Zvinorevei SVR Kune Vanhu vane Hepatitis C?

Zvemukati

• Mimwe mhinduro dzevirologic
• Maitiro ekuita SVR
• Ko genotypes inoenderana sei neSVR?
• Yemazuva ano HCV mishonga
• Ko kana usinga zadzise SVR?
• Outlook
• Vaka network yekutsigira

Chii chinonzi SVR?

Chinangwa che hepatitis C kurapwa ndechekubvisa ropa rako kubva kune hepatitis C hutachiona (HCV).Panguva yekurapwa, chiremba wako anozotarisa huwandu hwehutachiona muropa rako (hutachiona huwandu). Kana hutachiwana hwacho husisakwanise kuonekwa, inonzi mhinduro ye virologic, zvinoreva kuti kurapwa kwako kuri kushanda.

Iwe ucharamba uchingogara uine kuongororwa kweropa nguva nenguva kuti utarise chero RNA inoonekwa, iyo genetic zvinhu zvehutachiona hweH hepatitis C. Yakagadziriswa virologic mhinduro (SVR) inoitika kana bvunzo dzako dzeropa dzichienderera dzichiratidza kuti hapana RNA inoonekwa mumasvondo gumi nemaviri kana kupfuura mushure mekurapwa.

Nei SVR ichidikanwa? Nekuti 99 muzana yevanhu vanowana SVR vanoramba vasina hutachiona kwehupenyu hwese uye vanogona kunzi vanorapwa.

Paunenge wawana SVR, hausisina hutachiona muhurongwa hwako, saka haufanire kunetseka nezve kutapurira hutachiona kune mumwe munhu. Mushure meSVR, chiropa chako hachisisiri kurwiswa. Asi kana iwe watove wakatsigira kumwe kukuvara kwechiropa, ungangoda kumwe kurapwa.

Ropa rako rinogara riine hepatitis C antibodies. Izvo hazvireve kuti haugone kutapurirwazve. Iwe unofanirwa kutora matanho ekudzivirira kuti usapinda pamatambudziko mazhinji eHCV.

Mimwe mhinduro dzevirologic

Nguva nenguva kuongororwa kweropa kunoongorora kushanda kwerapi. Mazwi anoshandiswa kutsanangura virologic mhinduro anogona kunge akavhiringidza zvishoma.

Heino runyorwa rwemashoko akajairwa uye zvadzinoreva.

• SVR12. Apa ndipo apo bvunzo dzako dzeropa dzinoratidza yakasimba virologic mhinduro (SVR), kana pasina huwandu hunowanikwa hweHCV, mushure memasvondo gumi nemaviri ekurapwa. Panguva ino, unofungidzirwa kuti wakaporeswa pahepatitis C. Mucherechedzo wemushonga waimbove SVR24, kana kuti hapana huwandu hunowanikwa hweHCV muropa rako mushure memavhiki makumi maviri nemana ekurapwa. Asi nemishonga yemazuva ano, SVR12 yave kutorwa seyakarapa chiratidzo.
• SVR24. Apa ndipo apo bvunzo dzako dzinoratidza yakasimba virologic mhinduro (SVR), kana pasina inoonekwa huwandu hweHCV muropa rako, mushure memasvondo makumi maviri nemana ekurapwa. Izvi zvaiwanzo kuve muyero wekurapa, asi nemishonga mitsva yemazuva ano, SVR12 ikozvino yawanzo kutarisirwa semushonga.
• Kupindura zvishoma. Huwandu hweHCV hwakadzika panguva yekurapwa, asi hutachiona hunowonekwa muropa rako.
• Kusaterera kana kupindura zvisina basa. Iko kushomeka kana kushomeka muhutachiona hweHCV semhedzisiro yekurapwa.
• Kudzokazve. Hutachiona hwanga husingaonekwe muropa rako kwekanguva, asi hwakaonekwa zvakare. Kudzoka kwaro kunogona kuitika panguva kana mushure mekurapwa. Chiremba wako achakubatsira iwe kusarudza pane dzimwe nzira dzekurapa.

Maitiro ekuita SVR

Kune nzira dzinoverengeka dzekusvika pakurapwa. Izvo zvinogona kunge zvichisanganisira musanganiswa wemishonga, mazhinji acho izvo zvasanganiswa kuita mapiritsi rimwe chete. Saka unogona kutora piritsi rimwe chete pazuva.

Chiremba wako anokurudzira regimen yakavakirwa pane yako:

• zera uye hutano hwakakwana
• yakatarwa hepatitis genotype
• huwandu hwekukuvara kwechiropa, kana paine
• kugona kutevedzera marapirwo
• mhedzisiro yemhedzisiro

Kuunzwa kweakananga-kuita antiviral madhiragi (DAAs) muna 2011 kwakachinja zvachose kurapwa kwechirwere cheshuga C.

