Chii mosaicism uye ayo makuru mhedzisiro

Zvemukati

• Main maficha
• Migumisiro yekushongedza

Mosaicism izita rakapihwa kune rudzi rwemageneti kutadza panguva yekukura kweiyo embryo mukati mechibereko chaamai, umo munhu anotanga kuve nemaviri akasarudzika majini zvigadzirwa, iro rinoumbwa nemubatanidzwa wezai nourume hwevabereki. , uye imwe inomuka nekuda kwekuchinja kwesero mukukura kwe "embryo".

Nekudaro, munhu anozovandudza musanganiswa wemasero, iine muzana yemasero akajairwa uye imwe muzana yemasero ane shanduko, sezvakaratidzwa mumufananidzo unotevera:

Main maficha

Mosaicism inoitika kana shanduko ikaitika mu "embryo cell", kazhinji kurasikirwa kana kudzokororwa kwechromosome, izvo zvinoita kuti munhu agadzire muviri wake nemhando mbiri dzemasero, uye maviri marudzi emagene. Iyi shanduko inogona kuve yemhando mbiri:

• Kuwedzera kana Gonadal: inokanganisa urume kana mazai, neshanduko dzinogona kupfuudzwa kuvana. Mimwe mienzaniso yezvirwere zvinokonzerwa neshanduko mumasero ehutachiona Turner's syndrome, isina kukwana osteogenesis uye Duchenne muscular dystrophy;
• Somatics: mune ayo maseru kubva kune chero chikamu chemuviri anotakura shanduko iyi, angave kana kwete iye munhu angaite shanduko yemuviri inokonzerwa nazvo. Nekudaro, iko kutaura kwemuviri kweshanduko kunoenderana nekuti ndeapi uye mangani maseru mumuviri anokanganiswa. Somatic mosaicism inogona kupfuudzwa kubva kuvabereki kuenda kuvana, uye mimwe mienzaniso yezvirwere zvinokonzerwa iDown's syndrome uye neurofibromatosis.

Zvakavhenganiswa mosaicism, kune rumwe rutivi, zvinoitika kana munhu aine mhando mbiri dze mosaicism, zvese zvinomera uye somatic.

Mosaicism yakasiyana neichi chimerism mune kuti, mune ino mamiriro, iyo embruyo yemagetsi ekugadzirwa inoteedzerwa nekusanganiswa kwemaviri akasiyana mazai, ayo anova one. Dzidza zvakawanda nezve iyi mamiriro mune chimerism.

Migumisiro yekushongedza

Kunyangwe zviitiko zvakawanda zvekushongedza zvisina kukonzera zviratidzo kana chero mhedzisiro yehutano hwemunhu, mamiriro ezvinhu aya anogona kukonzera kutaridzika kwezvinetso zvakawanda nezvirwere zveiye anotakura munhu, uye mimwe mienzaniso ndeiyi:

• Kugadziriswa kwekenza;
• Shanduko mukukura;
• Kugadziriswa kwekubvisa zvoga;
• Shanduko muiyo pigmentation pateni yeganda;
• Ocular heterochromia, umo munhu wacho anogona kuve neziso rimwe rerudzi rumwe nerumwe;
• Down chirwere;
• Turner chirwere;
• Osteogenesis imperfecta;
• Duchenne tsandanyama dystrophy;
• McCune-Albright syndromes;
• Pallister-Killian chirwere;
• Proteus chirwere.

Uye zvakare, zvakaonekwa kuti mosaicism inowedzera mamiriro ekurwara kwehuropi, senge Alzheimer's kana Parkinson, semuenzaniso.