BCR ABL Genetic Bvunzo

Zvemukati

• Chii chinonzi BCR-ABL genetic test?
• Chii chinoshandiswa?
• Nei ndichida BCR-ABL genetic test?
• Chii chinoitika panguva yeBCR-ABL genetic test?
• Ndichafanira here kuita chero chinhu kugadzirira bvunzo?
• Pane here njodzi kune bvunzo?
• Zvinorevei mhedzisiro yacho?
• Pane chimwe chinhu here chandinofanira kuziva nezve BCR-ABL genetic test?
• Zvinyorwa

Chii chinonzi BCR-ABL genetic test?

A BCR-ABL genetic test inotarisa genet mutation (shanduko) pane yakasarudzika chromosome.

Chromosomes ndiwo maseru emasero ako ane magene ako. Magene zvikamu zveDNA zvakapfuudzwa kubva kuna mai nababa vako. Ivo vanotakura ruzivo rwunotarisa hunhu hwako hwakasarudzika, senge kukwirira uye ruvara rwemaziso.

Vanhu vanowanzove nemakromosomes makumi mana nematanhatu, akapatsanurwa kuita makumi maviri nematatu, mune rimwe sero. Rimwe remakromosomes rimwe nerimwe rinobva kuna amai vako, uye rimwe racho rinobva kuna baba vako.

BCR-ABL ishanduko inoumbwa nekubatanidzwa kwemajini maviri, anozivikanwa seBCR neABL. Iyo dzimwe nguva inonzi fusion gene.

• Iyo BCR geni inowanzo pane chromosome nhamba 22.
• Iyo ABL geni inowanzo pane chromosome nhamba 9.
• Iko BCR-ABL shanduko inoitika kana zvidimbu zveBCR neABL magene atsemuka nekuchinja nzvimbo.
• Iko kushanduka kunoratidza pane chromosome 22, uko chidimbu che chromosome 9 chakazvibatanidza.
• Chromosome yakachinjika 22 inonzi chromosome yePhiladelphia nekuti ndiro guta rakatanga kuwanikwa nevatsvakurudzi.
• Iyo BCR-ABL geni haisi iyo mhando yekuchinja iyo inogarwa nhaka kubva kuvabereki vako. Iyo mhando yesomatic shanduko, zvinoreva kuti hauna kuzvarwa nayo. Unozviwana gare gare muhupenyu.

Iyo BCR-ABL geni inoratidza kumusoro kune varwere vane mamwe marudzi eleukemia, kenza yemongo wemapfupa nemasero machena eropa. BCR-ABL inowanikwa munenge mune vese varwere vane mhando yeleukemia inonzi chisingaperi myeloid leukemia (CML). Rimwe zita reCML rinogara myelogenous leukemia. Mazita maviri aya anoreva chirwere chimwe chete.

Iyo BCR-ABL geni inowanikwawo mune vamwe varwere vane fomu yeacute lymphoblastic leukemia (YOSE) uye kashoma kune varwere vane acute myelogenous leukemia (AML).

Mimwe mishonga yekenza inoshanda zvakanyanya pakurapa varwere veleukemia vane BCR-ABL gene mutation. Iyi mishonga zvakare ine mashoma mhedzisiro pane mamwe marapirwo ekenza. Mishonga imwe chete iyoyo haishande pakurapa mhando dzakasiyana dzeleukemia kana mamwe kanzura.

Mamwe mazita: BCR-ABL1, BCR-ABL1 fusion, Philadelphia chromosome

Chii chinoshandiswa?

A BCR-ABL bvunzo inowanzo shandiswa kuongorora kana kutonga chisingaperi myeloid leukemia (CML) kana imwe fomu yeacute lymphoblastic leukemia (YOSE) inonzi Ph-positive ZONSE. Ph-positive zvinoreva chromosome yePhiladelphia yakawanikwa. Muedzo hausi kushandiswa kuongorora mamwe marudzi eleukemia.

Muedzo unogona zvakare kushandiswa ku:

• Ona kana kurapwa kwegomarara kuri kushanda.
• Tarisa uone kana murwere ave nekuramba kumwe kurapwa. Izvi zvinoreva kuti kurapwa kwaimbove kushanda hakusi kushanda.

Nei ndichida BCR-ABL genetic test?

Unogona kuda bvunzo yeBCR-ABL kana uine zviratidzo zvechirwere chemyeloid leukemia (CML) kana Ph-positive acute lymphoblastic leukemia (ALL). Izvi zvinosanganisira:

• Kuneta
• Kupindwa nechando
• Kuonda
• Kutuka kwehusiku (kudikitira zvakanyanya uchirara)
• Joint kana kurwadziwa kwepfupa

Vamwe vanhu vane CML kana Ph-positive VOSE havana zviratidzo, kana zviratidzo zvakapfava, kunyanya mumatanho ekutanga echirwere. Saka mupi wako wezvehutano anogona kuraira bvunzo iyi kana huwandu hweropa hwakazara kana kumwe kuongorora kweropa kwakaratidza zvabuda zvainge zvisina kujairika. Iwe unofanirwa zvakare kurega mupi wako azive kana iwe uine chero zviratidzo zvinokunetsa iwe. CML uye Ph-positive ZVESE zviri nyore kurapa kana wawanikwa kare.

Iwe unogona zvakare kuda uyu bvunzo kana iwe parizvino uchirapwa CML kana Ph-positive ZVESE. Muedzo unogona kubatsira mupi wako kuona kana kurapwa kwako kuri kushanda.