Izvi zvisati zvaitika, kurapwa kwaiwanzonyanya majekiseni emishonga inonzi interferon uye ribavirin, pamwe nemimwe mishonga mufomu yepiritsi. Kurapa kwaiwanzo kusashanda, uye mhedzisiro, kusanganisira kushushikana, kusvotwa, uye kupererwa neropa, zvaive zvakakomba.

Muna 2014, yechipiri wave yeanonyanya kushanda maDAA akaunzwa. Iyi mitsva yemishonga inorwisa hutachiona yakava musimboti wekurapa kwemazuva ano kwechirwere cheshuga C muUnited States. Vanorwisa hutachiona zvakananga uye vanoshanda zvakanyanya kupfuura iyo yekutanga mishonga.

MaDAA matsva anogona kutorwa nemuromo, kazhinji mupiritsi rimwe zuva nezuva. Ivo vane mashoma mhedzisiro, anowedzera ekurapa mitengo, uye akaderedzwa nguva yekurapa pane mamwe madhiragi emishonga emakore mashanu chete apfuura.

Chechipiri-wave maDAA anokwanisa zvakare kurapa yakafara nhanho yeanomwe anozivikanwa ehepatitis C genotypes, kana mageneral strains. Mamwe emaDAA matsva anogona kubata ese genotypes nekubatanidza akasiyana mapiritsi mumapiritsi kunongedza akasiyana genotypes.

Mimwe yekutanga-wave maDAA achiri kushandiswa musanganiswa ne interferon ne roburin, asi mazhinji echipiri-wave maDAA anoshandiswa ega.

Ivhareji yekurapa mwero, kana SVR, yemazuva ano maDA regimens izvozvi ingangoita 95 muzana yakazara. Uyu mwero unowanzo kuve mukuru kune vanhu vasina cirrhosis, kana vanga, rechiropa uye vasina kumbobvira varapwa hepatitis C yapfuura.

Kubva pakuwedzeredzwa kwemaDAA anoshanda kubvira 2014, mamwe emaawa ekutanga-wave maDAA akapererwa nenguva, uye vagadziri vavo vakaabvisa pamusika.

Izvi zvinosanganisira chinodhaka Olysio (simeprevir), chakamiswa muna Chivabvu 2018, uye zvinodhaka Technivie (ombitasvir / paritaprevir / ritonavir) uye Viekira Pak (ombitasvir / paritaprevir / ritonavir plus dasabuvir), iyo yakamiswa muna Ndira 1, 2019.

Ese maDAA mubatanidzwa wemishonga. Masayendisiti akaona kuti kusanganisa mishonga inotarisana nehutachiona zvakasiyana kunogona kuwedzera mukana wekurapa. Vanhu vari kurapwa kazhinji vanonwa mapiritsi akasiyana siyana, kunyangwe marapirwo mazhinji izvozvi achisanganisira piritsi rimwe chete rinosangana nemishonga yakasiyana siyana. Vanowanzo tora mishonga kwevhiki gumi nemaviri kusvika makumi maviri nemana, kana kupfuura.

Chiremba wako achakubatsira kusarudza pamushonga wako wemishonga, zvinoenderana neyako nhoroondo yezvekurapa uye hepatitis C genotype yauinayo. Hapana mushonga unowanikwa wehepatitis C sezvo uripo wehepatitis A uye B.

Ko genotypes inoenderana sei neSVR?

Hepatitis C mishonga inowanzo kuverengerwa neiyo genotype yehutachiona iyo yavakagadzirirwa kurapa. Iyo genotype yakasarudzika yemhando yehutachiona iyo inogadzirwa sehutachiona hunoshanduka.

Ikozvino pane manomwe anozivikanwa HCV genotypes, pamwe anozivikanwa madiki mukati meaya majenotypes.

Genotype 1 ndiyo yakajairika muUnited States, ichikanganisa vangangoita 75 muzana yevaAmerican vane HCV. Genotype 2 ndiyo yechipiri yakajairika, ichikanganisa makumi maviri kusvika makumi maviri muzana muzana yevaAmerican vane HCV. Vanhu vanobata genotypes 3 kusvika ku7 kazhinji vari kunze kweUnited States.

Mimwe mishonga inobata zvese kana zvakawanda zveHCV genotypes, asi mimwe mishonga inotarisa imwe chete genotype. Kunyatsoenzanisa mishonga yako kune genotype yehutachiona hweHCV kunogona kukubatsira kuti uwane SVR.

Chiremba wako achakuedza kuti uone genotype yako yeHCV hutachiona, iyo inonzi genotyping. Mishonga marongero uye dosing mashedhi akasiyana akasiyana ejenotypes.

Yemazuva ano HCV mishonga

Kutevera rondedzero yemimwe yemazuva ano antiviral mishonga inowanzo shandiswa kurapa hepatitis C, yakarongedzwa muchidimbu. Unogona kuwana rumwe ruzivo rwakadzama nezve iripo HCV mishonga pano.

Ruzivo mune irworwo pazasi rwunotorwa kubva kune iyo inogamuchirwa hepatitis C mishonga. Iro zita rechiratidzo remushonga wega wega rinoteverwa nemazita akajairika ezvinoumba.

