Mavyret (glecaprevir / pibrentasvir)

Zvemukati

• Chii chinonzi Mavyret?
• Kubudirira
• FDA tendero
• Mavyret generic
• Mavyret mutengo
• Mari uye inishuwarenzi rubatsiro
• Mavyret mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Rutivi mhedzisiro mhedzisiro
• Zvikanganiso muvana
• Mavyret muyero
• Mafomu emishonga uye simba
• Chiyero chehepatitis C
• Chiremba wevana
• Ko kana ndikapotsa dosi?
• Ndichada here kushandisa mushonga uyu kwenguva refu?
• Mavyret nedoro
• Dzimwe nzira dzeMavyret
• Mavyret vs. Harvoni
• About
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Mavyret vs. Epclusa
• About
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Mavyret yehepatitis C
• Kubudirira
• Mavyret yevana
• Kubatana kwaMavyret
• Mavyret nemimwe mishonga
• Mavyret nemishonga uye zvinowedzera
• Mavyret nepamuviri
• Mavyret uye kuyamwisa
• Maitiro ekutora Mavyret
• Nguva yekutora
• Kutora Mavyret nechikafu
• Mavyret inogona kupwanywa, kupatsanurwa, kana kutsengwa here?
• Mashandiro anoita Mavyret
• Zvinotora nguva yakareba sei kuti zvishande?
• Mibvunzo yakajairika nezveMavyret
• Ndinogona kutora Mavyret kana ndine hutachiona hweHIV uye hepatitis C?
• Mavyret anobudirira sei pakurapa hepatitis C?
• Kana ndikatora mamwe marapirwo ehepatitis C, ndinogona kushandisa Mavyret?
• Ini ndichazoda chero bvunzo pamberi kana panguva yeMavyret kurapwa?
• Ndinogona here kushandisa Mavyret kana ndine cirrhosis?
• Kuchengetedza kweMavyret
• FDA yambiro: hepatitis B hutachiwana hutachiona
• Dzimwe yambiro
• Mavyret ovhadhozi
• Zvekuita kana ovhadhozi
• Mavyret kupera, kuchengetedza, uye kurasa
• Kuchengetedza
• Kubvisa
• Ruzivo rwehunyanzvi rweMavyret
• Zviratidzo
• Nzira yekuita
• Pharmacokinetics uye metabolism
• Contraindications
• Kuchengetedza

Chii chinonzi Mavyret?

Mavyret izita rezita remushonga mushonga unoshandiswa kurapa hutachiona hwehutachiona hweH hepatitis C (HCV). Utachiona uhu hunokanganisa chiropa chako uye hunokonzera kuzvimba.

Mavyret inogona kushandiswa nevanhu vane chero yemhando nhanhatu dzeHCV idzo dzisina cirrhosis (chironda chekushaiwa chiropa) kana vakadzora (zvinyoro) cirrhosis. Mavyret inogona zvakare kushandiswa kurapa HCV mhando 1 muvanhu vakamborapwa (asi vasina kurapwa) neimwe mhando yekurapa.

Mavyret inogamuchirwa kuti ishandiswe muvakuru. Inotenderwawo kuti ishandiswe muvana vane makore gumi nemaviri zvichikwira, kana ayo anorema anosvika makumi mashanu emakirogiramu (anenge mapaundi makumi mapfumbamwe nemapfumbamwe).

Mavyret inouya sehwendefa rimwe chete rine maviri antiviral mishonga: glecaprevir (100 mg) uye pibrentasvir (40 mg). Inotorwa nemuromo kamwe pazuva.

Kubudirira

Mumakiriniki ekuedzwa, vanhu vakuru vane HCV (mhando 1, 2, 3, 4, 5, uye 6) vasina kumbobvira varapwa hutachiona vakapihwa Mavyret. Pakati pevanhu ava, 98% kusvika 100% vakaporeswa mushure memasvondo masere kusvika gumi nemaviri ekurapwa. Muzvidzidzo izvi, kurapwa kwaireva kuti kuongororwa kweropa kwevanhu, kwakaitwa mwedzi mitatu mushure mekurapwa, hakuna kuratidza zviratidzo zvehutachiona hweHCV mumuviri wavo.

Kuti uwane rumwe ruzivo nezve kugona, ona chikamu che "Kubudirira" pasi pe "Mavyret ye hepatitis C" pazasi.

FDA tendero

Mavyret yakagamuchirwa neKudya neDrug Administration (FDA) muna Kubvumbi 2017 kurapa chirwere chisingaperi chehepatitis C (mhando 1, 2, 3, 4, 5, uye 6) muvakuru.

MunaEpril 2019, iyo FDA yakawedzera mvumo yemushonga kusanganisira kushandiswa kwayo muvana. Inotenderwa kushandiswa muvana vane makore gumi nemaviri zvichikwira, kana ayo anorema angangoita 45 kg (anenge 99 lbs.).

Mavyret generic

Mavyret inowanikwa chete sezita-zita remishonga. Haisi ikozvino inowanikwa mune generic fomu.

Mavyret ine maviri anoshanda zvinodhaka zvinoshandiswa: glecaprevir uye pibrentasvir.

Mavyret mutengo

Sezvo nemishonga yese, mutengo weMavyret unogona kusiyana. Kuti uwane mitengo yazvino yeMavyret munharaunda yako, tarisa GoodRx.com.

Mari yaunowana paGoodRx.com ndiyo yaunogona kubhadhara pasina inishuwarenzi. Mutengo chaiwo wauchabhadhara unoenderana nehurongwa hweinishuwarenzi, nzvimbo yauri, uye khemisi yaunoshandisa.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari kubhadhara Mavyret, kana kana iwe uchida rubatsiro kuti unzwisise inishuwarenzi yako yekuvhara, rubatsiro rwuripo.

Abbvie, mugadziri weMavyret, anopa chirongwa chinonzi Mavyret Patient Support, icho chinogona kupa rubatsiro kudzikisa mutengo wako wechirwere. Kuti uwane rumwe ruzivo uye uzive kana iwe uchikodzera rutsigiro, fona 877-628-9738 kana shanyira iyo webhusaiti chirongwa.

Mavyret mhedzisiro

Mavyret inogona kukonzera munyoro kana zvakakomba mhedzisiro. Aya anotevera mazita ane zvimwe zvakakosha mhedzisiro mhedzisiro inogona kuitika uchitora Mavyret. Aya mazita haabatanidzi ese anogona kuitika mhedzisiro.

Kuti uwane rumwe ruzivo nezve zvingangoitika mhedzisiro yeMavyret, taura nachiremba wako kana wemishonga. Ivo vanogona kukupa iwe matipi ekuti ungatarise sei nechero mhedzisiro mhedzisiro inogona kunetsa.

Zvimwe zvakajairika mhedzisiro

Iyo inowanzoitika mhedzisiro mhedzisiro yeMavyret inogona kusanganisira:

• musoro
• kunzwa kuneta
• kusvotwa
• manyoka
• yakakwidziridzwa bilirubin mwero (bvunzo bvunzo inoongorora yako chiropa mashandiro)

Mazhinji emhedzisiro iyi anogona kuenda mukati memazuva mashoma kana vhiki dzinoverengeka. Kana vakanyanya kuoma kana kuti vasingaendi, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Matambudziko akakomba kubva kuMavyret haana kujairika, asi anogona kuitika. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Yakanyanya mhedzisiro, iyo inokurukurwa pazasi mu "Side mhedzisiro ruzivo," inosanganisira zvinotevera:

• hepatitis B hutachiona hwehutachiona (hutachiona hwehutachiona, kana hwatova mukati memuviri wako) *
• zvakanyanya kukanganiswa nemagetsi

Rutivi mhedzisiro mhedzisiro

Unogona kushamisika kuti kangani mamwe maratidziro anoitika nemushonga uyu, kana kuti zvimwe mhedzisiro ine chekuita nazvo. Heano mamwe emamwe madambudziko emushonga uyu unogona kana kusakonzera.

