Hyperimmunoglobulin E chirwere

Hyperimmunoglobulin E syndrome chirwere chisingawanzo, chakagara nhaka. Zvinokonzera matambudziko neganda, zvitadzo, mapapu, mapfupa nemeno.

Hyperimmunoglobulin E syndrome inonziwo Jobho chirwere. Inotumidzwa zita remunhu wemubhaibheri Jobho, uyo kutendeka kwake kwakayedzwa nechirwere nekusvina maronda eganda uye pustules. Vanhu vane chirwere ichi vane kwenguva refu, zvakakomba hutachiona hweganda.

Zviratidzo zvinowanzo kuve zviripo muhucheche, asi nekuda kwekuti chirwere ichi hachiwanzoitika, zvinotora makore akawanda usati waongororwa chaiwo.

Ongororo ichangobva kuitika inoratidza kuti chirwere ichi chinowanzo kukonzerwa nekuchinja kwemajini (mutation) kunoitika mu STAT3geni pane chromosome 17. Kuti kusarongeka kwemajini kunokonzera sei zviratidzo zvechirwere kusanzwisisike. Nekudaro, vanhu vane chirwere vane huwandu hwepamusoro-kupfuura-hwakajairwa hwemasoja anonzi IgE.

Zviratidzo zvinosanganisira:

• Mafupa uye mazino akaremara, kusanganisira kutsemuka uye kurasikirwa nemazino emwana kunonoka
• Eczema
• Ganda mapundu uye hutachiona
• Yakadzokororwa hutachiona hwechivi
• Kudzokororwa kwemapapu

Kuongorora kwepanyama kunogona kuratidza:

• Kupora kwemuzongoza (kyphoscoliosis)
• Osteomyelitis
• Dzokorora hutachiona hwechivi

Kuyedza kunoshandiswa kusimbisa kuongororwa kunosanganisira:

• Mhedziso eosinophil kuverenga
• CBC neropa kusiyanisa
• Serum globulin electrophoresis kutsvaga yakakwira ropa IgE nhanho
• Kuongorora genetic kwe STAT3 geni

Kuongorora kwemaziso kunogona kuratidza zviratidzo zveoma ziso syndrome.

X-ray yechipfuva inogona kuburitsa mapundu emapapu.

Mimwe bvunzo inogona kuitwa:

• CT scan yechifuva
• Tsika dzenzvimbo ine hutachiona
• Special kuongororwa ropa kuti utarise zvikamu zvemuviri
• X-ray yemapfupa
• CT scan yezvitadzo

Iyo yekugaya system inosanganisa akasiyana matambudziko eiyo Hyper IgE syndrome inogona kushandiswa kubatsira kuita kuti kuongororwa.

Iko hakuna kurapwa kunozivikanwa kweichi chiitiko. Chinangwa chekurapa ndechekudzivirira hutachiona. Mishonga inosanganisira:

• Mishonga inorwisa mabhakitiriya
• Antifungal uye antiviral mishonga (pazvinenge zvakakodzera)

Kuvhiya dzimwe nguva kunodiwa kubvisa mapundu.

Gamma globulin inopihwa kuburikidza netsinga (IV) inogona kubatsira kuvaka immune system kana uine hutachiona hwakanyanya.

Hyper IgE syndrome ndeye hupenyu hwese husingaperi mamiriro. Humwe hutachiona hutsva hunoda kurapwa.

Zvinetso zvinogona kusanganisira:

• Dzokororo hutachiona
• Sepsis

Fonera wako mupi wezvehutano kana iwe uine zviratidzo zveHyper IgE syndrome.

Iko hakuna yakaratidza nzira yekudzivirira Hyper IgE syndrome. Hutsanana hwakakwana hunobatsira mukudzivirira hutachiona hweganda.

Vamwe vanopa vanogona kukurudzira kudzivirira maantibhakitiriya kune vanhu vanokura hutachiona hwakawanda, kunyanya na Staphylococcus aureus. Uku kurapa hakuchinje mamiriro, asi kunogona kudzikisira matambudziko aro.

Jobho chirwere; Hyper IgE chirwere

Chong H, Green T, Larkin A. Allergy uye immunology. Mune: Zitelli BJ, McIntire SC, Nowalk AJ, eds. Zitelli naDavis 'Atlas yePediatric Panyama Kuongorora. 7th ed. Philadelphia, PA: Elsevier; 2018: chits. 4.

Holland SM, Gallin JI. Kuongororwa kwemurwere nekufungidzirwa kuti immunodeficiency. Mune: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, uye Bennett's Maitiro uye Maitiro Ezvirwere zvinotapukira. 9th ed. Philadelphia, PA: Elsevier; 2020: chits. 12.

Hsu AP, Davis J, Puck JM, Holland SM, Freeman AF. Autosomal yakakura hyper IgE syndrome. Gene Ongororo. 2012; 6. PMID: 20301786 www.ncbi.nlm.nih.gov/pubmed/20301786. Yakagadziridzwa June 7, 2012. Yakasvika muna Chikunguru 30, 2019.