Prokinetic Agents

Zvemukati

• Mhando dzeProkinetics
• Bethanechol
• Cisapride
• Metoclopramide

Mune hutano hwemunhu, kumedza kunokonzeresa kutanga peristalsis. Aya ndiwo mabara anofambisa chikafu chako pasi pesophagus uye kuburikidza neese ako ekugaya masisitimu. Nekudaro, gastroesophageal reflux inokonzeresa yechipiri wave yemasuru contractions iyo inobvisa iyo esophagus, kusundira chikafu pasi kuburikidza neyepazasi esophageal sphincter (LES) uye mudumbu.

Zvisinei, kune vamwe vanhu, iyo LES inogona kuzorora kana kuvhura zvoga, ichibvumira zvemukati zvemudumbu, kusanganisira acids, kuti vadzokerezve kugomba. Izvi zvinonzi acid Reflux uye zvinogona kutungamira kuzviratidzo sekurwadzisa kwehana.

Prokinetic vamiririri, kana prokinetics, mishonga inobatsira kudzora acid Reflux. Prokinetics inobatsira kusimbisa ezasi esophageal sphincter (LES) uye kukonzera izvo zviri mukati medumbu kuburitsa nekukurumidza. Izvi zvinobvumira nguva shoma yeacid reflux kuti iitike.

Nhasi, prokinetics inowanzo shandiswa neimwe gastroesophageal Reflux chirwere (GERD) kana mishonga yekurwadziwa nekurwadziwa, senge proton pump inhibitors (PPIs) kana H2 receptor blockers. Kusiyana neiyi mamwe maasidhi Reflux mishonga, ayo anowanzo kuve akachengeteka, prokinetics inogona kuve yakakomba, kana kutotyisa, mhedzisiro. Ivo anowanzo shandiswa chete mumatambudziko akakomba eGERD.

Semuenzaniso, prokinetics inogona kushandiswa kurapa vanhu vane chirwere cheshuga-chinoenderana neshuga, kana vacheche uye vana vane ura hwakanyanya husina kana kupera zvakanyanya kana kupatirwa kusinga pindire kune kumwe kurapwa.

Mhando dzeProkinetics

Bethanechol

Bethanechol (Urecholine) mushonga unosimudzira dundira uye unobatsira iwe kupfuudza weti kana uchinetseka kuburitsa dundira rako. Inobatsira kusimbisa iyo LES, uye inoita kuti dumbu rive risina chinhu nekukurumidza. Inobatsirawo kudzivirira kusvotwa uye kurutsa. Inowanikwa mune fomu yepiritsi.

Nekudaro, kubatsira kwayo kunogona kukurirwa nemhedzisiro mhedzisiro. Migumisiro yaro inogona kusanganisira:

• kushushikana
• kuora mwoyo
• kutsimwaira
• kuneta
• matambudziko epanyama senge kusazvibata kufamba uye mhasuru mhasuru

Cisapride

Cisapride (Propulsid) inoshanda pane serotonin receptors mudumbu. Iyo yainyanyo shandiswa kuvandudza mhasuru toni muLES. Nekudaro, nekuda kwemhedzisiro yayo, senge isina kujairika kurova kwemoyo, yakabviswa pamusika munyika dzinoverengeka, kusanganisira United States. Iyo yaimboonekwa seinobudirira pakurapa GERD seH2 receptor blockers senge famotidine (Pepcid). Cisapride ichiri kungoshandiswa mukurapa kwezvipfuyo.

Metoclopramide

Metoclopramide (Reglan) prokinetic mumiriri iyo yakashandiswa kurapa GERD nekuvandudza mhasuru chiito mudumbu. Inowanikwa mune ese mahwendefa uye mafomu emvura. Kufanana nemamwe prokinetics, kushanda kwemetoclopramide kunokanganiswa nemhedzisiro yakakomba.

Zvimwe zvinokanganisa zvinogona kusanganisira kuwedzera njodzi yemamiriro etsinga senge tardive dyskinesia, iyo inokonzeresa kusadzokorora kwekufamba. Iyi mhedzisiro yakave ichizivikanwa kuti inoitika kune vanhu vanogara pamushonga kweinopfuura mwedzi mitatu. Vanhu vanotora metoclopramide vanofanirwa kungwarira zvakanyanya pavanotyaira kana kushandisa michina inorema kana michina.

Shanda nachiremba wako kuti uone chirongwa chekurapa chakakukodzera. Ita shuwa iwe uteedzere mafambiro aunopihwa nachiremba wako. Dana chiremba wako kana iwe uchinzwa sekuti mishonga yako yakonzera zvakashata mhedzisiro.