HER2 (Breast Cancer) Kuedzwa

Zvemukati

• Chii chinonzi HER2 cancer cancer kuyedza?
• Chii chinoshandiswa?
• Nei ndichida HER2 kuyedzwa kenza yemazamu?
• Chii chinoitika panguva yeHER2 kenza yemazamu bvunzo?
• Ndichafanira here kuita chero chinhu kugadzirira bvunzo?
• Pane here njodzi kune bvunzo?
• Zvinorevei mhedzisiro yacho?
• Pane chimwe chinhu here chandinofanira kuziva nezve HER2 kenza yemazamu kuyedzwa?
• Zvinyorwa

Chii chinonzi HER2 cancer cancer kuyedza?

HER2 inomiririra munhu epidermal kukura chinhu chinogamuchira 2. Iyo geni inogadzira protein inowanikwa pamusoro pemasero ese emuzamu. Inobatanidzwa mukukura kwesero.

Mageneti ndiwo akakosha mayuniti enhaka, akapfuudzwa kubva kuna mai nababa vako. Mune mamwe kanzira, kunyanya kenza yemazamu, iyo HER2 geni inoshanduka (inochinja) uye inoita mamwe makopi ejeni. Kana izvi zvikaitika, iyo HER2 geni inogadzira yakawandisa HER2 protein, ichikonzera maseru kuti apatsanure nekukura nekukurumidza.

Cancers ine yakakwira mizinga yeiyo HER2 protein inozivikanwa seHER2-yakanaka. Gomarara rine mashoma maprotein anozivikanwa seHER2-negative. Inenge makumi maviri muzana yekenza yemazamu ndeye HER2-yakanaka.

HER2 kuyedzwa kunotarisa semuenzaniso wetumhu tishu. Nzira dzakajairika dzekuyedza bundu remuviri ndedzinotevera:

• Immunohistochemistry (IHC) kuyera kuyera iyo HER2 protein pamusoro pemasero
• Fluorescence in situ kusanganiswa (FISH) kuyedzwa kunotarisa mamwe makopi eiyo HER2 geni

Ese maviri marudzi ebvunzo anogona kutaurira kana uine HER2-yakanaka kenza. Mishonga inonyatso tarisa HER2-yakanaka kenza yemazamu inogona kushanda zvakanyanya.

Mamwe mazita: epidermal kukura kwevanhu chinhu receptor 2, ERBB2 kukwidziridzwa, HER2 overexpression, HER2 / neu bvunzo

Chii chinoshandiswa?

HER2 kuyedzwa kunonyanya kushandiswa kutsvaga kana kenza iri HER2-yakanaka. Iyo zvakare dzimwe nguva inoshandiswa kuona kana gomarara riri kupindura kurapwa kana kenza yadzoka mushure mekurapwa.

Nei ndichida HER2 kuyedzwa kenza yemazamu?

Kana iwe wakamboonekwa uine kenza yemazamu, ungangoda bvunzo iyi kuti uone kana kenza yako iri HER2-yakanaka kana HER2-isina. Kana iwe uchiri kutorapwa kenza yemazamu yeHER2-yakanaka, ungangoda bvunzo iyi ku:

• Tsvaga kana kurapwa kwako kuri kushanda. Akajairwa mazinga eHER2 zvinogona kureva kuti uri kupindura kurapwa. Matunhu akakwirira anogona kureva kuti kurapwa hakusi kushanda.
• Tsvaga kana gomarara rakadzoka mushure mekurapwa.

Chii chinoitika panguva yeHER2 kenza yemazamu bvunzo?

Yakawanda HER2 kuyedza kunosanganisira kutora sampuro yemota yeturu mune imwe nzira inonzi biopsy. Iko kune matatu makuru marudzi ebiopsy maitiro:

• Yakanaka tsono aspiration biopsy, iyo inoshandisa tsono yakatetepa kubvisa samu yemazamu maseru kana fluid
• Core tsono biopsy, iyo inoshandisa tsono hombe kubvisa sampuli
• Kuvhiya biopsy, inobvisa sampuro mune diki, yekurapa maitiro

Yakanaka tsono kushuvira uye yakakosha tsono biopsies kazhinji inosanganisira anotevera matanho:

