Mishonga ye psoriasis: mafuta uye mapiritsi

Zvemukati

• Musoro mishonga (makirimu nemafuta)
• 1. Corticoids
• 2. Calcipotriol
• 3. Zvinyoro-nyoro uye zvinogutsa
• Systemic chiito mishonga (mahwendefa)
• 1. Acitretin
• 2. Methotrexate
• 3. Cyclosporine
• 4. Biological vamiririri

Psoriasis chirwere chisingaperi uye chisingarapike, zvisinei, zvinokwanisika kudzikisira zviratidzo uye kuwedzera kuregererwa kwechirwere kwenguva yakareba pamwe nekurapwa kwakakodzera.

Kurapa kwe psoriasis kunoenderana nerudzi, nzvimbo uye kukura kwezvironda, uye zvinogona kuitwa nemakirimu kana mafuta ekuzora ane corticosteroids uye retinoids kana mishonga yemumuromo, se cyclosporine, methotrexate kana acitretin, semuenzaniso, pane kurudziro yechiremba.

Pamusoro pekurapwa kwemishonga, zvakakoshawo kuti unyorove ganda zuva nezuva, kunyanya matunhu akanganisa, pamwe nekudzivirira zvigadzirwa zvinokonzeresa zvinokonzeresa kutsamwa kweganda uye kuoma kwakanyanya.

Mimwe mishonga iyo inowanzo gadzwa nachiremba kurapwa kwe psoriasis ndeiyi:

Musoro mishonga (makirimu nemafuta)

1. Corticoids

Musoro wecorticosteroids unoshanda pakurapa zviratidzo, kunyanya kana chirwere ichi chichiganhurirwa kudunhu diki, uye chinogona kusanganiswa necalcipotriol uye systemic zvinodhaka.

Mimwe mienzaniso yetopical corticosteroids inoshandiswa pakurapa psoriasis ndeye clobetasol cream kana 0.05% capillary solution uye dexamethasone cream 0.1%, semuenzaniso.

Ndiani asingafanire kushandisa: vanhu vane hypersensitivity kune izvo zvikamu, vane maronda eganda anokonzerwa nemavhairasi, fungi kana bhakitiriya, vanhu vane rosacea kana vasingadzorwe perioral dermatitis.

Zvinogona kuitika mhedzisiro: kuvaviwa, kurwadziwa uye kupisa paganda.

2. Calcipotriol

Calcipotriol yakafanana nevhithamini D, iyo pahuwandu hwe0.005% inoratidzirwa pakurapa psoriasis, nekuti inobatsira pakudzikisira kwekuumbwa kweporiori plaque. Muzviitiko zvakawanda, calcipotriol inoshandiswa pamwe chete necorticosteroid.

Ndiani asingafanire kushandisa: vanhu vane hypersensitivity kune izvo zvinhu uye hyperkalaemia.

Zvinogona kuitika mhedzisiro: kutsamwa kweganda, kuputika, kurira, keratosis, kuvaviwa, erythema uye kusangana dermatitis.

3. Zvinyoro-nyoro uye zvinogutsa

Emollient makirimu uye mafuta anofanirwa kushandiswa mazuva ese, kunyanya sekurapa kwekuchengetedza mushure mekushandisa kwecorticosteroids, iyo inobatsira kudzivirira kudzokororazve kune vanhu vane psoriasis nyoro.

Aya makirimu uye mafuta ekuzora anofanirwa kuve neurea mune zvinokamuraniswa zvinogona kusiyana pakati pe5% kusvika 20% uye / kana salicylic acid muzvikamu zviri pakati pe3% uye 6%, zvinoenderana nerudzi rweganda uye huwandu hwezviyero.

Systemic chiito mishonga (mahwendefa)

1. Acitretin

Acitretin ndeye retinoid inowanzo kuratidzwa kurapa kwakakomba mafomu e psoriasis pazvinofanirwa kudzivirira immunosuppression uye inowanikwa mune doses ye10 mg kana 25 mg.

