Zvinodhaka-zvinokonzerwa lupus erythematosus

Zvinodhaka-zvinokonzerwa lupus erythematosus chirwere che autoimmune chinokonzereswa nekuita kumushonga.

Zvinodhaka-zvinoita lupus erythematosus yakafanana asi haina kufanana ne systemic lupus erythematosus (SLE). Iyo autoimmune kusagadzikana. Izvi zvinoreva kuti muviri wako unorwisa hutano hwakanaka nekutadza. Izvo zvinokonzerwa nekuita kumushonga. Mamiriro akafanana ane zvinodhaka-zvinokamurwa cutaneous lupus uye zvinodhaka-zvinokonzereswa ANCA vasculitis.

Iyo inonyanya kuzivikanwa mishonga inozivikanwa yekukonzera zvinodhaka-inosimudzira lupus erythematosus ndeiyi:

• Isoniazid
• Hydralazine
• Procainamide
• Tumor-necrosis factor (TNF) alpha inhibitors (senge etanercept, infliximab uye adalimumab)
• Minocycline
• Quinidine

Mimwe mishonga isinganyanyozivikanwa inogona kukonzera mamiriro acho. Izvi zvinogona kusanganisira:

• Mishonga yekudzivirira kubata
• Capoten
• Chlorpromazine
• Methyldopa
• Sulfasalazine
• Levamisole, kazhinji sechinhu chinosvibisa checocaine

Kenza immunotherapy mishonga yakadai sepembrolizumab inogona zvakare kukonzera akasiyana siyana autoimmune reaction kusanganisira zvinodhaka-zvinokonzerwa lupus.

Zviratidzo zvezvinodhaka-zvinokonzerwa ne lupus zvinowanzoitika mushure mekutora mushonga kweinenge 3 kusvika kumwedzi mitanhatu.

Zviratidzo zvinogona kusanganisira:

• Kupindwa nechando
• Kazhinji kurwara kunzwa (malaise)
• Joint kurwadziwa
• Joint kuzvimba
• Kupererwa nechido
• Pleuritic chifuva kurwadziwa
• Kuputika kweganda munzvimbo dzakashongedzwa nezuva

Anopa hutano anoita bvunzo dzepanyama uye anoteerera chipfuva chako ne stethoscope. Iye mupi anogona kunzwa kurira kunodaidzwa kunzi kupesana kwemoyo kana kukwikwidza kukwikwidza rub.

Kuongorora kweganda kunoratidza kuputika.

Majoini anogona kunge achizvimba uye akapfava.

Miedzo inogona kuitwa inosanganisira:

• Antihistone antibody
• Antinuclear nyukiliya (ANA) pani
• Antineutrophil cytoplasmic antibody (ANCA) pani
  
• Yakazara kuverenga ropa (CBC) nemusiyano
• Yakakwana kemisitiri pani
• Kuongorora urinal

Bhokisi x-ray rinogona kuratidza zviratidzo zve pleuritis kana pericarditis (kuzvimba kwakatenderedza jira repapu kana moyo). ECG inogona kuratidza kuti moyo unokanganiswa.

Kazhinji yenguva, zviratidzo zvinopera mukati memazuva akati wandei kusvika mavhiki mushure mekumisa mushonga wakakonzera mamiriro acho.

Kurapa kunogona kusanganisira:

• Nonsteroidal anti-inflammatory drug (NSAIDs) kurapa arthritis uye pleurisy
• Corticosteroid makirimu ekurapa mapundu eganda
• Antimalarial zvinodhaka (hydroxychloroquine) kurapa ganda uye arthritis zviratidzo

Kana mamiriro ari kukanganisa moyo wako, itsvo, kana huta, unogona kupihwa madosi epamusoro ecorticosteroids (prednisone, methylprednisolone) uye immune system suppressants (azathioprine kana cyclophosphamide). Izvi hazviwanzo.

Kana chirwere ichi chave kushanda, unofanirwa kupfeka mbatya dzekudzivirira uye magirazi ezuva kudzivirira zuva rakawandisa.

Yakawanda yenguva, zvinodhaka-zvinokonzerwa ne lupus erythematosus haina kunyanyisa seSLE. Zviratidzo zvinowanzoenda mukati memazuva mashoma kusvika mavhiki mushure mekumisa mushonga wawanga uchitora. Kazhinji, kuzvimba kwetsvo (nephritis) kunogona kukura nemushonga-unokonzerwa nemushonga unokonzerwa neTNF inhibitors kana neANCA vasculitis nekuda kwehydralazine kana levamisole. Nephritis inogona kuda kurapwa ne prednisone uye immunosuppressive mishonga.

Dzivisa kutora mushonga uyo wakakonzera kuitika mune ramangwana. Zviratidzo zvinogona kudzoka kana ukadaro.

Zvinetso zvinogona kusanganisira:

• Utachiona
• Thrombocytopenia purpura - kubuda ropa padyo neganda pamusoro, zvichikonzerwa nenhamba shoma yemaplatelet muropa
• Hemolytic kupererwa neropa
• Myocarditis
• Pericarditis
• Nephritis

Fonera mupiki wako kana:

• Iwe unovandudza zviratidzo zvitsva kana uchitora chero yemishonga yakanyorwa pamusoro.
• Zviratidzo zvako hazviite zvirinani mushure mekumira kutora mushonga wakonzera mamiriro acho.

Tarisa uone zviratidzo zvekuita kana iwe uri kutora chero emamwe mishonga anogona kukonzera dambudziko iri.

Lupus - zvinodhaka zvinokonzerwa

• Lupus, discoid - maonero ezve maronda pachifuva
• Antibodies

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Dooley MA. Zvinodhaka-zvinoita lupus. Mune: Tsokos GC, ed. Yakarongeka Lupus Erythematosus. Cambridge, MA: Elsevier Dzidzo Press; 2016: chits.

Radhakrishnan J, Perazella MA. Chirwere-chinokonzera glomerular chirwere: kutarisirwa kunodiwa! Kliniki J Am Soc Nephrol. 2015; 10 (7): 1287-1290. PMID: 25876771 www.ncbi.nlm.nih.gov/pubmed/25876771.

Richardson BC. Zvinodhaka-zvinoita lupus. Mu: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7th ed. Philadelphia, PA: Elsevier; 2019: chitsiko 141.

Rubin RL. Zvinodhaka-zvinoita lupus. Nyanzvi Opin Drug Saf. 2015; 14 (3): 361-378. PMID: 25554102 www.ncbi.nlm.nih.gov/pubmed/25554102.

Vaglio A, Grayson PC, Fenaroli P, et al. Zvinodhaka-zvinokonzerwa lupus: echinyakare uye mitsva pfungwa. Autoimmun Zvak. 2018; 17 (9): 912-918. PMID: 30005854 www.ncbi.nlm.nih.gov/pubmed/30005854.