Cushing syndrome nekuda kweadrenal bundu

Cushing syndrome inokonzerwa neadrenal tumor fomu yeCushing syndrome. Izvo zvinoitika apo bundu readrenal gland rinoburitsa yakawandisa huwandu hwehormoni cortisol.

Cushing syndrome idambudziko rinoitika kana muviri wako uine yakakwira kupfuura yakajairwa chikamu chehomoni cortisol. Iyi hormone inogadzirwa mune adrenal gland. Yakawandisa cortisol inogona kunge yakakonzerwa nematambudziko akasiyana siyana. Imwe yedambudziko rakadai bundu pane rimwe remadonal gland. Adrenal tumors inoburitsa cortisol.

Adrenal tumors hazviwanzo. Vanogona kunge vasina cancer (benign) kana cancer (yakaipa).

Asinganzwisisike mamota anogona kukonzera Cushing syndrome anosanganisira:

• Adrenal adenomas, bundu rakajairika iro risingawanzo kuita cortisol yakawandisa
• Macronodular hyperplasia, iyo inokonzeresa kuti maadrenal glands awedzere uye awedzere cortisol

Cancer mamota anogona kukonzera Cushing syndrome anosanganisira adrenal carcinoma. Ichi chibundu chisingawanzoitika, asi chinowanzoita cortisol yakawandisa.

Vazhinji vanhu vane Cushing syndrome vane:

• Denderedzwa, tsvuku, izere kumeso (kumeso kwemwedzi)
• Inononoka kukura mwero muvana
• Kurema kwekurema nemafuta kuwanda padanda, asi kurasikirwa kwemafuta kubva pamaoko, makumbo, uye magaro (wepakati kufutisa)

Kuchinja kweganda kunowanzoonekwa:

• Zvirwere zveganda
• Purple yakatambanudza mamaki (1/2 inch kana 1 sentimita kana kupfuura yakafara), inonzi striae, paganda redumbu, zvidya, kumusoro maoko, uye mazamu
• Ganda rakatetepa nekupwanya kuri nyore

Tsandanyama uye pfupa shanduko dzinosanganisira:

• Backache, inoitika nemabasa enguva dzose
• Kurwadziwa kwepfupa kana hunyoro
• Unganidzo yemafuta pakati pemapfudzi uye pamusoro pekora pfupa
• Ribvu uye musana kutsemuka kunokonzerwa nekuonda kwemapfupa
• Misungo isina kusimba, kunyanya yehudyu nemapendekete

Muviri-wakapamhama (systemic) shanduko dzinosanganisira:

• Nyora 2 chirwere cheshuga mellitus
• Kuwedzera kweropa
• Kuwedzera cholesterol uye triglycerides

Vakadzi vanowanzove ne:

• Bvudzi rakawandisa kukura pachiso, mutsipa, chifuva, dumbu, uye zvidya (zvakajairika kupfuura mamwe marudzi eCushing syndrome)
• Nguva dzinova dzisina kujairika kana kumira

Varume vanogona kuva:

• Yakadzikira kana isina chishuwo chebonde (yakaderera libido)
• Matambudziko ekugadzirisa

Zvimwe zviratidzo zvinogona kuitika zvinosanganisira:

• Pfungwa shanduko, senge kushushikana, kushushikana, kana shanduko mumaitiro
• Kuneta
• Kutemwa nemusoro
• Kuwedzera nyota uye kuita weti

Anopa hutano anoita bvunzo dzepanyama uye obvunza nezve zviratidzo zvako.

Kuyedza kuratidza Cushing syndrome:

• Maawa makumi maviri nemasere weti muyero kuyera cortisol uye creatinine mazinga
• Ropa bvunzo kutarisa ACTH, cortisol, uye potasiamu mazinga
• Dexamethasone kudzvinyirira bvunzo
• Ropa cortisol mazinga
• Ropa DHEA mwero
• Saliva cortisol nhanho

Kuyedza kuona chikonzero kana matambudziko anosanganisira:

• Abdominal CT
• ACTH
• Bone chicherwa kuwanda
• Cholesterol
• Kutsanya glucose

Kuvhiya kunoitwa kubvisa adrenal bundu. Kazhinji, iyo yose adrenal gland inobviswa.

Glucocorticoid kutsiva kurapwa kunowanzo kudikanwa kusvikira imwe adrenal gland yapora kubva pakuvhiya. Unogona kuda kurapwa uku kwemwedzi mitatu kusvika gumi nemiviri.

Kana kuvhiya kusingakwanisike, senge mune kenza yeadrenal yakapararira (metastasis), mishonga inogona kushandiswa kumisa kuburitswa kwecortisol.

Vanhu vane adrenal bundu vanovhiyiwa vane maonero akanaka. Kune adrenal cancer, kuvhiya dzimwe nguva hakugoneke. Kana kuvhiya kuchiitwa, hazviwanzo kurapa kenza.

Cancer adrenal tumors inogona kupararira kuchiropa kana mapapu.

Fonera mupiki wako kana iwe ukagadzira chero zviratidzo zveCushing syndrome.

Kurapa kwakakodzera kwematumbo adrenal kunogona kudzikisa njodzi yezvinetso mune vamwe vanhu vane adrenal tumor-inoenderana neCushing syndrome.

Adrenal bundu - Cushing syndrome

• Endocrine masero
• Adrenal metastases - CT scan
• Adrenal Tumor - CT

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Nieman LK, Biller BM, Kutsvaga JW, et al. Kurapa kweCushing's syndrome: iyo Endocrine Society kiriniki yekudzidzira nhungamiro. J Clin Endocrinol Metab. 2015; 100 (8): 2807-2831. PMID: 26222757 www.ncbi.nlm.nih.gov/pubmed/26222757.

Stewart PM, Newell-Mutengo JDC. Iyo adrenal cortex. Mune: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Chinyorwa cheEndocrinology. 13 ed. Philadelphia, PA: Elsevier; 2016: chits.