Ndiani asingafanire kushandisa: vanhu vane hypersensitivity kune izvo zvikamu, vakadzi vane nhumbu nevakadzi vanoshuvira kuve nepamuviri mumakore anotevera, vakadzi vanonwisa uye vanhu vane chiropa chakakomba kana itsvo kukundikana

Zvinogona kuitika mhedzisiro: musoro, kuoma uye kuzvimba kweiyo mucous membranes, yakaoma muromo, nyota, thrush, gastrointestinal kusagadzikana, cheilitis, kuvaviwa, kurasikirwa nevhudzi, kubvunda mumuviri wese, kurwadziwa kwemhasuru, kuwedzerwa ropa cholesterol uye triglycerides uye generalized edema.

2. Methotrexate

Methotrexate inoratidzirwa pakurapa kwakasimba psoriasis, sezvo ichideredza kuwanda uye kuzvimba kwemasero eganda. Mushonga uyu unowanikwa mune 2.5 mg mapiritsi kana 50 mg / 2mL ampoules.

Ndiani asingafanire kushandisa: vanhu vane hypersensitivity kune izvo zvikamu, vakadzi vane pamuviri uye vanokamwisa, vanhu vane cirrhosis, chirwere cheethyl, chiropa chinoshanda, kutadza kwechiropa, hutachiona hwakakomba, immunodeficiency syndromes, aplasia kana musana hypoplasia, thrombocytopenia kana anemia yakakosha uye chakanyanya gastric ulcer.

Zvinogona kuitika mhedzisiro: kurwadziwa nemusoro kwakakomba, kuomesa kwemutsipa, kurutsa, kupisa muviri, kutsvuka kweganda, kuwedzera uric acid, kudzikisira huwandu hwehurume muvarume, thrush, kuzvimba kwerurimi uye matadza, manyoka, yakaderedza chena yeropa masero uye platelet kuverenga, itsvo kutadza uye pharyngitis.

3. Cyclosporine

Cyclosporine mushonga unodzivirira muviri unoratidzwa kurapa psoriasis zvine mwero, uye haifanire kupfuura makore maviri ekurapwa.

Ndiani asingafanire kushandisa: vanhu vane hypersensitivity kune izvo zvinoriumba, zvakanyanya hypertension, kusagadzikana uye kusadzora nemishonga, inoshanda hutachiona nekenza.

Zvinogona kuitika mhedzisiro: itsvo kusagadzikana, neBP uye kushaya simba immune system.

4. Biological vamiririri

Mumakore achangopfuura, kufarira kuvandudza mamakemikari anoverengeka ane immunosuppressive zvivakwa ayo ari kunyanya kusarudza kupfuura cyclosporine yakawedzera kuitira kuti ivandudze chimiro chechengetedzo che psoriasis zvinodhaka.

Mimwe mienzaniso yezvinhu zvipenyu zvichangobva kugadzirirwa kurapwa kwe psoriasis ndeiyi

• Adalimumab;
• Etanercept;
• Infliximab;
• Ustecinumab;
• Secukinumab.

Iyi kirasi nyowani yemishonga ine mapuroteni kana monoclonal antibodies anogadzirwa nezvipenyu, kuburikidza nekushandisa recombinant biotechnology, iyo yakaratidza kuvandudzika kwezvironda uye kudzikira mukuwedzera kwayo.

Ndiani asingafanire kushandisa: vanhu vane hypersensitivity kune izvo zvinoriumba, vane kutadza kwemoyo, demyelinating chirwere, nhoroondo yazvino yeNeoplasia, hutachiona hunoshanda, kushandiswa kweanorarama akadzivirirwa uye majekiseni epamuviri.

Zvinogona kuitika mhedzisiro: jekiseni saiti kusagadzikana, kutapukirwa, tibhii, kugadziriswa kweganda, neoplasms, kuora mwoyo kwehosha, kutemwa nemusoro, dzungu, manyoka, kuvaviwa, kurwadziwa kwemhasuru uye kuneta.