Marapirwo matsva neMishonga yeUlcerative Colitis

Zvemukati

• Kurapa kwazvino
• Aminosalicylates
• Corticosteroids
• Immunomodulators
• TNF vanovharira
• Kuvhiya
• Mishonga mitsva
• Tofacitinib (Xeljanz)
• Biosimilars
• Mishonga iri kuongororwa
• Fecal kuisazve
• Stem cell kurapa
• Kliniki miedzo
• Tora woenda nazvo

Mhedziso

Paunenge uine ulcerative colitis (UC), chinangwa chekurapa ndechekumisa immune system yako kubva pakurwisa hura hwemukati mako. Izvi zvinounza pasi kuzvimba kunokonzera zviratidzo zvako, uye kukuisa mukuregererwa. Chiremba wako anogona kusarudza kubva pamhando dzakasiyana dzemishonga kuti akubatsire kuzadzisa zvinangwa izvi.

Mumakore mashoma apfuura, nhamba yemishonga inoshandiswa kurapa UC yawedzera. Vatsvagiri vari kudzidza mamwe marapirwo matsva uye pamwe akavandudzwa mumakiriniki ekuedzwa.

Kurapa kwazvino

Mhando shoma dzakasiyana dzemishonga dziripo yekurapa UC. Chiremba wako achakubatsira iwe kusarudza imwe yeiyi marapirwo anoenderana ne:

• kuoma kwechirwere chako (nyoro, zvine mwero, kana zvakanyanya)
• mishonga ipi yawakatotora
• wanyatsopindura sei kumishonga iya
• hutano hwako hwese

Aminosalicylates

Iri boka remishonga rine chinongedzo 5-aminosalicylic acid (5-ASA). Zvinosanganisira:

• sulfasalazine (Azulfidine)
• mesalamine (Canasa)
• olsalazine (Dipentum)
• balsalazide (Colazal, Giazo)

Paunotora madhiragi aya nemuromo kana seemaema, anobatsira kuunza pasi kuzvimba mumukati mako. Aminosalicylates anoshanda zvakanyanya kune UC munyoro-ku-mwero, uye inogona kubatsira kudzivirira marasha.

Corticosteroids

Corticosteroids (steroid zvinodhaka) inodzvinyirira immune system kuunza pasi kuzvimba. Mienzaniso inosanganisira:

• zvideo
• kuuchi
• methylprednisolone
• budesonide

Chiremba wako anogona kuraira imwe yemishonga iyi kwenguva pfupi-kudzikamisa chiratidzo chinopisa. Haisi pfungwa yakanaka kugara pasteroids kwenguva refu, nekuti zvinogona kukonzera matambudziko senge shuga yakakwira muropa, kuwedzera huremu, hutachiona, uye kurasikirwa nefupa.

Immunomodulators

Iyi mishonga inodzvinyirira immune system yako kuti idzivirire kubva mukukonzera kuzvimba. Unogona kutanga kutora imwe yemishonga iyi kana aminosalicylates isina kubatsira zviratidzo zvako. Mienzaniso yea immunomodulators inosanganisira:

• azathioprine (Azasan)
• 6-mercaptopurine (6MP) (Purinethol)
• cyclosporine (Sandimmune, Neoral, vamwe)

TNF vanovharira

TNF blockers rudzi rwebiologic drug. Biologics inogadzirwa kubva kumageneti anogadzirwa nemajini kana zvimwe zvinhu zvakasikwa. Ivo vanoita pane chaiwo zvikamu zvemuviri wako immune izvo zvinotya kuzvimba.

Anti-TNF zvinodhaka zvinodzivirira immune system protein inonzi tumor necrosis factor (TNF) iyo inokonzeresa kuzvimba. Ivo vanogona kubatsira vanhu vane mwero-kusvika-kwakasimba UC vane zviratidzo zvisina kuvandudzika vachiri pane mimwe mishonga.

TNF blockers inosanganisira:

• adalimumab (Humira)
• golimumab (Simponi)
• infliximab (Remicade)
• vedolizumab (Entyvio)

Kuvhiya

Kana kurapwa kwawaedza kusingadzori zviratidzo zvako kana kumira kushanda, ungangoda kuvhiyiwa. Maitiro anonzi proctocolectomy anobvisa iyo yakazara colon uye rectum kudzivirira kumwe kuzvimba.

