Hormone kurapwa kwekenza yeprostate

Hormone yekurapa kenza yeprostate inoshandisa kuvhiya kana zvinodhaka kudzikisa iwo mahormone evarume pabonde mumuviri wemurume. Izvi zvinobatsira kudzora kukura kwekenza yeprostate.

Androgens ari echikadzi echikadzi mahormone. Testosterone ndiyo imwe mhando huru ye androgen. Kazhinji testosterone inogadzirwa nemachende. Iyo adrenal gland inogadzirawo diki shoma.

Androgens inokonzera masero emukenza eprostate kukura. Hormone kurapwa kwekenza yeprostate inoderedza huremo hwekuita hwee androgens mumuviri. Inogona kuita izvi na:

• Kumisa machende kubva mukugadzira uyerogenji uchishandisa kuvhiya kana mishonga
• Kuvhara chiitiko che androgens mumuviri
• Kumisa muviri kubva kugadzira androgens

Hormone therapy haina kumbobvira yashandiswa kune vanhu vane Stage I kana Stage II kenza yeprostate.

Inonyanya kushandiswa ku:

• Kenza yepamberi yakapararira kupfuura iyo gland yeprostate
• Gomarara rakatadza kupindura pakuvhiyiwa kana nemwaranzi
• Gomarara rakadzokazve

Inogona zvakare kushandiswa:

• Pamberi pemwaranzi kana kuvhiyiwa kubatsira kudzora mamota
• Pamwe pamwe nemwaranzi kurapwa kwecancer iyo inogona kudzokazve

Mushonga wakajairika kutora mishonga inoderedza huwandu hwee androgens inogadzirwa nemachende. Iwo anonzi luteinizing hormone-inosunungura mahormone (LH-RH) analogs (majekiseni) uye anti-androgens (mapiritsi emuromo). Iyi mishonga inoderedza uyerogen mazinga pamwe chete nekuvhiya kunoita. Rudzi urwu rwekurapa dzimwe nguva runonzi "chemakemikari."

Varume vanogamuchira uyerogen kunyimwa kurapwa vanofanirwa kuve nekutevera-bvunzo nachiremba achitsanangura mishonga:

• Mukati memwedzi mitatu kusvika kumatanhatu mushure mekutanga kurapwa
• Kamwe chete pagore, kuongorora kuwedzerwa kweropa uye kuita shuga yeropa (glucose) uye kuyedza kwecholesterol
• Kuti uwane PSA kuongororwa kweropa kuti utarise kuti kurapa kuri kushanda sei

LH-RH analogs dzinopihwa sepfuti kana sediki diki rakaiswa pasi peganda. Ivo vanopihwa chero kupi kubva kamwe pamwedzi kusvika kamwe pagore. Iyi mishonga inosanganisira:

• Leuprolide (Lupron, Eligard)
• Goserelin (Zoladex)
• Triptorelin (Trelstar)
• Histrelin (Vantas)

Mumwe mushonga, degarelix (Firmagon), mupikisi weLH-RH. Iyo inoderedza uyerogen uyero nekukurumidza uye ine mashoma mhedzisiro mhedzisiro. Iyo inoshandiswa muvarume vane gomarara repamberi.

Vamwe vanachiremba vanokurudzira kumira uye kutangazve kurapwa (kwepakati kurapwa). Maitiro aya anoita sekubatsira kudzikisa madhiragi ekurapa mitezo. Zvisinei, hazvisi pachena kana kurapwa kwepakati kunoshanda pamwe nekuenderera mberi kurapa. Zvimwe zvidzidzo zvinoratidza kuti kurapwa kwakapfuurira kunonyanya kushanda kana kuti kurapwa kwepakati kunofanirwa kungoshandiswa chete pakusarudza mhando dzekenza yeprostate.

Kuvhiya kubvisa machende (castration) kunomisa kugadzirwa kwemazhinji uyerogen mumuviri. Izvi zvinoderedza kana kumira gomarara reprostate kubva mukukura. Kunyange ichishanda, varume vazhinji havasarudze iyi sarudzo.

Mimwe mishonga inoshanda nekuvharira mhedzisiro ye androgen pane cancer maseru ekenza. Iwo anonzi anti-androgens. Iyi mishonga inotorwa semapiritsi. Ivo anowanzo shandiswa kana mishonga kudzikisa uyerogenji mazinga asisiri kushanda futi.