• Iwe unozorara parutivi rwako kana kugara patafura yebvunzo.
• Anopa hutano anozochenesa iyo biopsy saiti uye ojoinise neanesthetic kuti usazonzwa chero kurwadziwa panguva yekuita.
• Kana imwe nzvimbo yangova chiveve, mupi anoisa kana yakanaka aspiration tsono kana yakakosha biopsy tsono mune iyo biopsy saiti uye kubvisa sampuro yetissue kana fluid.
• Unogona kunzwa kumanikidzwa kuduku kana muyenzaniso wabviswa.
• Dzvinyiriro inozoiswa kune iyo biopsy saiti kusvikira kubuda kweropa kwamira.
• Wako mupi achazadza chena bhandiji pane iyo biopsy saiti.

Mune biopsy yekuvhiya, chiremba anovhiya anozoita kucheka kudiki paganda rako kubvisa zvese kana chikamu chebundu remuzamu. Bhiopsy yekuvhiya dzimwe nguva inoitwa kana bundu risingakwanise kusvikwa neine tsono biopsy. Kuvhiya biopsies kunowanzo sanganisira anotevera matanho.

• Iwe ucharara pamusoro petafura yekushandisa. IV (mutsetse unopinza) unogona kuiswa muruoko rwako kana ruoko.
• Unogona kupihwa mushonga, unonzi kunyaradza, kuti ubatsire kuzorora.
• Iwe unozopihwa zvemuno kana zvakajairika kutindivadza kuti usazonzwa kurwadziwa panguva yekuita
  • Kune yeanesthesia yemuno, mupi wezvehutano anojowa iyo biopsy saiti nemushonga kuti ubaye nzvimbo.
  • Kune general anesthesia, nyanzvi inonzi anesthesiologist inokupa mushonga saka unenge usisazive panguva yekuita.
• Kana iyo nzvimbo yebhaopsy yave chiveve kana iwe usinga zive, chiremba anovhiya anozoita kucheka kudiki muzamu uye kubvisa chikamu kana bundu rese. Dzimwe nyama dzakakomberedza bundu dzinogona zvakare kubviswa.
• Iyo yakatemwa mukati meganda rako ichavharwa nezvisungo kana zvidimbu zvekunamira.

Mhando yebhiopsy yauinayo inoenderana nezvinhu zvakasiyana, kusanganisira saizi nenzvimbo yebundu. HER2 inogona zvakare kuyerwa mukuyerwa kweropa, asi kuongororwa kweropa kweHER2 hakuna kuratidzwa kuve kunobatsira kune vazhinji varwere. Saka hazviwanzo kukurudzirwa.

Mushure mekunge yako sampuro sampuro yatorwa, ichaedzwa mune imwe yenzira mbiri:

• HER2 mapuroteni mazinga anozoyerwa.
• Muenzaniso unotariswa kutsvaga mamwe makopi eiyo HER2 geni.

Ndichafanira here kuita chero chinhu kugadzirira bvunzo?

Iwe hauzodi chero gadziriro yakasarudzika kana iwe uri kuwana yemuno anesthesia (chiveve cheiyo biopsy saiti). Kana iwe uri kuwana general anesthesia, iwe ungangoda kutsanya (kwete kudya kana kunwa) kwemaawa akati wandei usati wavhiyiwa. Chiremba wako anovhiya anokupa yakanyanya kurongeka mirairo. Zvakare, kana iwe uri kuwana inonyaradza kana yakajairwa anesthesia, ita shuwa yekuronga kuti mumwe munhu akutyaire kumba. Iwe unogona kunge uchigunun'una uye uchivhiringidzika mushure mekunge wamuka kubva munzira.

Pane here njodzi kune bvunzo?

Iwe unogona kuve nekupwanya zvishoma kana kubuda ropa pane iyo biopsy saiti. Dzimwe nguva saiti inotapukirwa. Kana izvo zvikaitika, iwe unozorapwa nemishonga inorwisa mabhakitiriya. Bhiopsy yekuvhiya inogona kukonzera mamwe marwadzo uye kusagadzikana. Anokuchengetedza hutano anogona kukurudzira kana kupa mishonga kuti ikubatsire kunzwa zviri nani.