Chii chinoitika panguva yeBCR-ABL genetic test?

Kuongororwa kweBCR-ABL kunowanzo kuongororwa ropa kana maitiro anonzi mapfupa ekutsvaira uye biopsy.

Kana iwe uri kuongorora ropa, nyanzvi yehutano anotora muyero weropa kubva mutsinga iri muruoko rwako, achishandisa tsono diki. Mushure mekunge tsono yaiswa, kashoma reropa kanounganidzwa muthubhu yekuyedza kana muhombodo. Unogona kunzwa kakuruma kana tsono ichipinda kana kubuda. Izvi zvinowanzotora maminetsi asingasviki mashanu.

Kana iwe uri kuwana pfupa remongo chishuwo uye biopsy, maitiro ako anogona kusanganisira anotevera matanho:

• Iwe ucharara pasi nedivi rako kana dumbu rako, zvichienderana nekuti ipfupa ripi rinoshandiswa kuyedzwa. Mazhinji mapfupa emongo bvunzo anotorwa kubva muchiuno bone.
• Muviri wako uchafukidzwa nemachira, zvekuti iyo chete nzvimbo yakatenderedza saiti yekuyedza iri kuratidza.
• Saiti iyi ichave yakacheneswa ne antiseptic.
• Iwe unowana jekiseni remhinduro inovhiringidza. Zvinogona kuruma.
• Kana nzvimbo yacho yangove chiveve, mutapi wezvehutano anotora muyenzaniso. Iwe unozofanirwa kunyepera kunyarara panguva dzekuyedzwa.
  • Zvekuda kwemongo wemapfupa, izvo zvinowanzoitwa pekutanga, mupi wezvehutano anoisa tsono kuburikidza nepfupa uye oburitsa mafupa emvura uye masero. Unogona kunzwa kurwadziwa kwakapinza asi kupfupi apo tsono inopinzwa.
  • Kune bone marrow biopsy, mupi wezvehutano anoshandisa chakakosha chishandiso chinomonyoroka mupfupa kutora sampuro yemapfupa emwongo. Iwe unogona kunzwa kumanikidzwa pane ino saiti apo sampuro ichitorwa.
• Zvinotora maminetsi gumi kuti uite miviri bvunzo.
• Mushure mekuyedzwa, mupi wezvehutano anozovhara saiti nebhandeji.
• Ronga kuti mumwe munhu akutyaire kumba, nekuti unogona kupihwa sedative pamberi pebvunzo, izvo zvinogona kukuwisira.

Ndichafanira here kuita chero chinhu kugadzirira bvunzo?

Iwe kazhinji haudi chero yakakosha gadziriro yeropa kana yemafupa bvunzo.

Pane here njodzi kune bvunzo?

Pane njodzi shoma yekuongororwa ropa. Unogona kunge uine marwadzo mashoma kana kupwanya panzvimbo yakaiswa tsono, asi zviratidzo zvizhinji zvinokurumidza kupera.

Mushure mekuyedzwa kwemongo wemapfupa, unogona kunzwa kuomarara kana kurwadziwa panzvimbo yejekiseni. Izvi zvinowanzoenda mumazuva mashoma. Wako wekuchengeta hutano anogona kukurudzira kana kuraira anodzora marwadzo kuti abatsire.

Zvinorevei mhedzisiro yacho?

Kana zvawanikwa zvichiratidza kuti une BCR-ABL geni, pamwe neakawandisa masero machena eropa, ungangozoonekwa uine chirwere chisingaperi chemyeloid leukemia (CML) kana Ph-positive, acute lymphoblastic leukemia (ALL).

Kana iwe parizvino uri kurapwa CML kana Ph-positive ZVESE, mhedzisiro yako inogona kuratidza:

• Kuwanda kweBCR-ABL muropa rako kana pfupa remongo kuri kuwedzera. Izvi zvinogona kureva kuti kurapwa kwako hakusi kushanda uye / kana iwe wave kuramba kurwisa kune kumwe kurapwa.
• Huwandu hweBCR-ABL muropa rako kana mwongo wemapfupa uri kudzikira. Izvi zvinogona kureva kuti kurapwa kwako kuri kushanda.
• Huwandu hweBCR-ABL muropa rako kana mwongo wemapfupa hauna kuwedzera kana kuderera. Izvi zvinogona kureva kuti chirwere chako chakatsiga.

Kana iwe uine mibvunzo nezve mhedzisiro yako, taura nemupi wako wezvehutano.

Dzidza zvakawanda nezve bvunzo dzemarabhoritari, mareferenzi masosi, uye mhinduro dzekunzwisisa

Pane chimwe chinhu here chandinofanira kuziva nezve BCR-ABL genetic test?

Kurapa kwechirwere chisingaperi chinonzi myeloid leukemia (CML) uye Ph-positive, acute lymphoblastic leukemia (ALL) chakabudirira kune varwere vane mhando idzi dzeleukemia. Zvakakosha kuona mutapi wako wehutano nguva dzose kuti ave nechokwadi chekuti kurapwa kwako kunoramba kuchishanda. Kana iwe ukava unoshora kurapwa, mupi wako anogona kukurudzira mamwe marudzi ekenza kurapwa.

Zvinyorwa

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Ruzivo ruri pane ino saiti harufanire kushandiswa sekutsiva kwehunyanzvi kurapwa kana kurairwa. Bata mupi wehutano kana iwe uine mibvunzo nezve hutano hwako.