Ndingaite Sei Kuti Ndibatsire Wangu Wandinoda Kuti Aite Zvakawandisa Kuziva Nezve Ivo Parkinson Kurapwa?

Zvemukati

• Dopamine mishonga
• Carbidopa-levodopa
• Dopamine agonists
• MAO B inhibitors
• COMT inhibitors
• Mimwe mishonga yaPasinson
• Anticholinergics
• Amantadine
• Kunamatira kuchirongwa chekurapa
• Chii chinoitika kana mishonga yaPasinson yamira kushanda
• Tora woenda nazvo

Vatsvakurudzi havasati vawana mushonga wechirwere chePasinson, asi kurapwa kwakauya nenzira refu mumakore apfuura. Nhasi, mishonga yakati wandei uye mimwe mishonga yekurapa inowanikwa kudzora zviratidzo sekudedera uye kuomarara.

Zvakakosha kuti mudiwa wako atore mishonga yavo chaizvo sekurairwa nachiremba. Iwe unogona zvakare kupa rutsigiro uye zvinyoro zviyeuchidzo.

Kuti ubatsire, unofanirwa kuziva kuti ndeipi mishonga inorapa chirwere chePasinson, uye mashandiro avo.

Dopamine mishonga

Vanhu vane Parkinson vane kushaya dopamine, inova kemikari yeuropi iyo inobatsira kuchengetedza kufamba kwakatsetseka. Ichi ndicho chikonzero vanhu vane chirwere vanofamba zvishoma nezvishoma uye vane mhasuru dzakaomarara. Mishonga mikuru inoshandiswa kurapa basa raParkinson nekuwedzera huwandu hwedopamine muuropi.

Carbidopa-levodopa

Mushonga unonzi levodopa, kana L-DOPA, ndiyo yave iri yekurapa kukuru kwechirwere cheParkinson kubvira mukupera kwema1960. Inoenderera ichive chinonyanya kushanda mushonga nekuti inotsiva isipo dopamine muuropi.

Vanhu vazhinji vane chirwere chePasinson vachatora levodopa imwe nguva panguva yekurapa kwavo. Levodopa inoshandurwa kuita dopamine muuropi.

Mishonga yakawanda inosanganisa levodopa ne carbidopa. Carbidopa inodzivirira levodopa kubva pakupunzika mumatumbu kana zvimwe zvikamu zvemuviri uye kuishandura kuita dopamine isati yasvika kuuropi. Kuwedzera carbidopa kunobatsirawo kudzivirira mhedzisiro svoto uye kurutsa.

Carbidopa-levodopa inouya nenzira dzakasiyana dzakasiyana:

• hwendefa (Parcopa, Sinemet)
• piritsi rinoburitsa zvishoma nezvishoma kuitira kuti mhedzisiro yaro igare kwenguva refu (Rytary, Sinemet CR)
• infusion iyo inounzwa muura kuburikidza nehubhu (Duopa)
• inhaled upfu (Inbrija)

Mhedzisiro kubva kumishonga iyi inosanganisira:

• kusvotwa
• dzungu
• dzungu kana wakamira (orthostatic hypotension)
• kushushikana
• tiki kana kumwe kushamisa kwemhasuru kufamba (dyskinesia)
• kuvhiringidzika
• kuona kana kunzwa zvinhu zvisiri zvechokwadi (kufungidzira)
• hope

Dopamine agonists

Iyi mishonga haishanduki kuita dopamine muuropi. Pane kudaro, vanoita sedopamine. Vamwe vanhu vanotora dopamine agonists pamwechete nelevodopa kudzivirira zviratidzo zvavo kudzoka panguva iyo levodopa inopera.

Dopamine agonists anosanganisira:

• pramipexole (Mirapex, Mirapex ER), piritsi uye yakawedzera-kuburitsa piritsi
• ropinirole (Chidimbu, Chinodiwa XL), piritsi uye yakawedzera-kuburitsa piritsi
• apomorphine (Apokyn), jekiseni rekuita-pfupi
• rotigotine (Neupro), chigamba

Iyi mishonga inokonzeresa imwe yemhedzisiro mhedzisiro se carbidopa-levodopa, kusanganisira kuda kurutsa, dzungu, uye kurara. Zvinogona zvakare kukonzera maitiro ekumanikidza, akadai sekubhejera uye kudya zvakanyanya.

MAO B inhibitors

Iri boka remishonga rinoshanda zvakasiyana pane levodopa kuwedzera dopamine mazinga muuropi. Ivo vanovhara enzyme iyo inoputsa pasi dopamine, iyo inowedzera mhedzisiro ye dopamine mumuviri.