Pane njodzi shoma yekuongororwa ropa. Unogona kunge uine marwadzo mashoma kana kupwanya panzvimbo yakaiswa tsono, asi zviratidzo zvizhinji zvinokurumidza kupera.

Zvinorevei mhedzisiro yacho?

Kana HER2 mapuroteni akakwira kupfuura akajairwa kana mamwe makopi eiyo HER2 geni akawanikwa, zvinogona kureva kuti une kenza yeHER2-yakanaka. Kana zvabuda zvichiratidza zvakaenzana huwandu hweHER2 protein kana akajairwa manhamba HER2 majini, pamwe une HER2-isina cancer.

Kana mhedzisiro yako yanga isina kunyatsojeka kana isina kunaka, ungangozodzokororwa, kungave kushandisa imwe bundu sampuro kana kushandisa imwe nzira yekuyedza. Kazhinji kazhinji, IHC (kuyedza HER2 protein) kunoitwa kutanga, kwoteverwa neFISH (kuyedza mamwe makopi ejeni). IHC kuyedza hakuna kudhura uye inopa mhedzisiro nekukurumidza kupfuura FISH. Asi vazhinji mazamu mazamu vanofunga kuti FISH kuyedza kwakanyanya.

Mishonga yeHER2-yakanaka kenza yemazamu inogona kudzikisira mamota ane gomarara, iine mashoma mhedzisiro. Aya marapiro haashande muHER2-negative cancer.

Kana iwe uri kurapwa kune HER2-yakanaka kenza, zvakajairika mhedzisiro zvinogona kureva kuti uri kupindura kurapwa. Mhedzisiro inoratidza yakakwira kupfuura yakajairwa mari inogona kureva kuti kurapwa kwako hakusi kushanda, kana kuti gomarara rakadzoka mushure mekurapwa.

Dzidza zvakawanda nezve bvunzo dzemarabhoritari, mareferenzi masosi, uye mhinduro dzekunzwisisa

Pane chimwe chinhu here chandinofanira kuziva nezve HER2 kenza yemazamu kuyedzwa?

Kunyange ichinyanya kuwanikwa muvakadzi, gomarara repazamu, kusanganisira HER2-inovhenekera kenza yemazamu, inogona zvakare kukanganisa varume. Kana murume akawanikwa aine chirwere chekenza yemazamu, kuongororwa kweHER2 kunogona kukurudzirwa.

Uye zvakare, vese varume nevakadzi vangangoda HER2 kuyedzwa kana vakaonekwa vaine mamwe maronda emudumbu uye esophagus. Aya makenza dzimwe nguva ane akakwirisa eiyo HER2 protein uye anogona kupindura mushe kune HER2-inovheneka kenza kurapwa.

