Inozivikanwa Mediterranean fever

Kuzivikanwa kweMediterranean fever (FMF) chirwere chisingawanzoitika chakapfuura kuburikidza nemhuri (nhaka). Inosanganisira inodzokororwa nefivha uye kuzvimba izvo zvinowanzo kukanganisa mubato wedumbu, chipfuva, kana majoini.

FMF inowanzo kukonzereswa nekuchinja kwemajini anonzi MEFV. Iri geni rinogadzira protein inobatanidzwa mukudzora kuzvimba. Chirwere ichi chinoonekwa chete muvanhu vakagamuchira maviri makopi ejeni rakachinja, rimwe kubva kumubereki mumwe nemumwe. Izvi zvinodaidzwa kuti autosomal yakawandisa.

FMF inowanzo bata vanhu veMediterranean madzitateguru. Izvi zvinosanganisira vasiri maAshkenazi (Sephardic) maJuda, maArmenian, nemaArabu. Vanhu vanobva kumamwe marudzi emadzinza vanogona zvakare kukanganiswa.

Zviratidzo zvinowanzotanga pakati pemakore mashanu ne15. Kuzvimba mukati memukati medumbu, chifuva, ganda, kana majoini kunoitika pamwe chete nefivha yakakura iyo inowanzo kwira mumaawa gumi nemaviri kusvika makumi maviri nemana. Kurwiswa kunogona kusiyana mukuomarara kwezviratidzo. Vanhu kazhinji havana chiratidzo-pakati pekurwiswa.

Zviratidzo zvinogona kusanganisira zvakadzokororwa zvikamu zve:

• Marwadzo emudumbu
• Kurwadziwa pachifuva kwakapinza uye kunowedzera kana uchifema
• Fivha kana kuchinjanisa kutonhora uye kupisa
• Joint kurwadziwa
• Maronda eganda (maronda) akatsvuka uye kuzvimba uye anotangira pamasendimita mashanu kusvika makumi maviri

Kana kuongorora kwemajini kuchiratidza kuti iwe une MEFV gene mutation uye zviratidzo zvako zvinowirirana neyakajairika pateni, kuongororwa kwacho kunenge kuri kwechokwadi. Rabhoritari bvunzo kana x-mwenje inogona kutonga kunze zvimwe zvinokwanisika zvirwere kubatsira kuita kuongororwa.

Nhanho dzehumwe kuongororwa kweropa dzinogona kuve dzakakwira kupfuura zvakajairwa kana zvikaitwa panguva yekurwiswa. Miedzo inogona kusanganisira:

• Yakazara kuverenga kweropa (CBC) iyo inosanganisira chena masero eropa kuverenga
• C-inoshanda mapuroteni kutarisa kuzvimba
• Erythrocyte sedimentation rate (ESR) kutarisa kuzvimba
• Fibrinogen bvunzo yekutarisa kuvhara ropa

Chinangwa chekurapa cheFMF kudzora zviratidzo. Colchicine, mushonga unoderedza kuzvimba, unogona kubatsira panguva yekurwiswa uye unogona kudzivirira kumwe kurwiswa. Inogona zvakare kubatsira kudzivirira kusangana kwakakomba kunonzi systemic amyloidosis, iyo inozivikanwa kune vanhu vane FMF.

NSAID dzinogona kushandiswa kurapa fivhiri uye kurwadziwa.

Iko hakuna kurapwa kunozivikanwa kweFMF. Vanhu vazhinji vanoramba vachirwiswa, asi huwandu uye kuomarara kwekurwiswa kwakasiyana pamunhu nemunhu.

Amyloidosis inogona kutungamira kukuvara kweitsvo kana kusakwanisa kutora zvinovaka muviri kubva kuchikafu (malabsorption). Matambudziko ekubereka muvakadzi nevarume uye arthritis zvakare matambudziko.

Bata mupi wako kana iwe kana mwana wako muchikura zviratidzo zveichi chiitiko.

Inozivikanwa paroxysmal polyserositis; Periodic peritonitis; Dzokororo polyserositis; Benign paroxysmal peritonitis; Periodic chirwere; Periodic fever; FMF

• Kuyera kupisa

Verbsky JW. Hereditary periodic fever syndromes uye zvimwe zvehurongwa hwehutachiona hwehutachiona. Mune: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Chinyorwa chePediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020: chits. 188.

Shohat M. Anozivikanwa muMediterranean fever. Muna: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, eds. GeneReviews [Internet]. University of Washington, Seattle, WA: 2000 Aug 8 [yakagadziridzwa 2016 Dec 15]. PMID: 20301405 www.pubmed.ncbi.nlm.nih.gov/20301405/.