Anti-androgens inosanganisira:

• Flutamide (Eulexin)
• Enzalutamide (Xtandi)
• Abiraterone (Zytiga)
• Bicalutamide (Casodex)
• Nilutamide (Nilandron)

Androgens inogona kugadzirwa mune dzimwe nzvimbo dzemuviri, senge adrenal gland. Mamwe maseru ekenza yeprostate anogona zvakare kugadzira androgens. Mishonga mitatu inobatsira kumisa muviri kubva pakugadzira uyerogenes kubva munyama isiri yemachende.

Mishonga miviri, ketoconazole (Nizoral) uye aminoglutethimide (Cytradren), inorapa zvimwe zvirwere asi dzimwe nguva inoshandiswa kurapa gomarara reprostate. Yechitatu, abiraterone (Zytiga) inorapa gomarara reprostate iro rapararira kune dzimwe nzvimbo mumuviri.

Nekufamba kwenguva, kenza yeprostate inova inopokana nehomoni yekurapa. Izvi zvinoreva kuti kenza inongoda yakaderera nhanho ye androgen kuti ikure. Kana izvi zvikaitika, mimwe mishonga kana mamwe marapirwo anogona kuwedzerwa.

Androgens ane zvinokanganisa muviri wese. Nekudaro, marapirwo anoderedza aya mahormone anogona kukonzera akawanda akasiyana mhedzisiro. Paunotora nguva yakareba uchitora mishonga iyi, ndipo paunonyanya kuve nemhedzisiro.

Zvinosanganisira:

• Dambudziko rekumira uye usiri kufarira bonde
• Kuderera machende nepenisi
• Kupisa kunopisa
• Kuneta kana kutyoka mabhonzo
• Diki, isina kusimba mhasuru
• Shanduko mumafuta eropa, senge cholesterol
• Shanduko muropa shuga
• Kurera huremu
• Mafungiro anochinja
• Kuneta
• Kukura kwemazamu tishu, chipfuva nyoro

Androgen kunyimwa kurapa kunogona kuwedzera njodzi dzeshuga uye chirwere chemwoyo.

Kufunga nezve kurapwa kwehomoni yekenza yeprostate kunogona kunge kwakaomarara uye kunyange kwakaoma sarudzo. Mhando yekurapa inogona kuvimba ne:

• Ngozi yako yekenza kudzoka
• Kenza yako yakura zvakadii
• Kunyangwe mamwe marapirwo amira kushanda
• Kana gomarara rapararira

Kutaura nemupi wako nezve zvaunogona kuita uye mabhenefiti nenjodzi dzekurapwa kwega kwega kunogona kukubatsira iwe kuita sarudzo yakanakira iwe.

Androgen kunyimwa kurapa; ADT; Androgen kudzvinyirira kurapa; Yakabatanidzwa uyerogen blockade; Orchiectomy - kenza yeprostate; Castration - kenza yeprostate

• Utano hwemurume hwekubereka

American Cancer Society webhusaiti. Hormone kurapwa kwekenza yeprostate. www.cancer.org/cancer/prostate-cancer/treating/hormone-therapy.html. Yakagadziridzwa Zvita 18, 2019. Yakasvika paKurume 24, 2020.

National Cancer Institute webhusaiti. Hormone kurapwa kwekenza yeprostate. www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet. Yakagadziridzwa Kukadzi 28, 2019. Yakasvika December 17, 2019.

National Cancer Institute webhusaiti. Prostate cancer kurapwa (PDQ) - hutano nyanzvi vhezheni. www.cancer.gov/types/prostate/hp/prostate-treatment-pdq. Yakagadziridzwa Ndira 29, 2020. Yakasvika paKurume 24, 2020.

National Yakakwana Cancer Network webhusaiti. NCCN kiriniki yekudzidzira maitiro mune oncology (NCCN nhungamiro): kenza yeprostate. Shanduro 1.2020. www.nccn.org/professionals/physician_gls/pdf/prostate.pdf. Yakagadziridzwa Kurume 16, 2020. Yakasvika paKurume 24, 2020.

Eggener S. Hormonal kurapwa kwekenza yeprostate. Mune: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. Campbell-Walsh Urology. 12th ed. Philadelphia, PA: Elsevier; 2021: chits. 161.

• Kenza yeprostate