Allergic reaction

Sezvo nemishonga yakawanda, vamwe vanhu vanogona kuita zvinopesana nehutachiona mushure mokutora Mavyret. Hazvizivikanwe zvechokwadi kuti kangani vanhu vanotora mushonga uyu vane allergiki maitiro. Zviratidzo zvehunhu husina kugadzikana hunogona kusanganisira:

• kuputika kweganda
• kuvava
• kuburitsa (kudziya uye kutsvuka mukati meganda rako)

Imwe yakanyanya kukonzeresa kusagadzikana isingawanzo asi inogoneka. Zviratidzo zveakanyanya kusagadzikana maitiro zvinogona kusanganisira:

• kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka
• kuzvimba kwerurimi rwako, muromo, kana huro
• kunetseka kufema kana kutaura

Danaidza chiremba wako ipapo kana iwe uine chirwere chakakomba cheMergret. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Itching

Unogona kusangana nekurumwa paunenge uchishandisa Mavyret.Mumakiriniki miedzo, vamwe vanhu vaibata vachinwa mushonga uyu. Kuvava kazhinji kwakaitika chete muvanhu vanotora mushonga uyo aive nezvirwere zvetsvo zvisingaperi uye hepatitis C hutachiona (HCV). Muboka iri, vangangoita 17% yevanhu vakashuma kuchenesa semhedzisiro.

Itching zvakare dzimwe nguva chiratidzo chinokonzerwa neHCV. Itching inowanikwa mune makumi maviri kubva muzana yevanhu vane HCV. Ichi chiratidzo chingangoita nekuda kwekuvakwa kwemakemikari anonzi bilirubin mumuviri wako. Itching inokonzerwa neHCV inogona kunge iri munzvimbo imwechete kana inogona kunge iri pamusoro pemuviri wako.

Kana iwe uchinetseka nezvekuve neganda rinochenesa paunenge uchitora Mavyret, taura nachiremba wako. Ivo vanogona kukurudzira nzira dzekubatsira kudzora iyi divi mhedzisiro iwe paunenge uchishandisa mushonga.

Hepatitis B kugadzirisazve

Iwe unogona kuve nenjodzi yakawedzera yehutachiona hwehepatitis B (HBV) kugadzirisazve (kupisa) paunenge uchitora Mavyret.

Mavyret kurapwa kunowedzera njodzi yeHBV kugadzirisazve mune vanhu vane HBV neHCV. Muzviitiko zvakakomba, kumutsidzira kweHBV kunogona kukonzera kukundikana kwechiropa kana kutofa.

Zviratidzo zveHBV kugadzirisazve zvinogona kusanganisira:

• kurwadziwa kurudyi kwedumbu rako
• Chiedza chine ruvara
• kunzwa kuneta
• kuita yero kweganda rako kana kuchena kwemeso ako

Usati watanga Mavyret, chiremba wako anokuyedza HBV. Kana uine HBV, ungangoda kurapwa nezvayo usati watanga kutora Mavyret. Kana chiremba wako anogona kukurudzira kuongororwa panguva yako yeMavyret kurapwa kuti uone HBV kugadzirisa zvakare uye kurapa mamiriro acho kana zvichidikanwa.

Kurema kwehuremu (kwete mhedzisiro)

Kurera huremu uye kuwedzera huremu hazvina kutaurwa semhedzisiro yeMavyret panguva yekiriniki yekuedzwa. Zvisinei, Mavyret inogona kukonzera kushungurudza, izvo zvinogona kutungamirira kukurema kwevamwe vanhu. Kana iwe uchinzwa kusvotwa paunenge uchitora ichi chinwiwa, iwe ungangove uchidya chikafu chidiki, izvo zvinogona kukonzeresa kuonda.

Kana iwe uine zvinetsekana nezve huremu hwekuwedzera kana uremu paunenge uchitora Mavyret, taura nachiremba wako. Vanogona kukubatsira kuronga chikafu chine hutano panguva yekurapa kwako.

Mapundu eganda (kwete mhedzisiro)

Kuputika kweganda hakuna kutaurwa senge divi mhedzisiro yeMavyret panguva yekiriniki miedzo. Zvisinei, HCV pachayo dzimwe nguva inogona kukonzera kuputika kweganda. Izvi zvinogona kukanganisa nemhedzisiro mhedzisiro yemushonga. Iko kuputika kunokonzerwa neHCV kunogona kuve chero kupi pamuviri wako, kusanganisira kumeso kwako, chipfuva, kana maoko. Izvo zvakare zvinogona kukuita kuti unzwe kuda.

Kana iwe uine kuputika kweganda uchishandisa Mavyret, taura nachiremba wako. Vanogona kuratidza nzira dzekudzora zviratidzo zvako uye kukurudzira kurapwa kana zvichidikanwa.

Zvikanganiso muvana

Munguva yezvidzidzo zvemakiriniki, mhedzisiro inoonekwa muvana (makore gumi nemaviri kusvika gumi nemanomwe) kutora Mavyret kwakafanana nemhedzisiro inoonekwa muvakuru vachinwa mushonga. Muzvidzidzo izvi, hapana vana vakamira kurapwa nekuda kwemhedzisiro.

Zvakajairika mhedzisiro mhedzisiro inoonekwa muvana inosanganisira:

• kunzwa kuneta
• kusvotwa
• musoro
• yakakwidziridzwa bilirubin mwero (bvunzo bvunzo inoongorora yako chiropa mashandiro)

Kana iwe uine hanya nezve mhedzisiro inoitika mumwana uchishandisa Mavyret, taura nachiremba wako. Ivo vanogona kuve vanokwanisa kukurudzira nzira dzekudzora iyi mhedzisiro panguva yekurapa.

Mavyret muyero

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Zvisinei, iva nechokwadi chekutora muyero uyo chiremba wako anokuraira iwe. Chiremba wako achasarudza yakanakisa dosi kuti ienderane nezvaunoda.

Mafomu emishonga uye simba

Mavyret inouya sehwendefa inotorwa nemuromo. Hwendefa rega rega rine 100 mg ye glecaprevir uye 40 mg yepibrentasvir.

Chiyero chehepatitis C

Muyero weMavyret weusingaperi hepatitis C hutachiona (HCV) mapiritsi matatu anotorwa nemuromo kamwe chete pazuva. Mushonga uyu unofanirwa kutorwa nechikafu. Inofanirawo kutorwa panenge panguva imwe chete zuva rega rega.

Chiremba wako anoona kuti inguvai yaunoda kutora Mavyret. Iyi sarudzo inoenderana nechero marapirwo ekare eHCV awakashandisa.

Kureba kwemunhu wega wega kunogona kusiyana, asi vanhu vazhinji vanotora Mavyret chero kupi kubva pamasvondo masere kusvika kumavhiki gumi nematanhatu. Iyo yakajairwa kureba kweMavyret kurapwa ndeinotevera:

• Kana usati wamborapwa HCV, uye iwe usina cirrhosis (chironda chekushaiwa chiropa), ungangodaro unorapwa kwemavhiki masere.
• Kana usati wamborapwa HCV, uye iwe wakabhadhara (zvinyoro) cirrhosis, iwe ungangodaro unorapwa kwemasvondo gumi nemaviri.
• Kana iwe wakamborapwa HCV, uye kurapwa kwako kwanga kusingaite (hakuna kuporesa hutachiona hwako), kureba kwako kwekurapa neMavyret kunogona kusiyana. Inogona kugara chero kubva pamasvondo masere kusvika kumavhiki gumi nematanhatu. Iyo chaiyo kureba kwekurapa kwako kunoenderana nekuti ndeapi maHCV marapirwo awakamboshandisa munguva yakapfuura.