Mushure mekuvhiyiwa, hauzove nekoloni yekuchengetedza tsvina. Chiremba wako anovaka chikwama kunze kwemuviri wako unonzi ileostomy, kana mukati memuviri wako kubva pachikamu chemuviri wako mudiki (ileum).

Kuvhiya idanho hombe, asi rinogonesa zviratidzo zveUC.

Mishonga mitsva

Mumakore mashoma apfuura, mashoma mashoma marapirwo eUK akabuda.

Tofacitinib (Xeljanz)

Xeljanz ndeyekirasi yemishonga inozivikanwa saJanus kinase (JAK) inhibitors. Iyi mishonga inovhara iyo enzyme JAK, iyo inoita kuti masero ezvirwere zvemuviri abudise kuzvimba.

Xeljanz yakagamuchirwa kubvira 2012 kurapa rheumatoid arthritis (RA), uye kubvira 2017 kurapa psoriatic arthritis (PsA). Muna 2018, FDA yakabvumidzawo kurapa vanhu vane UC vane mwero-kusvika-kwakasimba vasina kupindura maTN blockers.

Ichi chinodhaka ndiyo yekutanga kurapa kwenguva refu kwemuromo kurapwa kwe UC kusvika pakati. Mimwe mishonga inoda kuiswa kana jekiseni. Mhedzisiro kubva kuXeljanz inosanganisira yakakwira cholesterol, kutemwa nemusoro, manyoka, dzihwa, kuputika, uye shingles.

Biosimilars

Biosimilars kirasi nyowani nyowani yemishonga iyo yakagadzirirwa kutevedzera mhedzisiro ye biologics. Kunge biologics, aya madhiragi anotarisa immune system mapuroteni anobatsira mukuzvimba.

Biosimilars inoshanda nenzira imwecheteyo nebiologics, asi inogona kudhura zvakanyanya. Mavara mana akawedzerwa kumagumo kwezita kubatsira kusiyanisa iyo biosimilar mushonga kubva kune yekutanga biologic.

Iyo FDA yakabvumidza akawanda biosimilars eUC mumakore mashoma apfuura, anosanganisira:

• infliximab-abda (Renflexis)
• infliximab-dyyb (Inflectra)
• infliximab-qbtx (Ixifi)
• adalimumab-adbm (Cyltezo)
• adalimumab-atto (Amjevita)

Mishonga iri kuongororwa

Vatsvakurudzi vari kuramba vachitsvaga nzira dziri nani dzekudzora UC. Heano mashoma marapirwo matsva ari kuongororwa.

Fecal kuisazve

Kuisa fecal, kana kuisa chituru, inzira yekuyedza inoisa mabhakitiriya ane hutano kubva pachigaro chemupi kupinda mukoloni yemumwe munhu ane UC.Pfungwa yacho inogona kunzwika isingafadzi, asi mabhakitiriya akanaka anobatsira kupodza kukuvara kubva kuUK uye kudzorera hutano hwakanaka hwehutachiona mumatumbu.

Stem cell kurapa

Masero emadzinde ndiwo maseru madiki anokura kuita ese akasiyana maseru nematishu mumiviri yedu. Ivo vane mukana wekurapa ese marudzi ekukuvara kana isu tikasunga nekuishandisa nemazvo. MuUC, masero emadzinde anogona kushandura immune system nenzira inobatsira kudzikisa kuzvimba uye kuporesa kukuvara.

Kliniki miedzo

Vanachiremba vane huwandu hwakawanda hwesarudzo dzekurapa kweUC kupfuura nakare kose. Kunyangwe paine mishonga yakawanda kudaro, vamwe vanhu vanonetseka kuwana imwe inovashandira.

Vatsvakurudzi vari kugara vachidzidza nzira nyowani dzekurapa mumiedzo yekiriniki. Kubatana nechimwe chezvidzidzo izvi kunogona kukupa mukana kune mushonga usati wawanikwa kune veruzhinji. Kumbira chiremba uyo anobata UC yako kana kiriniki kuyedzwa munzvimbo yako kungave kwakakodzera iwe.

Tora woenda nazvo

Maonero evanhu vane UC ari nani nhasi, nekuda kwemishonga mitsva inogona kudzikamisa hutumbu kuzvimba. Kana iwe wakamboedza mushonga uye hauna kukubatsira, ziva kuti dzimwe sarudzo dzinogona kuvandudza zviratidzo zvako. Ramba uchishingirira, uye shanda padhuze nachiremba wako kuti uwane kurapwa uko pakupedzisira kunoshanda kwauri.