Inozivikanwa lipoprotein lipase kushomeka

Yakakurumbira lipoprotein lipase kushomeka iboka rezvisingawanzo maitiro ekurwara umo munhu asina puroteni inodiwa kuputsa mafuta mamorekuru. Iko kusagadzikana kunokonzera huwandu hwakawanda hwemafuta kuvaka muropa.

Inozivikanwa lipoprotein lipase kushomeka kunokonzerwa neyakaremara jeni inopfuudzwa kuburikidza nemhuri.

Vanhu vane chirwere ichi vanoshaya enzyme inonzi lipoprotein lipase. Pasina iyi enzyme, muviri haugone kupaza mafuta kubva kuchikafu chakagayiwa. Mafuta emafuta anonzi chylomicrons anovaka muropa.

Njodzi zvinhu zvinosanganisira nhoroondo yemhuri ye lipoprotein lipase kushomeka.

Mamiriro acho anowanzoonekwa pakutanga paucheche kana paudiki.

Zviratidzo zvinogona kusanganisira chero zvinotevera:

• Kusuruvara kwepamuviri (kungaratidzika secoli muvacheche)
• Kupererwa nechido
• Nausea, kurutsa
• Marwadzo mumhasuru nemapfupa
• Yakawedzera chiropa uye spleen
• Kukundikana kubudirira muvacheche
• Mafuta anoiswa muganda (xanthomas)
• High triglyceride mazinga muropa
• Pale retinas uye neropa-chena tsinga dzeropa mumaziso
• Kusingaperi kuzvimba kwerwatata
• Kupenya kweziso uye ganda (jaundice)

Anopa hutano anozoongorora muviri uye obvunza nezve zviratidzo.

Kuongororwa kweropa kuchaitwa kutarisa cholesterol uye triglyceride mazinga. Dzimwe nguva, kuongororwa kweropa kwakakosha kunoitwa mushure mekunge iwe wapiwa vatete veropa kuburikidza netsinga. Muedzo uyu unotarisa lipoprotein lipase chiitiko muropa rako.

Genetic bvunzo dzinogona kuitwa.

Kurapa kunovavarira kudzora zviratidzo uye neropa triglyceride mazinga ane yakaderera-mafuta kudya. Wako mupi angangokurudzira kuti iwe usadya anopfuura makumi maviri magiramu emafuta pazuva kudzivirira zviratidzo kubva mukudzoka.

Makumi maviri magiramu emafuta akaenzana nechimwe cheizvi:

• Magirazi maviri e8-ounce (240 milliliters) emukaka wakazara
• 4 mashupuni (9.5 gramu) yemargarine
• 4 ounces (113 gramu) kushumira nyama

Ivhareji yekudya kweAmerica ine mafuta anosvika kusvika ku45% yehoriyamu macalorie. Mafuta-anogadzikana mavhitaminzi A, D, E, uye K uye zvicherwa zvinowedzera zvinokurudzirwa kune vanhu vanodya yakaderera-mafuta kudya. Iwe ungangoda kukurukura zvako zvekudya zvinodiwa nemupi wako uye akanyoreswa dietitian.

Pancreatitis inoenderana neepoprotein lipase kushomeka inopindura kurapwa kwechirwere ichocho.

Izvi zviwanikwa zvinogona kupa rumwe ruzivo nezve yemhuri lipoprotein lipase kushomeka:

• National Sangano reRare Dambudziko - rarediseases.org/rare-diseases/familial-lipoprotein-lipase-deficiency
• NIH Genetics Kumba Referensi - ghr.nlm.nih.gov/condition/familial-lipoprotein-lipase-deficiency

Vanhu vane chirwere ichi vanotevera kudya kwakaderera-mafuta vanogona kurarama mukukura.

Pancreatitis uye zvinowanzoitika zvikamu zvekurwadziwa mudumbu zvinogona kukura.

Xanthomas haiwanzo kurwadza kunze kwekunge yakwizwa zvakanyanya.

Fonera mupiki wako kuti aongorore kana mumwe munhu mumhuri yako aine lipoprotein lipase kushomeka. Genetic counselling inokurudzirwa kune chero munhu ane mhuri nhoroondo yechirwere ichi.

Iko hakuna kunozivikanwa kudzivirira kweichi chisingawanzo, chakagara nhaka kusagadzikana. Kuziva nezve njodzi kunogona kubvumidza kutanga kuona. Kuteedzera kudya kwakaderera-mafuta kunogona kugadzirisa zviratidzo zvechirwere ichi.

Type I hyperlipoproteinemia; Inozivikanwa chylomicronemia; Kuzivikanwa kweLPL kushomeka

• Coronary tsinga chirwere

Genest J, Libby P. Lipoprotein kusagadzikana uye chirwere chemoyo. Mune: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Chirwere Chemwoyo cheBraunwald: A Chinyorwa cheCardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019: chitsuwa 48.

Semenkovich CF, Goldberg AC, Goldberg IJ. Kushushikana kwe lipid metabolism. Mune: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Chinyorwa cheEndocrinology. 13 ed. Philadelphia, PA: Elsevier; 2016: chits. 37.