MAO B inhibitors anosanganisira:

• selegiline (Zelapar)
• rasagiline (Azilect)
• safinamide (Xadago)

Iyi mishonga inogona kukonzera mhedzisiro senge:

• kunetseka kurara (kusarara)
• dzungu
• kusvotwa
• kuvimbiswa
• mudumbu kugumbuka
• kufamba kusingawanzo (dyskinesia)
• kuona zvisipo
• kuvhiringidzika
• musoro

MAO B inhibitors anogona kuwirirana nevamwe:

• chikafu
• mishonga inopfuura pakaunda
• mishonga yemishonga
• zvinowedzera

Ita shuwa kuti iwe unotaura nachiremba wako nezveese mishonga uye zvinowedzera izvo mudiwa wako anotora.

COMT inhibitors

Iyo mishonga entacopine (Comtan) uye tolcapone (Tasmar) zvakare inodzivirira enzyme iyo inoputsa dopamine muuropi. Stalevo isanganiswa yemishonga inosanganisira zvese carbidopa-levodopa uye COMT inhibitor.

COMT inhibitors inokonzera yakawanda yakafanana mhedzisiro se carbidopa-levodopa. Vanogona zvakare kukuvadza chiropa.

Mimwe mishonga yaPasinson

Kunyangwe zvinodhaka zvinowedzera dopamine mazinga ari izvo zvakakosha zvekurapa kwaPasinson, mimwe mishoma mishonga inobatsirawo kudzora zviratidzo.

Anticholinergics

Trihexyphenidyl (Artane) uye benztropine (Cogentin) inoderedza kudengenyeka kubva kuchirwere chePasinson. Migumisiro yavo inosanganisira:

• kuoma maziso nemuromo
• kuvimbiswa
• dambudziko kuburitsa weti
• matambudziko ekurangarira
• kuora mwoyo
• kuona zvisipo

Amantadine

Mushonga uyu unogona kubatsira vanhu vane chirwere chepakutanga chePasinson vane zviratidzo zvinyoro chete. Inogona zvakare kusanganiswa neye carbidopa-levodopa kurapwa mune anotevera matanho echirwere.

Zvimwe zvinokanganisa zvinosanganisira:

• kuzvimba gumbo
• dzungu
• mavara paganda
• kuvhiringidzika
• kuoma maziso nemuromo
• kuvimbiswa
• hope

Kunamatira kuchirongwa chekurapa

Kurapa kwekutanga kwechirwere chePasinson kunotevera maitiro akareruka. Mudiwa wako anotora carbidopa- levodopa kashoma pazuva pazuva rakatarwa.

Mushure memakore mashoma pakurapwa, maseru ehuropi anorasikirwa nekwaniso yavo yekuchengetedza dopamine uye vanova nehanya zvakanyanya nemushonga. Izvi zvinogona kukonzera kuti mushonga wekutanga wemishonga umire kushanda isati yasvika nguva yedosi inotevera, iyo inonzi "kupfeka."

Kana izvi zvikaitika, chiremba wemudiwa wako achashanda navo kugadzirisa mushonga wemushonga kana kuwedzera mumwe mushonga kudzivirira "kure" nguva. Zvinogona kutora nguva uye moyo murefu kuti utore mhando yemushonga nedosi zvakaringana.

Vanhu vane chirwere cheParkinson avo vanga vachitora levodopa kwemakore akati wandei vanogona zvakare kugadzira dyskinesia, iyo inokonzeresa kufamba kusingaite. Vanachiremba vanogona kugadzirisa mishonga yekudzikisa dyskinesia.

Nguva yakakosha kana zvasvika pakutora mishonga yaPasinson. Kudzora zviratidzo, mudiwa wako anofanira kutora mishonga yavo muhosi chaiyo uye panguva yakakodzera zuva rega rega. Iwe unogona kubatsira panguva yekuchinja kwemushonga nekuvayeuchidza kuti vatore mapiritsi avo pane iyo nyowani purogiramu, kana nekuvatengera iwo otomatiki mapiritsi ekupa kuti dosing ive nyore.

Chii chinoitika kana mishonga yaPasinson yamira kushanda

Nhasi, vanachiremba vane mishonga yakasiyana siyana yekudzora zviratidzo zvePasinson. Zvichida mudiwa wako anowana mumwe mushonga - kana mubatanidzwa wemishonga - inoshanda.

Dzimwe mhando dzekurapa dziripowo, kusanganisira zvakadzama zvehuropi zvinokurudzira (DBS). Mukurapa uku, waya inonzi lead inotungamirwa ichiiswa muchikamu chehuropi chinodzora kufamba. Iyo waya yakasungirirwa kune pacemaker-senge mudziyo unonzi impulse jenareta iyo inoiswa pasi pekoloni. Chishandiso chinotumira zvidhina zvemagetsi kusimudzira huropi uye kumisa zvisizvo zvehuropi zvinokonzeresa zviratidzo zveParkinson.

Tora woenda nazvo

Kurapa kwaPasinson kwakanaka kwazvo pakudzora zviratidzo. Mhando yemishonga uye madhizaizi aunodiwa nemunhu waunoda angangoda kuchinjiswa pamusoro pemakore. Unogona kubatsira nemaitiro aya nekudzidza nezvemishonga iripo, uye nekupa rutsigiro kubatsira mudiwa wako kunamatira pane kwake kurapwa maitiro.