Chylomicronemia chirwere

Chylomicronemia syndrome chirwere umo muviri usaputsa mafuta (lipids) nenzira kwayo. Izvi zvinokonzeresa mafuta zvikamu zvinonzi chylomicrons kuvaka muropa. Hosha yacho inopfuudzwa kuburikidza nemhuri.

Chylomicronemia syndrome inogona kuitika nekuda kweyakajairika geni kusagadzikana uko protein (enzyme) inonzi lipoprotein lipase (LpL) yakaputsika kana kushayikwa. Inogona zvakare kukonzerwa nekushaikwa kwechipiri chinhu chinonzi apo C-II, iyo inoita kuti LpL ishandise. LpL inowanzo kuwanikwa mumafuta uye mhasuru. Inobatsira kuputsa mamwe lipids. Kana LpL ikashaikwa kana kuputswa, mafuta anorema anonzi chylomicrons anovaka muropa. Iyi buildup inonzi chylomicronemia.

Kukanganisa muapolipoprotein CII uye apolipoprotein AV kunogona kukonzera chirwere zvakare. Izvi zvinowanzoitika kana vanhu vakafanotarisirwa kuve nehupamhi triglycerides (sevaya vane mhuri yakabatana hyperlipidemia kana yemhuri hypertriglyceridemia) vanokura chirwere cheshuga, kufutisa kana kuratidzwa kune mimwe mishonga.

Zviratidzo zvinogona kutanga mucheche uye zvinosanganisira:

• Kusuruvara kwepamuviri nekuda kwepancreatitis (kuzvimba kwepancreas).
• Zviratidzo zvekukuvara kwetsinga, senge kurasikirwa kwekunzwa mutsoka kana makumbo, uye kurasikirwa ndangariro.
• Yero inochengeterwa mafuta zvinhu muganda zvinodaidzwa kuti xanthomas. Uku kukura kunogona kuoneka kumusana, kumagaro, pasi petsoka, kana pamabvi nemagokora.

Kuongorora kwepanyama uye bvunzo dzinogona kuratidza:

• Yakawedzera chiropa uye spleen
• Kuzvimba kwepancreas
• Mafuta anoisa pasi peganda
• Zvichida mafuta anoiswa mu retina yeziso

Chikamu chinotapira chichaonekwa kana ropa richitenderera mumuchina wevarabhoritari. Rukoko ichi kunokonzerwa chylomicrons muropa.

Iyo triglyceride nhanho yakanyanya kukwirira.

Chikafu chisina mafuta, chisina doro chinodiwa. Ungangoda kumira kutora mimwe mishonga inogona kuita kuti zviratidzo zviwedzere. Usarega kutora chero mushonga usati watanga kutaura nemupi wako wezvehutano. Mamiriro ezvinhu akadai sekushayiwa mvura uye chirwere cheshuga anogona kuita kuti zviratidzo zviwedzere. Kana ichionekwa, aya mamiriro anoda kurapwa uye kudzorwa.

Kudya-kusina mafuta kunogona kuderedza zviratidzo zvakanyanya.

Kana isina kurapwa, iyo yakawandisa chylomicrons inogona kutungamira kune mabhureki epancreatitis. Aya mamiriro anogona kuva anorwadza zvikuru uye kunyange kutyisidzira hupenyu.

Tsvaga kurapwa nguva pfupi kana uine kurwadziwa kwemudumbu kana zvimwe zviratidzo zvekuyambira kwepascreatitis.

Fonera mupi wako kana iwe uine yako pachako kana yemhuri nhoroondo yemazinga epamusoro e triglyceride.

Iko hakuna nzira yekudzivirira mumwe munhu kuti agare nhaka iyi chirwere.

Kuzivikanwa lipoprotein lipase kushomeka; Inozivikanwa hyperchylomicronemia syndrome, Type I hyperlipidemia

• Hepatomegaly
• Xanthoma pamabvi

Genest J, Libby P. Lipoprotein kusagadzikana uye chirwere chemoyo. Mune: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Chirwere Chemwoyo cheBraunwald: A Chinyorwa cheCardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019: chitsuwa 48.

Robinson JG. Kushushikana kwe lipid metabolism. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chits. 195.