Chii chakakosha thrombocythemia, zviratidzo, kuongororwa uye maitiro ekurapa

Zvemukati

• Zviratidzo zvikuru
• Inokosha kenza yeprombocythemia?
• Maitiro ekuongororwa kunoitwa
• Kurapa kweakakosha thrombocythemia

Yakakosha thrombocythemia, kana TE, chirwere chehematological chinoonekwa nekuwedzera kwehuwandu hweplatelets muropa, izvo zvinowedzera mukana we thrombosis nekubuda ropa.

Ichi chirwere chinowanzo asymptomatic, ichiwanikwa chete mushure mekujairwa kweropa. Nekudaro, kuongororwa kwacho kunosimbiswa nachiremba mushure mekusiya zvimwe zvinokonzeresa zvekuwedzera kwemaplatelet, senge kushomeka kwesimbi, semuenzaniso.

Kurapa kunowanzoitwa nemishonga inokwanisa kudzikisa huwandu hwemaplatelet muropa uye kudzikisa njodzi ye thrombosis, uye inofanirwa kushandiswa sekurairwa nachiremba mukuru kana wehematologist.

Zviratidzo zvikuru

Yakakosha thrombocythemia inowanzo asymptomatic, ichicherechedzwa chete mushure mekuve neropa rakazara kuverenga, semuenzaniso. Nekudaro, zvinogona kukonzeresa zvimwe zviratidzo, makuru acho ari:

• Kupisa kwekunzwa mumakumbo nemaoko;
• Splenomegaly, ndiko kuwedzera kwepleen;
• Kurwadziwa pachifuva;
• Kudikitira;
• Kushaya simba;
• Kurwadziwa nemusoro;
• Kupofumadza kupofomara, kungave kusarura kana kukwana;
• Kuonda.

Uye zvakare, vanhu vanoonekwa kuti vane yakakosha thrombocythemia vari panjodzi yekuwedzera ye thrombosis uye kubuda ropa. Chirwere ichi chinowanzoitika muvanhu vanodarika makumi matanhatu, asi chinogonawo kuitika kuvanhu vari pasi pemakumi mana.

Inokosha kenza yeprombocythemia?

Inokosha thrombocythemia haisi kenza, nekuti hapana kuwanda kwemasero akaipa, asi masero akajairwa, mune iyi kesi, maplatelet, anoratidzira mamiriro e thrombocytosis kana thrombocytosis. Chirwere ichi chinoramba chakadzikama kweanenge makore gumi kusvika makumi maviri uye chine mwero wakaderera wekushanduka kweropa, pasi pe5%.

Maitiro ekuongororwa kunoitwa

Kuongororwa kunoitwa nachiremba mukuru kana wehematologist zvichienderana nezviratidzo nezvakaratidzwa nemurwere, pamusoro pemhedzisiro yekuongororwa kwerabhoritari. Izvo zvakakoshawo kusabvisa zvimwe zvikonzero zveakawedzera maplatelet, senge kuzvimba kwezvirwere, myelodysplasia uye kushomeka kwesimbi, semuenzaniso. Ziva zvikonzero zvikuru zvekuwedzera kweplatelet.

Rabhoritari kuongororwa kweakakosha thrombocythemia kunoitwa kutanga kuburikidza nekuongororwa kweiyo huwandu hweropa, umo kuwedzera kwemaplatelet kunoonekwa, ine kukosha kwakapfuura mazana mana mazana mana ezviuru zvemaplatelets / mm³ eropa. Kazhinji, iyo platelet kusungwa kunodzokororwa pamazuva akasiyana kuti uone kana kukosha kuchiramba kuchiwedzera.

Kana maplatelet akatsigirwa, kuongororwa kwemajini kunoitiswa kuti kuvepo kweshanduko ingangodaro inoratidza kukosha kweiyo thrombocythemia, iyo JAK2 V617F mutation, iyo irimo mune anopfuura makumi mashanu muzana evarwere. Kana kuvepo kweiyi shanduko kwasimbiswa, zvakafanira kusabvisa kuitika kwezvimwe zvirwere zvinotyisa uye kutarisa zviwanikwa zvine iron iron.

Mune zvimwe zviitiko, bone marrow biopsy inogona kuitwa, umo kuwedzera kwekusungwa kwemamegakaryocyte, ayo ari anotungamira masero eropa emaplatelet, anogona kucherechedzwa.

Kurapa kweakakosha thrombocythemia

Kurapa kweakakosha thrombocythemia kunovavarira kudzikisa njodzi ye thrombosis uye kubuda ropa, uye zvinowanzo kurudzirwa nachiremba kushandisa mishonga kudzikisa huwandu hwemaplatelet muropa, senge Anagrelide uye Hydroxyurea, semuenzaniso.

Hydroxyurea ndiwo mushonga unowanzokurudzirwa kuvanhu vanofungidzirwa kunge vari panjodzi huru, kureva kuti, vane makore anodarika makumi matanhatu ekuberekwa, vakave nechikamu chetrombosis uye vane platelet count pamusoro pe1500000 / mm³ yeropa. Nekudaro, uyu mushonga une mimwe mhedzisiro, senge hyperpigmentation yeganda, kuda kurutsa uye kurutsa.

Kurapa kwevarwere kunoonekwa sengozi yakaderera, vari avo vari pasi pemakore makumi mana ekuberekwa, kazhinji kunoitwa neacetylsalicylic acid zvinoenderana nekutungamira kwese general chiremba kana hematologist.

Uye zvakare, kudzikisa njodzi yetrombosis zvakakosha kuti usapute uye ubate zvinokwanisika hosha, dzakadai sehypertension, kufutisa uye chirwere cheshuga, sezvo vachiwedzera njodzi yetrombosis. Ziva zvekuita kudzivirira thrombosis.