Vagadziri vemishonga iyi vanowanzopa ruzivo rwakadzama uye zvirevo zvekushanda kwemajenotype ekuwedzera pane avo mawebhusaiti. Chiremba wako anogona kukubatsira kuti uongorore ruzivo urwu. Zvimwe zvacho zvinogona kunge zvichishanda, nepo zvimwe zvacho zvingawedzeredzwa kana kuti zvisiri zvemamiriro ako.

Ive neshuwa yekukurukura nachiremba wako kuti ndeapi mishonga akakukodzera iwe kuti ikubatsire iwe kuenda kuSVR.

• Daklinza (daclatasvir). Kazhinji inosanganiswa ne sofosbuvir (Sovaldi). Yakagamuchirwa muna2015 kurapa genotype 3. Kurapa kunowanzo kuve vhiki gumi nembiri.

• Ko kana usinga zadzise SVR?

  Haasi munhu wese anosvika kuSVR. Mhedzisiro yakakomba inogona kukonzera kuti iwe umire kurapwa nekukurumidza. Asi vamwe vanhu havangopindure, uye hazviwanzo kujekesa nei. Chiremba wako anogona kukurudzira kuti iwe uyedze musanganiswa wakasiyana wemishonga.

  Kunyangwe iwe ukasasvika kuSVR, aya marapiro anogona kubatsira kudzora hutachiona uye kubatsira chiropa chako.

  Kana usiri kuzoedza imwe antiviral drug chero chikonzero, haufanire kuda kuwedzera hutachiona kuyerwa. Asi iwe uchiri uine hutachiona hunoda kutariswa. Izvi zvinoreva kuongororwa kweropa nguva dzose uye bvunzo dzechiropa. Nekushanda padhuze nachiremba wako, unogona kukurumidza kugadzirisa chero matambudziko anomuka.

  Kana iwe wakamboedza akati wandei ekurapa pasina kubudirira, ungangoda kufunga nezvekunyorera kukiriniki kutongwa. Iyi miedzo dzimwe nguva inokutendera iwe kuyedza mishonga mitsva iyo ichiri muchikamu chekuyedza. Kliniki miedzo inowanzo kuve nemitemo yakasimba, asi chiremba wako anofanira kukwanisa kupa rumwe ruzivo.

  Outlook

  Kunyangwe iwe usina zviratidzo zvakawanda izvozvi, hepatitis C chirwere chisingaperi. Saka zvakakosha kuti utarisire hutano hwako hwese, uchinyanya kutarisisa chiropa chako. Ita hutano hwako hukuru hwako hwepamusoro.

  Unofanira:

  • Chengetedza hukama hwakanaka nachiremba wako. Mhan'ara zviratidzo zvitsva ipapo, kusanganisira kushushikana uye kushushikana. Tarisa nachiremba wako usati watora mishonga mitsva kana zvinowedzera, sezvo zvimwe zvinogona kukuvadza chiropa chako. Chiremba wako anogona zvakare kukuzivisa iwe nezvekufambira mberi kwekurapa.
  • Idya kudya kwakaringana. Kana iwe uchinetseka neizvi, bvunza chiremba wako kuti akurudzire nyanzvi yezvokudya kuti akutungamirire munzira kwayo.
  • Gara uchiekisesaiza. Kana jimu isiri yako, kunyangwe kufamba kwezuva nezuva kunobatsira. Zvinogona kuve nyore kana iwe ukawana shamwari yekurovedza.
  • Wana kurara zvakakwana usiku. Kupisa kenduru kumicheto miviri kunotora muhombe mukuru pamuviri wako.
  • Usanwa. Doro rinokuvadza kuchiropa chako, saka zviri nani kuti urege.
  • Usapute. Dzivisa zvigadzirwa zvefodya nekuti zvinokanganisa hutano hwako.

  Vaka network yekutsigira

  Kugara neyakagara mamiriro kunogona kunge uchiedza dzimwe nguva. Kunyangwe hama dzepedyo neshamwari vanogona kunge vasingazive nezvekunetseka kwako. Kana vanogona kusaziva zvekutaura. Saka tora pamusoro pako kuvhura nzira dzekutaurirana. Kumbira rutsigiro rwepfungwa uye rubatsiro runoshanda paunenge uchirida.

  Uye yeuka, hausi wega. Vanopfuura mamirioni matatu vanhu muUnited States vari kurarama nechirwere cheshuga C.

  Funga kujoinha online kana in-munhu rutsigiro boka kuti iwe ugone kubatana nevamwe vanonzwisisa zvauri kupfuura nazvo. Mapoka ekutsigira anogona kukubatsira kufamba neruzivo uye zviwanikwa zvinogona kuita mutsauko une musoro muhupenyu hwako.

  Zvinogona zvakare kukonzera kusingaperi, hukama hunobatsira. Iwe unogona kutanga kutsvaga rutsigiro uye munguva pfupi uzviwane iwe mune chinzvimbo chekubatsira vamwe.