Kana iwe uine chero mibvunzo nezvekuti inguvai yauchazoda kutora Mavyret, taura nachiremba wako. Vanogona kukurudzira chirongwa chakanakisa chekurapa iwe.

Chiremba wevana

Dhivhosi yevana yeMavyret yakafanana nezviri zvevakuru: Mahwendefa matatu akatorwa nemuromo (nechikafu) kamwe chete pazuva. Pediatric dosing inoshanda kune vana:

• makore gumi nemaviri kusvika kumakore gumi nemanomwe, kana
• avo vanorema angangoita 45 kg (anenge 99 mapaundi)

Mavyret haisati yatenderwa kuti ishandiswe muvana vadiki vane makore gumi nemaviri ekuberekwa kana mune avo vanorema mashoma 45 kg.

Ko kana ndikapotsa dosi?

Kana iwe ukarasikirwa neiyo dose yeMavyret, hezvino zvaunofanira kuita:

• Kana zvisingasviki maawa gumi nemasere kubva pawaifanira kutora Mavyret, enda kumberi utore dosi rako nekukurumidza sekurangarira kwako. Ipapo, tora yako inotevera dosi panguva yakajairwa nguva.
• Kana iri anopfuura maawa gumi nemasere kubva paunofanirwa kutora Mavyret, ingo dambura iro dosi. Iwe unogona kutora yako inotevera dosi panguva yakajairwa nguva.

Kuti ubatsire kuve nechokwadi chekuti hauna kupotsa dosi, edza kuseta chiyeuchidzo pafoni yako. Iyo yekurapa timer inogona kubatsira, zvakare.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Iyo yakareba yenguva yauchazoda kutora Mavyret zvinoenderana nezvinhu zvishoma. Izvi zvinosanganisira kana iwe wakamborapwa HCV kare, uye kana uine chero chiropa chekushaiwa (cirrhosis).

Kazhinji, kurapwa neMavyret kunotora chero kupi kubva pamasvondo masere kusvika gumi nematanhatu. Kazhinji haigare kwenguva yakareba kupfuura mavhiki gumi nematanhatu.

Mavyret nedoro

Mavyret haina hukama hunozivikanwa nedoro. Zvisinei, haufanire kunwa doro kana uine hutachiona hwehepatitis C (HCV). Doro rinoita kuti HCV iwedzere, izvo zvinogona kukonzeresa kukuvadza kwakanyanya (cirrhosis) muropa rako.

Kana iwe uchinwa doro, uye iwe uine hanya nezve nzira yekurega kunwa, taura nachiremba wako.

Dzimwe nzira dzeMavyret

Mimwe mishonga iripo inokwanisa kurapa hutachiona husingaperi hwehepatitis C (HCV). Zvimwe zvinogona kunge zvakakukodzera iwe kupfuura vamwe. Kana iwe uchifarira kutsvaga imwe nzira yeMavyret, taura nachiremba wako. Vanogona kukuudza nezvemimwe mishonga inogona kukushandira zvakanaka.

Mimwe mishonga yekurapa, iyo ine musanganiswa wemishonga inorwisa hutachiona yekurapa HCV, inosanganisira zvinotevera:

• ledipasvir uye sofosbuvir (Harvoni)
• sofosbuvir uye velpatasvir (Epclusa)
• velpatasvir, sofosbuvir, uye voxilaprevir (Vosevi)
• elbasvir uye grazoprevir (Zepatier)
• simeprevir (Olysio) uye sofosbuvir (Sovaldi)

Kunyangwe vasingauyi semubatanidzwa mushonga, Simeprevir (Olysio) uye sofosbuvir (Sovaldi) inogona zvakare kutorwa pamwechete kurapa HCV.

Mavyret vs. Harvoni

Unogona kushamisika kuti Mavyret anofananidzwa sei nemimwe mishonga inorayirwa kuti ishandiswe zvakafanana. Pano tinotarisa kuti Mavyret naHarvoni vakafanana uye vakasiyana sei.

About

Mavyret ine mishonga glecaprevir uye pibrentasvir. Harvoni ine mishonga ledipasvir uye sofosbuvir. Ose Mavyret neHarvoni ane musanganiswa wemishonga inorwisa mishonga, uye ndevekirasi imwechete yemishonga.

Zvishandiso

Mavyret inogamuchirwa kurapa hutachiona husingaperi hwehepatitis C (HCV) muvanhu vakuru. Inotenderwawo kuti ishandiswe muvana vane makore gumi nemaviri kana kupfuura, kana avo vanorema anosvika makumi mana nemashanu makirogiramu, ayo anenge makumi mapfumbamwe nemapfumbamwe.

Mavyret inoshandiswa kurapa marudzi ese (1, 2, 3, 4, 5, uye 6) eHCV muvanhu:

• pasina kuora kwechiropa (cirrhosis), kana kune avo vane cirrhosis vasina chero zviratidzo zvemamiriro acho.
• avo vakagamuchira chiropa kana itsvo kuisirwa
• vane HIV

Mavyret inogona zvakare kushandiswa kurapa HCV mhando 1 muvanhu vakamborapwa (asi vasina kurapwa) neimwe mhando yekurapa.

Harvoni inobvumidzwa kurapa HCV muvakuru. Inogona kushandiswa kurapa anotevera marudzi eHCV:

• mhando 1, 2, 5, kana 6 muvanhu vasina kuora kwechiropa (cirrhosis), kana kune avo vane cirrhosis vasina zviratidzo zvemamiriro acho.
• Nyora 1 muvanhu vane cirrhosis ine zviratidzo zveiyo mamiriro (mune vanhu ava, Harvoni inofanira kusanganiswa ne ribavirin)
• Nyora 1 kana 4 muvanhu vakagashira chiropa, uye kana vasina chiropa, kana vane chironda chekushaya chiropa pasina zviratidzo (mune vanhu ava, Harvoni inofanirawo kusanganiswa ne ribavirin)

Harvoni inobvumidzwawo kuti ishandiswe muvana vane makore gumi nemaviri zvichikwira, kana avo vanorema anosvika makumi matatu nemashanu makirogiramu, ayo angangoita makumi manomwe nenomwe. Inogona kushandiswa muvana vanotevera:

• avo vane HCV mhando 1, 4, 5, kana 6
• vana vasina kupera kwechiropa (cirrhosis), kana avo vane cirrhosis asi vasina zviratidzo zvemamiriro acho

Mafomu emishonga uye manejimendi

Mavyret inouya semapiritsi, ayo anotorwa nemuromo (nechikafu) kamwe chete pazuva. Inowanzo kupihwa kwenguva yemasvondo masere, gumi nemaviri, kana gumi nematanhatu zvichienderana neyako yekurapa nhoroondo uye kuti chirwere chechiropa chako chakakomba sei.

Harvoni inouyawo semapiritsi, ayo anotorwa nemuromo (pamwe kana pasina chikafu) kamwe chete pazuva. Inowanzo kupihwa kwenguva ingangoita masvondo masere, gumi nemaviri, kana makumi maviri nemana zvichienderana nehutano hwako uye mamiriro echiropa chako.

Side migumisiro uye njodzi

Mavyret naHarvoni havana mishonga imwechete, asi ivo vari chikamu chekirasi imwechete yemishonga. Iyi mishonga inogona kukonzera mamwe akafanana mhedzisiro uye mamwe akasiyana mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemamwe anowanzoitika mhedzisiro anogona kuitika naMavyret, naHarvoni, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika naMavyret:
  • manyoka
  • yakakwidziridzwa bilirubin mwero (bvunzo bvunzo inoongorora yako chiropa mashandiro)
• Zvinogona kuitika naHarvoni:
  • kunzwa kupera simba
  • kushaya hope (kunetseka kurara)
  • kukosora
  • kunzwa kushatirwa
• Zvinogona kuitika pamwe naMavyret naHarvoni:
  • musoro
  • kunzwa kuneta
  • kusvotwa

Yakakomba mhedzisiro

Zvakakomba mhedzisiro mhedzisiro inogona kuitika pamwe neMavyret neHarvoni (kana ikatorwa yega) inosanganisira zvinotevera:

• hepatitis B hutachiona hwehutachiona (hutachiona hwehutachiona, kana hwatova mukati memuviri wako) *
• zvakanyanya kukanganiswa nemagetsi

Kubudirira

Vaviri Mavyret naHarvoni vanobvumidzwa kurapa hutachiona husingaperi hwehepatitis C (HCV). Zvisinei, imwe mishonga inogona kuva yakakunakira iwe kupfuura imwe, zvichienderana nerudzi rweHCV iwe uye kana iwe une chirwere chechiropa (cirrhosis).

