Zollinger-Ellison chirwere

Zollinger-Ellison syndrome mamiriro umo muviri unoburitsa zvakawandisa zvehomoni gastrin. Kazhinji yenguva, bundu diki (gastrinoma) mupancreas kana ura hudiki ndiyo sosi yekuwedzera gastrin muropa.

Zollinger-Ellison syndrome inokonzerwa nemamota. Uku kukura kunowanzo kuwanikwa mumusoro wepancreas uye mudumbu repamusoro dumbu. Mamota anonzi gastrinomas. Yakakwira mazinga egastrin anokonzeresa kugadzirwa kweakawanda dumbu acid.

Gastrinomas inoitika semamota asina kuroorwa kana mapundu akati wandei. Imwe hafu kusvika zviviri muzvitatu zvegastrinomas imwe chete ine cancer (yakaipa) mamota. Aya mamota anowanzopararira kuchiropa uye pedyo node node.

Vanhu vazhinji vane gastrinomas vane mamota akati wandei sechikamu chemamiriro anonzi akawanda endocrine neoplasia mhando I (MEN I). Tumota dzinogona kukura mupituitary gland (uropi) uye parathyroid gland (mutsipa) pamwe nepancreas.

Zviratidzo zvinogona kusanganisira:

• Marwadzo emudumbu
• Manyoka
• Kusvipa ropa (dzimwe nguva)
• Yakakura esophageal reflux (GERD) zviratidzo

Zviratidzo zvinosanganisira maronda mudumbu uye mudumbu ura.

Miedzo inosanganisira:

• Abdominal CT scan
• Calcium infusion bvunzo
• Endoscopic Ultrasound
• Kuvhiya kwekuongorora
• Gastrin reropa
• Octreotide scan
• Secretin kukurudzira bvunzo

Zvinodhaka zvinonzi proton pump inhibitors (omeprazole, lansoprazole, nezvimwe) zvinoshandiswa kurapa dambudziko iri. Iyi mishonga inoderedza kugadzirwa kweasidhi nedumbu. Izvi zvinobatsira maronda ari mudumbu uye dumbu ura kupora. Iyi mishonga inoderedza marwadzo emimba uye manyoka.

Kuvhiya kubvisa imwe gastrinoma kunogona kuitwa kana mamota asina kupararira kune dzimwe nhengo. Kuvhiya padumbu (gastrectomy) kudzora kugadzirwa kweasidhi hakuwanzo kudikanwa.

Mwero wekurapa wakaderera, kunyangwe kana ukawanikwa nekukurumidza uye bundu rinobviswa. Zvisinei, gastrinomas inokura zvishoma nezvishoma.Vanhu vane chirwere ichi vanogona kurarama kwemakore akawanda mushure mekunge bundu rawanikwa. Acid-inodzvinyirira mishonga inoshanda nemazvo kudzora zviratidzo.

Zvinetso zvinogona kusanganisira:

• Kukundikana kuwana iro bundu panguva yekuvhiyiwa
• Utumbo kubuda ropa kana gomba (kupera) kubva mumaronda mudumbu kana duodenum
• Manyoka akanyanya uye kuonda
• Kupararira kwebundu kune dzimwe nhengo

Fonera wako mupi wezvehutano kana iwe uine kurwadziwa kwakanyanya mudumbu kusingaendi, kunyanya kana kukaitika nemanyoka.

ZE chirwere; Gastrinoma

• Endocrine masero

Jensen RT, Norton JA, Oberg K. Neuroendocrine mamota. Muna: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger uye Fordtran's Gastrointestinal uye Chirwere Chiropa. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits. 33.

Vella A. Mahormoni emudumbu uye matumbu endocrine tumarara. Mune: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Chinyorwa cheEndocrinology. 13 ed. Philadelphia, PA: Elsevier; 2016: chitsiko 38.