Zvinyorwa

1. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Chipfuva Biopsy [yakagadziridzwa 2017 Gumiguru; yakataurwa 2018 Aug 11]; [angangoita mana skrini. Inowanikwa kubva ku: https://www.cancer.org/cancer/breast-cancer/screening-tests-and-early-detection/breast-biopsy.html
2. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Kenza Yezamu HER2 Chimiro [yakagadziridzwa 2017 Sep 25; yakataurwa 2018 Aug 11]; [angangoita mana skrini. Inowanikwa kubva ku: https://www.cancer.org/cancer/breast-cancer/ Understanding-a-breast-cancer-diagnosis/breast-cancer-her2-status.html
3. Breastcancer.org [Internet]. Ardmore (PA): Breastcancer.org; c2018. HER2 Mamiriro [akagadziridzwa 2018 Feb 19; yakataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.breastcancer.org/symptoms/diagnosis/her2
4. Cancer.net [Internet]. Alexandria (VA): American Society yeKiriniki Oncology; c2005–2018. Kenza Yezamu: Kuongorora; 2017 Apr [yataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.cancer.net/cancer-types/breast-cancer/diagnosis
5. Cancer.net [Internet]. Alexandria (VA): American Society yeKiriniki Oncology; c2005–2018. Gomarara repazamu: Nhanganyaya; 2017 Apr [yataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva: https://www.cancer.net/cancer-types/breast-cancer/introduction
6. Johns Hopkins Mushonga [Internet]. Iyo Johns Hopkins University; Hutano Raibhurari: Gomarara repazamu: maGrade uye Matanho [akataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva: https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/breast_health/breast_cancer_grades_and_stages_34,8535-1
7. Lab Kuedza Pamhepo [Internet]. Washington D.C .; American Association yeKiriniki Chemistry; c2001–2018. HER2 [yakagadziridzwa 2018 Jul 27; yakataurwa 2018 Aug 11]; [angangoita maviri skrini. Inowanikwa kubva: https://labtestsonline.org/tests/her2
8. Mayo Clinic [Indaneti]. Mayo Foundation Yekurapa Dzidzo uye Tsvagiridzo; c1998–2018. Chipfuva Biopsy: Nezve 2018 Mar 22 [yakataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva: https://www.mayoclinic.org/tests-procedures/breast-biopsy/about/pac-20384812
9. Mayo Clinic [Indaneti]. Mayo Foundation Yekurapa Dzidzo uye Tsvagiridzo; c1998–2018. General Anesthesia: Nezve; 2017 Dec 29 [yakataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva: https://www.mayoclinic.org/tests-procedures/anesthesia/about/pac-20384568
10. Mayo Clinic [Indaneti]. Mayo Foundation Yekurapa Dzidzo uye Tsvagiridzo; c1998–2018. HER2-yakanaka kenza yemazamu: Chii icho ?; 2018 Mar 29 [yataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva: https://www.mayoclinic.org/breast-cancer/expert-answers/faq-20058066
11. Mayo Clinic: Mayo Medical Laboratories [Internet]. Mayo Foundation Yekurapa Dzidzo uye Tsvagiridzo; c1995–2018. Bvunzo ID: HERDN: HER2, Chipfuva, DCIS, Chiyero Immunohistochemistry, Chinyorwa Hapana Reflex: Kliniki uye Dudziro [yakataurwa 2018 Aug 11]; [angangoita mana skrini. Inowanikwa kubva: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/71498
12. MD Anderson Cancer Center [Indaneti]. Yunivhesiti yeTexas MD Anderson Cancer Center; c2018. Kenza Yezamu [yakataurwa 2018 Aug 11]; [angangoita mana skrini. Inowanikwa kubva: https://www.mdanderson.org/cancer-types/breast-cancer.html
13. Chirangaridzo Sloan Kettering Cancer Center [Internet]. New York: Chirangaridzo Sloan Kettering Cancer Center; c2018. Zvaunofanira Kuziva Nezve Metastatic Breast Cancer; 2016 Oct 27 [yataurwa 2018 Aug 11]; [angangoita mana skrini. Inowanikwa kubva: https://www.mskcc.org/blog/what-you-should-now-about-metastatic-breast
14. Merck Chinyorwa Chevatengi Vhezheni [Internet]. Kenilworth (NJ): Merck & Co, Inc .; c2018. Kenza Yezamu [yakataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva: https://www.merckmanuals.com/home/women-s-health-issues/breast-disorders/breast-cancer
15. National Chipfuva cheCancer Foundation [Internet]. Frisco (TX): National Chipfuva Cancer Foundation Inc.; c2016. Lab Miedzo [yakataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.nationalbreastcancer.org/breast-cancer-lab-tests
16. National Mwoyo, Mapapu, uye Ropa Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. Kuedzwa kweropa [kwakataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva: https://www.nhlbi.nih.gov/health-topics/blood-tests
17. National Cancer Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. NCI Duramazwi reMitemo yeCancer: geni [yakataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva ku: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
18. National Cancer Institute [Internet]. Bethesda (MD): Dhipatimendi reUtano reU.S. NCI Duramazwi reMitemo yeCancer: HER2 bvunzo [yakataurwa 2018 Aug 11]; [angangoita matatu skrini. Inowanikwa kubva: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=HER2
19. Yunivhesiti yeRochester Medical Center [Internet]. Rochester (NY): Yunivhesiti yeRochester Medical Center; c2018. Health Encyclopedia: HER2 / neu [yataurwa 2018 Aug 11]; [angangoita maviri skrini.Inowanikwa kubva: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=her2neu

Ruzivo ruri pane ino saiti harufanire kushandiswa sekutsiva kwehunyanzvi kurapwa kana kurairwa. Bata mupi wehutano kana iwe uine mibvunzo nezve hutano hwako.