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki. Asi zvidzidzo zvakasiyana zvakawana kuti Mavyret naHarvoni vanoshanda pakurapa HCV.

Mariro

Mavyret naHarvoni vese vari vaviri vane zita-zita zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira paGoodRx.com, Mavyret naHarvoni vanowanzobhadhara zvakafanana. Mutengo chaiwo wauchabhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa, kwaunogara, uye pharmacy yaunoshandisa.

Mavyret vs. Epclusa

Unogona kushamisika kuti Mavyret anofananidzwa sei nemimwe mishonga inorayirwa kuti ishandiswe zvakafanana. Pano tinotarisa kuti Mavyret naEpclusa vakafanana uye vakasiyana sei.

About

Mavyret ine mishonga glecaprevir uye pibrentasvir. Epclusa ine mishonga velpatasvir uye sofosbuvir. Ose Mavyret naEpclusa vane musanganiswa wemishonga inorwisa hutachiona, uye ndevekirasi imwechete yemishonga.

Zvishandiso

Mavyret inogamuchirwa kurapa hutachiona husingaperi hwehepatitis C (HCV) muvanhu vakuru. Inotenderwawo kuti ishandiswe muvana vane makore gumi nemaviri kana kupfuura, kana avo vanorema anosvika makumi mana nemashanu makirogiramu, ayo anenge makumi mapfumbamwe nemapfumbamwe.

Mavyret inoshandiswa kurapa marudzi ese (1, 2, 3, 4, 5, uye 6) eHCV muvanhu:

• pasina kuora kwechiropa (cirrhosis), kana kune avo vane cirrhosis vasina chero zviratidzo zvemamiriro acho.
• avo vakagamuchira chiropa kana itsvo kuisazve
• vane HIV

Mavyret inogona zvakare kushandiswa kurapa HCV mhando 1 muvanhu vakamborapwa (asi vasina kurapwa) neimwe mhando yekurapa.

Zvakawanda saMavyret, Epclusa inobvumidzwawo kurapa HCV isingaperi inokonzerwa nemhando dzese dzehutachiona (mhando 1, 2, 3, 4, 5, uye 6). Inoshandiswa kune vanhu vakuru vasina chirwere chekushaya chiropa (cirrhosis), kana kune avo vane chironda chekushaya chiropa vasina zviratidzo zvemamiriro acho.

Epclusa inogona zvakare kushandiswa kune vanhu vakuru vane cirrhosis vane zviratidzo zvemamiriro acho.

Epclusa haina kubvumidzwa kuti ishandiswe muvana.

Mafomu emishonga uye manejimendi

Mavyret inouya semapiritsi, ayo anotorwa nemuromo (nechikafu) kamwe chete pazuva. Inowanzo kupihwa kwenguva yemasvondo masere, gumi nemaviri, kana gumi nematanhatu zvichienderana neyako yekurapa nhoroondo uye kuti chirwere chechiropa chako chakakomba sei.

Epclusa inouyawo semapiritsi, ayo anotorwa nemuromo kamwe chete pazuva. Epclusa inogona kutorwa pamwe kana pasina chikafu. Inowanzo kupihwa kwenguva yemasvondo gumi nemaviri.

Side migumisiro uye njodzi

Mavyret naEpclusa havana mishonga yakafanana mavari. Nekudaro, ivo ndevekirasi imwechete yemishonga. Naizvozvo, ese ari maviri mishonga anogona kukonzera akafanana mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yezvakawanda zvinowanzoitika mhedzisiro inogona kuitika naMavyret, neEpclusa, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika naMavyret:
  • manyoka
  • yakakwidziridzwa bilirubin mwero (bvunzo bvunzo inoongorora yako chiropa mashandiro)
• Zvinogona kuitika neEpclusa:
  • kunzwa kupera simba
  • kushaya hope (kunetseka kurara)
• Zvinogona kuitika pamwe naMavyret naEpclusa:
  • musoro
  • kunzwa kuneta
  • kusvotwa

Yakakomba mhedzisiro

Yakakomba mhedzisiro mhedzisiro inogona kuitika pamwe neMavyret naEpclusa (kana ikatorwa yega) inosanganisira zvinotevera:

• hepatitis B hutachiona hwehutachiona (hutachiona hwehutachiona, kana hwatova mukati memuviri wako) *
• zvakanyanya kukanganiswa nemagetsi

Kubudirira

Mavyret naEpclusa vese vanoshandiswa kurapa ese matanhatu marudzi easingaperi HCV. Chiremba wako anogona kukurudzira kuti utore Epclusa kana Mavyret zvichienderana nerudzi rweHCV iwe uye nemamiriro echiropa chako.

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki. Asi zvidzidzo zvakasiyana zvakaona kuti vese Mavyret naEpclusa vanoshanda pakurapa HCV.

Mariro

Mavyret naEpclusa vese vane zita rezita zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira paGoodRx.com, Mavyret naEpclusa vanowanzo dhura zvakafanana. Mutengo chaiwo wauchabhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa, kwaunogara, uye pharmacy yaunoshandisa.

Mavyret yehepatitis C

Chikafu neDrug Administration (FDA) inobvumidza mishonga yemishonga yakadai saMavyret kurapa mamwe mamiriro.

Mavyret FDA-inogamuchirwa kurapa hutachiona husingaperi hunokonzerwa nehutachiona hwehepatitis C (HCV). Utachiona uhu hunokanganisa chiropa chako uye hunokonzera kuzvimba, izvo dzimwe nguva zvinogona kutungamira kukuvadzwa kwechiropa (chinonzi cirrhosis). HCV inogona kukonzera zviratidzo zvakadai se:

• yero yeganda rako uye nekuchena kwemeso ako
• mvura inovaka mudumbu rako
• kupindwa nechando
• matambudziko enguva refu, akadai sekutadza kwechiropa

HCV inopararira kuburikidza neropa rinotapukirwa nehutachiona. Kufambisa (kupararira) kunoitika kazhinji kuburikidza nevanhu vanogovana tsono dzakashandiswa. Sekureva kweCenters for Disease Control and Prevention (CDC), muna2016 vanhu vangangoita mamirioni 2,4 muUnited States vaive nechirwere chehepatitis C.

Mavyret inogamuchirwa kurapa HCV muvakuru. Inotenderwawo kuti ishandiswe muvana vane makore gumi nemaviri kana kupfuura, kana avo vanorema anosvika makumi mana nemashanu makirogiramu, ayo anenge makumi mapfumbamwe nemapfumbamwe. Inoshandiswa kurapa ese HCV mhando (1, 2, 3, 4, 5, uye 6) muvanhu:

• pasina kuora kwechiropa (cirrhosis), kana kune avo vane cirrhosis vasina zviratidzo zvemamiriro acho (anonzi akabhadharwa cirrhosis)
• avo vakagamuchira chiropa kana itsvo kuisirwa
• vane HIV

Mavyret inogona zvakare kushandiswa kurapa HCV mhando 1 muvanhu vakamborapwa (asi vasina kurapwa) neimwe mhando yekurapa.

