Alpha-1 antitrypsin kushomeka

Alpha-1 antitrypsin (AAT) kushomeka chiitiko umo muviri usingaite zvakakwana yeAAT, puroteni inodzivirira mapapu nechiropa kubva mukukuvara. Mamiriro acho anogona kutungamira kuCOPD uye chirwere chechiropa (cirrhosis).

AAT rudzi rweprotein inonzi protease inhibitor. AAT inogadzirwa muchiropa uye inoshanda kudzivirira mapapu nechiropa.

Kushomeka kweAAT kunoreva kuti hakuna kukwana kweichi protein mumuviri. Izvo zvinokonzerwa nehurema hwechibereko. Mamiriro acho akajairika pakati pevokuEurope neNorth America vekuEurope.

Vakuru vane kushaikwa kwakanyanya kweAAT vanozoita emphysema, dzimwe nguva vasati vasvika makore makumi mana ekuberekwa. Kusvuta kunogona kuwedzera njodzi yeemphysema uye kuita kuti zviitike pakutanga.

Zviratidzo zvinogona kusanganisira chero zvinotevera:

• Kufema kwekufema pamwe uye pasina kushingairira, uye zvimwe zviratidzo zveCOPD
• Zviratidzo zvekutadza kwechiropa
• Kurasikirwa nehuremu pasina kuyedza
• Kushungurudza

Kuongorora kwepanyama kunogona kuratidza chipfuva chakaita kunge dhiramu, kufema, kana kudzikisira kurira kwemhepo. Iyi miedzo inotevera inogona zvakare kubatsira pakuongorora:

• AAT kuongorora ropa
• Arterial eropa magasi
• Chest x-ray
• CT scan yechifuva
• Kuongorora genetic
• Lung basa bvunzo

Mutapi wako wezvehutano anogona kukufungidzira kuti une mamiriro aya kana iwe ukagadzira:

• COPD isati yasvika makore makumi mana nemashanu
• COPD asi iwe hauna kumbobvira wasvuta kana kuve pachena kune chepfu
• COPD uye iwe une nhoroondo yemhuri yemamiriro acho
• Cirrhosis uye hapana chimwe chikonzero chinogona kuwanikwa
• Cirrhosis uye iwe une nhoroondo yemhuri yechiropa chirwere

Kurapa kwekushomeka kweAAT kunosanganisira kutsiva iyo isina kuwanikwa AAT protein. Protein inopihwa kuburikidza netsinga vhiki imwe neimwe kana vhiki ina dzese. Izvi zvinongoshanda zvishoma pakudzivirira kukuvara kwemapapu kune vanhu vasina chirwere chekupedzisira. Iyi nzira inonzi yekuwedzera kurapa.

Kana iwe uchisvuta, unofanirwa kurega.

Mimwe mishonga inoshandiswawo kuCOPD uye cirrhosis.

Kuisa mapapu kunogona kushandiswa pachirwere chakakomba chemapapu, uye kuisirwa kwechiropa kunogona kushandiswa pakurwara kwakanyanya kwechirrhosis.

Vamwe vanhu vane uku kushomeka havazogadziri chirwere cheropa kana chemapapu. Kana iwe ukarega kuputa, iwe unogona kudzora kufambira mberi kwechirwere chemapapu.

COPD uye cirrhosis inogona kutyisidzira hupenyu.

Matambudziko ekushomeka kweAAT anosanganisira:

• Bronchiectasis (kukuvara kwemahara makuru emhepo)
• Chirwere chisingaperi chinodzivirira pulmonary chirwere (COPD)
• Chiropa kutadza kana gomarara

Bata mupi wako kana iwe ukaita zviratidzo zvekushomeka kweAAT.

Kushomeka kweAAT; Alpha-1 kushomeka kweprotease; COPD - alpha-1 antitrypsin kushomeka; Cirrhosis - alpha-1 antitrypsin kushomeka

• Mapapu
• Chiropa anatomy

Han MK, Razaro SC. COPD: kliniki kuongororwa uye manejimendi. Mune: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray naNadel Chinyorwa cheRefiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits 44.

Hatipoglu U, Mutambi JK. a1 -antitrypsin kushomeka. Kliniki Chest Med. 2016; 37 (3): 487-504. PMID: 27514595 www.pubmed.ncbi.nlm.nih.gov/27514595/.

Winnie GB, Boas SR. a1 -antitrypsin kushomeka uye emphysema. Mune: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Chinyorwa chePediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020: chap 421.