Takayasu arteritis

Takayasu arteritis iko kuzvimba kwemitsinga mikuru yakadai seaorta nematavi ayo makuru. Iyo aorta ndiyo tsinga inotakura ropa kubva pamoyo ichienda kune wese muviri.

Chikonzero chaTakayasu arteritis hachizivikanwe. Chirwere ichi chinonyanya kuitika kuvana nevakadzi vane makore ari pakati pemakumi maviri kusvika makumi mana. Chinyanya kuwanikwa muvanhu vekuEast Asia, Indian kana Mexico. Zvisinei, iko zvino yave kuoneka kazhinji kazhinji mune mamwe mativi epasi. Mageneti akati wandei anowedzera mukana wekuva nedambudziko iri akawanikwa munguva pfupi yapfuura.

Takayasu arteritis inoita kunge autoimmune mamiriro. Izvi zvinoreva kuti immune system inokanganisa kurwisa zvinyama zvine hutano mumadziro eropa. Mamiriro acho anogona zvakare kusanganisira mamwe masisitimu enhengo.

Aya mamiriro ane akawanda maficha akafanana nehofori cell arteritis kana temporal arteritis muvanhu vakura.

Zviratidzo zvinogona kusanganisira:

• Simba kushaya simba kana kurwadziwa nekushandisa
• Kurwadziwa pachifuva
• Dzungu
• Kuneta
• Kupindwa nechando
• Musoro wakareruka
• Tsandanyama kana kurwadza kwemajoini
• Mapundu eganda
• Night sweats
• Chiono chinoshanduka
• Kuonda
• Yakadzora radial pulses (pachiuno)
• Musiyano mukumanikidza kweropa pakati pemaoko maviri
• Kuwedzera kweropa (hypertension)

Panogona zvakare kuve nezviratidzo zvekuputika (pericarditis kana pleuritis).

Iko hakuna kuongororwa kweropa kunowanikwa kuti uwane chaiyo kuongororwa. Iko kuongororwa kunoitwa kana munhu aine zviratidzo uye yekufungidzira bvunzo dzinoratidza ropa reropa kusagadzikana kunoratidza kuzvimba.

Bvunzo dzinogona kuitika dzinosanganisira:

• Angiogram, kusanganisira coronary angiography
• Yakazara kuverenga ropa (CBC)
• C-inoshanda mapuroteni (CRP)
• Electrocardiogram (ECG)
• Erythrocyte sedimentation chiyero (ESR)
• Magnetic resonance angiography (MRA)
• Magnetic resonance imaging (MRI)
• Yakagadzirwa tomography angiography (CTA)
• Positron emission tomography (PET)
• Ultrasound
• X-ray yechipfuva

Kurapa kwaTakayasu arteritis kwakaoma. Nekudaro, vanhu vane kurapwa kwakakodzera vanogona kuvandudza. Izvo zvakakosha kuti uzive mamiriro acho pakutanga. Chirwere chinowanzo kuve chisingaperi, chinoda kushandiswa kwenguva refu kwemishonga inorwisa-kupisa.

MISHONGA

Vazhinji vanhu vanotanga kurapwa nemadosi epamusoro ecorticosteroids senge prednisone. Sezvo chirwere ichi chinodzorwa muyero we prednisone wakadzikira.

Mune angangoitika ese, zvinodhaka zvinodzivirira muviri zvinowedzerwa kudzikisa kudiwa kwekushandisa kwenguva yakareba prednisone uye zvakadaro chengetedza chirwere.

Zvakajairika immunosuppressive vamiririri senge methotrexate, azathioprine, mycophenolate, cyclophosphamide, kana leflunomide inowanzo kuwedzerwa.

Biologic vamiririri vanogona zvakare kushanda. Izvi zvinosanganisira TNF inhibitors senge infliximab, etanercept, uye tocilizumab.

Kuvhiya

Kuvhiya kana angioplasty kunogona kushandiswa kuvhura yakatetepa tsinga kuti ipe ropa kana kuvhura iyo yekumanikidza.

Aortic vheji yekutsiva inogona kudikanwa mune dzimwe nguva.

Ichi chirwere chinogona kuuraya pasina kurapwa. Nekudaro, nzira yakasanganiswa yekurapa uchishandisa mishonga uye kuvhiya zvakaderedza mwero wekufa. Vakuru vane mukana wakanaka wekupona kupfuura vana.

Zvinetso zvinogona kusanganisira:

• Ropa rakavhara
• Kumira kurova kwemoyo
• Kutadza kwemoyo
• Pericarditis
• Aortic vharuvhu kusakwana
• Pleuritis
• Kurohwa
• Kubuda ropa mudumbu kana kurwadziwa nekuvharika kwematumbo eropa

Fonera wako mupi wezvehutano kana iwe uine zviratidzo zveichi chiitiko. Kuchengetedza kwekukurumidza kunodiwa kana iwe uine:

• Kupomba kushoma
• Kurwadziwa pachifuva
• Kufema kunetseka

Chirwere chisina pulse, Huru-mudziyo vasculitis

• Mwoyo - chikamu kuburikidza nepakati
• Mwoyo mavharuvhu - anterior maonero
• Mavharuvhu emwoyo - maonero epamusoro

Alomari I, Patel PM. Takayasu arteritis. Muna: Ferri FF, rakanyorwa. Ferri's Clinical Mupi wezano 2020. Philadelphia, PA: Elsevier; 2020: 1342.e4-1342.e7.

Barra L, Yang G, Pagnoux C; Canadian Vasculitis Network (CanVasc). Asiri-glucocorticoid zvinodhaka zvekurapa Takayasu's arteritis: Kuongorora kwakarongeka uye meta-ongororo. Autoimmun Zvak. 2018; 17 (7): 683-693. PMID: 29729444 pubmed.ncbi.nlm.nih.gov/29729444/.

Dejaco C, Ramiro S, Duftner C, et al. EULAR kurudziro yekushandiswa kwekufungidzira mune hombe mudziyo vasculitis mukiriniki tsika. Ann Rheum Dis. 2018; 77 (5): 636-643. PMID: 29358285 pubed.ncbi.nlm.nih.gov/29358285/.

Ehlert BA, Abularrage CJ. Takayasu chirwere. Mune: Sidawy AN, Perler BA, eds. Rutherford Kuvhiya kweVascular uye Endovascular Therapy. 9th ed. Philadelphia, PA: Elsevier; 2019: chits. 139.

Serra R, Butrico L, Fugetto F, uye al. Kugadziridzwa mune pathophysiology, kuongororwa uye manejimendi yaTakayasu arteritis. Ann Vasc Kuvhiya. 2016; 35: 210-225. PMID: 27238990 pubmed.ncbi.nlm.nih.gov/27238990/.