Kubudirira

Mumakiriniki ekuedzwa, vanhu vakuru vane HCV (mhando 1, 2, 3, 4, 5, uye 6) vasina kumbobvira varapwa hutachiona vakapihwa Mavyret. Pakati pevanhu ava, 98% kusvika 100% vakaporeswa mukati memasvondo masere kusvika gumi nemaviri ekurapwa. Muzvidzidzo izvi, kurapwa kwaireva kuti kuongororwa kweropa kwevanhu, kwakaitwa mwedzi mitatu mushure mekurapwa, hakuna kuratidza zviratidzo zvehutachiona hweHCV mumuviri wavo.

Pakati pevanhu vese vari muzvidzidzo (vese avo vakamborapwa HCV uye avo vanga vasina), pakati pe92% ne100% vakaporeswa HCV. Mhedzisiro yacho yaisiyana zvichienderana nekuti vanhu vakamborapwa kare uye nerudzi rweHCV yavaive nayo

Kliniki miedzo zvakare yakafananidza Mavyret nemubatanidzwa wemamwe maviri antiviral zvinodhaka zvinonzi sofosbuvir (Sovaldi) uye daclatasvir (Daklinza). Imwe ongororo yakatarisa vanhu vane HCV mhando 3, vasina kumbobvira varapwa kare. Vanhu ava vanga vasina chiropa chinotyisa (cirrhosis).

Mushure memasvondo gumi nemaviri, 95,3% yevanhu vaitora Mavyret vaifungidzirwa kuti vaporeswa (vanga vasina hutachiona hweHCV mukuongororwa kweropa). Kune avo vanotora sofosbuvir uye daclatasvir, 96.5% yakave nemhedzisiro yakafanana.

Mavyret yevana

Mavyret inogamuchirwa kurapa HCV muvana vane makore gumi nemaviri zvichikwira, kana kune avo vanorema makumi mana nemashanu makirogiramu, anenge 99 lbs.

Kubatana kwaMavyret

Mavyret inogona kusangana nemimwe mishonga yakati wandei. Iyo inogona zvakare kuyanana pamwe nezvimwe zvinowedzera.

Kukurukurirana kwakasiyana kunogona kukonzera mhedzisiro. Semuenzaniso, kumwe kudyidzana kunogona kukanganisa mashandiro anoita mushonga. Kumwe kudyidzana kunogona kuwedzera mhedzisiro kana kuita kuti ive yakaoma.

Mavyret nemimwe mishonga

Pazasi pane zvinyorwa zvemishonga inogona kusangana naMavyret. Aya mazita haana mishonga yose inogona kuwirirana naMavyret.

Usati watora Mavyret, taura nachiremba wako uye wemishonga. Vaudze nezvese zvinyorwe, pamusoro-pe-counter, uye mimwe mishonga yaunotora. Vaudzewo nezve chero mavitamini, mahebhu, uye zvinowedzera zvaunoshandisa. Kugovera ruzivo urwu kunogona kubatsira iwe kudzivirira kusangana kunogona kuitika.

Kana iwe uine mibvunzo nezve kudyidzana kwezvinodhaka zvinogona kukukanganisa, bvunza chiremba wako kana wemishonga.

Mavyret uye carbamazepine (Tegretol)

Kutora carbamazepine neMavyret kunogona kudzikisa huwandu hweMavyret mumuviri wako. Izvi zvinogona kukonzera kuti mushonga usashande zvakare, izvo zvinogona kutungamira kune yako hepatitis C hutachiona (HCV) isiri kurapwa zvizere. Zvakakosha kudzivisa kutora carbamazepine uye Mavyret pamwechete.

Mavyret uye warfarin (Coumadin)

Kutora warfarin neMavyret kunogona kuchinja mwero wewarfarin mumuviri wako. Izvi zvinogona kukonzeresa shanduko mukukora kweropa rako, zvichikonzera kuti riite rakatetepa kana rakanyanya. Kana izvi zvikaitika, unogona kunge uri panjodzi yezvimwe zvinetso, sekubuda ropa kana kuve neropa rakagwamba.

Kana iwe uri kutora Mavyret newarfarin, zvakakosha kuti uwane kumwe kuongororwa kweropa kunoitwa kazhinji kuti uone kukora kweropa rako. Kana iwe uchida kutora iyi mishonga pamwe chete, chiremba wako anokurudzira nzira dzekubatsira kuona kuchengetedzeka kwako panguva yekurapwa.

Mavyret uye digoxin (Lanoxin)

Kutora Mavyret ne digoxin kunogona kuwedzera mwero wedigoxin mumuviri wako. Izvi zvinogona kukonzera zviratidzo zvakadai se:

• kusvotwa
• kurutsa
• manyoka
• irregular moyo mutinhimira

Kana iwe uri kutora digoxin paunenge uchishandisa Mavyret, chiremba wako angangoda kudzikisa dosi yako ye digoxin. Izvi zvinobatsira kudzivirira ako digoxin mazinga kubva mukukwira zvakanyanya uye zvichikonzera mhedzisiro. Chiremba wako anogona kutarisa ako digoxin mazinga pakuongororwa kweropa kazhinji kazhinji kupfuura iwe paunenge uchitora Mavyret.

Mavyret uye dabigatran (Pradaxa)

Kutora Mavyret nedabigatran kunowedzera iwo mazinga edabigatran mumuviri wako. Kana iyi nhanho ikakwira zvakanyanya, uchave nenjodzi yakawedzera yekubuda ropa kana kupwanya. Iwe unogona zvakare kunzwa kupera simba. Zviratidzo izvi dzimwe nguva zvinogona kuve zvakakomba.

Kana iwe uri kutora dabigatran paunenge uchishandisa Mavyret, chiremba wako angangoda kudzikisa dosi yako yedabigatran. Izvi zvinobatsira kudzivirira izvi zviratidzo kubva pakuitika.

Mavyret uye rifampin (Rifadin)

Kutora Mavyret ne rifampin kunodzikisira mazinga eMavyret mumuviri wako. Kana iyo nhanho yeMavyret mumuviri wako yakadzikiswa, mushonga wacho ungasashande zvakare kurapa HCV. Iwe unofanirwa kudzivirira kutora Mavyret naRifampin panguva imwe chete.

Mavyret uye mimwe mishonga yekudzivirira kuberekwa

Mimwe mishonga yekudzivirira kuberekwa ine chinodhaka chinonzi ethinyl estradiol. Kutora mushonga uyu pamwe chete neMavyret kunogona kuwedzera mwero wemuviri wako weimwe enzyme yechiropa inonzi alanine aminotransferase (ALT). Kuwedzera kweAIDS kunogona kuita kuti zviratidzo zvako zvehepatitis zviwedzere.

Zvinokurudzirwa kuti usashandise kuberekwa kune ethinyl estradiol paunenge uchitora Mavyret.

Mienzaniso yemapiritsi ekudzivirira kuberekwa ane ethinyl estradiol anosanganisira:

• levonorgestrel uye ethinyl estradiol (Lessina, Levora, Seasonique)
• desogestrel uye ethinyl estradiol (Apri, Kariva)
• norethindrone uye ethinyl estradiol (Balziva, Junel, Loestrin / Loestrin Fe, Microgestin / Microgestin Fe)
• norgestrel uye ethinyl estradiol (Cryselle, Lo / Ovral)
• drospirenone uye ethinyl estradiol (Loryna, Yaz)
• norgestimate uye ethinyl estradiol (Ortho Tri-Cyclen / Ortho Tri-Cyclen Lo, Sprintec, Tri-Sprintec, TriNessa)

Iri harisi rondedzero izere yemapiritsi ekudzivirira kuberekwa ayo ane ethinyl estradiol. Kana iwe usina chokwadi kana kuberekwa kwako kune ethinyl estradiol mairi, ita chokwadi chekubvunza chiremba wako kana wemishonga.

