CPK bvunzo: ndeyei uye nei ichichinjwa
Zvemukati
Creatinophosphokinase, inozivikanwa nechidimbu CPK kana CK, enzyme inoshanda zvakanyanya pamhasuru yemhasuru, huropi nemoyo, uye muyero wayo unokumbirwa kuti uongorore kukuvara kunogona kuitika kunhengo idzi.
Chiremba anogona kuraira bvunzo iyi kana munhu asvika kuchipatara achinyunyuta nezvekurwadziwa pachipfuva kana kutarisa zviratidzo zvekurohwa kana chero chirwere chinokanganisa mhasuru, semuenzaniso.
Referensi tsika
Iwo mareferenzi kukosha kweakasika phosphokinase (CPK) ari 32 uye 294 U / L yevarume uye 33 kusvika 211 U / L yevakadzi asi zvinogona kusiyana zvichienderana neirabhoritari kunoitiswa bvunzo.
Chii ichochi
Iyo creatinophosphokinase (CPK) bvunzo inobatsira kubatsira kuongorora zvirwere zvakaita sekurwadziwa nemoyo, itsvo kana kutadza kwemapapu, pakati pevamwe. Iyi enzyme yakakamurwa kuita matatu marudzi zvichienderana nenzvimbo yayo:
- CPK 1 kana BB: Inogona kuwanikwa mumapapu uye muuropi, kunyanya;
- CPK 2 kana MB: Inowanikwa mumhasuru yemwoyo uye nekudaro inogona kushandiswa sechiratidzo che infarction, semuenzaniso;
- CPK 3 kana MM: Iripo mumhasuru yemhasuru uye inomiririra 95% yezvose zvisikwa phosphokinases (BB uye MB).
Muyero wemhando yega yega yeCK inoitwa nenzira dzakasiyana dzerabhoritari zvinoenderana nehunhu hwayo uye maererano nechiratidzo chekurapa. Kana CPK dosage ikakumbirwa kuongorora infarction, semuenzaniso, CK MB inoyerwa mukuwedzera kune mamwe mamaki emoyo, senge myoglobin uye troponin, kunyanya.
Iko kukosha kweCK MB yakaenzana kana kuti isingasvike pa5 ng / mL inoonekwa seyakajairika uye kusangana kwayo kunowanzo kuve kwakakwirira kana chirwere chemwoyo chikaitika. Iwo mazinga eCK MB anowanzo wedzera 3 kusvika kumaawa mashanu mushure meiyo infarction, inosvika pamusoro kusvika kumaawa makumi maviri nemana uye kukosha kwacho kunodzokera kune zvakajairika pakati pe48 kusvika 72 maawa mushure mekufenda. Kunyangwe ichionekwa seyakanaka moyo mucherechedzo, kuyerwa kweCK MB yekuongororwa kwe infarction kunofanira kuitwa pamwe chete ne troponin, kunyanya nekuti iyo troponin tsika inodzokera kune yakasarudzika mazuva angangoita gumi mushure me infarction, iri, nekudaro, yakanyanya kujeka. Ona kuti iyo troponin bvunzo ndeyei.
Zvinorevei uye zvakaderera CPK zvinoreva
Kuwedzera kwevasungwa kweiyo creatinophosphokinase enzyme inogona kuratidza:
| Yakakwira CPK | Yakadzika CPK | |
| CPK BB | Infarction, sitiroko, bundu repfungwa, pfari, kutadza kwemapapu | -- |
| CPK MB | Kuzvimba kwemoyo, kukuvara pachifuva, kuvhunduka kwemagetsi, mune kesi yemoyo defibrillation, kuvhiya moyo | -- |
| MM CPK | Kupwanya kukuvara, kurovedza muviri kwakanyanya, kuremadza kwenguva refu, kushandiswa kwezvinodhaka zvisiri pamutemo, kuzvimba mumuviri, muscular dystrophy, mushure meelectromyography | Kurasikirwa kwemhasuru, cachexia uye kushaya zvinovaka muviri |
| CHETE CPK | Kunyanyisa kunwa zvinwiwa zvinodhaka, nekuda kwekushandiswa kwemishonga yakadai seamphotericin B, clofibrate, ethanol, carbenoxolone, halothane uye succinylcholine inopihwa pamwechete, kuisa chepfu nemabharbiturate | -- |
Kuita CPK dosing, kutsanya hakumanikidzi, uye kunogona kana kusingakurudzirwe nachiremba, zvisinei zvakakosha kuti udzivise kuita kunetesa muviri muviri kwemazuva maviri usati waita bvunzo, sezvo iyi enzyme inogona kukwidziridzwa mushure mekurovedza muviri nekuda kugadzirwa kwayo nemhasuru, pamusoro pekumiswa kwemishonga, senge Amphotericin B uye Clofibrate, semuenzaniso, sezvo vachigona kukanganisa mhedzisiro yemuedzo.
Kana bvunzo ikakumbirwa nechinangwa chekuongorora chirwere chemwoyo, zvinokurudzirwa kuti hukama huripo pakati peCPK MB neCPK huongororwe pachishandiswa fomu inotevera: 100% x (CK MB / CK yakazara). Kana mhedzisiro yehukama uhwu yakakura kudarika 6%, inoratidza kukuvara kumutsipa wemwoyo, asi kana iri pasi pe6%, chiratidzo chekukuvara kumhasuru yemhasuru, uye chiremba anofanira kuongorora chikonzero.
Zvinonakidza
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