudzivirira mastectomy kwakaratidzirwa kudzikisa njodzi yekenza yemazamu neanosvika makumi mapfumbamwe muzana muzana muvakadzi vane BRCA geni mutation. Asi uku kuvhiya kukuru, kunokurudzirwa chete kune vakadzi vari panjodzi huru yekubatwa nekenza.

Iwe unofanirwa kutaura nemubatsiri wako wezvehutano kuti uone matanho akakunakira iwe.

Zvinyorwa

1. American Society yeKiriniki Oncology [Internet]. American Society yeKiriniki Oncology; 2005-2018. Hereditary Chipfuva uye Ovarian Cancer; [yakataurwa 2018 Mar 19]; [angangoita matatu skrini. Inowanikwa kubva: https://www.cancer.net/cancer-types/hereditary-breast-and-ovarian-cancer
2. Hinkle J, Cheever K. Brunner & Suddarth's Handbook yeLabhoritari uye Yekuongorora Yekuongorora. 2nd Ed, Kindle. Philadelphia: Wolters Kluwer Hutano, Lippincott Williams & Wilkins; c2014. Kuedza kwe BRCA; 108 p.
3. Lab Kuedza Pamhepo [Internet]. Washington DC: American Association yeKiriniki Chemistry; c2001–2018. BRCA Gene Mutation Kuedzwa [yakagadziridzwa 2018 Jan 15; yakataurwa 2018 Feb 23]; [angangoita maviri skrini. Inowanikwa kubva: https://labtestsonline.org/tests/brca-gene-mutation-testing
4. Mayo Clinic [Indaneti]. Mayo Foundation Yekurapa Dzidzo uye Tsvagiridzo; c1998–2018. BRCA geni bvunzo yechipfuva uye ovari kenza njodzi; 2017 Dec 30 [yakataurwa 2018 Feb 23]; [angangoita matatu skrini. Inowanikwa kubva: https://www.mayoclinic.org/tests-procedures/brca-gene-test/about/pac-20384815
5. Chirangaridzo Sloan Kettering Cancer Center [Internet]. New York: Chirangaridzo Sloan Kettering Cancer Center; c2018. BRCA1 uye BRCA2 Genesisi: Njodzi yeCancer uye Ovarian Cancer [yakataurwa 2018 Feb 23]; [angangoita mashanu skrini. Inowanikwa kubva: https://www.mskcc.org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counselling/brca1-brca2-genes-risk-breast-ovarian
6. National Cancer Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. BRCA Shanduko: Kenza Njodzi uye Kuongorora kweGenetic [yakataurwa 2018 Kukadzi 23]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet#q1
7. National Cancer Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. NCI Duramazwi reMitemo yeCancer: shanduko [yakataurwa 2018 Feb 23]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=mutation
8. National Mwoyo, Mapapu, uye Ropa Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Kuedzwa kweropa [kwakataurwa 2018 Feb 23]; [angangoita matatu skrini. Inowanikwa kubva: https://www.nhlbi.nih.gov/health-topics/blood-tests
9. NIH U.S. National Raibhurari yeMishonga: Genetics Kumba Referensi [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. BRCA1 geni; 2018 Mar 13 [yataurwa 2018 Mar 18]; [angangoita matatu skrini. Inowanikwa kubva ku: https://ghr.nlm.nih.gov/gene/BRCA1 # mamiriro
10. NIH U.S. National Raibhurari yeMishonga: Genetics Kumba Referensi [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. BRCA2 geni; 2018 Mar 13 [yataurwa 2018 Mar 18]; [angangoita matatu skrini. Inowanikwa kubva ku: https://ghr.nlm.nih.gov/gene/BRCA2# mamiriro
11. NIH U.S. National Raibhurari yeMishonga: Genetics Kumba Referensi [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Chii chinonzi gene? 2018 Feb 20 [yataurwa 2018 Feb 23]; [angangoita matatu skrini. Inowanikwa kubva: https://ghr.nlm.nih.gov/primer/basics/gene
12. Yunivhesiti yeRochester Medical Center [Internet]. Rochester (NY): Yunivhesiti yeRochester Medical Center; c2018. Health Encyclopedia: BRCA [yataurwa 2018 Feb 23]; [angangoita maviri skrini. Inowanikwa kubva ku: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid;=brca
13. UW Hutano [Internet]. Madison (WI): Yunivhesiti yeWisconsin Zvipatara uye Makiriniki Chiremera; c2018. Kenza Yezamu (BRCA) Gene Bvunzo: Ungagadzirira Sei [yakagadziridzwa 2017 Jun 8; yakataurwa 2018 Feb 23]; [angangoita mashanu skrini. Inowanikwa kubva: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6465
14. UW Hutano [Internet]. Madison (WI): Yunivhesiti yeWisconsin Zvipatara uye Makiriniki Chiremera; c2018. Kenza Yezamu (BRCA) Gene Bvunzo: Mhedzisiro [yakagadziridzwa 2017 Jun 8; yakataurwa 2018 Feb 23]; [angangoita 9 skrini. Inowanikwa kubva ku: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6469
15. UW Hutano [Internet]. Madison (WI): Yunivhesiti yeWisconsin Zvipatara uye Makiriniki Chiremera; c2018. Kenza Yezamu (BRCA) Gene Bvunzo: Ongororo Yekutarisa [yakagadziridzwa 2017 Jun 8; yakataurwa 2018 Feb 23]; [angangoita maviri skrini. Inowanikwa kubva: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html
16. UW Hutano [Internet]. Madison (WI): Yunivhesiti yeWisconsin Zvipatara uye Makiriniki Chiremera; c2018. Kenza Yezamu (BRCA) Gene Bvunzo: Nei Yaitwa [yakagadziridzwa 2017 Jun 8; yakataurwa 2018 Feb 23]; [angangoita mana skrini. Inowanikwa kubva: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu646

Ruzivo ruri pane ino saiti harufanire kushandiswa sekutsiva kwehunyanzvi kurapwa kana kurairwa. Bata mupi wehutano kana iwe uine mibvunzo nezve hutano hwako.