Dzimwe nzira dzekudzora kunze kwemapiritsi dzinewo ethinyl estradiol. Idzi nzira dzinosanganisira dziviriro yekudzivirira (Ortho Evra) uye rin'i yemukadzi (NuvaRing).

Kana iwe uri kushandisa yekuzvarwa ine ethinyl estradiol, taura nachiremba wako nezve dzimwe sarudzo dzekudzivirira kubata pamuviri paunenge uchitora Mavyret.

Mavyret uye imwe mishonga yeHIV antiviral

Mimwe mishonga yeHIV (inonzi antivirals) inogona kukanganisa huwandu hweMavyret mumuviri wako. Mienzaniso yemishonga inorwisa mabhakitiriya inogona kuchinja huwandu hweMavyret mumuviri wako unosanganisira:

• atazanavir (Reyataz)
• darunavir (Prezista)
• lopinavir uye ritonavir (Kaletra)
• ritonavir (Norvir)
• efavirenz (Sustiva)

Atazanavir haifanire kutorwa naMavyret. Kutora mishonga iyi pamwechete kunowedzera mwero wemuviri wako weimwe enzyme yechiropa inonzi alanine aminotransferase (ALT). Kuwedzera kweAIDS kunogona kuita kuti zviratidzo zvako zvehepatitis zviwedzere.

Kutora Mavyret ne darunavir, lopinavir, kana ritonavir haina kukurudzirwa zvakare. Izvi zvinodaro nekuti iyi antiviral mishonga inogona kuwedzera iwo mazinga eMavyret mumuviri wako. Izvi zvinogona kutungamira mukuwedzera mhedzisiro kubva kuMavyret.

Kutora Mavyret ne efavirenz kunoderedza iwo mazinga eMavyret mumuviri wako. Izvi zvinogona kukonzera kuti Mavyret isashande zvakare. Iwe unofanirwa kudzivirira kushandisa efavirenz uchitora Mavyret.

Mavyret uye mimwe mishonga yecholesterol

Kutora Mavyret pamwe chete nemamwe mishonga yemafuta inonzi cholesterol inowedzera huwandu hwesitin mumuviri wako. Kuve nekuwedzera kwehuwandu hwemasisitimu kunowedzera njodzi yako yemhedzisiro (senge kurwadziwa kwemhasuru) kubva pasitemu.

Mienzaniso yematemoni inosanganisira:

• atorvastatin (Lipitor)
• lovastatin (Mevacor)
• simvastatin (Zocor)
• pravastatin (Pravachol)
• rosuvastatin (Crestor)
• fluvastatin (Lescol)
• pitavastatin (Livalo)

Zvinokurudzirwa kuti usatora Mavyret pamwe neatorvastatin, lovastatin, kana simvastatin. Aya ma statins ane njodzi yakanyanya yekuwedzera mhedzisiro pavanotorwa neMavyret.

Pravastatin inogona kutorwa neMavyret kana chiremba wako achikurudzira kuti unoda mushonga wecholesterol. Muyero wako wepravastatin unoda kudzikiswa usati watanga kutora Mavyret. Izvi zvinobatsira kudzikisa njodzi yako yemhedzisiro kubva kusisitin.

Kana fluvastatin uye pitavastatin zvichitorwa naMavyret, vanofanirwa kupihwa pane yakaderera dhisiki inogoneka. Izvi zvinobatsira kudzikisa njodzi yako yekuve nekuwedzera mhedzisiro kubva kuma statins.

Mavyret uye cyclosporine (Sandimmune)

Mavyret haina kukurudzirwa kuti ishandiswe muvanhu vari kutora zvinopfuura zana mg pazuva recyclosporine. Ichi chinodhaka chinowedzera iwo mazinga eMavyret mumuviri wako, izvo zvinogona kuwedzera njodzi yako yemhedzisiro kubva kuMavyret.

Kana iwe uri kutora cyclosporine, taura nachiremba wako nezveyero ipi yecyclosporine yakachengeteka kwazvo kwauri.

Mavyret uye omeprazole (kwete kudyidzana)

Iko hakuna kusangana kunozivikanwa pakati pe omeprazole neMavyret. Omeprazole dzimwe nguva inopihwa kuvanhu vanotora Mavyret kana vachishungurudzika panguva yekurapwa. Dzimwe nguva, kuda kurutsa kunokonzerwa neacid buildup mudumbu rako. Kutora omeprazole kunobatsira kudzikisa huwandu hweacid mudumbu rako, izvo zvinogona kubatsira kudzikisira mhedzisiro iyi.

Mavyret uye ibuprofen (kwete kudyidzana)

Iko hakuna kumwe kuzivikanwa kuwirirana pakati pebuprofen neMavyret. Ibuprofen inogona kushandiswa kurapa kutemwa nemusoro muvanhu vanotora Mavyret. Kutemwa nemusoro chinhu chinowanzoitika padivi chinogona kuitika kana uchitora Mavyret. Ibuprofen inogona kubatsira kudzikisa marwadzo uye kusagadzikana kwemusoro.

Mavyret nemishonga uye zvinowedzera

Mavyret inogona kusangana nemimwe miriwo uye zvinowedzera, kusanganisira St. John's wort (iyo yakatsanangurwa pazasi). Iko kudyidzana kunogona kukanganisa mashandiro anoita Mavyret mumuviri wako.

Iwe unofanirwa kuongorora yese yemishonga yaunotora (kusanganisira chero mahebhu uye zvinowedzera) nachiremba wako kana wemishonga usati watanga kutora Mavyret.

Mavyret uye St. John's wort

Kutora wort yeSt.John neMavyret kunogona kudzikira zvakanyanya mazinga eMavyret mumuviri wako. Izvi zvinogona kukonzera kuti Mavyret isashande zvakare mukurapa hutachiona hweH hepatitis C. Zvinokurudzirwa kuti usatora St. John's wort paunenge uchishandisa Mavyret.

Mavyret nepamuviri

Iko hakuna kumbove nechero zvidzidzo muvanhu zvichitarisa kuti kana kwete Mavyret yakachengeteka kutora panguva yekuzvitakura.

Mukudzidza kwemhuka, hapana kukuvara kwakaonekwa mumucheche anaamai vake vakapihwa Mavyret panguva yepamuviri. Zvisinei, mhedzisiro yezvidzidzo zvemhuka hazviwanzo kufanotaura zvichaitika muvanhu.

Kana iwe uri nepamuviri kana uchigona kuve nepamuviri uchishandisa Mavyret, taura nachiremba wako. Vanogona kukurukura newe njodzi uye mabhenefiti ekushandisa mushonga uyu panguva yepamuviri.

Mavyret uye kuyamwisa

Iko hakuna kumbove nechero zvidzidzo muvanhu kuziva kuti kana kwete Mavyret inopinda mumukaka wemukaka, kana kana iine chero chinokanganisa mwana anoyamwa.

Muzvidzidzo zvemhuka, Mavyret akapinda mumukaka wemakonzo anokamwisa. Nekudaro, uyu mukaka hauna kukanganisa mhuka dzaunodya. Ramba uchifunga kuti izvi zvinoguma zvave zvakasiyana muvanhu.

Kana iwe uchiyamwisa, kana kuronga kuyamwisa uchitora Mavyret, taura nachiremba wako nezve iyi sarudzo yakachengeteka. Ivo vanogona kukurudzira dzimwe nzira dzakanaka dzekudyisa mwana wako.

Maitiro ekutora Mavyret

Iwe unofanirwa kutora Mavyret zvinoenderana nachiremba wako kana rairo yemupi wezvehutano.

Nguva yekutora

Izvo hazvina basa kuti inguvai yezuva yaunosarudza kutora Mavyret, asi iwe unofanirwa kuitora panguva inenge yakafanana zuva rega rega. Izvi zvinobatsira kuti mushonga ushande nenzira kwayo mukati memuviri wako.

