Uchishandisa Imuran Kurapa Ulcerative Colitis (UC)

Zvemukati

• Imurani inoshanda sei
• Chipimo chemushonga
• Side migumisiro yeImuran
• Kuwedzera njodzi yemamwe marudzi ekenza
• Kuwedzera kwehutachiona
• Allergic reaction
• Pancreatitis
• Yambiro nekudyidzana
• Taura nachiremba wako

Kunzwisisa ulcerative colitis (UC)

Ulcerative colitis (UC) chirwere chemuviri. Izvo zvinoita kuti immune system yako irwise zvikamu zvemuviri wako. Kana iwe uine UC, immune system yako inokonzera kuzvimba uye maronda mumutsara wekoloni yako.

UC inogona kushanda zvakanyanya pane dzimwe nguva uye isingashande kune vamwe. Kana ichinyanya kushanda, une zvimwe zviratidzo. Iyi nguva dzinozivikanwa sekupenga-kumusoro.

Kubatsira kudzivirira kupisa-kumusoro, iwe unogona kuyedza kudzikisa huwandu hwefibhi mukudya kwako kana kudzivirira zvimwe zvekudya zvakanyanyisa. Zvisinei, vanhu vazhinji vane UC vanodawo rubatsiro rwemishonga.

Imuran mushonga wemumuromo unogona kukubatsira kubata zviratidzo zve UC kusvika pamwero wakakomba, kusanganisira mudumbu maronda uye kurwadziwa, manyoka, uye chigaro cheropa.

Imurani inoshanda sei

Zvinoenderana neazvino maratidziro emakiriniki, marapirwo akasarudzika ekuderedza kuregererwa muvanhu vane mwero kusvika kune wakakomba UC anosanganisira:

• corticosteroids
• anti-tumor necrosis factor (anti-TNF) kurapa neiyo biologic zvinodhaka adalimumab, golimumab, kana infliximab
• vedolizumab, imwe biologic drug
• tofacitinib, mushonga wemuromo

Vanachiremba vanowanzo gadza Imuran kune vanhu vakaedza mimwe mishonga, yakadai secorticosteroids uye aminosalicylates, izvo zvisina kubatsira kubvisa zviratidzo zvavo.

Imuran iri zita rezita reiyo generic drug azathioprine. Icho chiri chekirasi yemishonga inonzi immunosuppressants. Inoshanda nekuderedza immune system yako kupindura.

Izvi zvichaita:

• kuderedza kuzvimba
• chengetedza zviratidzo zvako
• dzikisa mukana wako wekubuda-kumusoro

Imuran inogona kushandiswa padivi pe infliximab (Remicade, Inflectra) kukurudzira kuregererwa kana pachayo kuchengetedza kuregererwa. Zvisinei, izvi ndezvekure-mazita ekushandisa kweImuran.

Off-label kushandisa zvinodhaka zvinoreva mushonga unobvumidzwa neDFA nechinangwa chimwe unoshandiswa nechinangwa chakasiyana icho chisati chagamuchirwa. Nekudaro, chiremba achiri kugona kushandisa mushonga wechinangwa icho. Izvi zvinodaro nekuti iyo FDA inodzora kuyedzwa uye kubvumidzwa kwemishonga, asi kwete mashandisiro anoita vanachiremba mishonga yekurapa varwere vavo. Nekudaro, chiremba wako anokwanisa kukunyorera mushonga asi ivo vanofunga zvakanakira iwe.

Zvinogona kutora kusvika kumwedzi mitanhatu kuti Imuran atange kubvisa zviratidzo zvako. Imuran inogona kudzora kukanganisa kubva kuzvimba kunogona kutungamira kushanya kuchipatara uye kudiwa kwekuvhiyiwa.

Izvo zvakare zvakaratidzwa kudzikisa kudiwa kwecorticosteroids iyo inowanzo shandiswa kurapa UC. Izvi zvinogona kubatsira, sezvo corticosteroids inogona kukonzeresa mhedzisiro kana ichishandiswa kwenguva yakareba.

