Mishonga ye osteoporosis

Osteoporosis chirwere chinokonzeresa kuti mapfupa apwanye uye anogona kutsemuka (kutyoka). Ne osteoporosis, mapfupa anorasikirwa nehuremu. Kuwanda kwepfupa ihwo huwandu hweyakaenzana mapfupa emapfupa ari mumapfupa ako.

Chiremba wako anogona kupa mimwe mishonga kuti ubatsire kudzikisa njodzi yako yekutyoka. Iyi mishonga inogona kuita kuti mapfupa muhudyu mako, musana, uye dzimwe nzvimbo dzirege kuzotyoka.

Chiremba wako anogona kupa mishonga kana:

• Kuongororwa kwechipfupa kunoratidza kuti une osteoporosis, kunyangwe kana usati wambotyoka kare, asi njodzi yako yekutyoka yakakwira.
• Une kutyoka kwepfupa, uye kuyerwa kwefupa kunoratidza kuti une mutete kupfuura mapfupa akajairwa, asi kwete osteoporosis.
• Une pfupa rinotsemuka rinoitika pasina chero chakakomba kukuvara.

Bisphosphonates ndiyo mishonga mikuru inoshandiswa kune vese kudzivirira nekubata kurasikirwa kwepfupa. Ivo vanowanzo kutorwa nemuromo. Unogona kutora piritsi kamwechete pasvondo kana kamwe chete pamwedzi. Iwe zvakare unogona kuwana bisphosphonates kuburikidza nevevheni (IV). Kazhinji kazhinji izvi zvinoitwa kamwe kana kaviri pagore.

Zvinowanzoitika mhedzisiro ne bisphosphonates inotorwa nemuromo kuputika kwehana, kuda kurutsa, uye kurwadziwa mudumbu. Paunotora bisphosphonates:

• Tora ivo vasina chinhu mudumbu mangwanani ne6 kusvika ku8 ounces (oz), kana 200 kusvika 250 milliliters (mL), emvura isina mvura (kwete kabhoni mvura kana muto).
• Mushure mekutora piritsi, gara wakagara kana kumira kwemaminitsi makumi matatu.
• Usadye kana kunwa kwemaminitsi makumi matatu kusvika makumi matanhatu.

Kazhinji mhedzisiro mhedzisiro ndeiyi:

• Yakaderera ropa calcium calcium
• Rumwe rudzi rwegumbo-bone (femur) kuputsika
• Kukuvadza kune shaya pfupa
• Kurumidza, kujairika kwemwoyo (atrial fibrillation)

Chiremba wako anogona kuti iwe umire kutora mushonga uyu mushure memakore angangoita mashanu. Kuita izvi kunoderedza njodzi yemamwe mhedzisiro. Iri rinonzi zororo remishonga.

Raloxifene (Evista) inogona zvakare kushandiswa kudzivirira nekubata osteoporosis.

• Inogona kudzora njodzi yekutyoka kwemusana, asi kwete mamwe marudzi ezvimedu.
• Iyo yakakomba mhedzisiro mhedzisiro idiki diki njodzi yekuvhara ropa mukati memakumbo etsinga kana mumapapu.
• Mushonga uyu unogona zvakare kubatsira kudzikisa njodzi yehosha yemoyo nekenza yemazamu.
• Dzimwe sarudzo estrogen receptor modulators (SERMs) inoshandiswawo kurapa osteoporosis.

Denosumab (Prolia) mushonga unodzivirira mapfupa kuti asanyanya kusimba. Mushonga uyu:

• Inopihwa sejekiseni mushure memwedzi mitanhatu.
• Inogona kuwedzera kuwedzera kwefupa kupfuura bisphosphonates.
• Kazhinji haisi yekutanga-kurapwa kurapwa.
• Ngasave sarudzo yakanaka kune vanhu vane immune system isina kusimba kana vanotora mishonga inokanganisa immune system.

Teriparatide (Forteo) iri bio-mainjiniya fomu yeparathyroid hormone. Mushonga uyu:

• Inogona kuwedzera kuwedzera kwefupa uye kudzikisa njodzi yekutyoka.
• Inopihwa sejekiseni pasi peganda kumba, kazhinji mazuva ese.
• Inoita kunge isina chakakomba chenguva refu mhedzisiro, asi inogona kukonzera kusvotwa, dzungu, kana makumbo makumbo.

Estrogen, kana hormone kutsiva kurapa (HRT). Mushonga uyu:

• Inoshanda kwazvo mukudzivirira uye kurapa osteoporosis.
• Waive mushonga unonyanya kushandiswa osteoporosis kwemakore mazhinji. Kushandiswa kwaro kwakadzikira nekuda kwekunetseka kuti uyu mushonga wakonzera chirwere chemwoyo, gomarara repazamu, uye kugwamba kweropa.
• Ichi ichiri chakanaka sarudzo kune vakawanda vakadzi vadiki (makore makumi mashanu kusvika makumi matanhatu ekuberekwa). Kana mukadzi achitora estrogen kare, iye nachiremba wake vanofanirwa kukurukura njodzi uye zvakanakira kuzviita.

Romosuzomab (Evenity) inotarisa nzira yehormone mupfupa inonzi sclerostin. Mushonga uyu:

• Inopihwa pamwedzi sejekiseni pasi peganda kwegore rimwe.
• Inoshanda pakuwedzera kuwanda kwemapfupa.
• Inogona kuita kuti macalcium akanyanya kuderera.
• Zvinogona kuwedzera njodzi yekurwadziwa kwemoyo uye sitiroko.

Parathyroid kemikari

• Mushonga uyu unopihwa sekufurwa kwemazuva ese pasi peganda. Chiremba wako kana mukoti achakudzidzisa maitiro ekuzvipa iwe kupfura uku kumba.
• Parathyroid hormone inoshanda zvirinani kana usati wambotora bisphosphonates.

Calcitonin mushonga unoderedza mwero wekurasikirwa nemapfupa. Mushonga uyu:

• Dzimwe nguva inoshandiswa mushure mekupwanyika kwepfupa nekuti inoderedza marwadzo emapfupa.
• Zvakanyanya kushomeka kupfuura bisphosphonates.
• Inouya seyomumhino yemhino kana jekiseni.

Fonera chiremba wako nezve izvi zviratidzo kana mhedzisiro:

• Kurwadziwa pachifuva, chirungurira, kana matambudziko kumedza
• Kusvotwa uye kurutsa
• Ropa muzvigaro zvako
• Kuzvimba, kurwadziwa, kutsvuka mune rimwe remakumbo ako
• Fast moyo yakarova
• Mapundu eganda
• Marwadzo muhudyu yako kana muhudyu
• Marwadzo mushaya yako

Alendronate (Fosamax); Ibandronate (Boniva); Risedronate (Actonel); Zoledronic acid (Reclast); Raloxifene (Evista); Teriparatide (Forteo); Denosumab (Prolia); Romosozumab (Manheru); Low mapfupa arambe achirema - mishonga; Osteoporosis - mishonga

• Osteoporosis

De Paula FJA, Nhema DM, Rosen CJ. Osteoporosis: yakakosha uye yekiriniki maficha. Mune: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Chinyorwa cheEndocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020: chits.

Eastell R, Rosen CJ, Black DM, Cheung AM, Murad MH, Shoback D. Pharmacological manejimendi yemaosteoporosis mune postmenopausal vakadzi: Endocrine Society * Clinical Practice Guideline. J Clin Endocrinol Metab. 2019; 104 (5): 1595-1622. PMID: 30907953 pubmed.ncbi.nlm.nih.gov/30907953/.

• Osteoporosis