Kuti ubatsire kuve nechokwadi chekuti hauna kupotsa dosi, edza kuseta chiyeuchidzo pafoni yako. Iyo yekurapa timer inogona kubatsira, zvakare.

Kutora Mavyret nechikafu

Mavyret inofanira kutorwa nechikafu. Izvi zvinobatsira muviri wako kutora zvirinani mushonga.

Mavyret inogona kupwanywa, kupatsanurwa, kana kutsengwa here?

Kwete, Mavyret haifanire kupatsanurwa, kupwanywa, kana kutsengwa. Mahwendefa acho anofanirwa kumedzwa zvakakwana. Kuapwanya, kuapwanya, kana kuatsenga kunogona kudzikisa huwandu hwemushonga unopinda mumuviri wako. Izvi zvinogona kukonzera kuti Mavyret isashande zvakare mukurapa hutachiona hweH hepatitis C.

Mashandiro anoita Mavyret

Mavyret inogamuchirwa kurapa hutachiona husingaperi hwehepatitis C (HCV). Utachiona uhu hunokonzera hutachiona mumuviri wako hunokanganisa chiropa chako. HCV inogona kutungamira kukuvadza kwakakomba kwechiropa kana ikasarapwa nenzira kwayo.

Mavyret ine mishonga miviri: glecaprevir uye pibrentasvir. Inoshanda nekumisa hutachiona hwehepatitis C kubva pakuwanda (kugadzira hutachiona hwakawanda) mukati memuviri wako. Nekuti hutachiona haugone kuwanda, inozopedzisira yafa.

Kana hutachiona hwese hwafa, uye husisiri mukati memuviri wako, chiropa chako chinogona kutanga kupora. Mavyret inoshanda kurapa ese matanhatu marudzi (1, 2, 3, 4, 5, uye 6) eHCV.

Zvinotora nguva yakareba sei kuti zvishande?

Munguva yezvidzidzo zvemakiriniki, 92% kusvika 100% vanhu vane HCV vakaporeswa mushure mekutora Mavyret kwenguva yavo yakatarwa. Iyi yakareba yenguva yakatarwa kubva pa8 kusvika kumavhiki e16.

Muzvidzidzo izvi, kurapwa kwaireva kuti kuongororwa kweropa kwevanhu, kwakaitwa mwedzi mitatu mushure mekurapwa, hakuna kuratidza zviratidzo zvehutachiona hweHCV mumuviri wavo.

Mibvunzo yakajairika nezveMavyret

Heano mhinduro kumimwe mibvunzo inowanzo bvunzwa pamusoro paMavyret.

Ndinogona kutora Mavyret kana ndine hutachiona hweHIV uye hepatitis C?

Hongu, unogona kutora Mavyret kana uine hutachiona hweHIV uye hepatitis C (HCV). Kuva neHIV hakuchinje mashandiro anoita Mavyret mumuviri wako kurapa HCV.

Mavyret anobudirira sei pakurapa hepatitis C?

Mavyret yakaratidzirwa kuve inoshanda kwazvo mukurapa hepatitis C hutachiona (HCV) hutachiona. Mumakiriniki ekuedzwa, pakati pe98% ne100% yevanhu vanotora Mavyret vakaporeswa paHCV.

Muzvidzidzo izvi, kurapwa kwaireva kuti kuongororwa kweropa kwevanhu, kwakaitwa mwedzi mitatu mushure mekurapwa, hakuna kuratidza zviratidzo zvehutachiona hweHCV. Iyo huwandu hwevanhu vakaporeswa hwaitsamira pamhando yeHCV yavaive nayo, uye nemhando dzipi dzekurapa dzavaishandisa kare.

Kana ndikatora mamwe marapirwo ehepatitis C, ndinogona kushandisa Mavyret?

Kana iwe waedza imwe mishonga ye hepatitis C yako isina kushanda (kurapa hutachiona hwako), unogona achiri kushandisa Mavyret. Zvichienderana nemishonga ipi yawakamboshandisa munguva yakapfuura, kureba kwako kwekurapa naMavyret kunogona kunge kuri kubva pamasvondo masere kusvika gumi nematanhatu.

Kana iwe uine mibvunzo nezve kana iwe uchigona kushandisa Mavyret, taura nachiremba wako.

Ini ndichazoda chero bvunzo pamberi kana panguva yeMavyret kurapwa?

Usati watanga kurapwa neMavyret, chiremba wako anozoongorora ropa rako kune hepatitis B hutachiona (HBV). Kana iwe uine HBV, inogona kumisazve (kubuda) panguva yeMavyret kurapwa. Kugadziriswa kweHBV kunogona kukonzera matambudziko akakomba echiropa, kusanganisira kukundikana kwechiropa uye kufa.

Kana uine HBV, chiremba wako achakurudzira kuongororwa kweropa panguva yako yeMavyret kurapwa kuti utarise HBV kugadzirisazve. Ungangoda kurapwa kweHBV usati watanga kutora Mavyret.

Ndinogona here kushandisa Mavyret kana ndine cirrhosis?

Iwe unogona kunge uchikwanisa, asi zvinoenderana nekuti yakanyanya sei yako cirrhosis (chiropa chekushaura) iri.

Mavyret inogona kushandiswa kana iwe wakabhadhara (zvinyoro) cirrhosis. Nechiitiko ichi, chiropa chako chine maronda, asi iwe hauna kana zviratidzo zvechiitiko uye chiropa chako chichiri kushanda zvakajairika.

Mavyret haisati yatenderwa kuti ishandiswe mune vanhu vane decompensated cirrhosis. Nemamiriro aya, chiropa chako chine maronda uye une zviratidzo zvechimiro. Zviratidzo zvinogona kusanganisira:

• kuita yero kweganda rako kana kuchena kwemeso ako
• kuwedzerwa mvura mudumbu rako
• kuwedzerwa mitsipa yeropa pahuro pako, izvo zvinogona kukonzera kubuda ropa

Kana iwe uine cirrhosis asi usina chokwadi kuti rudzii, taura nachiremba wako.

Kuchengetedza kweMavyret

Mushonga uyu unouya pamwe nezvakawanda zvekuchengetedza.

FDA yambiro: hepatitis B hutachiwana hutachiona

Mushonga uyu une yambiro yebhokisi. Iyi ndiyo yambiro yakanyanya kubva kuFood and Drug Administration (FDA). Yambiro yebhokisi inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.

Mavyret kurapwa kunowedzera njodzi yehutachiona hwehepatitis B (HBV) kugadzirisazve (kupisa-up) muvanhu vane HBV uye hepatitis C hutachiona (HCV). Muzviitiko zvakakomba, kumutsidzira kweHBV kunogona kukonzera kukundikana kwechiropa kana kutofa.

Usati watanga Mavyret, chiremba wako anokuyedza HBV. Kana uine HBV, ungangoda kurapwa nezvayo usati watanga kutora Mavyret. Kana chiremba wako anogona kukurudzira kuongororwa panguva yako yeMavyret kurapwa kuti utarise HBV kugadzirisazve.