Chipimo chemushonga

Kune vanhu vane UC, iyo yakajairwa muyero weazathioprine ndeye 1.5-2.5 milligrams pamakirogiramu ehuremu hwemuviri (mg / kg). Imuran inongowanikwa se 50-mg piritsi.

Side migumisiro yeImuran

Imuran inogona zvakare kukonzeresa zvakakomba mhedzisiro. Paunenge uchizvitora, ipfungwa yakanaka kuti uone chiremba wako kazhinji sezvavanotaura. Nenzira iyoyo, ivo vanokwanisa kukutarisa padhuze nemhedzisiro.

Iyo yakaipa mhedzisiro mhedzisiro yeImuran inogona kusanganisira kusvotwa uye kurutsa. Iyo yakanyanya kukanganisika mhedzisiro yemushonga iyi ndeiyi:

Kuwedzera njodzi yemamwe marudzi ekenza

Kushandisa Imuran kwenguva yakareba kunogona kuwedzera njodzi yako yekenza yeganda uye lymphoma. Lymphoma kenza inobata yako maseru emunodzivirira.

Kuwedzera kwehutachiona

Imuran inoderedza mashandiro e immune system yako. Izvi zvinoreva kuti immune system yako haigone kushanda zvakare kurwisa hutachiona. Nekuda kweizvozvo, anotevera marudzi ehutachiona ndiwo akajairika maitiro mhedzisiro:

• fungal
• bhakitiriya
• hutachiona
• protozoal

Kunyangwe zvavo zvakajairika, hutachiona hunogona kuve hwakakomba.

Allergic reaction

Zviratidzo zveanokanganisa maitiro zvinowanzoitika mukati memavhiki ekutanga ekurapwa. Zvinosanganisira:

• kusvotwa
• kurutsa
• manyoka
• mapundu
• kupindwa nechando
• kuneta
• tsandanyama aches
• dzungu

Kana iwe uine izvi zviratidzo, bata chiremba wako ipapo ipapo.

Pancreatitis

Pancreatitis, kana kuzvimba kwepancreas, isingawanzo mhedzisiro mhedzisiro yeImuran. Kana iwe uine zviratidzo zvakadai sekurwadziwa kwakanyanya kwemudumbu, kurutsa, kana zvigaro zvine mafuta, dana chiremba wako ipapo ipapo.

Yambiro nekudyidzana

Imuran inogona kusangana nemishonga inotevera:

• aminosalicylates, senge mesalamine (Canasa, Lialda, Pentasa), ayo anowanzo gadzirirwa vanhu vane UC munyoro kusvika pakati.
• ropa rakatetepa warfarin (Coumadin, Jantoven)
• angiotensin-inoshandura enzyme (ACE) inhibitors, iyo inoshandiswa kurapa yakakwira BP
• allpurinol (Zyloprim) uye febuxostat (Uloric), iyo inogona kushandiswa kune mamiriro akadai segout
• ribavirin, hepatitis C mishonga
• co-trimoxazole (Bactrim), mushonga unorwisa mabhakitiriya

Kana iwe parizvino uri kutora mumwe wemishonga iyi, chiremba wako anogona kunge iwe warega kushandisa kwayo usati watanga Imuran.

Ivo vanogona zvakare kukurudzira iyo Imuran dosi yako iwe idiki pane yakajairwa Imuran muyero. Chiyero chidiki chinobatsira kudzikisira kudyidzana kwemishonga.

Taura nachiremba wako

Chiremba wako anogona kuratidza Imuran kana zvinodhaka senge aminosalicylates uye corticosteroids zvisina kushanda kudzora zviratidzo zvako zveUC. Zvinogona kubatsira kudzikisira kupisa-kumusoro uye kukubatsira iwe kugadzirisa zviratidzo zvako.

Imuran inouya nenjodzi yemhedzisiro, kusanganisira kuwedzera njodzi yekenza uye hutachiona. Nekudaro, kutora Imuran kunogona zvakare kukubatsira iwe kudzivirira iyo yakakomba mhedzisiro iyo inosanganisirwa neyakareba-yakareba corticosteroid kushandiswa.

Taura nachiremba wako kuti uone kana Imuran iri sarudzo yakanaka kwauri.