Immune hemolytic kupererwa neropa

Anemia mamiriro ezvinhu umo muviri usina masero matsvuku eropa akagwinya. Masero matsvuku eropa anopa okisijeni kumatumbu emuviri.

Masero matsvuku eropa anogara kwemazuva angangoita zana nemakumi maviri muviri usati waabvisa. Mune hemolytic anemia, matsvuku eropa muropa anoparadzwa pakutanga pane zvakajairwa.

Immune hemolytic anemia inoitika apo masoja ekudzivirira muviri anopesana nemaseru eropa mutsvuku uye nekuaparadza. Izvi zvinoitika nekuti immune system inoziva zvisirizvo aya masero eropa seenyika.

Zvimwe zvikonzero zvinogona kusanganisira:

• Mamwe makemikari, zvinodhaka, uye chepfu
• Zvirwere
• Kuisirwa ropa kubva kune anenge apa nerudzi rweropa rwusingaenderane
• Dzimwe kenza

Kana maantibhakitiriya akaumbwa achipesana nemaseru matsvuku eropa pasina chikonzero, mamiriro acho anonzi idiopathic autoimmune hemolytic anemia.

Masoja ekudzivirira chirwere anogona kukonzerwa ne:

• Kukanganiswa kwechimwe chirwere
• Kuwedzerwa kweropa kwakapfuura
• Kubata (kana rudzi rweropa rwemwana rwakasiyana neraamai)

Njodzi zvinhu zvine chekuita nezvakakonzera.

Iwe unogona kunge usina zviratidzo kana iyo anemia iri nyoro. Kana dambudziko rikakura zvishoma nezvishoma, zviratidzo zvinogona kutanga kuitika zvinosanganisira:

• Kunzwa kupera simba kana kuneta kazhinji kazhinji kupfuura zvakajairwa, kana nekurovedza muviri
• Kutemwa nemusoro
• Matambudziko ekuisa pfungwa kana kufunga

Kana kushomeka kweropa kuchikura, zviratidzo zvinogona kusanganisira:

• Musoro wakareruka paunosimuka
• Ruvara rweganda rakachenuruka (pallor)
• Kufema kwekufema
• Rurimi rwakaipa

Ungangoda bvunzo dzinotevera:

• Mhedziso reticulocyte kuverenga
• Yakananga kana isina kunangana Coombs bvunzo
• Hemoglobin mune weti
• LDH (mwero weiyi enzyme inomuka semhedzisiro yekukuvara kwetishu)
• Red blood cell count (RBC), hemoglobin, uye hematocrit
• Serum bilirubin chikamu
• Serum isina hemoglobin
• Serum haptoglobin
• Donath-Landsteiner bvunzo
• Cold agglutinins
• Yemahara hemoglobin mune iyo serum kana weti
• Hemosiderin mune weti
• Platelet kuverenga
• Mapuroteni electrophoresis - serum
• Pyruvate kinase
• Serum haptoglobin chikamu
• Weti uye fecal urobilinogen

Mushonga wekutanga wakaedzwa unowanzo kuve mushonga we steroid, senge prednisone. Kana mushonga weSteroid usingavandudze mamiriro acho, kurapwa neine intravenous immunoglobulin (IVIG) kana kubviswa kwepleen (splenectomy) kunogona kutariswa.

Iwe unogona kugamuchira kurapwa kudzvinyirira immune immune yako kana ukasapindura kune steroids. Mishonga yakadai saazathioprine (Imuran), cyclophosphamide (Cytoxan), uye rituximab (Rituxan) yakashandiswa.

Kuwedzerwa ropa kunoitwa nekuchenjerera, nekuti iro ropa rinogona kunge risingawirirane uye rinogona kukonzera kuwanda kwemasero matsvuku eropa.

Chirwere ichi chinogona kutanga nekukurumidza uye chakakomba zvakanyanya, kana chinogona kuramba chiri munyoro uye chisingade kurapwa kwakasarudzika.

Muvanhu vazhinji, steroids kana splenectomy inogona zvachose kana zvishoma kudzora anemia.

Kukosha kweanemia hakuwanzo kutungamira kurufu. Hutachiona hwakakomba hunogona kuitika sekumanikidza kwekurapwa nemaSteroids, mimwe mishonga inodzvinyirira immune system, kana splenectomy. Mishonga iyi inokanganisa kugona kwemuviri kurwisa hutachiona.

Fonera wako mupi wezvehutano kana iwe usina kutsanangurwa kuneta kana kurwadziwa kwepfupa, kana zviratidzo zvehutachiona.

Kuongorora masoja ekudzivirira muropa rakapihwa uye mune anogamuchira kunogona kudzivirira hemolytic anemia inoenderana neropa.

Kupererwa neropa - immune hemolytic; Autoimmune hemolytic kupererwa neropa (AIHA)

• Antibodies

Michel M. Autoimmune uye intravascular hemolytic anemias. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chits. 151.

Michel M, Jäger U. Autoimmune hemolytic kupererwa neropa. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chits.