Dzimwe yambiro

Usati watora Mavyret, taura nachiremba wako nezve nhoroondo yako yehutano. Mavyret inogona kunge isingave yakakunakira iwe kana uine mamwe marapirwo. Izvi zvinosanganisira:

• Chiropa kutadza. Kana iwe uine kutadza kwechiropa, kutora Mavyret kunogona kukuvadza mamiriro ako. Taura nachiremba wako kana iwe uine chero nhoroondo yechiropa chirwere kana kutadza kwechiropa usati watanga kurapwa naMavyret.
• Ikozvino kushandiswa kweatazanavir kana rifampin. Mavyret haifanire kushandiswa mune vanhu vanotora inga atazanavir kana rifampin. Kutora Mavyret uye rifampin pamwe chete kunogona kudzikira mazinga eMavyret mumuviri wako. Izvi zvinogona kuita kuti Mavyret isanyanya kushanda kwauri. Kutora atazanavir neMavyret kunogona kuwedzera muhuwandu hweMavyret mumuviri wako. Izvi zvinogona kuwedzera mazinga enzyme yechiropa (inonzi alanine aminotransferase), iyo inogona kuve nenjodzi. Ona chikamu che "Mavyret kudyidzana" chikamu kune rumwe ruzivo. Gara uchitaura nachiremba wako nezve chero mishonga yauri kutora usati watanga Mavyret.
• Kubata. Hazvizivikanwe kana Mavyret inogona kukanganisa nhumbu iri kukura. Mukudzidza kwemhuka, Mavyret haina kukonzera kukuvara painoshandiswa panguva yekuzvitakura. Nekudaro mhedzisiro iyi inogona kuve yakasiyana muvanhu. Kuti uwane rumwe ruzivo, ndapota ona chikamu che "Mavyret nepamuviri" pamusoro.
• Kuyamwisa. Hazvizivikanwe kana Mavyret achipfuura mumukaka wemunhu wemukaka, kana kana zvichikuvadza mwana anoyamwa. Muzvidzidzo zvemhuka, Mavyret akapinda mumukaka wemukaka, asi hazvina kukuvadza mhuka dzinodya mukaka wemuzamu. Nekudaro, mhedzisiro iyi inogona kuve yakasiyana muvanhu. Kuti uwane rumwe ruzivo, ndapota ona chikamu che "Mavyret nekuyamwisa" pamusoro.

Ongorora: Kuti uwane rumwe ruzivo nezve zvingangoitika zvakaipa zveMavyret, ona iyo "Mavyret mhedzisiro" chikamu pamusoro.

Mavyret ovhadhozi

Kushandisa kupfuura yakadomerwa muyero weMavyret kunogona kutungamira kune zvakakomba mhedzisiro. Usambofa wakatora zvinopfuura chiyero icho chiremba wako anokuraira.

Zvekuita kana ovhadhozi

Kana iwe uchifunga kuti watora zvakawandisa zvemushonga uyu, fonera chiremba wako. Iwe unogona zvakare kufonera iyo American Association yePoison Control Centres pa800-222-1222 kana kushandisa yavo yepamhepo chishandiso. Asi kana zviratidzo zvako zvakakomba, fonera 911 kana kuenda kukamuri yepedyo yevanokurumidza ipapo.

Mavyret kupera, kuchengetedza, uye kurasa

Paunowana Mavyret kubva kukhemisi, wemishonga anowedzera zuva rekupera kune zvakanyorwa pabhodhoro. Zuva iri rinowanzo kuve gore rimwe kubva pazuva ravakapa mushonga.

Zuva rekupera rinobatsira kuvimbisa kushanda kwemushonga panguva ino. Chimiro chazvino cheKudya neDrug Administration (FDA) ndechekudzivirira kushandisa akapera mishonga. Kana iwe usina kushandisa mishonga yakapfuura nguva yekupera, taura nachiremba wako nezvekuti ungangokwanisa kuishandisa.

Kuchengetedza

Inguva yakareba sei mushonga unoramba wakanaka unogona zvinoenderana nezvinhu zvakawanda, zvinosanganisira kuti unochengetera mushonga kupi uye kupi.

Mahwendefa eMavyret anofanirwa kuchengetwa mukamuri tembiricha (pazasi pe86 ° F / 30 ° C) mumudziyo wakasungwa wakasungwa, kure nechiedza. Dzivisa kuchengeta uyu mushonga munzvimbo dzaunganyorove kana kunyorova, senge mudzimba dzekugezera.

Kubvisa

Kana iwe usisiri kuda kutora Mavyret uye uine mishonga yasara, zvakakosha kuirasa zvakachengeteka. Izvi zvinobatsira kudzivirira vamwe, kusanganisira vana nezvipfuwo, kubva pakutora mushonga netsaona. Izvo zvinobatsirawo kuchengetedza mushonga kubva mukukuvadza nharaunda.

Iyo FDA webhusaiti inopa akati wandei matipi anobatsira pakuraswa kwemishonga. Iwe unogona zvakare kubvunza wako wemishonga kuti uwane ruzivo rwekuti ungarase sei mushonga wako.

Ruzivo rwehunyanzvi rweMavyret

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Zviratidzo

Mavyret inoratidzirwa pakurapa chirwere chisingaperi chehepatitis C (HCV) genotypes 1, 2, 3, 4, 5, uye 6. kg.

Inofanira chete kushandiswa kune varwere vasina cirrhosis, kana kune avo vane cirrhosis yakabhadharwa.

Mavyret inoratidzirwawo kubata genotype 1 hepatitis C hutachiona hwehutachiona muvanhu vakarapwa kare vasina kubudirira. Aya marapirwo epamberi anofanirwa kusanganisira ingave HCV NS5A inhibitor kana NS3 / 4A protease inhibitor.

Mavyret haina kuratidzwa kuti ishandiswe mune varwere vane kurapwa kwekutanga kwakatadza kushandisa ese ari HCV NS5A inhibitor uye NS3 / 4A protease inhibitor.

Nzira yekuita

Mavyret ine glecaprevir uye pibrentasvir. Iyi mishonga inonanga-inoshanda antiviral mishonga inorwisa HCV.

Glecaprevir ndeye NS3 / 4A protease inhibitor. Inoshanda nekutarisa NS3 / 4A protease, izvo zvinodikanwa mukuvandudza hutachiona hwehepatitis C.

Pibrentasvir ndeye NS5A inhibitor. Nekuvharira NS5A, pibrentasvir inonyanya kumira hepatitis C kudzokorora kwehutachiona.

Mavyret inoshanda kurwisa hepatitis C hutachiona genotypes 1, 2, 3, 4, 5, uye 6.

Pharmacokinetics uye metabolism

Mune ongororo inosanganisira vasina-HCV vane hutachiona vanhu vaionekwa sevane hutano, kunwiwa kweMavyret kwakakanganiswa zvakanyanya nekuvapo kwechikafu. Kana ikatorwa pamwe nekudya, kunwa kwe glecaprevir kwakawedzera ne83% kusvika 163%. Kubata kwepibrentasvir kwakawedzerwa ne40% kusvika 53%. Naizvozvo, Mavyret inokurudzirwa kutorwa nechikafu kuti chiwedzere kunakirwa kwayo.

Kunonyanyisa plasma wevasungwa Mavyret kunoitika paanenge maawa mashanu post-dose. Hafu yeupenyu ye glecaprevir maawa matanhatu, nepo hafu-hupenyu hwepibrentasvir maawa gumi nematatu.

Mavyret inonyanyo kuburitswa kuburikidza neiyo biliary-fecal nzira. Ruzhinji rwezvose zviri zviviri glecaprevir uye pibrentasvir ipuroteni yeplasma yakasungwa.

Contraindications

Mavyret inopesana nevarwere vane chirwere chakakomba chehepatic, chinotsanangurwa seMwana-Pugh C mamaki.

Mavyret zvakare inopesana nevarwere vari kutora inga atazanavir kana rifampin. Iko kusungirirwa kweMavyret kwakadzikira zvakanyanya neififin, iyo inogona kudzora kana kudzvinyirira kurapwa kweMavyret. Mavyret haifanire kutorwa neatazanavir nekuti kusanganiswa kwemishonga kunogona kuwedzera alanine aminotransferase (ALT) mazinga, zvichikonzera kuwanda kwenjodzi yekundika kwechiropa.

Kuchengetedza

Mavyret inofanirwa kuchengetwa pasi kana pazasi pe86 ° F (30 ° C) mune yakavharika, yakaoma mudziyo.

Disiki: Medical News Nhasi yaedza nepese painogona napo kuti ive neruzivo rwekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.